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| 1 | Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients显示文摘Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients. | Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff Wenzel Sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 5 |
| 2 | Outcomes of extended versus limited indications for patients undergoing a liver resection for colorectal cancer liver metastases显示文摘 | Ronald M. Dam Toine M. Lodewick Maartje A.J. Broek Mechteld C. Jong Jan Willem Greve Rob L.H. Jansen Marc H.A. Bemelmans Ulf P. Neumann Steven W.M. Olde Damink Cornelis H.C. Dejong | 2014 | HPB2014，，6： | 1 |
| 3 | Intrapatient comparison of 308-nm monochromatic excimer light and localized narrow-band UVB phototherapy in the treatment of vitiligo:a randomized controlled trial 显示文摘 | Verhaeghe E Lodewick E van Geel N | 2011 | Dermatology2011，223，4： | 1 |
| 4 | Asthma economics : focusing on therapies thatimprove costly outcomes 显示文摘 | Gendo K Lodewick MJ | 2005 | Curr Opin Pulm Med2005，11，1： | 1 |
| 5 | Intrapatient comparison of 308-nm monochromatic excimer light and ocalized narrow-band UVB phototherapy in the treatment of vitiligo:a randomized controlled trial显示文摘 | Verhaeghe E Lodewick E van Geel N | 2011 | Dermatology2011，223，4： | 1 |
| 6 | Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway显示文摘 | Lodewick J Lamsoul I Polania A | 2009 | Virology2009，386，1： | 1 |
| 7 | Asthma economics: focusing on therapies that improve costly outcomes 显示文摘 | Gendo K Lodewick MJ | 2005 | Curr Opin Pulm Med2005，11，： | 1 |
| 8 | Intrapatient comparison of 308nm monochromatic excimer light and lo- calized narrow-band UVB phototherapy in the treatment of Vitiligo: a randomized controlled trial 显示文摘 | Verllaeghe E Lodewick E van Geel N | 2011 | Dermatology2011，223，4： | 1 |
| 9 | 查看详情显示文摘 | Keim W Hoffmann B Lodewick R | | 0，，： | 1 |
| 10 | Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein显示文摘 | LAMSOUL I LODEWICK J LEBRUN S | 2005 | Mol Cell Biol2005，25，10： | 1 |
| 11 | 显示文摘 | Hoffmann E Lodewick R | 1979 | J Mol Catal1979，6，： | 1 |
| 12 | Outcomes of extended versus limited indications for patients undergoing a liver resection for colorectal cancer liver metastases 显示文摘 | van Dam RM Lodewick TM van den Brock MA | 2014 | HPB (Oxford)2014，16，6： | 1 |
| 13 | Acetylation of the human T-cell leukenfia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway 显示文摘 | Lodewick J Lamsoul I Polania A | 2009 | Virology2009，386，1： | 1 |
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