|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 2 | Synthesis of polypyrrole mi- cro/nanofibers via a self-assembly process 显示文摘 | Feng Jiangtao Yan Wei Zhang Linzi | 2009 | Microchim Acta2009，166，： | 1 |
| 3 | Cyclic and Linear Thiopeptides from Soil-Derived Streptomyces sp.CPCC 203702 with Antiviral and Antibacterial Activities显示文摘A new cyclic thiopeptide,berninamycin F(3),three new linear thiopeptides,berninamycins G—I(4-6),and two known berninamycin derivatives,berninamycins C and D(1 and 2)were isolated from Streptomyces sp.CPCC 203702.Their structures were elucidated through HRESIMS and one-and two-dimensional NMR data,and the absolute configurations were assigned using Marfey's method.Compounds 4-6 are the first examples of linear berninamycin analogs.Notably,compound 4 is the first example of linear thiopeptide with a 1-(oxazol-2-yl)ethan-1-one group,compound 6 is the first linear thiopeptide derivative with methylated oxoacetate moiety.Compounds 1-6 exhibited excellent anti-Zika virus activities with IC_(50) values in the range of 4.4-10.5μmol/L,which were superior to that of the positive control ribavirin(IC_(50)=49.2μmol/L).Compounds 1 and 3 showed strong anti-influenza A virus activities with the IC_(50) values of 15.6 and 3.2μmol/L,respectively.Compound 1 exhibited good antibacterial activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp.pathogens. | Dewu Zhang Yujia Wang Xinxin Hu Xiaoyu Wang Linzi Li Guowei Gu Bingyuan Zhang Shan Cen Xuefu You Liyan Yu | 2021 | Chinese Journal of Chemistry2021，39，12： | 1 |
| 4 | Electrochemically time-dependent oxidative coupling/couplingcyclization reaction between heterocycles:tunable synthesis of polycyclic indole derivatives with fluorescence properties显示文摘A mild and practical protocol for selectively time-dependent dehydrogenative C–C coupling,as well as tandem couplingcyclization reaction between indoles or/and other heteroaromatics via electrochemically oxidative process has been demonstrated.The reaction runs under noble catalyst,external oxidant and inert gas free condition,allowing tunable access to a wide variety of synthetically useful symmetrical or nonsymmetrical heteroarene with aggregation-induced emission(AIE),and polycyclic 3-D indole derivatives with aggregation-caused quenching(ACQ)fluorescence properties.Finally,preliminary mechanistic study indicated that tunable generation of indole cation under various electrolysis potential via regulating Nprotecting group was the key to achieve cross-coupling between indoles and other heteroaromatics. | Zuozhou Ning Zhicheng Zhang Qingsong Yan Naifu Zhou Linzi Wen Xichao Peng Yu Tang Pengju Feng | 2022 | Science China Chemistry2022，65，10： | 0 |
| 5 | On the Well-Posedness for Stochastic Schrodinger Equations with Quadratic Potential显示文摘The authors investigate the influence of a harmonic potential and random perturbations on the nonlinear Schrdinger equations.The local and global well-posedness are proved with values in the space Σ(■n)={f∈H1(■n),|·|f∈L2 (■n)}.When the nonlinearity is focusing and L2-supercritical,the authors give sufficient conditions for the solutions to blow up in finite time for both confining and repulsive potential.Especially for the repulsive case,the solution to the deterministic equation with the initial data satisfying the stochastic blow-up condition will also blow up in finite time.Thus,compared with the deterministic equation for the repulsive case,the blow-up condition is stronger on average,and depends on the regularity of the noise.If φ=0,our results coincide with the ones for the deterministic equation. | Daoyuan FANG Linzi ZHANG Ting ZHANG | 2011 | Chinese Annals of Mathematics,Series B2011，32，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员