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| 1 | Gastrin,somatostatin,and experimental disturbance of the gastrointestinal tract in rats显示文摘INTRODUCTIONThe field of gastrointestinal hormones has expanded at a dizzying rate[1-4].Gastrointestinal hormones as regulatory peptides that appear to be major components of bodily integration and have important regulatory actions on physioligical function of the gastrointestinal tract .The successful isolation of some gastrointestinal hormones and the development of sensitive methods for their detection have led to the unexpected finding that they also exist in the brain . | Yong Li Yao~1 Bo Xu~2 Wan Dai Zhang~1 Yu Gang Song~1 ~1Institute of Gastrointestinal Diseases,Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2Department of Orthopedics Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaYong Li Yao graduated from First Military Mcdical University with a master degree in 1998.She now works in the Institute of Gastrointestinal Diseases,Nanfang Hospital as a doctoral candidate majoring gastrointestinal diseases and gastrointestinal hormones,she has published 8 papers. | 2001 | World Journal of Gastroenterology2001，7，3： | 12 |
| 2 | a Biomarker for Genetic Susceptibility to Hypersensitivity Dermatitis Induced by Trichloroethylene among Workers in China 显示文摘 | HAISHAN LI HLA-B*1301 as YUFEI DAI HANLIN HUANG | 2007 | Environmental Health Perspectives2007，115，11： | 1 |
| 3 | Fractional resurfacing:a new therapeutic modality for Becker's nevus显示文摘 | Glaich AS Goldberg LH Dai T | 2007 | Arch Dermatol2007，143，12： | 1 |
| 4 | BRIT1 regulates early DNA damage response,chromosomal integrity and cancer显示文摘 | Rai R Dai H Multani AS | 2006 | Cancer Cell2006，10，2： | 1 |
| 5 | Patterns and localization of gene expression during intramembranous bone regeneration in the rat femoral marrow ablation model显示文摘 | Kuroda S Virdi AS Dai Y | 2005 | CalcifTissue Int2005，77，4： | 1 |
| 6 | BRIT1 regulates early DNA damage response,chromosomal integrity and cancer显示文摘 | Rai R Dai H Multani AS | | 0，，02： | 1 |
| 7 | BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer 显示文摘 | Rai R Dai H Multani AS et ai | 2006 | Cancer Cell2006，10，2： | 1 |
| 8 | IL-15 as memory T-cell adjuvant for topical HIV-1 DermaVir vaccine显示文摘 | Calarotaa AS Dai A Trocio NJ | 2008 | Vaccine2008，26，40： | 1 |
| 9 | BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer显示文摘 | Rai R Dai H Muhani AS et aI | 2006 | Cancer Cell2006，10，2： | 1 |
| 10 | Britl regulates early DNA damage response,chromosomal integrity,and canc- er显示文摘 | Rai R Dai H Multani AS | 2006 | Cancer Cell2006，10，2： | 1 |
| 11 | Frac- tional resurfacing: a new therapeutic modali- ty for Becker's nevus 显示文摘 | Glaich AS Goldberg LH Dai T | 2007 | Arch Dermatol2007，143，12： | 1 |
| 12 | The Common Land Model 显示文摘 | Dai Y Zeng X Dickinson RE Baker I Bonan GB Bosilovich MG Denning AS Dirmeyer PA Houser PR Niu G Oleson KW Schlosser CA Yang Z-L | | Bulletin of the American Meteorological Society0，84，： | 1 |
| 13 | Patterns and localization of gene expression during intramcmbranous bone regeneration in the rat femoral marrow ablation model 显示文摘 | Kuroda S Virdi AS Dai Y | 2005 | Calcif Tissue Int2005，77，： | 1 |
| 14 | Frac- tional photothermolysis for the treatment of telangiectatic matting : a case report 显示文摘 | Glaich AS Goldberg LH Dai T | 2007 | Cos- met Laser Ther2007，9，2： | 1 |
| 15 | Effects of functionalized and nonfunctionalized single-walled carbon nanotubes on root elongation of select crop species显示文摘 | Ca(n)as J E Long M Nations S Vadan R Dai L Luo M Ambikapathi R Lee E H Olszyk D | | 0，，09： | 1 |
| 16 | BRITI regulates early DNA damage response, chromosomal integrity, and cancer 显示文摘 | Rai R Dai H Muhani AS et ol | 2006 | Cancer Cell2006，10，2： | 1 |
| 17 | Explanation of the mechanism of carcinogenesis and syntheses of anticancer agents with high selectivity显示文摘In 1979, the mechanism of chemical carcinogenesis, a challenging and difficult scientific problem pending for a number of years, was explained by Dai Qianhuan. The mechanism named di-region theory predicted that a carcinogen always metabolizes to form a special bi-functional alky-lating agent. This agent induces cross-linkages between the complementary base pairs in DNA and switches on initial mutageneses in genomes including point and frameshift mutations. This, in turn, induces further deep mutageneses including the production of various chimeric chromosomes, dele-tions and other aberrations found in genomes. In the end this initiates carcinogenesis of the whole cell through the reverse transcription mechanism after a lengthy incubation period. Recently, this labora-tory has verified that physical carcinogenesis, including the oncogenesis induced by radiation and asbestos as well as the carcinogenesis induced by endogenous factors such as estrogen or diethyl-stilbestrol switch on carcinogenesis by inducing the formation of cross-linkages between the com-plementary base pairs in DNA. Di-region theory has now been supported by many experimental observations such as mutational spectra of various carcinogens. The potential for carcinogenesis, teratogenesis, sterility and mutagenesis lumped together as genetic toxicity appears to originate almost uniformly from the cross-linking between complementary bases, i.e. malignant cross-linking, which is in accordance with di-region theory. Other forms of cross-linking between non-complementary bases, benign cross-linkings, show bi-functional alkylation anticancer activity but lack genetic toxicity. The predict-able design and synthesis of a high selectivity anticancer agent with high efficacy and low genetic toxicity, a goal long pursued in cancer chemotherapy, have been realized for the first time in this laboratory by inhibiting malignant and heightening benign cross-linking using the principles of di-region theory. A series of patented new anticancer platinum complexes called di-regioplatins, based on the above predetermined design, have been reported. In these cancer cell kill rates, tu-mor-inhibition rates and the ultimate life-span for two mouse carcinoma models using several com-pounds of cis-di-substituted-benzylaminodihaloplatinum (II) are notably higher than those of cisplatin, but their toxicities all are much lower than cisplatin. Based on a predictive design using di-region the-ory and group theory, a new anticancer complex, cis-diammine-cyclopentane-1,1-dicarboxylato- platinum (II) called minoplatin, has been synthesized in this laboratory by making the minimal struc-tural revision of adding an CH2 unit on the four-member ring of carboplatin.The water solubility of minoplatin is almost double that of carboplatin, yet its lipid solubility is much higher than carboplatin. Animal acute toxicity of minoplatin is only half that of carboplatin, and the curative effect of minoplatin in a rapid growing animal tumor model of the ascites-type is remarkably higher than that of carboplatin. Genetic toxicity of minoplatin as measured by reverse mutagenesis with the TA 102 strain is only 1/200 of cisplatin and 1/10 of carboplatin. Minoplatin, as opposed to cisplatin, shows no teratogenesis to the offspring of pregnant female mice. Additionally, some recent empirical research results on anticancer platinum complexes have been explained by the di-region theory, and comments from the perspective of predicting the selectivity of anticancer agents have been presented. We anticipate that future clinical testing will demonstrate that minoplatin and di-regioplatins are the first examples in a class consisting of highly selective, low toxicity, and tailored second generation anticancer agents. | DAI Qianhuan1,2 1. Center of Chemistry and Bioengineering of Cancer Research, Beijing Polytechnic University (Now known as Beijing Univer-sity of Technology), Beijing 100022, China 2. Center of Environmental Sciences, Peking University, Beijing 100871, China | 2006 | Science China Chemistry2006，49，1： | 1 |
| 18 | BRIT1 regulates early DNA damage response,chromosomal integrity,and cancer显示文摘 | Rai R Dai H Multani AS | 2006 | Cancer Cell2006，10，2： | 1 |
| 19 | BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer 显示文摘 | Rai R Dai H Muhani AS Li K Chin K | 2006 | Cancer Cell2006，10，： | 1 |
| 20 | Fractional photothermolysis for the treatment of telangiectatic matting: a case report 显示文摘 | Glaich AS Coldberg LH Dai T | 2007 | J Cosmet Laser Ther2007，9，2： | 1 |
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