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您的检索式：作者名="Linxiang Cheng"
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| 1 | Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment显示文摘Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even death.Although studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in RA remains unclear.In the current study,we demonstrated that STING activation was pivotal in RA pathogenesis.As the accumulation of dsDNA,a specific stimulus for STING,is a feature of RA,we developed a spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with STING antagonist C-176(PEI-PDA@C-176 NPs)for treating RA.The fabricated NPs with biocompatibility had high DNA adsorption ability and could effectively inhibit the STING pathway and inflammation in macrophages.Intra-articular administration of PEI-PDA@C-176 NPs could effectively reduce joint damage in mice models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting STING pathway.We concluded that materials with synergistic effects of STING inhibition might be an efficacious strategy to treat RA. | Haotian Shen Lulu Jin Qiangqiang Zheng Ziqiang Ye Linxiang Cheng Yuxu Wu Honghao Wu Tae Gyong Jon Wenduo Liu Zongyou Pan Zhengwei Mao Yue Wang | 2023 | Bioactive Materials2023，，6： | 1 |
| 2 | Calculating single layer production contribution of heavy oil commingled wells by analysis of aromatic parameters in whole-oil GC-MS显示文摘Traditional fluid production profile logging is not usually suitable for heavy-viscous crude oil wells. Biodegradation of heavy oil can lead to the loss of n-alkanes, and the use of chromatogram fingerprint techniques in studying the production contributions of single layers in heavy oil commingled wells has limitations. However, aromatic compounds are relatively well preserved. We took the heavy oil commingled wells of small layers NG55 and NG61 in the ninth area of the Gudong oil field as examples. Based on the principle of chromatography, the whole-oil GC-MS was used, and the aromatic parameters which have a strongly linear relationship with the ratio of mixed two end member oils were verified and selected in laboratory. Studies showed that the ratio of(1, 4, 6-+ 2, 3, 6-trimethylnaphthalene) to 1, 2, 5-trimethylnaphthalene has a strongly linear relationship with the ratio of the mixed two end member oils(R2=0.992). The oil contributions from single layers NG55 and NG61 in six commingled heavy oil wells were calculated using established charts and this relationship. The calculated results are consistent with the results of long period dynamic monitoring and logging interpretation in the study area and can provide a scientific basis for monitoring production performance and hierarchical management of reservoirs. The study provides a new geochemical method for calculation of the contributions of single layers in heavy oil commingled wells when conventional fluid production profile logging is not suitable. | Xu Yaohui Ma Li Li Linxiang Cui Wenfu Cheng Xiaowei Wang Xiaoping | 2014 | Petroleum Science2014，11，1： | 0 |
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