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| 1 | The late Paleoproterozoic extension event:aulacogens and dyke Swarms in the North China craton显示文摘在北方中国 Craton (NCC ) 的延期结构和构造牵连基于 mafic 塘群和地球年代学在这篇论文被讨论,与 aulacogens 的地球年代学结合。迟了的 Paleoproterozoic 时间是在 NCC 的前寒武纪的进化的重要拐弯处点。延期系统(例如 aulacogens 和塘群) 在 NCC 是普遍的,它与类似于现代的板的僵硬特征标记 NCC 的碳化。当模特儿的 paleostress 地建议塘聚集, aulacogens 是标记超级大陆,不是 synorogenic 的开始的 arogenic 扩展和 postorogenic 扩展。在 NCC 的 mafic 塘群主要从 1.83 ~ 1.77 Ga 。NCC 的延期是很有限的易碎的扩展,平均延期比率仅仅是 0.35% 由 mafic 塘群延期计算给,大多数在 NCC 的扩展被 aulacogens 因此贡献。mafic 塘群在起源与 aulacogens 被联系。 | HOU Guiting LI Jianghai LIU Yulin QIAN Xianglin | 2006 | Progress in Natural Science:Materials International2006，16，2： | 13 |
| 2 | Discriminated sgRNAs-Based SurroGate System Greatly Enhances the Screening Efficiency of Plant Base-Edited Cells显示文摘The development of CRISPR/Cas9-mediated base editing has made genomic modification more efficient. However, selection of genetically modified cells from millions of treated cells, especially plant cells, is still challenging. In this study, an efficient surrogate reporter system based on a defective hygromycin resistance gene was established in rice to enrich base-edited cells. After step-by-step optimization, the Discriminated sgRNAs-based SurroGate system (DisSUGs) was established by artificially differentiating the editing abilities of a wild-type single guide RNA (sgRNA) targeting the surrogate reporter gene and an enhanced sgRNA targeting endogenous sites. The DisSUGs enhanced the efficiency of screening base-edited cells by 3- to 5-fold for a PmCDA1-based cytosine-to-tyrosine base editor (PCBE), and 2.5- to 6.5-fold for an adenine base editor (ABE) at endogenous targets. These targets showed editing efficiencies of <25% in the conventional systems. The DisSUGs greatly enhanced the frequency of homozygous substitutions and expanded the activity window slightly for both a PCBE and an ABE. Analyses of the total number of single-nucleotide variants from whole-genome sequencing revealed that, compared with the no-enrichment PCBE strategy, the DisSUGs did not alter the frequency of genome-wide sgRNA-independent off-target mutations, but slightly increased the frequency of target-dependent off-target mutations. Collectively, the DisSUGs developed in this study greatly enhances the efficiency of screening plant base-edited cells and will be a useful system in future applications. | Wen Xu Yongxing Yang Ya Liu Guiting Kang Feipeng Wang Lu Li Xinxin Lv Si Zhao Shuang Yuan Jinling Song Ying Wu Feng Feng Xiaoqing He Chengwei Zhang Wei Song Jiuran Zhao Jinxiao Yang | 2020 | Molecular Plant2020，13，1： | 8 |
| 3 | Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing显示文摘Baicalin,extracted from traditional Chinese medicine Scutellaria baicalensis Georg,possesses multiple pharmacological activities and has great potential for chronic skin wound repair.However,the poor solubility and lack of suitable vehicles greatly limit its further application.Herein,we proposed a convenient and robust strategy,employing PBS solution as solvent,to enhance the solubility of baicalin.Furthermore,we constructed injectable baicalin/F127 hydrogels to study their application in skin wound treatment.The composition and temperature sensitivity of baicalin/Pluronic®F-127 hydrogels were confirmed by FTIR and rheological testing,respectively.In vitro release measurement indicated that the first order model was best fitted with the release profile of baicalin from hydrogel matrix.Besides,MTT assay,AO/EO staining assay as well as hemolytic activity test revealed the excellent cytocompatibility of baicalin/F127 hydrogels.Antioxidant activity assay demonstrated the cytoprotective activity of baicalin/F127 hydrogels against reactive oxygen species(ROS).Furthermore,the in vivo experiments exhibited the ability of baicalin/F127 hydrogel to accelerate wound healing.In conclusion,this novel injectable baicalin/F127 hydrogel should have bright application for chronic wound treatment. | Guiting Liu Ziting Bao Jun Wu | 2020 | Chinese Chemical Letters2020，31，7： | 4 |
| 4 | 2D nanomaterials for tissue engineering application显示文摘Recently,tissue engineering has developed into a powerful tool for repairing and reconstructing damaged tissues and organs.Tissue engineering scaffolds play a vital role in tissue engineering,as they not only provide structural support for targeted cells but also serve as templates that guide tissue regeneration and control the tissue structure.Over the past few years,owing to unique physicochemical properties and excellent biocompatibility,various types of two-dimensional(2D)nanomaterials have been developed as candidates for the construction of tissue engineering scaffolds,enabling remarkable achievements in bone repair,wound healing,neural regeneration,and cardiac tissue engineering.These efforts have significantly advanced the development of tissue engineering.In this review,we summarize the latest advancements in the application of 2D nanomaterials in tissue engineering.First,each typical 2D nanomaterial is introduced briefly,followed by a detailed description of its applications in tissue engineering.Finally,the existing challenges and prospects for the future of the application of 2D nanomaterials in tissue engineering are discussed. | Jingyang Zhang Haolin Chen Meng Zhao Guiting Liu Jun Wu | 2020 | Nano Research2020，13，8： | 3 |
| 5 | Progress on intelligent hydrogels based on RAFT polymerization:Design strategy, fabrication and the applications for controlled drug delivery显示文摘Although intelligent hydrogels have shown bright potential application in biomedical fields,they were prepared by conventional methods and still face many serious challenges,such as uncontrollable stimulus-response and low response sensitivity.Recently,RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties,owing to the ability to efficiently construct hydrogel precursors with well-defined structure,such as block copolymer,graft copolymer,star copolymer.In this review,we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery. | Caihong Xian Qijuan Yuan Ziting Bao Guiting Liu Jun Wu | 2020 | Chinese Chemical Letters2020，31，1： | 3 |
| 6 | A gene that underwent adaptive evolution, LAC2 (LACCASE), in Populus euphratica improves drought tolerance by improving water transport capacity显示文摘Drought severely limits plant development and growth;accordingly,plants have evolved strategies to prevent water loss and adapt to water deficit conditions.However,experimental cases that corroborate these evolutionary processes are limited.The LACCASEs(LACs)family is involved in various plant development and growth processes.Here,we performed an evolutionary analysis of LACs from Populus euphratica and characterized the functions of LACs in Arabidopsis and poplar.The results showed that in PeuLACs,multiple gene duplications led to apparent functional redundancy as the result of various selective pressures.Among them,PeuLAC2 underwent strong positive selection.Heterologous expression analyses showed that the overexpression of PeuLAC2 alters the xylem structure of plants,including thickening the secondary cell wall(SCW)and increasing the fiber cell length and stem tensile strength.Altogether,these changes improve the water transport capacity of plants.The analysis of the physiological experimental results showed that PeuLAC2-OE lines exhibited a stronger antioxidant response and greater drought tolerance than WT.Three genes screened by transcriptome analysis,NAC025,BG1,and UGT,that are associated with SCW synthesis and drought stress were all upregulated in the PeuLAC2-OE lines,implying that the overexpression of PeuLAC2 thickened the SCW,improved the water transport capacity of the plant,and further enhanced its drought tolerance.Our study highlights that genes that have undergone adaptive evolution may participate in the development of adaptive traits in P.euphratica and that PeuLAC2 could be a candidate gene for molecular genetic breeding in trees. | Zhimin Niu Guiting Li Hongyin Hu Jiaojiao Lv Qiwei Zheng Jianquan Liu Dongshi Wan | 2021 | Horticulture Research2021，8，1： | 2 |
| 7 | A novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity for enhanced diabetic wound repair显示文摘Enhanced diabetic wound repair remained a global challenge.Herein,we reported a novel hydrogel with glucose-responsive hyperglycemia regulation and antioxidant activity for enhanced diabetic wound repair.In this study,gallic acid(GA)with strong antioxidant activity was grafted onto chitosan(CS)chains by one-step synthesis,and then incorporated into poly(ethylene glycol)diacrylate(PEG-DA)hydrogel matrix to obtain a novel antioxidant hybrid hydrogel(PEG-DA/CS-GA).Meanwhile,polyethyleneimine(PEI)was modified with a unique glucose-sensitive phenylboronic acid(PBA)molecule to load insulin(PEIPBA/insulin nano-particles,PEI-PBA/insulin NPs),which could be immobilized in the PEG-DA/CS-GA hybrid hydrogel by the formation of dynamic borate bond between the phenylboronic acid groups on the PEI-PBA and the polyphenol groups on the CSGA.The results indicated that the PEG-DA/PEI-PBA/insulin/CS-GA(PPIC)hydrogel platform not only had remarkable biocompatibility,but also displayed extraordinary antioxidant properties(DPPH scavenging rate>95.0%),and effectively protected cells from oxidative damage(decreased MDA levels,increased Superoxide dismutase(SOD)levels and stable GSH/GSSG levels).Meanwhile,the PPIC hydrogel also exhibited unique glucose-responsive insulin release characteristics,and effectively regulated the blood glucose level.The in vitro and in vivo results demonstrated that our PPIC hydrogel could promoted angiogenesis(increased VEGF and CD 31 expression),reshaped the inflammatory microenvironment(decreased IL-6 and increased IL-10 level),and achieved wound closure within 20 days.All these results strongly indicated that the PPIC hydrogel represented a tough and efficient platform for diabetic wound treatment. | Zejun Xu Guiting Liu Qing Li Jun Wu | 2022 | Nano Research2022，15，6： | 2 |
| 8 | Etiological role of Ahernaria alternata in human esophageal cancer显示文摘 | LIU Guiting QIAN Yuzhen ZHANG Peng | 1992 | Chin Med J (Engl)1992，105，5： | 1 |
| 9 | Identification of an aberrant cell line among human adipose tissue-derived stem cell isolates显示文摘 | Hongxiu Ning Gang Liu Guiting Lin Maurice Garcia Long-Cheng Li Tom F. Lue Ching-Shwun Lin | 2008 | Differentiation2008，，2： | 1 |
| 10 | Risk reserveconstrained economic dispatch of wind power penetrated powersystem based on UPSMC and SAGA algorithms 显示文摘 | LIU Yujiao JIANG Chuanwen XUE Guiting | 2013 | ResearchJournal of Applied Sciences Engineering and Technology2013，5，3： | 1 |
| 11 | Whole wheat flour coating with antioxidant property accelerates tissue remodeling for enhanced wound healing显示文摘As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural antioxidants.Herein,owing to the significant biomedical potential,the effect of whole wheat flour solution as antioxidant wound coating for enhanced wound healing has been studied.The results show that the low concentration of whole wheat flour solutions have good biocompatibility and can scavenge radical and intracellular ROS in vitro,accelerating tissue remodeling in vivo to promote wound healing.This kind of whole wheat flour solution has great potential application for cutaneous wound repair. | Caihong Xian Zhipeng Gu Guiting Liu Jun Wu | 2020 | Chinese Chemical Letters2020，31，6： | 1 |
| 12 | Tofu as excellent scaffolds for potential bone regeneration显示文摘Biomimetic scaffolds present the promising potential for bone regeneration.As a natural gel-like traditional food,tofu with porous architecture and proved biological safety indicated a good potential to be a natural scaffold and easy to be improved by surface modification.Hereon,we fabricated the tofubased scaffolds and systematically explored the potential for bone tissue engineering.In addition,the collagen has been introduced by simple coating to further enha nce the surface compatibility of the tofubased scaffold in bone regeneration.The results showed that the tofu-based scaffolds possessed good porous structure and cytocompatibility.Notably,the tofu-based scaffolds could improve the expression of osteogenesis-related genes and proteins,leading to better bone regeneration after 2 months of implantation.All the results indicated that to fu would become an outstanding sustainable natural porous scaffold for bone regeneration with excellent bioactivities. | Keqing Huang Guiting Liu Zhipeng Gu Jun Wu | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 13 | Etiological role of Alternaria ahernata in human esophageal cancer显示文摘 | Liu Guiting Qian Yuzhen Zhang Peng | 1992 | Chin Med J ( Engl)1992，105，5： | 1 |
| 14 | Mutage- nicity of Ahernaria alternata and Penicillium cyclopium isolated from grains in an area of high incidence of oesophageal cancer Linxian, China 显示文摘 | Zhen Yingzhong Xu Youmei Liu Guiting | 1991 | IARC Sci Publ1991，，105： | 1 |
| 15 | A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds显示文摘High oxidative stress injury and bacterial infection are the main challenges that impair wound healing in diabetic patients.Therefore,a hydrogel with enhanced antimicrobial and antioxidant properties was developed for rapid healing of diabetic wounds.In this study,chitosan methacrylate-gallic acid(CSMA-GA)polymer with antioxidant activity,antimicrobial activity,and ultraviolet(UV)-triggered gelling properties was developed as a hydrogel precursor.Meanwhile,amphiphilic Pluronic F127 molecules were used to load hydrophobic chlorhexidine drug molecules to obtain F127/chlorhexidine nanoparticle(NP)with strong antibacterial activity.Subsequently,F127/chlorhexidine NPs were encapsulated in CSMA-GA hydrogel to further enhance its antibacterial activity.The hybrid hydrogel platform(CSMA-GA/F127/chlorhexidine(CMGFC))exhibited high antibacterial efficiency(>99.9%)and strong reactive oxygen species(ROS)scavenging ability(>80.0%),which effectively protected cells from external oxidative stress(upregulated superoxide dismutase(SOD)and glutathione/oxidized glutathione disulfide(GSH/GSSG)levels and downregulated malondialdehyde(MDA)levels).Moreover,in vivo results proved that the CMGFC hydrogel significantly reduced inflammatory responses(downregulated interleukin-6(IL-6)and upregulated interleukin-10(IL-10)levels),promoted angiogenesis(upregulated vascular endothelial growth factor(VEGF)and platelet endothelial cell adhesion molecule-1(CD 31)levels),and wound healing(enhanced collagen deposition and tissue remodelling).Overall,the CMGFC hydrogel with enhanced antimicrobial and antioxidant properties demonstrated significant potential to enhance diabetic wound healing. | Zejun Xu Guiting Liu Li Zheng Jun Wu | 2023 | Nano Research2023，16，1： | 0 |
| 16 | Electrochemical construction of porous gold nanostructures on DVD substrate and its application as nonenzymatic hydrogen peroxide sensor显示文摘A simple acid-etching method was used to leach out silver from a bimetallic gold-silver based Digital Video Disc(DVD), which was further treated via a cyclic voltammetric scanning in 1 mmol/L HAu Cl4 solution to create a porous gold nanostructure. The as-fabricated electrode was characterized by field-emission scanning electron microscopy, energy-dispersed X-ray spectroscopy and X-ray diffraction. The high electro-catalytic activity of the resulting electrode toward the reduction of hydrogen peroxide(H2O2) presented excellent linear relationship in the range of 8.0×10?5 to 1.26×10?2 mol/L with the detection limit of 2.0×10-5 mol/L(S/N=3). The as-developed non-enzyme-sensor showed good reproducibility, stability, and selectivity. | Huifen Chen Xiaoping Wang Guiting Liu Aijing Lin Ying Wen Haifeng Yang | 2015 | Science China Chemistry2015，58，10： | 0 |
| 17 | L-Arginine based polyester amide/hyaluronic acid hybrid hydrogel with dual anti-inflammation and antioxidant functions for accelerated wound healing显示文摘Nowadays, there are still many challenges to skin regeneration. As a new type of skin substitute, hydrogel has emerging gradually with its excellent properties. However, it is still a challenge to combine with biological active agents to facilitate skin regeneration. Under the circumstance, we synthesized argininebased poly(ester amide)(Arg-PEA) and hyaluronic acid(HA-MA), and combined them into new hybrid hydrogels via photo-crosslinking. We found that the internal structure and physicochemical properties of hybrid hydrogels were greatly improved with the increase of content of Arg-PEA. Therefore, we designed hybrid hydrogels with 5 wt% and 10 wt% of Arg-PEA content, respectively. Besides, we selected the corresponding anti-inflammatory(CRP, TNF-α) indicators to detect the anti-inflammatory properties of the hybrid hydrogels at the protein level, and the corresponding antioxidant indicators(SOD, GSH/GSSG, MDA)were selected to investigate the antioxidant properties of hybrid hydrogels at the cellular level in vitro.In addition, we also selected relevant genes to test the effect of hybrid hydrogels on fibrosis and vascularization in the process of skin wound healing in vitro and verified them in vivo with a mouse dorsum wound model. The results confirmed that Arg-PEA/HA-MA(AH) hybrid hydrogel was a prospective scaffold material for skin regeneration. | Tong Liu Guiting Liu Jianhua Zhang Zhangfan Ding Yike Li Krishna Sigdel Xiaoyi Wang Huixu Xie | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 18 | Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair显示文摘Diabetic wounds lead to a decrease in quality of life and an increase in mortality.Current treatment strategies include preventing bacterial adhesion while improving microcirculation.As a new type of wound dressing that imitates natural skin,hydrogel has gradually emerged with its excellent properties.However,existing hydrogels rarely achieve satisfactory results in promoting wound repair and antibacterial simultaneously.In this case,we prepared methacrylic anhydride chemically modified hyaluronic acid as a hydrogel matrix,added polyhexamethylene biguanide as an antibacterial component,and loaded sodium alginate/salidroside composite microspheres which could sustainably release salidroside and thus promote angiogenesis.Hybrid hydrogel(HAMA/PHMB-Ms)was synthesized via photocrosslinking,and its chemical structure,particle size distribution and microstructure were characterized.The satisfactory antibacterial properties of the HAMA/PHMB(15%)-Ms hydrogel were studied in vitro,and its antibacterial rates against E.coli and S.aureus were 97.85%and 98.56%,respectively.In addition,after demonstrating its good biocompatibility,we verified that the HAMA/PHMB-Ms hydrogel has increased granulation tissue formation,more collagen deposition,more subcutaneous capillary formation,and better wound healing than blank control,HAMA and HAMA/PHMB hydrogel on the back wound model of diabetic mice.The results confirmed that HAMA/PHMB-Ms hydrogel was a promising material for the treatment of the diabetic wounds. | Yike Li Huiyu Zheng Yaxian Liang Ming Xuan Guiting Liu Huixu Xie | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 19 | High performance solid-state thermoelectric energy conversion via inorganic metal halide perovskites under tailored mechanical deformation显示文摘Solid-state thermoelectric energy conversion devices attract broad research interests because of their great promises in waste heat recycling,space power generation,deep water power generation,and temperature control,but the search for essential thermoelectric materials with high performance still remains a great challenge.As an emerging low cost,solution-processed thermoelectric material,inorganic metal halide perovskites CsPb(I_(1–x)Br_(x))_(3) under mechanical deformation is systematically investigated using the first-principle calculations and the Boltzmann transport theory.It is demonstrated that halogen mixing and mechanical deformation are efficient methods to tailor electronic structures and charge transport properties in CsPb(I_(1–x)Br_(x))_(3) synergistically.Halogen mixing leads to band splitting and anisotropic charge transport due to symmetry-breakinginduced intrinsic strains.Such band splitting reconstructs the band edge and can decrease the charge carrier effective mass,leading to excellent charge transport properties.Mechanical deformation can further push the orbital energies apart from each other in a more controllable manner,surpassing the impact from intrinsic strains.Both anisotropic charge transport properties and ZT values are sensitive to the direction and magnitude of strain,showing a wide range of variation from 20%to 400%(with a ZT value of up to 1.85)compared with unstrained cases.The power generation efficiency of the thermoelectric device can reach as high as approximately 12%using mixed halide perovskites under tailored mechanical deformation when the heat-source is at 500 K and the cold side is maintained at 300 K,surpassing the performance of many existing bulk thermoelectric materials. | Lifu YAN Lingling ZHAO Guiting YANG Shichao LIU Yang LIU Shangchao LIN | 2022 | Frontiers in Energy2022，16，4： | 0 |
| 20 | Janus hydrogel with dual antibacterial and angiogenesis functions for enhanced diabetic wound healing显示文摘Anti-infection and neovascularization at the wound site are two vital factors that accelerate diabetic wound healing. However, for a wound healing dressing, the two functions need to work at different sites(inner and outer), giving big challenges for dressing design. In this study, we fabricated a novel sodium alginate/chitosan(SA/CS) Janus hydrogel dressing by the assembly of SA hydrogel loaded with silver nanoparticles(Ag NPs) and CS hydrogel impregnated with L-arginine loaded sodium alginate microspheres(Arg MSs) based on electrostatic interactions to combine the two functions. The outer SA-Ag NP hydrogel could prevent infection while avoiding the deposition of Ag NPs in the wound site, and the inner CS-Arg MS hydrogel on the wound surface could realize the sustained release of L-arginine and promote vascular regeneration. The composition, morphology and swelling/degradation of the SA-Ag NP/CS-Arg MS hydrogel were characterized systematically. L-Arginine release behavior has been tested and SA-Ag NP/CSArg MS hydrogel has been confirmed for excellent biocompatibility. Antibacterial and angiogenesis assays demonstrated the antibacterial and angiogenesis characteristics of the SA-Ag NP/CS-Arg MS hydrogel. Finally, in vivo diabetic wound healing assay demonstrated that the SA-Ag NP/CS-Arg MS hydrogel could significantly accelerate re-epithelialization, granulation tissue formation, collagen deposition and angiogenesis, thereby resulting in enhanced diabetic wound healing。 | Guiting Liu Yuan Zhou Zejun Xu Ziting Bao Li Zheng Jun Wu | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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