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| 1 | Multi-institutional retrospective analysis of FOLFIRI in patients with advanced biliary tract cancers显示文摘BACKGROUND Gemcitabine plus platinum is the standard of care first-line treatment for advanced biliary tract cancers(BTC).There is no established second-line therapy,and retrospective reviews report median progression-free survival(PFS)less than 3 mo on second-line therapy.5-Fluorouracil plus irinotecan(FOLFIRI)is a commonly used regimen in patients with BTC who have progressed on gemcitabine plus platinum,though there is a paucity of data regarding its efficacy in this population.AIM To assess the efficacy of FOLFIRI in patients with biliary tract cancers.METHODS We retrospectively identified patients with advanced BTC who were treated with FOLFIRI at MD Anderson,University of Michigan and Mayo Clinic in Jacksonville.Data were collected on patient demographics,BTC subtype,response per RECIST v1.1,progression and survival.RESULTS Ninety-eight patients were included of which 74(75%)had metastatic and 24(25%)had locally advanced disease at the time of treatment with FOLFIRI.The median age was 60(range,22-86)years.The number of patients with extrahepatic cholangiocarcinoma,gall bladder cancer and intrahepatic cholangiocarcinoma were 10,17 and 71,respectively.FOLFIRI was used as 1st,2nd,3rd or 4th–Nth lines in 8,50,36 and 4 patients,respectively.Median duration on FOLFIRI in the entire cohort was 2.2(range,0.5-8.4)mo.The median PFS and overall survival were 2.4(95%confidence interval(CI):1.7-3.1)and 6.6(95%CI:4.7-8.4)mo,respectively.Median PFS for patients treated with FOLFIRI in 1st,2nd,3rd or 4th–Nth lines were 3.1,2.5,2.3 and 1.5 mo,respectively.Eighteen patients received concurrent bevacizumab(n=13)or EGFR-targeted therapy(n=5)with FOLFIRI,with a median PFS of 2.7 mo(95%CI:1.7-5.1).CONCLUSION In this largest multi-institution retrospective review of 98 patients with BTC treated with FOLFIRI,efficacy appears to be modest with outcomes similar to other cytotoxic chemotherapy regimens. | Jonathan D Mizrahi Valerie Gunchick Kabir Mody Lianchun Xiao Phanikeerthi Surapaneni Rachna T Shroff Vaibhav Sahai | 2020 | World Journal of Gastrointestinal Oncology2020，12，1： | 2 |
| 2 | 5-Amidinobenzothiophenes as dual inhibitors of factors IXa and Xa 显示文摘 | QIAOJ X CHENG X H MODI D P | 2005 | Bioorg Med Chem Lett2005，15，1： | 1 |
| 3 | Glucagon-like peptide-1 in- creases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression显示文摘 | Comu M Modi H Kawamori D | 2010 | J Bi- ol Chem2010，285，10： | 1 |
| 4 | Assessment of lexical semantic judgment abilities in alcohol-dependent subjects: an fMRI study显示文摘 | Bagga D Singh N Modi S | 2013 | J Biosci2013，38，5： | 1 |
| 5 | Structure of the dengue virus envelope protein after membrane fusion显示文摘 | Modis Y Ogata S Clements D | 2004 | Nature2004，427，6972： | 1 |
| 6 | GLUT1 expression in human breast carcinoma: correlation with known prognostic mark- ers 显示文摘 | Younes M Brown R W Mody D R | 1995 | Anticancer Res1995，15，6： | 1 |
| 7 | A survey on security issues and solutions at different layers of cloud computing 显示文摘 | Modi C Patel D Borisaniya B | 2013 | The Journal of Supercomputing2013，63，2： | 1 |
| 8 | Structure of the dengue virus envelope protein after membrane fusion显示文摘 | MODIS Y OGATA S CLEMENTS D | 2004 | Nature2004，427，6972： | 1 |
| 9 | Imipenem resistance of Pseudomonas in pneumonia: a systematic Literature reterature review显示文摘 | Zilberg M D Chen J Mody S H | 2010 | BMC Pulm Med2010，26，10： | 1 |
| 10 | Patient and physician satisfaction with proton pump inhibitors (PPIs): are there opportunities for improvement? 显示文摘 | Chey W D Mody R R Izat E | 2010 | Dig Dis Sci2010，55，12： | 1 |
| 11 | Multicenter experience with metallic ureteral stents for malignant and chronic benign ureteral obstruction显示文摘 | Modi AP Ritch CR Arend D | 2010 | J Endourol2010，24，7： | 1 |
| 12 | Bisphosphonates as antimyeloma drugs显示文摘 | Modi N D Lentzsch S | 2012 | Leu-kemia2012，26，4： | 1 |
| 13 | Operative versus nonopemtive treatment of acute undisplaced and minimally displaced scaphoid waist fractures-a systematic review显示文摘 | Modi CS Nancoo T Powers D | 2009 | Injury2009，40，3： | 1 |
| 14 | A survey of intrusion detection techniques in cloud显示文摘 | Modi C Patel D Borisaniya B | 2013 | Journal of Network and Computer Applications2013，36，1： | 1 |
| 15 | Structure of the dengue virus envelope protein after membrane fusion 显示文摘 | Modis Y Ogata S Clements D Harrison SC | 2004 | Nature2004，427，6972： | 1 |
| 16 | A survey of intru- sion detection techniques in cloud显示文摘 | Modi C Patel D Borisaniya B | 2013 | Journal of Network and Computer Applications2013，36，1： | 1 |
| 17 | High performance thin-layer chromatographic method for the determination of sparfloxacin in human plasma and its use in pharmacokinetic stusies显示文摘 | May D V Pandys K K Satia M C Modi I A Modi I R Gandhi T P | 1998 | J Pharm Biomed Anal1998，16，8： | 1 |
| 18 | Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT)sequence interconverts between asymmetric dimeric Gquadruplexes in solution显示文摘 | PHAN A T MODI Y S PATEL D J | 2004 | J Mol Biol2004，338，1： | 1 |
| 19 | International Investment Location Decisions:The Case of US Firms显示文摘 | Wheeler D Mody A | 1992 | Journal of International Economics1992，，33： | 1 |
| 20 | Resolution of recurrent conjunctival papilloma after topical and intralesional interferon a2b with partial excision in a child显示文摘 | Kothari M Mody K Chatterjee D | 2009 | J AAPOS2009，13，5： | 1 |
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