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| 1 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 2 | Prevalence of naturally occurring viral infections, Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from 2000 to 2003 显示文摘 | Schoondermark-van de Ven EM Philipse-Bergmann IM van der Logt JT | 2006 | Lab Anita2006，40，2： | 1 |
| 3 | Genus and species - specific identification of Mycoplasma by 16S rRNA amplifications 显示文摘 | Van Kuppeveld FJM Van Der Logt JTM Angulo AF | 1993 | Appl Environ Mierobiol1993，59，2： | 1 |
| 4 | Effects of dietaryant icarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuron osyltransferases显示文摘 | Van Der Logt EMJ Roelofs HMJ Van Lieshout EMM | 2004 | Anticancer research2004，24，2： | 1 |
| 5 | Role of epoxide hydrolase,NAD(P)H:quinone oxidoreductase,cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer显示文摘 | van der Logt EM Bergevoet SM Roelofs HM | 2006 | Mutat Res2006，593，12： | 1 |
| 6 | Genus- and Species-Specific Identification of Mycoplasmas by 16S rRNA Amplification 显示文摘 | van Kuppeveld F J van der Logt J T Angulo A F | 1993 | Appl Environ Microbiol1993，59，2： | 1 |
| 7 | Genus- and Species-Specific Identification of blycoplasmas by 16S rRNA Amplification 显示文摘 | van Kuppeveld F J van der Logt J T Angulo A F | 1992 | Appl Environ Microbiol1992，58，8： | 1 |
| 8 | The struc- ture of the llama heavy chain constant genes reveals a mecha- nism for heavy-chain antibody formation显示文摘 | Woolven B P Frenken L G van der Logt P | 1999 | Immunogenetics1999，50，12： | 1 |
| 9 | Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk显示文摘 | van der Logt EMJ Bergevoet SM Roelofs HMJ | 2004 | Car- cinogenesis vol2004，25，12： | 1 |
| 10 | S 100 A 12: A noninvasive marker of inflammation in inflammatory bowel disease显示文摘 | Floor Logt Andrew S Day | 2013 | Journal of Digestive Diseases2013，，： | 1 |
| 11 | Prevalence of naturally occurring viral infec-tions, Mycoplasma pulmonisand Clostridium piliformein laboratory rodents in Western Europe screened from 2000 to 2003 显示文摘 | Schoondermark-van de Ven Bergmann P Logt van der | 2006 | Lab Anita2006，40，： | 1 |
| 12 | S100A12: a noninvasive marker of in- flammation in inflammatory bowel disease 显示文摘 | van de Logt F Day AS | 2013 | J Dig Dis2013，14，2： | 1 |
| 13 | Prevalence of naturally occurring viral infections,Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from 2000-2003显示文摘 | Schoondermark-van de Ven EM Philipse-Bergmann IM Van Der Logt JT | 2006 | Lab Anim2006，40，： | 1 |
| 14 | Role of epoxide hydrolase,NAD(P)H:quinone oxidoreductase,cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer显示文摘 | van der Logt EM Bergevoet SM Roelofs HM | | 0，，1： | 1 |
| 15 | Ig G2a restriction of murine antibodies elicited by viral infections显示文摘 | COUTELIER J P VAN DER LOGT J T HEESSEN F W | 1987 | J Exp Med1987，165，1： | 1 |
| 16 | Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification 显示文摘 | van Kuppeveld FJ van der Logt JT Angulo AF | 1992 | Appl Environ Microbiol1992，58，8： | 1 |
| 17 | Prevalence of naturally occurring viral infections, Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from 2000 to 2003 显示文摘 | EME Schoondermark-van de Ven IMA Philipes-Bergmann JTM van der Logt | 2006 | Laboratory Animals2006，40，： | 1 |
| 18 | S100A12: a noninvasive marker of inflammation in inflammatory bowel disease 显示文摘 | DE LOGT F V DAY A S | 2013 | J Dig Dis2013，14，2： | 1 |
| 19 | Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk显示文摘 | Van der Logt E M Bergevoet S M Roelofs H M | 2004 | Carcinogenesis2004，25，12： | 1 |
| 20 | IgG2a restriction of murine antibodies elicited by viral infections 显示文摘 | Coutelier JP van der Logt JT | 1987 | J Exp Med1987，165，1： | 1 |
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