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| 1 | Can the Grain-for-Green Program Really Ensure a Low Sediment Load on the Chinese Loess Plateau?显示文摘The Chinese Loess Plateau is the most seriously eroded area in the world and contributes the vast majority of the sediment that goes into the Yellow River.Since the 1950s,progressive soil and water conservation measures have been implemented—in particular,large-scale ecological restoration has been ongoing since 1999—resulting in a significant reduction of the sediment load.However,the mechanism of the sediment transport dynamics is not fully understood due to multiple and complicated influencing factors including climate change and human activities(e.g.,ecological restoration).A challenging question,then,arises:Is the current low sediment level a“new normal”in this era and in the future?To address this question,we selected a typical loess hilly region where considerable ecological restoration has been implemented,and which is regarded as the site of the first and most representative Grainfor-Green program in the Loess Plateau.We investigated the evolution of discharge–sediment relationships in the past decades(1960–2010)and their association with the soil and water conservation measures in this area.The results showed that there was a distinct change in the regression parameters of the commonly used annual discharge–sediment regression equation—a continuously increasing trend of parameter b and a decreasing trend of parameter a,accompanying the ecological restoration.The increase in exponent b(i.e.,a steeper slope)implies a potential lower sediment load resulting from low discharge and a potential higher sediment load resulting from large discharge.This finding may question the new normal of a low sediment level and implies the potential risk of a large sediment load during extremely wet years. | Pengcheng Sun Yiping Wu Zhifeng Yang Bellie Sivakumar Linjing Qiu Shuguang Liu Yanpeng Cai | 2019 | Engineering2019，5，5： | 3 |
| 2 | Synthesis and properties of starch-graft-acrylamide/clay, superabsorbent composite显示文摘 | Wu J H LinJ M Zhou M | 2000 | Macromoleeular Rapid Communications2000，，： | 1 |
| 3 | Spinel/Layered Heterostructured Cathode Material for High‐Capacity and High‐Rate Li‐Ion Batteries显示文摘 | Feng Wu Ning Li Yuefeng Su Haofang Shou Liying Bao Wen Yang Linjing Zhang Ran An Shi Chen | 2013 | Adv Mater2013，，27： | 1 |
| 4 | Nature and signicance of the Ear- ly Cretaceous giant igneous event in Eastern China显示文摘 | Wu F Y LinJ Q Wilde S A | 2005 | Earth and Planetary Science Letters2005，233，1： | 1 |
| 5 | High H2 uptake by alkali-doped carbon nanotubes under ambient pressure and moderate temperatures 显示文摘 | Chen P Wu X LinJ | 1999 | Science1999，285，： | 1 |
| 6 | High-order rogue waves for the Hirota equation显示文摘 | Linjing Li Zhiwei Wu Lihong Wang Jingsong He | 2013 | Annals of Physics2013，，： | 1 |
| 7 | A new approach to mine frequent patterns using item-transformation methods显示文摘 | WU Fan CHIANG S W LINJ R | 2007 | Information Systems2007，32，7： | 1 |
| 8 | High H2 uptake by alkali- doped carbon nanotubes under ambient pressure and moderate temperatures显示文摘 | Chen P Wu X LinJ etal | 1999 | Science1999，285，： | 1 |
| 9 | Plasma protein corona forming upon fullerene nanocomplex:Impact on both counterparts显示文摘Protein corona refers to the structure composed of biomolecules adsorbed on the surface of nanomaterials.The study on the effect of the interaction between protein and nanoparticles can provide an important guide for the application of nanodrug delivery.To provide a reference for the research on fullerene(C60)nanocomplex drug delivery systems,this work studied the interaction between C60 nanocomplex and a variety of plasma proteins.Research showed that the protein binding with C60 nanocomplex did not change the charge properties of protein.The proteins induced the aggregation of C60 nanocomplex.The circular dichroism spectra showed that the secondary structure of the proteins changed after binding to C60 nanocomplex.The ultraviolet-visible spectra showed that the effect of C60 nanocomplex on proteins was concentration-dependent.The fluorescence spectra showed that C60 nanocomplex could intrinsic fluorescence alteration of proteins.The adsorption capacity of C60 nanocomplex to proteins was changed at 0 h and 4 h.The interaction between nanocomplex and proteins might affect the morphological characteristics of nanocomplex and the conformation of proteins.This work could provide a reference for the research and development of C60 nanocomplex and other carbon-based nanocomplex as nanoparticulate drug delivery systems. | Linjing Wu Fangqin Fu Wenhao Wang Wenhua Wang Zhengwei Huang Ying Huang Xin Pan Chuanbin Wu | 2023 | Particuology2023，，2： | 0 |
| 10 | The SMAD2/miR-4256/HDAC5/p16^(INK4a) signaling axis contributes to gastric cancer progression显示文摘The dysregulation of exosomal microRNAs(miRNAs)plays a crucial role in the development and progression of cancer.This study investigated the role of a newly identified serum exosomal miRNA miR-4256 in gastric cancer(GC)and the underlying mechanisms.The differentially expressed miRNAs were firstly identified in serum exosomes of GC patients and healthy individuals using next-generation sequencing and bioinformatics.Next,the expression of serum exosomal miR-4256 was analyzed in GC cells and GC tissues,and the role of miR-4256 in GC was investigated by in vitro and in vivo experiments.Then,the effect of miR-4256 on its downstream target genes HDAC5/p16^(INK4a) was studied in GC cells,and the underlying mechanisms were evaluated using dual luciferase reporter assay and Chromatin Immunoprecipitation(ChIP).Additionally,the role of the miR-4256/HDAC5/p16^(INK4a) axis in GC was studied using in vitro and in vivo experiments.Finally,the upstream regulators SMAD2/p300 that regulate miR-4256 expression and their role in GC were explored using in vitro experiments.miR-4256 was the most significantly upregulated miRNA and was overexpressed in GC cell lines and GC tissues;in vitro and in vivo results showed that miR-4256 promoted GC growth and progression.Mechanistically,miR-4256 enhanced HDAC5 expression by targeting the promoter of the HDAC5 gene in GC cells,and then restrained the expression of p16^(INK4a) through the epigenetic modulation of HDAC5 at the p16INK4a promoter.Furthermore,miR-4256 overexpression was positively regulated by the SMAD2/p300 complex in GC cells.Our data indicate that miR-4256 functions as an oncogene in GC via the SMAD2/miR-4256/HDAC5/p16^(INK4a) axis,which participates in GC progression and provides novel therapeutic and prognostic biomarkers for GC. | MIN WANG HAILIANG ZHAO WEIWEI CHEN CAIQUN BIE JINYING YANG WENRUI CAI CHUTIAN WU YANFANG CHEN SHUFEN FENG YING SHI YUTING LI HUIJUN TANG LIXIAN ZHONG LILIANGZI GUO SISI CHEN LINJING LONG SHAOHUI TANG | 2023 | Oncology Research2023，31，4： | 0 |
| 11 | Bibliometric landscape of the researches on protein corona of nanoparticles显示文摘Unclear biological fate hampers the clinical translation of nanoparticles for biomedical uses.In recent years,it is documented that the formation of protein corona upon nanoparticles is a critical factor leading to the ambiguous biological fate.Efforts have been made to explore the protein corona forming behaviors on nanoparticles,and rearrangement of the relevant studies will help to understand the current trend of such a topic.In this work,the publications about protein corona of nanoparticles in Science Citation Index Expanded database of Web of Science from 2007 to 2020(1417 in total)were analyzed in detail,and the bibliometrics landscape of them was showcased.The basic bibliometrics characteristics were summarized to provide an overall understanding.Citation analysis was performed to scrutinize the peer interests of these papers.The research hotspots in the field were evaluated,based on which some feasible topics for future studies were proposed.In general,the results demonstrated that protein corona of nanoparticles was a prospective research area,and had attracted global research interests.It was believed that this work could comprehensively highlight the bibliometrics landscape,inspire further exploitation on protein corona of nanoparticles,and ultimately promote the clinical translation of nanoparticles. | Zhengwei HUANG Fangqin FU Linjing WU Wenhao WANG Wenhua WANG Chaonan SHI Ying HUANG Xin PAN Chuanbin WU | 2021 | Frontiers of Materials Science2021，15，4： | 0 |
| 12 | The effect of organic ligand modification on protein corona formation of nanoscale metal organic frameworks显示文摘Nanoscale metal organic frameworks(NMOFs)have been widely reported in biomedical field for their unique porous structure and tunable multifunctionality.However,when administrated in vivo,the protein corona will be formed on the surface of NMOFs,significantly affecting their biodistribution,pharmacokinetics and drug release.Few studies paid attention to the protein corona formation process and its influencing factors of NMOFs.As a well-established strategy for altering structure features of NMOFs,the organic ligand modification may have effect on the protein corona formation process,which is to be investigated.In this study,the zirconium(Zr)-based UIO66 was chosen as model NMOFs,the organic ligand of which was modified with amino group(-NH_(2))or carboxyl group(-COOH)to synthesize UIO66-NH_(2)and UIO66-2COOH,respectively.Bovine serum albumin(BSA)was chosen as model protein to investigate the protein corona formation process of NMOFs.The current results showed that the-COOH modification remarkably enhanced the BSA adsorption on NMOFs while-NH_(2)slightly decreased the protein binding affinity.These differences may be ascribed to the two different dominate protein corona formation modes,i.e.,surface coating mode and porous embedded mode.The protein corona formation did not affect the crystal phase of NMOFs but increased the content ofα-helix of BSA.Ultimately,upon protein corona formation,the cellular uptake of NMOFs was significantly affected.We believe our study will provide a new research paradigm to the design and applications of NMOFs. | Wenhao Wang Huihui Liu Zhengwei Huang Fangqin Fu Wenhua Wang Linjing Wu Ying Huang Chuanbin Wu Xin Pan | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 13 | Toward Sustainable Revegetation in the Loess Plateau Using Coupled Water and Carbon Management显示文摘The'Grain-for-Green'project on the Loess Plateau is the largest revegetation program in the world.However,revegetation-induced land use changes can influence both water and carbon cycles,and the diverse consequences were not well understood.Therefore,the reasonability and sustainability of revegetation measures are in question.This study quantifies the impacts of revegetation-induced land use conversions on the water and carbon cycles in a typical watershed on the Loess Plateau and identifies suitable areas where revegetation of forest or grassland could benefit both soil and water conservation and carbon sequestration.We used a coupled hydro-biogeochemical model to simulate the changes of a few key components in terms of water and carbon by designing a variety of hypothetical land use conversion scenarios derived from revegetation policy.Compared to the baseline condition(land use in 2000),both sediment yield and water yield decreased substantially when replacing steep cropland with forest or grassland.Converting cropland with slopes larger than 25°,15°,and 6°to forest(CTF)would enhance the carbon sequestration with a negligible negative effect on soil water content,while replacing cropland with grassland(CTG)would result in a decline in net primary production but with a substantial increase in soil water content(3.8%-14.9%).Compared to the baseline,the soil organic carbon would increase by 0.9%-3.2% in CTF and keep relatively stable in CTG.Through testing a variety of hypothetical revegetation scenarios,we identified potential priority areas for CTF and CTG,where revegetation may be appropriate and potentially beneficial to conserving soil and water and enhancing carbon sequestration.Our study highlights the challenges in future water and carbon coupling management under revegetation policy,and our quantitative results and identification of potential areas for revegetation could provide information to policy makers for seeking optimal management on the Loess Plateau. | Fubo Zhao Yiping Wu Xiaowei Yin Georgii Alexandrov Linjing Qiu | 2022 | Engineering2022，8，8： | 0 |
| 14 | Can Turbulent, High-density Gas Form Stars in Molecular Clouds: A Case Study in Ophiuchus显示文摘Star formation is governed by the interplay between gravity and turbulence in most of molecular clouds.Recent theoretical works assume that dense gas,whose column density is above a critical value in the column density probability distribution function(N-PDF),where gravity starts to overcome turbulence,becomes star-forming gas and will collapse to form stars.However,these high-density gases will include some very turbulent areas in the clouds.Will these dense but turbulent gases also form stars?We test this scenario in Ophiuchus molecular cloud using N-PDF analysis and find that at least in some regions,the turbulent,dense gas is not forming stars.We identified two isolated high-density structures in Ophiuchus,which are gravitationally unbound and show no sign of star formation.Their high densities may come from turbulence. | Sihan Jiao Jingwen Wu Hao Ruan Yuxin Lin Chao-Wei Tsai Linjing Feng | 2022 | Research in Astronomy and Astrophysics2022，22，7： | 0 |
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