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| 1 | Intracellular and Extracellular Phosphatidylinositol 3-Phosphate Produced by Phytophthora Species Is Important for Infection显示文摘Phytophthora 病原体生产的 RxLR 受动器被建议了把 3 磷酸盐(PtdIns (3 ) P ) 绑在 phosphatidylinositol 调停他们的 translocation 进主人房间或到增加他们在 planta 的稳定性。因为在植物的 PtdIns (3 ) P 的层次是低的,我们检验了 Phytophthora 种类是否可以生产 PtdIns (3 ) 支持感染的 P。我们观察了 P 特定的 GFP 生物传感器能绑在 P 的那 PtdIns (3 ) 。parasitica 和 P。sojae hyphae 短暂地在 Nicotiana benthamiana 的感染期间离开 secreting 生物传感器,建议 hyphae 暴露了 PtdIns (3 ) 他们的血浆膜上的 P 或分泌 PtdIns (3 ) P。phosphatidylinositol 3-kinases (PI3K ) 的 Silencing 基因,有 LY294002 的处理,或 PtdIns (3 ) 的表示由 P 的 P 有约束力的蛋白质。sojae 在大豆上减少了病原体的毒力,显示综合病原体的 PtdIns (3 ) P 为完整的毒力被要求。PtdIns (3 ) 的分泌物 P 有约束力的蛋白质或由 N 的 PI3P-5-kinase。benthamiana 叶子显著地由 P 增加了抵抗的水平到感染。parasitica 和 P。capsici。一起,我们的结果支持假设那 Phytophthora 种生产外部 PtdIns (3 ) 帮助感染的 P,例如支持 RxLR 受动器的入口进宿主细胞。我们的结果源于 P。sojae RxLR 受动器 Avr1b 证实 N 终点和这个受动器的 C 终点能绑 PtdIns (3 ) P。 | Shan Lu | 2013 | Molecular Plant2013，6，5： | 7 |
| 2 | Synthesis of chain-like MoS_2 nanoparticles in W/O reverse microemulsion and application in photocatalysis显示文摘Chain-like MoS2assemblies consisting of hexagonal MoS2nanoparticles(20-60 nm) have been successfully synthesized in a Triton X-100/cyclohexane/hexanol/water W/O reverse microemulsion in the presence of(NH 4)2MoS 4 as the molybdenum source and NH2OH·HCl as the reducing agent.The products were characterized by X-ray powder diffraction(XRD),transmission electron microscopy(TEM) and UV-vis diffuse reflectance absorption spectra.The influence of synthetic parameters such as acidity,water/oil ratio(0),aging time and annealing temperature on the formation of MoS2assemblies was investigated.TEM analysis showed that these synthetic factors played important roles in controlling the size of MoS2nanoparticles and the length of the chain-like MoS2assemblies.XRD analysis indicated that the well-crystallized MoS2nanoparticles could be obtained by annealing the precursors at 700 C for2h under a flow of N2atmosphere.In addition,the as-prepared chain-like MoS2nanoparticles exhibited excellent photocatalytic H2activity in Ru(bpy) 3 2+-MoS2-H2A three-component molecular systems under visible light irradiation. | LIU MeiYing LI XiaoQian XU ZhiLing LI BoNa CHEN LinLin SHAN NanNan | 2012 | Chinese Science Bulletin2012，57，30： | 6 |
| 3 | Testosterone attenuates pulmonary epithelial inflammation in male rats of COPD model through preventing NRF1-derived NF-κB signaling显示文摘Testosterone deficiency is common in male patients with chronic obstructive pulmonary disease (COPD) and may correlate with the deterioration of COPD. Clinical research suggests that testosterone replacement therapy may slow the COPD progression, but the specific biological pathway remains unclear. In this study, we explored the effect of testosterone on pulmonary inflammation in male COPD rats. The animals were co-treated with lipopolysaccharide (LPS) and cigarette to induce COPD. In COPD rats, nuclear respiratory factor 1 (NRF1) and NF-κB p65 were upregulated. In cigarette smoke extract (CSE)-, LPS-, or the combination of CSE and LPS-treated L132 cells, NRF1 and p65 were also upregulated. Silencing NRF1 resulted in the downregulation of p65. ChIP‒seq, ChIP‒qPCR, and luciferase results showed that NRF1 transcriptionally regulated p65. Both male and female COPD rats showed an upregulated NRF1 level and similar pulmonary morphology. But NRF1 was further upregulated in male castrated rats. Further supplementing testosterone in castrated male rats significantly reduced NRF1, pulmonary lesions, and inflammation. Supplementation of testosterone also reduced the phosphorylation of p65 and IKKβ induced by LPS or CSE in L132 cells. Our results suggest that testosterone plays a protective role in pulmonary epithelial inflammation of COPD through inhibition of NRF1-derived NF-κB signaling and the phosphorylation of p65. | Xueting Wang Linlin Huang Shan Jiang Kang Cheng Dan Wang Qianqian Luo Xiaomei Wu Li Zhu | 2021 | Journal of Molecular Cell Biology2021，13，2： | 4 |
| 4 | SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice显示文摘Background:Cardiovascular diseases(CVDs)and diabetes mellitus(DM)are top two chronic comorbidities that increase the severity and mortality of COVID-19.However,how SARS-CoV-2 alters the progression of chronic diseases remain unclear.Methods:We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice.SARS-CoV-2’s impacts on pathogenesis of chronic diseases were studied through histopathological,virologic and molecular biology analysis.Results:Pre-existing CVDs resulted in viral invasion,ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection.Viral infection increased fasting blood glucose and reduced insulin response in DM model.Bone mineral density decreased shortly after infection,which associated with impaired PI3K/AKT/mTOR signaling.Conclusion:We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases.Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection,which further aggravated the pre-existing diseases.This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. | Yuanwu Ma Dan Lu Linlin Bao Yajin Qu Jiangning Liu Xiaolong Qi Lei Yu Xu Zhang Feifei Qi Qi Lv Yunpeng Liu Xudong Shi Caixian Sun Jing Li Jie Wang Yunlin Han Kai Gao Wei Dong Ning Liu Shan Gao Jing Xue Qiang Wei Sidan Pan Hong Gao Lianfeng Zhang Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，1： | 3 |
| 5 | Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA显示文摘Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is a member of the IGF2BP protein family consisting of IGF2BP1~3 with the capacity of binding to many transcripts and regulating RNA stability, localization, and translation. In this study, we discovered that expression of IGF2BP2 was upregulated and led to a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). IGF2BP2 protein was gradually elevated from normal pancreas, pancreatic intraepithelial neoplasia to PDAC in an LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre mouse model. Furthermore, we demonstrated that IGF2BP2 promoted aerobic glycolysis and PDAC cell proliferation through directly binding to and stabilizing GLUT1 mRNA. In summary, our study unveiled an important role of IGF2BP2 in PDAC development by modulating aerobic glycolysis and as a potential therapeutic target for PDAC treatment. | Shan Huang Zheng Wu Yunyun Cheng Wenzhen Wei Linlin Hao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 2 |
| 6 | RNAi?mediated knockdown of PRL?3 inhibits cell invasion and downregulatesERK 1/2 expression in the human gastric cancer cell line, SGC?7901显示文摘 | Yi Cao Yi Tu Jinhong Mei Zhengrong Li Zhigang Jie Shan Xu Linlin Xu Shanshan Wang Yifeng Xiong | 2013 | Molecular Medicine Reports2013，，6： | 2 |
| 7 | Genomic Characterization and High Prevalence of Bovaviruses in Swine 显示文摘 | Shan Tongling Lan Daoliang Li Linlin | 2011 | PLoS One2011，6，17： | 1 |
| 8 | Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase显示文摘We developed a Gaussia luciferase (Gluc) reporter replicon of West Nile virus (WNV) and used it to quantify viral translation and RNA replication. The advantage of the Gluc replicon is that Gaussia luciferase is secreted into the culture medium from cells transfected with Gluc replicon RNA, and the medium can be assayed directly for luciferase activity. Using a known Flavivirus inhibitor (NITD008), we demonstrated that the Gluc-WNV replicon could be used for antiviral screening. The Gluc-WNV-Rep will be useful for research in antiviral drug development programs, as well as for studying viral replication and pathogenesis of WNV. | Chao Shan Xiaodan Li Chenglin Deng Baodi Shang Linlin Xu Hanqing Ye Zhiming Yuan Bo Zhang | 2013 | Virologica Sinica2013，28，3： | 1 |
| 9 | A broadly neutralizing human monoclonal antibody against the hemagglutinin of avian influenza virus H7N9显示文摘Background:The new emerging avian influenza A H7N9 virus,causing severe human infection with a mortality rate of around 41%.This study aims to provide a novel treatment option for the prevention and control of H7N9.Methods:H7 hemagglutinin(HA)-specific B cells were isolated from peripheral blood plasma cells of the patients previously infected by H7N9 in Jiangsu Province,China.The human monoclonal antibodies(mAbs)were generated by amplification and cloning of these HA-specific B cells.First,all human mAbs were screened for binding activity by enzyme-linked immunosorbent assay.Then,those mAbs,exhibiting potent affinity to recognize H7 HAs were further evaluated by hemagglutination-inhibiting(HAI)and microneutralizationin vitro assays.Finally,the lead mAb candidate was selected and tested against the lethal challenge of the H7N9 virus using murine models.Results:The mAb 6-137 was able to recognize a panel of H7 HAs with high affinity but not HA of other subtypes,including H1N1 and H3N2.The mAb 6-137 can efficiently inhibit the HA activity in the inactivated H7N9 virus and neutralize 100 tissue culture infectious dose 50(TCID_(50))of H7N9 virus(influenza A/Nanjing/1/2013)invitro,with neutralizing activity as low as 78 ng/mL.In addition,the mAb 6-137 protected the mice against the lethal challenge of H7N9 prophylactically and therapeutically.Conclusion:The mAb 6-137 could be an effective antibody as a prophylactic or therapeutic biological treatment for the H7N9 exposure or infection. | Jingxin Li Li Zhang Linlin Bao Yuxiao Wang Lin Qiu Jialei Hu Rong Tang Huiyan Yu Jun Shan Yan Li Chuan Qin Fengcai Zhu | 2022 | Chinese Medical Journal2022，，7： | 1 |
| 10 | The fecal virome of pigs on a high - density farm 显示文摘 | Shan Tongling Li Linlin Simmonds Peter | 2011 | Journal of Virology2011，85，11： | 1 |
| 11 | Lignin dissolution in dialkylimidazolium-based ionic liquid–water mixtures显示文摘 | Yantao Wang Ligang Wei Kunlan Li Yingchong Ma Ningning Ma Shan Ding Linlin Wang Deyang Zhao Bing Yan Wenying Wan Qian Zhang Xin Wang Junmei Wang Hui Li | 2014 | Bioresource Technology2014，，： | 1 |
| 12 | Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway显示文摘 | Qing Xie Linlin Chen Xuefeng Shan Xiaoliang Shan Jia Tang Fan Zhou Qingmei Chen Huiqin Quan Dan Nie Wenlu Zhang Ai‐Long Huang Ni Tang | 2014 | Int. J. Cancer2014，，3： | 1 |
| 13 | Application and realization of key technologies in China railway e-ticketing system显示文摘Purpose–With the yearly increase of mileage and passenger volume in China’s high-speed railway,the problems of traditional paper railway tickets have become increasingly prominent,including complexity of business handling process,low efficiency of ticket inspection and high cost of usage and management.This paper aims to make extensive references to successful experiences of electronic ticket applications both domestically and internationally.The research on key technologies and system implementation of railway electronic ticket with Chinese characteristics has been carried out.Design/methodology/approach–Research in key technologies is conducted including synchronization technique in distributed heterogeneous database system,the grid-oriented passenger service record(PSR)data storage model,efficient access to massive PSR data under high concurrency condition,the linkage between face recognition service platforms and various terminals in large scenarios,and two-factor authentication of the e-ticket identification code based on the key and the user identity information.Focusing on the key technologies and architecture the of existing ticketing system,multiple service resources are expanded and developed such as electronic ticket clusters,PSR clusters,face recognition clusters and electronic ticket identification code clusters.Findings–The proportion of paper ticket printed has dropped to 20%,saving more than 2 billion tickets annually since the launch of the application of E-ticketing nationwide.The average time for passengers to pass through the automatic ticket gates has decreased from 3 seconds to 1.3 seconds,significantly improving the efficiency of passenger transport organization.Meanwhile,problems of paper ticket counterfeiting,reselling and loss have been generally eliminated.Originality/value–E-ticketing has laid a technical foundation for the further development of railway passenger transport services in the direction of digitalization and intelligence. | Xinghua Shan Zhiqiang Zhang Fei Ning Shida Li Linlin Dai | 2023 | Railway Sciences2023，2，1： | 0 |
| 14 | Effects of Low-pressure Annealing on the Performance of 3D Printed CF/PEEK Composites显示文摘The interlayer bonding properties are normally unsatisfying for 3D printed composites owing to the layer-by-layer formation process.In this study,low-pressure annealing was performed on 3D printed carbon fiber reinforced polyether ether ketone(CF/PEEK)to improve the interlayer bonding strength.The effects of annealing parameters on the mechanical properties and microstructure were studied.The results showed that the interlaminar shear strength(ILSS)of CF/PEEK improved by up to 55.4%after annealing.SEM and��-CT were also applied to reveal the reinforcing mechanism.This improvement could mainly be attributed to the increased crystallinity of the CF/PEEK after annealing.Additionally,annealing reduced the porosity of the printed CF/PEEK and improved the fiber-resin interface.This resulted in a reduction in the stress concentration areas during loading,thereby enhancing the interlayer bonding strength of CF/PEEK. | Xiao Yu Wenzhe Song Jinghua Zheng Yiwei Chen Linlin Luo Congze Fan Zhongde Shan | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，2： | 0 |
| 15 | Plant-based meat analogues aggravated lipid accumulation by regulating lipid metabolism homeostasis in mice显示文摘To determine the effects of plant-based meat analogues on the metabolic health and the possible mechanisms,mice were fed with a real pork diet(AP),a real beef diet(AB),a plant-based pork analogue diet(PP)and plant-based beef analogue diet(PB)for 68 days.Compared with real meat,the plant-based meat analogues increased food and energy intake,body weight,white fat and liver weight and caused adipocyte hypertrophy,hepatic lipid droplet accumulation,and inflammatory responses in mice.Metabolomics revealed that plantbased meat analogues altered the composition of serum metabolites,which regulated lipid metabolism homeostasis.The PB diet upregulated gene expression related to lipid synthesis,lipolysis and adipocyte differentiation while the PP diet upregulated expression of lipolysis-related genes but downregulated expression of adipocyte differentiation-related genes in white adipose tissue.Meanwhile,both PP and PB diets upregulated lipid influx-and synthesis-related genes but downregulated lipid oxidation-related genes in liver.The specific metabolite biomarkers may affect fat accumulation mainly by direct lipid metabolism pathways or indirect amino acid metabolism,protein digestion and absorption,bile secretion,aminoacyl-tRNA biosynthesis,neuroactive ligand-receptor interaction and ABC transporters pathways.These findings provide a new insight into understanding the differences in nutritional functions of meat and plant-based meat analogues. | Yunting Xie Linlin Cai Zhiji Huang Kai Shan Xinglian Xu Guanghong Zhou Chunbao Li | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 16 | Corrigendum to“One-pot tandem route to fused indolizidines and quinolizidines:Application in the synthesis of alkaloids and bioactive compounds”[Chinese Chemical Letters 32(2021)1713-1716]显示文摘The authors regret that an interesting work about amide activation left uncited in the above-titled publication.An corrigendum is given as follows:In 2017,Huang’s group[1]reported an interesting method consisting of the amide activation(Tf_(2)0)induced dehydracoupling of halo-genated secondary amides with alkenes and NaBH4 reduction triggered tandem cyclization reaction.It is an efficient strategy to construct substituted pyrrolidine,piperidine,indolizidine,quinolizidine ring systems,and enimino carbocycles. | Qiao Song Yan Liu Linlin Cai Xinyu Cao Shan Qian Zhouyu Wang | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 17 | One-pot tandem route to fused indolizidines and quinolizidines:Application in the synthesis of alkaloids and bioactive compounds显示文摘Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds.A one-pot tan dem route from amide to fused indolizidines and quinolizidines is disclosed.This method is con ducted in mild conditions and shows well tolerance of functional groups.It is also easy to be scaled up to gram scale and can be applied smoothly to the total synthesis of alkaloids such as(±)-crispine A,(±)-xylopinine,(±)-desbromoarborescidine A,(±)-harmicine and other bioactive substances. | Qiao Song Yan Liu Linlin Cai Xinyu Cao Shan Qian Zhouyu Wang | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
| 18 | Study on Coconut Shell Activated Carbon Temperature Swing Adsorption of Benzene and Formaldehyde显示文摘Adsorption can be used to recover effectively the volatile organic gases(VOCs)in the exhaust gas from factories through using an appropriate adsorption bed.Due to form a physical or chemical bond,adsorption occurs between the porous solid medium and the liquid or gas multi component fluid mixture.The regeneration capa-city of the adsorbent is as important as the adsorption capacity and it determines the economics of the adsorption system.The regeneration of adsorbent can be realized through changing the pressure or temperature of the system.Here,activated carbon samples from coconut shell were prepared and characterized.Benzene or formal-dehyde in the mixed air was used as the adsorption object,and the adsorption experiment was carried out in a U-shaped bed.Discussed how adsorption was affected by activated carbon type,adsorbate and temperature.The results show that oxidation modifed activated carbon can increase the adsorption effect of form aldehyde,but will reduce the ad sorption effect of benzene,because their ad sorption mechanism is different.At 30℃,the saturated adsorption apacity of AC-0 for benzene is 437.0 mg/g.and that of AC-1 for formaldehyde is 670.5 mg/g.In the experimental range,it is found that the adsorption capacity increases with the decrease of temperature,and their changes are very consistent with the ftted ExpDecay1 function. | Zhiguang Yang Gaojun Yan Xueping Liu Zhengyuan Feng Xinfeng Zhu Yanli Mao Songtao Chen Zhisheng Yu Ruimei Fan Linlin Shan | 2022 | Journal of Renewable Materials2022，10，12： | 0 |
| 19 | Mifepristone modulates serotonin transporter function显示文摘Regulating serotonin expression can be used to treat psychotic depression. Mifepristone, a glucocorticoid receptor antagonist, is an effective candidate for psychotic depression treatment. However, the underlying mechanism related to serotonin transporter expression is poorly understood. In this study, we cloned the human brain serotonin transporter into Xenopus oocytes, to establish an in vitro expression system. Two-electrode voltage clamp recordings were used to detect serotonin transporter activity. Our results show that mifepristone attenuates serotonin transporter activity by directly inhibiting the serotonin transporter, and suggests that the serotonin transporter is a pharmacological target of mifepristone for the treatment of psychotic depression. | Chaokun Li Linlin Shan Xinjuan Li Linyu Wei Dongliang Li | 2014 | Neural Regeneration Research2014，9，6： | 0 |
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