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| 1 | 线粒体乙醛脱氢酶在心肌缺血再灌注中的作用——从实验台到临床(英文)显示文摘急性心肌梗死是目前严重威胁人类健康的致死疾病之一,及时再灌注是限制心肌梗死面积的最有效方法,然而,再灌注本身会导致进一步的心肌损伤。线粒体乙醛脱氢酶(mitochondrial aldehyde dehydrogenase,ALDH2)被广泛熟知为代谢乙醛的酶。越来越多的证据表明ALDH2在心肌缺血再灌注中起到心肌保护的作用。动物实验表明ALDH2可减少心肌梗死面积,减轻心功能紊乱,防止再灌注性心律失常的发生。突变型ALDH2*2基因编码的ALDH2酶活性显著降低,而该基因的突变率在亚洲人群中约为40%。在亚洲人中的流行病学调查表明,ALDH2基因多态性与急性心肌梗死面积和冠状动脉疾病发生率紧密相关。因此,将ALDH2作为治疗心肌缺血再灌注损伤的靶点将很有前景。本文综述ALDH2对缺血再灌注心肌的保护作用及机制,并探讨ALDH2的转化应用研究前景。 | 庞佼佼 Linzi A.Barton 陈玉国 任骏 | 2015 | 生理学报2015，67，6： | 10 |
| 2 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 3 | The Australian legend: Writing Australian masculinity/writing ’Australian’ masculine显示文摘 | Linzi Murrie | 1998 | Journal of Australian Studies1998，，56： | 1 |
| 4 | The healing effects of autologous platelet gel on acute human skin wounds显示文摘 | Hom DB Linzie BM Huang TC | 2007 | Arch Facial Plast Surg2007，9，3： | 1 |
| 5 | 显示文摘 | 陈国南(ChenGN) 林振宇(LinZY) | 2004 | 世界科技研究与发展2004，26，： | 1 |
| 6 | The healing effects of autologous platelet gel on acute human skin wounds显示文摘 | Horn DB Linzie BM Huang TC | 2007 | Arch Facial Plast Surg2007，9，2： | 1 |
| 7 | Detection of Foreign Particles in Medical Solution Using Modified Affinity Propagation显示文摘A new detection method based on modified affinity propagation is proposed for detecting foreign particles in medical solution. The captured sequential images are used to generate moving tra jectories of possible foreign particles. The external disturbances and background are almost removed by using a series of simple and effective image processing. The extracted potential targets,including foreign particles and possible residual noises, are partitioned into a number of valid clusters by modified affinity propagation clustering, in which the new similarity measure can better reflect the intrinsic link of linearstructured datasets and the temporal constraint enforces the temporal continuity of data points. The foreign particles can be easily recognized by analyzing the cluster structure according to the continuity and smoothness of moving targets tra jectory. This algorithm combines modified affinity propagation method with the moving characteristics of different particles, and can achieve accurate partitions efficiently even though the clusters are badly adjacent. The experimental results indicate that the proposed algorithm can detect foreign particles effectively with high detection speed and accuracy. | PENG Hanghang XU Xuemei LI Lixian YIN linzi | 2018 | Chinese Journal of Electronics2018，27，1： | 1 |
| 8 | ANovelUWBCommunicationPulseDesignMethod显示文摘 | LinZY WeiP | 2006 | JournalonCommunications2006，27，6： | 1 |
| 9 | One-year and cumulative retention as predictors of success in methadone maintenance treatment: a comparison of two clinics in the United States and Israel 显示文摘 | PELES E LINZY S KREEK M | 2008 | JAddict Dis2008，27，4： | 1 |
| 10 | Synthesis of polypyrrole mi- cro/nanofibers via a self-assembly process 显示文摘 | Feng Jiangtao Yan Wei Zhang Linzi | 2009 | Microchim Acta2009，166，： | 1 |
| 11 | The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds 显示文摘 | Hom DB Linzie BM Huang TC | 2007 | Arch Facial Plast Surg2007，9，： | 1 |
| 12 | The healing effects of autol- ogous platelet gel on acute human skin wounds 显示文摘 | Hom DB Linzie BM Huang TC | 2007 | Arch Facial Plast Surg2007，9，3： | 1 |
| 13 | The healing effects of autologous platelet gel on acute human skin wounds显示文摘 | Hom DB Linzie BM Huang TC | | 0，，03： | 1 |
| 14 | The healing effects of autalogous platelet gel on acute human skin wounds显示文摘 | HOM DB LINZIE BM HUANG TC | 2007 | Arch Facial Plast Surg2007，9，： | 1 |
| 15 | Current issues in species identification for forensic science and the validity of using the eytoehrome oxidase I (COl) gene显示文摘 | Linzi W W Janette N James R | 2010 | Forensic Scienee Medicine and Pathology2010，6，3： | 1 |
| 16 | An MHC-defined Primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching显示文摘 | Larsen CP Page A Linzie KH | | 0，，11： | 1 |
| 17 | Effects of pacing parameters on entrainment of gastric slow waves in patients with gastroparesis显示文摘 | McCallum RW Schirmar B D | 1998 | J Physiol1998，274，1： | 1 |
| 18 | The healing effects of autologous platelet gel on acute human skin wounds显示文摘 | Hom DB Linzie BM Huang TC | 2007 | Arch Facial Plast Surg2007，9，： | 1 |
| 19 | Cyclic and Linear Thiopeptides from Soil-Derived Streptomyces sp.CPCC 203702 with Antiviral and Antibacterial Activities显示文摘A new cyclic thiopeptide,berninamycin F(3),three new linear thiopeptides,berninamycins G—I(4-6),and two known berninamycin derivatives,berninamycins C and D(1 and 2)were isolated from Streptomyces sp.CPCC 203702.Their structures were elucidated through HRESIMS and one-and two-dimensional NMR data,and the absolute configurations were assigned using Marfey's method.Compounds 4-6 are the first examples of linear berninamycin analogs.Notably,compound 4 is the first example of linear thiopeptide with a 1-(oxazol-2-yl)ethan-1-one group,compound 6 is the first linear thiopeptide derivative with methylated oxoacetate moiety.Compounds 1-6 exhibited excellent anti-Zika virus activities with IC_(50) values in the range of 4.4-10.5μmol/L,which were superior to that of the positive control ribavirin(IC_(50)=49.2μmol/L).Compounds 1 and 3 showed strong anti-influenza A virus activities with the IC_(50) values of 15.6 and 3.2μmol/L,respectively.Compound 1 exhibited good antibacterial activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp.pathogens. | Dewu Zhang Yujia Wang Xinxin Hu Xiaoyu Wang Linzi Li Guowei Gu Bingyuan Zhang Shan Cen Xuefu You Liyan Yu | 2021 | Chinese Journal of Chemistry2021，39，12： | 1 |
| 20 | Bone formation inec- topic and osteogenic tissue induced by a novel BMP-2-related peptide combined with rat tail collagen 显示文摘 | LIJ F LINZY ZHENGQX etal | 2010 | Biotechnol Bioprocess Eng2010，15，5： | 1 |
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