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| 1 | Lightweight 3D bioprinting with point by point photocuring显示文摘As photocrosslinkable materials,methacryloyl-modified hydrogels are widely used as bioinks in tissue engineering.Existing printing methods to use these hydrogels,including changing the viscosity of the material or mixing them with other printing components,have been explored,but their application has been limited due to low printing quality or high cost.In addition,the complex operation of bulky equipment restricts the application of these existing printing methods.This study presents a lightweight stereolithography-based three-dimensional(3D)bioprinting system with a smart mechanical and structural design.The developed bioprinter dimensions were 300 mm×300 mm×200 mm and it can be placed on a benchtop.The equipment has a mini bioink chamber to store a small amount of bioink for each printing.We systematically investigated the point-by-point curing process in the 3D bioprinting method,which can print mixed cells accurately and have good biocompatibility.Here,we provide a compact,low-cost stereolithography bioprinting system with excellent biocompatibility for 3D bioprinting with methacryloyl-modified hydrogels.It can be potentially used for drug screening,studying pathological mechanisms,and constructing biological disease models. | Peng Zhang Haoxuan Wang Peng Wang Yating Zheng Linxiang Liu Jun Hu Yande Liu Qing Gao Yong He | 2021 | Bioactive Materials2021，6，5： | 2 |
| 2 | Full-harmonic error separation technique显示文摘 | Wang Hong Li Xiongua | 1992 | Measurement Science and Technology1992，3，12： | 1 |
| 3 | Structure and mechanical properties of soy protein materials plasticized by thiodiglycol显示文摘 | Rakesh Kumar Linxiang Wang Lina Zhang | 2009 | Journal of Applied Polymer Science2009，111，2： | 1 |
| 4 | HPLCDAD-ESIMS analysis of phenolic compounds in bayberries显示文摘 | Zhongxiang Fang Min Zhang Linxiang Wang | | 0，，： | 1 |
| 5 | HPLCDAD-ESIMS analysis of phenolic compounds in bayberries显示文摘 | Zhongxiang Fang Min Zhang Linxiang Wang | 2006 | Food Chemistry2006，，： | 1 |
| 6 | Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl-methylenecyclopentanone hydrochlorides and related compounds显示文摘 | Wang jingli Zhao Linxiang Wang Rui | 2005 | Bioorganic & Medicinal Chemistry2005，13，4： | 1 |
| 7 | Identification and formation of sulfur-containing steroids in sulfur-rich heavy oils in the Jinxian Sag,Bohai Bay Basin,North China显示文摘High abundant sulfur-containing steroids were identified and detected in saturate hydrocarbon fractions of heavy oil with a high sulfur content in the Jinxian Sag,Bohai Bay Basin,North China.These sulfur-containing steroids were structurally merged into the D-ring of steroid nucleus with thiophene ring and/or combined into the C-22 in the side-chain.Based on the previous reports of sulfur-containing steroids with methylthio-steroids and intra-molecular form,four formation mechanisms of sulfur-containing steroids and diagenetic pathway of steroids under S-rich conditions were proposed in this paper according to the double bond positions in the sterene compounds.Hydrogenation and sulfurization both occurred in the diagenetic processes of olefinic bond in the side-chain of steroids:abiogenic chemical hydrogenation of H2S and HS-leads to the formation of regular steranes;a successful sulfurization process leads to the formation of the side-chain sulfur-containing steroids whereas unsuccessful cyclization and/or sulfurization result in the generation of short-chain steranes.This kind of mechanism of hydrogenation/sulfurization of side-chain olefinic bond provides a potential genesis clue for the occurrence of high abundance of short-chain steranes(higher than the common regular steroids,phytane and n-alkanes)in S-rich heavy oils and source rocks in the Jinxian Sag,Bohai Bay Basin,North China. | LU Hong WANG QingTao JIANG LinXiang ZHANG Hui LIU JinZhong SHENG GuoYing PENG PingAn | 2013 | Science China Earth Sciences2013，56，11： | 1 |
| 8 | Nonlinear vibration of circular corrugated plates 显示文摘 | WANG Xinzhi WANG Linxiang HU Xiaofang | 1987 | Appl Math Mech1987，8，3： | 1 |
| 9 | Oxygen-assisted spinodal structure achieves 1.5 GPa yield strength in a ductile refractory high-entropy alloy显示文摘Refractory high-entropy alloys(RHEAs)with room-temperature ductility are drawing growing attention for potential high-temperature applications.However,the most widely used metallurgical mechanisms appear weak in optimizing their strength and ductility.Here,we report that the nanoscale spinodal struc-ture in Ti_(41)V_(27)Hf_(15)Nb_(15)O_(2)leads to the highest tensile yield strength(∼1.5 GPa)among the existing RHEAs and good elongation of∼12%.With the aid of thermodynamic calculations,we show that oxygen plays a dominant role in controlling the formation of the spinodal structure by influencing the spinodal gap of the Ti-V-Hf-Nb system.Exploring the atomic structure of the spinodal structure(β+β^(∗)),we showed that the large lattice misfit of the spinodal phases is mainly responsible for the excellent strengthen-ing effect while the planar to wavy dislocation glide mode transition accounts for the retained ductility.This work provides a novel strategy to improve the mechanical properties of the RHEAs and deepens the understanding of their phase stabilities. | Dingcong Cui Yuyu Zhang Linxiang Liu Yue Li Lei Wang Zhijun Wang Junjie Li Jincheng Wang Feng He | 2023 | Journal of Materials Science & Technology2023，，26： | 1 |
| 10 | HPLC-DAD-ESIMS analysis of phenolic compounds in bayberries 显示文摘 | Zhongxiang Fang Min Zhang Linxiang Wang | 2007 | Food Chemistry2007，100，2： | 1 |
| 11 | Biopolymer passivation for high-performance perovskite solar cells by blade coating显示文摘Thin films of perovskite deposited from solution inevitably introduce large number of defects,which serve as recombination centers and are detrimental for solar cell performance.Although many small molecules and polymers have been delicately designed to migrate defects of perovskite films,exploiting credible passivation agents based on natural materials would offer an alternative approach.Here,an ecofriendly and cost-effective biomaterial,ploy-L-lysine(PLL),is identified to effectively passivate the defects of perovskite films prepared by blade-coating.It is found that incorporation of a small amount(2.5 mg mL^(-1))of PLL significantly boosts the performance of printed devices,yielding a high efficiency of 19.45% with an increase in open-circuit voltage by up to 100 mV.Density functional theory calculations combined with X-ray photoelectron spectroscopy reveal that the functional groups(-NH2,-COOH)of PLL effectively migrate the Pb-I antisite defects via Pb-N coordination and suppress the formation of metallic Pb in the blade-coated perovskite film.This work suggests a viable avenue to exploit passivation agents from natural materials for preparation of high-quality perovskite layers for optoelectronic applications. | Shudi Qiu Xin Xu Linxiang Zeng Zhen Wang Yijun Chen Culling Zhang Chaohui Li Jinlong Hu Tingting Shi Yaohua Mai Fei Guo | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 12 | Structure and Mechanical Properties of Soy Protein Materials Plasticized by Thiodiglycol 显示文摘 | Rakesh Kumar Linxiang Wang Lina Zhang | 2009 | Journal of Applied Poly- mer Science2009，111，2： | 1 |
| 13 | Embedded web server and database based on wap 显示文摘 | Wang ZhenXing Shi LinXiang Liu ZhongYuan Jiang Chuan- Qun | 2009 | International Conference on Computer and Automation Engineering2009，，： | 1 |
| 14 | Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment显示文摘Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even death.Although studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in RA remains unclear.In the current study,we demonstrated that STING activation was pivotal in RA pathogenesis.As the accumulation of dsDNA,a specific stimulus for STING,is a feature of RA,we developed a spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with STING antagonist C-176(PEI-PDA@C-176 NPs)for treating RA.The fabricated NPs with biocompatibility had high DNA adsorption ability and could effectively inhibit the STING pathway and inflammation in macrophages.Intra-articular administration of PEI-PDA@C-176 NPs could effectively reduce joint damage in mice models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting STING pathway.We concluded that materials with synergistic effects of STING inhibition might be an efficacious strategy to treat RA. | Haotian Shen Lulu Jin Qiangqiang Zheng Ziqiang Ye Linxiang Cheng Yuxu Wu Honghao Wu Tae Gyong Jon Wenduo Liu Zongyou Pan Zhengwei Mao Yue Wang | 2023 | Bioactive Materials2023，，6： | 1 |
| 15 | eALT-F:A New Non-Invasive Staging Method to Identify Medium to High-Risk Patients with HCC from Ultra-High HBV Viral Load Population—China,2010-2023显示文摘Background:The objective of this study was to examine the clinical characteristics of individuals with ultra-high hepatitis B virus(HBV)viral load and develop a novel staging method for chronic hepatitis B(CHB)that can more effectively identify patients with medium to high hepatocellular carcinoma(HCC)risk.Methods:A total of 2,118 patients with HBV DNA>1×10^(7) IU/mL who visited Peking University People’s Hospital between January 2010 and March 2023 were enrolled retrospectively.Clinical data from the first visit were obtained and analyzed.The traditional phases and new‘eALT-F’stages were compared to evaluate the risk of HCC.Results:In the overall patients,more than onethird of the patients were under 30 years old.Additionally,a small proportion of older people(>60 years)also had ultra-high HBV viral load(4.3%).9.1%and 6.7%of individuals with ultra-high HBV viral load showed FIB-4>3.25 and aMAP≥50,respectively.In the traditional stages of CHB,which are based on HBeAg and alanine aminotransferase(ALT)[the upper limit of normal(ULN)ALT level at 40 IU/L for both men and women],regardless of phase,a certain proportion of patients were at risk of developing HCC(4.1%,6.4%,25.0%,and 20.3%).However,in the new‘eALT-F’stages,which are based on HBeAg,ALT(the ULN of ALT level at 30 IU/L for men and 19 IU/L for women),and/or FIB-4 levels(>1.45),aMAP≥50 was only observed in chronic hepatitis patients with positive or negative HBeAg(6.4%and 22.1%,respectively).Conclusions:The‘eALT-F’staging method,based on HBeAg,ALT(males:the ULN of ALT was 30 IU/L,females:19 IU/L)and/or FIB-4 levels,was more effective in identifying medium to high-risk patients with HCC from patients with ultra-high HBV viral load than the traditional staging methods. | Jiarui Zheng Xiaoxiao Wang Zilong Wang Linxiang Huang Yandi Xie Suzhen Jiang Bo Feng | 2023 | China CDC weekly2023，5，49： | 0 |
| 16 | Calculating single layer production contribution of heavy oil commingled wells by analysis of aromatic parameters in whole-oil GC-MS显示文摘Traditional fluid production profile logging is not usually suitable for heavy-viscous crude oil wells. Biodegradation of heavy oil can lead to the loss of n-alkanes, and the use of chromatogram fingerprint techniques in studying the production contributions of single layers in heavy oil commingled wells has limitations. However, aromatic compounds are relatively well preserved. We took the heavy oil commingled wells of small layers NG55 and NG61 in the ninth area of the Gudong oil field as examples. Based on the principle of chromatography, the whole-oil GC-MS was used, and the aromatic parameters which have a strongly linear relationship with the ratio of mixed two end member oils were verified and selected in laboratory. Studies showed that the ratio of(1, 4, 6-+ 2, 3, 6-trimethylnaphthalene) to 1, 2, 5-trimethylnaphthalene has a strongly linear relationship with the ratio of the mixed two end member oils(R2=0.992). The oil contributions from single layers NG55 and NG61 in six commingled heavy oil wells were calculated using established charts and this relationship. The calculated results are consistent with the results of long period dynamic monitoring and logging interpretation in the study area and can provide a scientific basis for monitoring production performance and hierarchical management of reservoirs. The study provides a new geochemical method for calculation of the contributions of single layers in heavy oil commingled wells when conventional fluid production profile logging is not suitable. | Xu Yaohui Ma Li Li Linxiang Cui Wenfu Cheng Xiaowei Wang Xiaoping | 2014 | Petroleum Science2014，11，1： | 0 |
| 17 | PROPERTIES OF YTTRALUMINIZING COATING ON Ni-BASE SUPERALLOYS显示文摘The yttraluminizing coating on the Ni-base superalloys has been developed by dipping thespecimens in a specially made yttrium-containing slurry as an underlayer and over spraying aCr-Al slurry as a protective layer,then heating to 1060℃ and holding for 1 h under argonatmosphere.Analysis by EPMA showed that the yttrium was concentrated in the intermediatezone of the coating as metallic compound Ni-5Y.After exposure to air up to 1000℃,theoxidation test revealed that the anti-oxidation resistance of the yttraluminizing coating withpost-aluminizing is much superior to that with single aluminizing only. | WANG Fuhui LO U Hanyi BAI Linxiang Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang,China WANG Fuhui,Institute of Corrosion and Protection of Metals,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，11： | 0 |
| 18 | The dam design of Three Gorges Project显示文摘The dam of Three Gorges Project is a concrete gravity dam with the crest elevation of 185 m,the maximum height of 181 m and dam axis length of 2 309.5 m.The dam consists of spillway,powerhouse,non-over flow,ship-lift,temporary ship-lock,left diversion wall and longitudinal cofferdam blocks.Some key techniques relating to dam structure design are presented,including hydraulics of flood discharge structure,dam joint design,layout and structural type of penstock,deep anti-sliding stability of dam foundation,reconstruction of temporary ship-lock and closed drainage and pumping of dam foundation. | Wang Xiaomao Xu Linxiang Liao Renqiang | 2011 | Engineering Sciences2011，9，3： | 0 |
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