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| 1 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 2 | Ancient Changjiang channel system in the East China Sea continental shelf during the last glaciation显示文摘Based on the data of high-resolution seismic profiles, an ancient river channel sys-tem of the last glaciation occurred along the Zhedong and Xihu depression in the southeast of Hupijiao rise. The distribution of the channel fill system shows that the ancient Changjiang River went through the Changjiang depression into the low land plain of the outside continental shelf during the low sea level cycle of the last glaciation. The big channel fill into Okinawa Trough is not found due to the depletion of the river kinetic energy in the low land plain. The river discharge dispersal was of an important role to the dilution of the northern Okinawa Trough sea at that time. Six ancient river channel systems (A―F), which are main distributaries of ancient Changjiang in the East China Sea continental shelf during the last glaciation, may be buried off the modern Changjiang estuary. The distribution of these channels coincides with the zonal elevations in the sea floor. | LI Guangxue1,2, LIU Yong1, YANG Zigeng3, YUE Shuhong4, YANG Wenda5 & HAN Xibin1 1. College of Marine Geo-science, Ocean University of China, Qingdao 266003, China 2. Shandong Key Laboratory of Sea Floor Resource and Exploration Technique, Qingdao 266003, China 3. Qingdao Institute of Marine Geology, Qingdao 266071, China 4. College of Marine Environment, Ocean University of China, Qingdao 266003, China 5. First Survey Team of Marine Geology, Shanghai Bureau of Petroleum, Shanghai 201208, China | 2005 | Science China Earth Sciences2005，48，11： | 17 |
| 3 | N-terminal truncated RHT-1 proteins generated by translational reinitiation cause semi-dwarfing of wheat Green Revolution alleles显示文摘The unprecedented wheat yield increases during the Green Revolution were achieved through the introduc-tion of the Reduced height(Rht)-B1b and Rht-D1b semi-dwarfing alleles.These Rht-1 alleles encode growth-repressing DELLA genes containing a stop codon within their open reading frame that confers gibberellin(GA)-insensitive semi-dwarfism.In this study,we successfully took the hurdle of detecting wild-type RHT-1 proteins in different wheat organs and confirmed their degradation in response to GAs.We further demonstrated that Rht-B1b and Rht-D1b produce N-terminal truncated proteins through trans-lational reinitiation.Expression of these N-terminal truncated proteins in transgenic lines and in Rht-D1c,an allele containing multiple Rht-D1b copies,demonstrated their ability to cause strong dwarfism,resulting from their insensitivity to GA-mediated degradation.N-terminal truncated proteins were detected in spikes and nodes,but not in the aleurone layers.Since Rht-B 1b and Rht-D1b alleles cause dwarfism but have wild-type dormancy,this finding suggests that tissue-specific differences in translational reinitiation may explain why the Rht-1 alleles reduce plant height without affecting dormancy.Taken together,our findings not only reveal the molecular mechanism underlying the Green Revolution but also demonstrate that trans-lational reinitiation in the main open reading frame occurs in plants. | Karel Van De Velde Stephen GThomas Floor Heyse Rim Kaspar Dominique Van Der Straeten Antje Rohde | 2021 | Molecular Plant2021，14，4： | 8 |
| 4 | Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract显示文摘Esophageal atresia(EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia(72%) and gastroesophageal reflux(GER)(67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients. | Floor WT Vergouwe Madeleine Gottrand Bas PL Wijnhoven Hanneke IJsselstijn Guillaume Piessen Marco J Bruno René MH Wijnen Manon CW Spaander | 2018 | World Journal of Gastroenterology2018，24，9： | 3 |
| 5 | SOURCE RADIATION AND RESPONSES OF WAVE PROPAGATION显示文摘Recordings of seismic waves propagating from earthquake source to a station at the earth’s surface are a system response function. The convolution operator in time domain can be simplified as a multiplication operator in frequency domain. We discuss in frequency domain the separation of source, path and site effects for global scaling of earthquake source radiation. Also discussed are source scaling model, faulting mechanism, and the H/V inversion problems with crustal and near surface structures. Gross features of apparent source spectra appear to be not much region dependent although there may be difference between tectonic styles within a region of tectonic mixture for which we need further study as data accumulate. Vertical spectra may be a better approach to approximate source radiation, as it has less crustal amplification effects than horizontal spectra. The H/V ratio is evidently a comprehensive indicator of amplification effects from near surface to deep structure. This gives it potential as an inversion tool to deduce site crustal structure. | CHEN Sheng zao 1 and Gail M Atkinson 2 (1. Geomatrix Consultants, Inc., 2101 Webster St., 12 th Floor, Oakland, CA 94612, USA, formerly at Dept. Earth Sciences & Ottawa Carleton Geoscience Center, Carleton University, Ottawa, Canada 2. Dept. Ea | 2001 | Geotectonica et Metallogenia2001，25，1： | 2 |
| 6 | Quantitative resistance against Bemisia tabaci in Solanum pennellii:Genetics and metabolomics显示文摘The whitefly Bemisia tabaci is a serious threat in tomato cultivation worldwide as all varieties grown today are highly susceptible to this devastating herbivorous insect.Many accessions of the tomato wild relative Solanum pennellii show a high resistance towards B. tabaci. A mapping approach was used to elucidate the genetic background of whiteflyresistance related traits and associated biochemical traits in this species. Minor quantitative trait loci(QTLs) for whitefly adult survival(AS) and oviposition rate(OR) were identified and some were confirmed in an F2BC1 population, where they showed increased percentages of explained variance(more than 30%). Bulked segregant analyses on pools of whiteflyresistant and-susceptible F2 plants enabled the identification of metabolites that correlate either with resistance or susceptibility. Genetic mapping of these metabolites showed that a large number of them co-localize with whiteflyresistance QTLs. Some of these whitefly-resistance QTLs are hotspots for metabolite QTLs. Although a large number of metabolite QTLs correlated to whitefly resistance or susceptibility, most of them are yet unknown compounds and further studies are needed to identify the metabolic pathways and genes involved. The results indicate a direct genetic correlation between biochemical-based resistance characteristics and reduced whitefly incidence in S. pennellii. | Floor van den Oever-van den Elsen Alejandro F.Lucatti Sjaak van Heusden Colette Broekgaarden Roland Mumm Marcel Dicke Ben Vosman | 2016 | Journal of Integrative Plant Biology2016，58，4： | 2 |
| 7 | Cancer cells in epithelial-to-mesenchymal transition and tumor- propagating-cancer stem cells : distinct, overlapping or same populations 显示文摘 | Floor S van Staveren WC Larsimont D | 2011 | Oncogene2011，30，： | 1 |
| 8 | E3 ubiquitin-protein ligase activity of parkin is dependent on cooperative interaction of ring finger(TRIAD) elements显示文摘 | Rankin CA Joazeiro CA Floor E | 2001 | J Biomed Sci2001，6，： | 1 |
| 9 | Iron as a vulnerability factor in nigrostriatal degeneration in aging and Parkinson's disease 显示文摘 | Floor E | 2000 | Cell Mol Biol (Noisy-legrand)2000，46，4： | 1 |
| 10 | Seasonal mosquito fluctuationsin Da Nang,south Vietnam,based on three prevalent species显示文摘 | Floore TG Grothaus RH Miner WF | 1971 | Mosquito News1971，31，3： | 1 |
| 11 | Dietary fiber and coronary heart disease显示文摘 | Anderson JW Deakins DA Floore TL | 1990 | Crit Rev Food Sci Nutr1990，29，： | 1 |
| 12 | A Neurophysiological Study显示文摘 | Smith AR Hosker GL Warrell DW〉The Role of Partial Denervation of the Pelvic Floor in the Aetiology of Genitourinary Prolapse and Stress Incontinence of Urine | 1989 | Br J Obstet and Gynaecol1989，96，： | 1 |
| 13 | A functional assay in yeast for the human estrogen receptor displays wild type and variant estrogen receptor messenger RNAs present in breast carcinoma显示文摘 | Mariska AJ Floore AN kim IM | 1997 | Cancer Res1997，57，： | 1 |
| 14 | Converting a breast cancer microarray signature into a high-throughput diagnostic test显示文摘 | Glas AM Floore A Delahaye LJ | 2006 | BMC Genomics2006，7，： | 1 |
| 15 | Biomass energy and the poor in the developing countries显示文摘 | Barnes D Floor G | 1999 | Journal of International Affairs1999，53，1： | 1 |
| 16 | Converting a breast cancer microarray signature into a high-throughput diagnostic test 显示文摘 | Glas AM Floore A Delahaye LJ | 2006 | BMC Genomics2006，7，： | 1 |
| 17 | Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells 显示文摘 | DAVIES S ELLIOTT M H FLOOR E TRUSCOTT T G ZAREBA M SARNA T SHAMSIF A BOULTON M E | 2001 | Free Radic Biol Med2001，31，2： | 1 |
| 18 | Invivo bioluminescenee imaging of locally disseminated colon carcinoma in rats显示文摘 | Zeaman S Rumping G Floor B | 2004 | Br J Cancer2004，90，6： | 1 |
| 19 | Competitive adjustment and advancement in global commodity Chains:firm strategies and trajectories in the East-Asia apparel industry 显示文摘 | Leo van Grunsven Floor Smakman | 2001 | Singapore Journal of Tropical Georgrapfy2001，22，2： | 1 |
| 20 | Do Search and Selection Operators Play Important Roles in Multi-Objective Evolutionary Algorithms:A Case Study显示文摘Multi-objective Evolutionary Algorithm (MOEA) is becoming a hot research area and quite a few aspects of MOEAs have been studied and discussed. However there are still few literatures discussing the roles of search and selection operators in MOEAs. This paper studied their roles by solving a case of discrete Multi-objective Optimization Problem (MOP): Multi-objective TSP with a new MOEA. In the new MOEA, We adopt an efficient search operator, which has the properties of both crossover and mutation, to generate the new individuals and chose two selection operators: Family Competition and Population Competition with probabilities to realize selection. The simulation experiments showed that this new MOEA could get good uniform solutions representing the Pareto Front and outperformed SPEA in almost every simulation run on this problem. Furthermore, we analyzed its convergence property using finite Markov chain and proved that it could converge to Pareto Front with probability 1. We also find that the | Yan Zhen-yu, Kang Li-shan, Lin Guang-ming ,He MeiState Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Hubei, ChinaSchool of Computer Science, UC, UNSW Australian Defence Force Academy, Northcott Drive, Canberra, ACT 2600 AustraliaCapital Bridge Securities Co. ,Ltd, Floor 42, Jinmao Tower, Shanghai 200030, China | 2003 | Wuhan University Journal of Natural Sciences2003，8，S1： | 1 |
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