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| 1 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 2 | A review on cancer psychosomatic status interactions显示文摘 | LISSON I P CANGEM I P PIRATO D | 2001 | Neuroendocrinol Lett2001，22，3： | 1 |
| 3 | Location of alveolar clefts relative to the incisive fissure显示文摘 | Lisson JA Kjaer I | 1997 | Cleft Palate Craniofac J1997，34，4： | 1 |
| 4 | Comparison of the number and diameter of denfinal tubules in human and bovine dentine by scanning electron microscopic investigation 显示文摘 | Schilke R Lisson JA Bauss O | 2000 | Arch Oral Biol2000，45，2： | 1 |
| 5 | Primary bilateral parenchymal renal aspergillus infection显示文摘 | Scott W Lisson Walter C Hellinger Raul O Parra | 2002 | Urology2002，，2： | 1 |
| 6 | Cardioangioimmunology: the immune implication in the principle cardio vascular pathologies 显示文摘 | Lisson P Bami S Maur O | 1991 | G Ital Cardiol1991，21，6： | 1 |
| 7 | Ureteral endometriosis and coexistent urethral leiomyoma in a postmenopausal woman显示文摘 | Strang A Lisson SW Petrou SP | 2004 | Int Braz J Urol2004，30，6： | 1 |
| 8 | Interleukin 2 receptor positive cells and circulating soluble interleukin-2 receptors in patients with solid tumors are not correlated显示文摘 | Lisson P Rizzo V Barni S | 1989 | Int J Biol Markers1989，4，3： | 1 |
| 9 | The historical and future contribution of crop physiology and modelling research to sugarcane production systems显示文摘 | Lisson S N Inman-Bamber N G Robertson M J | 2005 | Field CropResearch2005，92，： | 1 |
| 10 | Determining the frequency, depth and velocity of preferential flow in the formation of hillslope runoff显示文摘 | Hardie M Lisson S Doyle R | 2010 | Vadose Zone Journal2010，9，2： | 1 |
| 11 | Transverse changes after surgical closure of complete cleft lip,alveolus and palate显示文摘 | Schilke R Trankmann J | 1999 | Clin Oral Investig1999，3，： | 1 |
| 12 | Determining the frequency,depth and velocity of preferential flow by high frequency soil moisture monitoring显示文摘 | Marcus Hardie Shaun Lisson Richard DoyleK | | 0，，01： | 1 |
| 13 | Determining the frequency, depth and velocity of preferential flow by high frequency soil moisture monitoring显示文摘 | Hardie M Lisson S Doyle R | 2013 | Journal of Contaminant Hydrology2013，144，1： | 1 |
| 14 | Blood BDNF level is gender spe- cific in severe depression显示文摘 | Kreinin A Lisson S Nesher E | 2015 | PInS One2015，10，5： | 1 |
| 15 | Treatment outcome in Angle Class Ⅱ,division I patients in pre-puberty and pubcrty after Jumping-the-bite Appliance显示文摘 | Wedler S Trankmann J Lisson JA | | 0，，02： | 1 |
| 16 | Transverse changes after surgical closure of complete cleft lip,alveolus and palate显示文摘 | Lisson JA Schilke R Trnkmann J | 1999 | Clin Oral Investig1999，3，1： | 1 |
| 17 | Comparsion of the num- ber and diameter of dentinal tubules in human and bovine den- tine by scanning electron microscopic investigation 显示文摘 | Schilke R Lisson JA Bauss O | 2000 | Arch Oral Biol2000，45，5： | 1 |
| 18 | A review on cancer psychosomatic status interactions显示文摘 | Lisson IP Cangem IP Pirato D | 2001 | Neuroendocrinol Lett2001，22，3： | 1 |
| 19 | Transverse changes after syrgical closure of complete cleft lip, alveolus and palate显示文摘 | Lisson JA Schilke R Trankmann J | 1999 | Clin Oral Investig1999，3，： | 1 |
| 20 | Modelling sugarcane production systems Ⅱ:Analysis of system performance and methodology issues显示文摘 | Lisson S N Robertson M J Keating B A | 2000 | Field Crops Research2000，68，： | 1 |
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