|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B显示文摘AIM: To evaluate the clinical efficacy of salvianolic acidB (SA-B) on liver fibrosis in chronic hepatitis B.METHODS: Sixty patients with definite diagnosis of liverfibrosis with hepatitis B were included in the trial.Interferon-γ (IFN-γ) was used as control drug. Thepatients took orally SA-B tablets or received muscularinjection of IFN-γ in the double blind randomized test,The complete course lasted 6 months. The histologicalchanges of liver biopsy specimen before and after thetreatment were the main evidence in evaluation, incombination with the results of contents of serum HA,LN, Ⅳ-C, P-Ⅲ-P, liver ultrasound imaging, andsymptoms and signs.RESULTS: Reverse rate of fibrotic stage was 36.67 % inSA-B group and 30.0 % in IFN-γgroup. Inflammatoryalleviating rate was 40.0 % in SA-B group and 36.67 %in IFN-γ group. The average content of HA and Ⅳ-Cwas significantly lower than that before treatment. Theabnormal rate also decreased remarkably. Overallanalysis of 4 serological fibrotic markers showedsignificant improvement in SA-B group as comparedwith the IFN-γgroup. Score of liver ultrasound imagingwas lower in SA-B group than in IFN-γgroup (HA 36.7 %vs80 %,Ⅳ-C 3.3 % vs23.2 %). Before the treatment,ALT AST activity and total bilirubin content of patientswho had regression of fibrosis after oral administrationof SA-B, were significantly lower than those of patientswho had aggravation of fibrosis after oraladministration of SA-B. IFN-γ showed certain sideeffects (fever and transient decrease of leukocytes,occurrence rates were 50 % and 3.23 %), but SA-Bshowed no side effects.CONCLUSION: SA-B could effectively reverse liverfibrosis in chronic hepatitis B. SA-B was better than IFN-γ in reduction of serum HA content, overall decrease of4 serum fibrotic markers, and decrease of ultrasoundimaging score. Liver fibrosis in chronic hepatitis B withslight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects. | Ping Liu Yi-Yang Hu Cheng Liu Hui-Ming Xue Zhi-Qiang Xu Lie-Ming Xu Cheng-Hai Liu Hong-Tu Gu Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Da-Yuan Zhu Shanghai Institute of Metaria Medica,Chinese Academy of Sciences,Shanghai 200031,China Zhi-Qing Zhang the 4~(th) Hualyin City Hospital,Hualan City,223000,JiangSu Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 85 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | 放射性颌骨骨坏死拔牙的危险因素及作用:国家层面的队列研究显示文摘该文旨在研究接受放疗并发生放射性颌骨骨坏死(ORNJ)的头颈癌患者的相关危险因素,尤其是接受某种药物治疗后及牙的变化情况。23,527例头颈癌患者纳入研究,Cox比例风险模型用于危险因素分析。结果:ORNJ的总发生率为3.93/100人/年,颊癌患者发生ORNJ的风险最高。 | Wang TH Liu CJ Chao TF 张凌 | 2017 | 中国口腔颌面外科杂志2017，15，3： | 4 |
| 4 | Small-sized HZSM-5 zeolite as highly active catalyst for gas phase dehydration of glycerol to acrolein显示文摘 | Chun-Jiang Jia Yong Liu Wolfgang Schmidt An-Hui Lu Ferdi Schüth | 2009 | Journal of Catalysis2009，，1： | 2 |
| 5 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 6 | Comparison Between F-18-FDG Positron Emission Tomography and Histology for the Assessment of Tumor Necrosis Rates in Primary Osteosareoma 显示文摘 | HUANG TL LIU R S CHEN TH | 2006 | J Chin Med Assoc2006，69，8： | 1 |
| 7 | The sweet potato sporamin promoter confers high- level phytase expression and improves organic phosphorus acquisition and tuber yield of transgenic potato 显示文摘 | Hong YF Liu CY Cheng KJ Hour AL Chan MT Tseng TH Chert KY Shaw JF Yu SM | 2008 | Plant Mol Biol2008，67，： | 1 |
| 8 | Expression of matrix metalloproteinase-9 in human platelets:regulation of platelet activation in in vitro and vivo studies显示文摘 | Sheu JR Fong Th Liu CM | 2004 | Pharmacol2004，143，1： | 1 |
| 9 | Long- term results of scaphoid nonun- ion treated by intercalated bone grafting and Herbert' s screw fixa- tion: a study of 49 patients for at least five years 显示文摘 | Huang YC Liu Y Chen TH | 2009 | Int Orthop2009，33，5： | 1 |
| 10 | Fixation of a tendo-Achilles avulsion fracture显示文摘 | Liu TH | 2009 | Foot AnkleSurg2009，15，： | 1 |
| 11 | Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study 显示文摘 | Shiao TH Liu C J Luo JC | 2013 | American Journal of Medicine2013，126，3： | 1 |
| 12 | The effects of the cyclosporin A,a P-glycoprotein inhibitor,on the pharmacokinetics of baicalein in the rat:a microdialysis study显示文摘 | Tsai TH Liu SC Tsai PL | 2002 | Br J Pharmacol2002，137，8： | 1 |
| 13 | Natural course and treatment of hepatitis D virus infection显示文摘 | Hsieh TH Liu CJ Chen DS | 2006 | J Formos Med Assoc2006，105，11： | 1 |
| 14 | Directed evolution for engineering pH profile of endoglucanase III from Trichoderma reesei 显示文摘 | Wang T Liu XM Yu Q Zhang X Qu YB Gao P J Wang TH | 2005 | Biomolecular Engineering2005，22，13： | 1 |
| 15 | Survival analysis in systemic lupus cry- thematosus patients on maintenance dialysis: a nationwide population- based study in Taiwan显示文摘 | Chang YS Liu CJ Wu TH | 2013 | Rheumatology (Oxford)2013，52，1： | 1 |
| 16 | Effects of dlp raerup torin a on interleukin -6 level and Fas,Bax,Bcl-2 protein expression in ischemia reperfusion myocardium显示文摘 | Chang TH Liu XY Zhang XH | 2002 | Acta Pharmacol Sin2002，23，9： | 1 |
| 17 | Quantitative Taqman RT-PCR for the detection and differentiation of European and North American strain porcine reproductive and respiratory syndrome virus显示文摘 | Egli C Thür B Liu L | 2001 | J Virol Methods2001，98，1： | 1 |
| 18 | Expressioon of matrix metalloproteinase - 9 in human platelets- regulation of platelet activation in nivitro and in vivo studies 显示文摘 | Shue JR Fong TH Liu CM | 2004 | Br J Pharmacol2004，143，1： | 1 |
| 19 | Relationship between mus-cle output and functional MRI-measured brain activation显示文摘 | Dai TH Liu JZ Sahgal V | 2001 | Experimental Brain Research2001，140，3： | 1 |
| 20 | Preparation of pyrene- functionalized fluorescent film with a benzene ring in spacer and sensitive detection to picric acid in aqueous phase 显示文摘 | Du HY He G Liu TH | 2011 | J Photochem Photobiol A: Chemistry2011，217，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员