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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Effects of rising CO2concentration on expression of photosynthrtic protein显示文摘 | Webber A N Nie G Y Long S P | 1994 | Photosynth Res1994，39，： | 1 |
| 3 | Trade,Wage Gapsand Specific Human Capital Accumulation显示文摘 | Long N V Riezman R Soubeyran A | 2007 | Review ofInternational Economics2007，15，6： | 1 |
| 4 | Acclimation of photosynthetic proteins to rising atmospheric CO2显示文摘 | Webber A N Nie G Long S P | 1994 | Photosynthesis Res1994，39，： | 1 |
| 5 | Comparison of leaf area index estimates from tree allometrics and measured light interception显示文摘 | Smith F W Sampson D A Long J N | 1991 | Forest Science1991，37，6： | 1 |
| 6 | Analyzing the responses of photosynthetic CO2 assimilation to long-term elevation of atmospheric CO2 concentration显示文摘 | LONG S P BAKER N R RAINES C A | 1993 | Vegetation1993，，： | 1 |
| 7 | Heat flux measurement techniques显示文摘 | Childs P R N Greenwood J R Long C A | 1999 | Pro Instn Mech Engrs1999，213，： | 1 |
| 8 | Analysis of the vacuum in fusion molding process 显示文摘 | Correia N C Robitaille F Long A C | 2005 | Analytical formulation Composites2005，，3： | 1 |
| 9 | The co evolution of new organization forms 显示文摘 | LEVIN A Y LONG C P CARROLL T N | 1999 | Organization Science1999，10，5： | 1 |
| 10 | The coevolution of new organizational forms显示文摘 | Lewin A Y Long C P Carroll T N | | 0，，10： | 1 |
| 11 | Vitamin BI2 deficiency associated with concomitant metformin and proton pump in hibitor use显示文摘 | Long A N Atwell C L Yoo W | 2012 | Diabetes Care2012，35，12： | 1 |
| 12 | A framework for three-dimensional mesoscale modeling of anisotropic swelling and mechanical deformation in lithium-ion electrodes显示文摘 | Roberts S A Brunini V E Long K N | 2014 | Journal of the Electrochemical Society2014，161，11： | 1 |
| 13 | In z,ivo addition of telomeric repeats to foreign DNA generates chromosomal DNAs in the taxol-producing fungus Pestalotiopsis microspora 显示文摘 | Long N E Smidmansky E D Archer A J | 1998 | Fungal Genet Biol1998，24，： | 1 |
| 14 | Phylogenetic analysis of the DNA sequence of the non - coding region of nuclear ribosomal DNA and chloroplast of Ephedra plants in China 显示文摘 | Long C Kakiuchi N Takahashi A Komatsu K Cai S Mikage M | 2004 | Planta Medica2004，70，11： | 1 |
| 15 | Knowledge of tuberculosis and associated heath-seeking behavior among rural Vietnamese adults with a cough for at least three weeks显示文摘 | HOA N P THORSON A E LONG N H | 2003 | Scand J Public Health Suppl2003，62，： | 1 |
| 16 | Analyzing the re- sponses of photosynthetic CO2 assimilation to long-term eleva- tion of atmospheric CO2 concentration 显示文摘 | LONG S P BAKER N R RAINS C A | 1993 | Vegetatio1993，104，： | 1 |
| 17 | Asymmetric contributions to research jointventures显示文摘 | Long N V Soubeyran A | 1999 | The Japanese Economics Review1999，50，2： | 1 |
| 18 | Active control of the vacuum infusion process显示文摘 | Modi D Correia N Johnson M Long A Rudd C Robitaille F | 2007 | Composites Part A: Applied Science and Manufacturing2007，38，5： | 1 |
| 19 | An adaptive optimal control strategy for dynamic stability enhancement of AC/DC power systems显示文摘 | Rostamkolai N Phadke A G Long W F | 1988 | IEEE Trans on Power Systems1988，3，3： | 1 |
| 20 | An adaptive optimal control stategy for dynamic stability enhancement of AC/DC power systems显示文摘 | N Rostamkolai A G Phadke W F Long | 1988 | IEEE Trans on Power Systems1988，3，3： | 1 |
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