|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lightweight 3D bioprinting with point by point photocuring显示文摘As photocrosslinkable materials,methacryloyl-modified hydrogels are widely used as bioinks in tissue engineering.Existing printing methods to use these hydrogels,including changing the viscosity of the material or mixing them with other printing components,have been explored,but their application has been limited due to low printing quality or high cost.In addition,the complex operation of bulky equipment restricts the application of these existing printing methods.This study presents a lightweight stereolithography-based three-dimensional(3D)bioprinting system with a smart mechanical and structural design.The developed bioprinter dimensions were 300 mm×300 mm×200 mm and it can be placed on a benchtop.The equipment has a mini bioink chamber to store a small amount of bioink for each printing.We systematically investigated the point-by-point curing process in the 3D bioprinting method,which can print mixed cells accurately and have good biocompatibility.Here,we provide a compact,low-cost stereolithography bioprinting system with excellent biocompatibility for 3D bioprinting with methacryloyl-modified hydrogels.It can be potentially used for drug screening,studying pathological mechanisms,and constructing biological disease models. | Peng Zhang Haoxuan Wang Peng Wang Yating Zheng Linxiang Liu Jun Hu Yande Liu Qing Gao Yong He | 2021 | Bioactive Materials2021，6，5： | 2 |
| 2 | A solid phase radioimmunoassay for free triiodothyronine in serum:assay development and validation显示文摘A solid phase radioimmunoassay for free triiodothyronine in serum was developed based on double-antibody coated tubes. The method was turned out to be reliable with good reproducibility, higher sensitivity and easy performance. The measurable range of FT3 in serum was 1.2 to 38 pmol/L. The mean coefficients of variation within and between assays were 1.79%-3.18% and 4.72%-9.31%, respectively. The FT3 concentrations in euthyroid serum as determined by this method were 2.8 to 7.8pmol/L. The FT3 values determined by this new method correlated well with those measured by a commercial radioimmunoassay (r=0.853). | LIU Fangyan ZHOU Meiying YIN Linxiang YANG Jianzhong HUA Chenglin (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800 ) | 1999 | Nuclear Science and Techniques1999，10，1： | 1 |
| 3 | Identification and formation of sulfur-containing steroids in sulfur-rich heavy oils in the Jinxian Sag,Bohai Bay Basin,North China显示文摘High abundant sulfur-containing steroids were identified and detected in saturate hydrocarbon fractions of heavy oil with a high sulfur content in the Jinxian Sag,Bohai Bay Basin,North China.These sulfur-containing steroids were structurally merged into the D-ring of steroid nucleus with thiophene ring and/or combined into the C-22 in the side-chain.Based on the previous reports of sulfur-containing steroids with methylthio-steroids and intra-molecular form,four formation mechanisms of sulfur-containing steroids and diagenetic pathway of steroids under S-rich conditions were proposed in this paper according to the double bond positions in the sterene compounds.Hydrogenation and sulfurization both occurred in the diagenetic processes of olefinic bond in the side-chain of steroids:abiogenic chemical hydrogenation of H2S and HS-leads to the formation of regular steranes;a successful sulfurization process leads to the formation of the side-chain sulfur-containing steroids whereas unsuccessful cyclization and/or sulfurization result in the generation of short-chain steranes.This kind of mechanism of hydrogenation/sulfurization of side-chain olefinic bond provides a potential genesis clue for the occurrence of high abundance of short-chain steranes(higher than the common regular steroids,phytane and n-alkanes)in S-rich heavy oils and source rocks in the Jinxian Sag,Bohai Bay Basin,North China. | LU Hong WANG QingTao JIANG LinXiang ZHANG Hui LIU JinZhong SHENG GuoYing PENG PingAn | 2013 | Science China Earth Sciences2013，56，11： | 1 |
| 4 | Oxygen-assisted spinodal structure achieves 1.5 GPa yield strength in a ductile refractory high-entropy alloy显示文摘Refractory high-entropy alloys(RHEAs)with room-temperature ductility are drawing growing attention for potential high-temperature applications.However,the most widely used metallurgical mechanisms appear weak in optimizing their strength and ductility.Here,we report that the nanoscale spinodal struc-ture in Ti_(41)V_(27)Hf_(15)Nb_(15)O_(2)leads to the highest tensile yield strength(∼1.5 GPa)among the existing RHEAs and good elongation of∼12%.With the aid of thermodynamic calculations,we show that oxygen plays a dominant role in controlling the formation of the spinodal structure by influencing the spinodal gap of the Ti-V-Hf-Nb system.Exploring the atomic structure of the spinodal structure(β+β^(∗)),we showed that the large lattice misfit of the spinodal phases is mainly responsible for the excellent strengthen-ing effect while the planar to wavy dislocation glide mode transition accounts for the retained ductility.This work provides a novel strategy to improve the mechanical properties of the RHEAs and deepens the understanding of their phase stabilities. | Dingcong Cui Yuyu Zhang Linxiang Liu Yue Li Lei Wang Zhijun Wang Junjie Li Jincheng Wang Feng He | 2023 | Journal of Materials Science & Technology2023，，26： | 1 |
| 5 | Embedded web server and database based on wap 显示文摘 | Wang ZhenXing Shi LinXiang Liu ZhongYuan Jiang Chuan- Qun | 2009 | International Conference on Computer and Automation Engineering2009，，： | 1 |
| 6 | Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment显示文摘Rheumatoid arthritis(RA)is a common autoimmune disease leading to pain,disability,and even death.Although studies have revealed that aberrant activation of STING was implicated in various autoimmune diseases,the role of STING in RA remains unclear.In the current study,we demonstrated that STING activation was pivotal in RA pathogenesis.As the accumulation of dsDNA,a specific stimulus for STING,is a feature of RA,we developed a spherical polyethyleneimine-coated mesoporous polydopamine nanoparticles loaded with STING antagonist C-176(PEI-PDA@C-176 NPs)for treating RA.The fabricated NPs with biocompatibility had high DNA adsorption ability and could effectively inhibit the STING pathway and inflammation in macrophages.Intra-articular administration of PEI-PDA@C-176 NPs could effectively reduce joint damage in mice models of dsDNA-induced arthritis and collagen-induced arthritis by inhibiting STING pathway.We concluded that materials with synergistic effects of STING inhibition might be an efficacious strategy to treat RA. | Haotian Shen Lulu Jin Qiangqiang Zheng Ziqiang Ye Linxiang Cheng Yuxu Wu Honghao Wu Tae Gyong Jon Wenduo Liu Zongyou Pan Zhengwei Mao Yue Wang | 2023 | Bioactive Materials2023，，6： | 1 |
| 7 | Design, Synthesis and Biological Evaluation of Novel Selective Thiol-based Histone Deacetylase(HDAC) Ⅵ Inhibitors Bearing Indeno[1,2-c]pyrazole or Benzoindazole Scaffold显示文摘 | XU Qihao YU Shujia CAI Yijun YANG Jinyu ZHAO Linxiang LIU Dan | 2018 | Chemical Research in Chinese Universities2018，34，1： | 0 |
| 8 | Purified protein derivative skin testing on HIV/AIDS patients and logistic regression analysis of its risk factors显示文摘Objective: To understand the reactivity of purified protein derivative skin test(PPD test) in HIV-infected persons and to determine the influential factors associated with PPD. Methods: 174 HIV/AIDS patients registered in the local center for disease control and prevention(CDC) participated this study from April to June in 2006. Questionnaire,CD4 count and thoracic roentgenogram were performed for all participants. Results: In this study, response rate of questionnaires was 83.65%. The majority of these participants had a different degree of immunodeficiency that accounted for 93.64%. Female patients had a higher CD4 count than that of males. The total positive rate of PPD was 38.15%. Analysis of single factor in our study indicated that CD4 count, previous tuberculosis history, tuberculosis contact history and thoracic roentgenogram manifestation of patients were related to their PPD diameters. Further analysis of multiple factors also supports the previous conclusion that CD4 count and previous tuberculosis history of patients were risk factors in the PPD test. Conclusion: The PPD test of HIV/AIDS patients could be affected by several factors. For persons infected with HIV, the confirmation of latent tuberculosis infection (LTBI) should be considered the combination effect of previous MTB infection and body cellular immune function. | Fengren Liu Jianjun Ye Changfu Xiong Jiguo Yin Weihua He Gaobo Li Dingyuan Zha Linxiang Ye | 2007 | Journal of Nanjing Medical University2007，21，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员