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| 1 | Application of P507 and isooctanol extraction system in recovery of scandium from simulated red mud leach solution显示文摘The current recovery technique of Sc was complicated and the chemical consumption was high,This was due to the low content of Sc in resources and the difficulty of stripping.In this research,the isooctanol was added into the 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester(P507)extraction system to reduce the extraction and improve the stripping of Sc.The maximum stripping ratio of Sc from loaded organic phase by sulfuric acid can increase from 10%(without isooctanol)to 99%(with 15 vol%isooctanol).In the extraction test of the simulated red mud leaching liquor,the separation factors between Sc and Zr,Sc and Ti are 36 and 350,separately.At the same time,other metals are almost not extracted.The high selectivity and stripping of Sc suggest that the P507 with isooctanol extraction system can be applied in the practical Sc recovery process. | Chuanying Liu Li Chen Ji Chen Dan Zou Yuefeng Deng Deqian Li | 2019 | Journal of Rare Earths2019，37，9： | 22 |
| 2 | Simultaneous changes in seed size, oil content and protein content driven by selection of SM/EEIhomologues during soybean domestication显示文摘Soybean accounts for more than half of the global production of oilseed and more than a quarter of the protein used globally for human food and animal feed.Soybean domestication involved parallel increases in seed size and oil content,and a concomitant decrease in protein content.However,science has not yet discovered whether these effects were due to selective pressure on a single gene or multiple genes.Here,re-sequencing data from>800 genotypes revealed a strong selection during soybean domestication on GmSWEETlOa.The selection of GmSWEETlOa conferred simultaneous increases in soybean-seed size and oil content as well as a reduction in the protein content.The result was validated using both near-isogenic lines carrying substitution of haplotype chromosomal segments and transgenic soybeans.Moreover,GmSWEETlOb was found to be functionally redundant with its homologue GmSWEETlOa and to be undergoing selection in current breeding,leading the the elite allele GrnSWEETlOb,a potential target for present-day soybean breeding.Both GmSWEETlOa and GmSWEETlOb were shown to transport sucrose and hexose,contributing to sugar allocation from seed coat to embryo,which consequently determines oil and protein contents and seed size in soybean.We conclude that past selection of optimal GmSWEETlOa alleles drove the initial domestication of multiple soybean-seed traits and that targeted selection of the elite allele GmSWEETlOb may further improve the yield and seed quality of modern soybean cultivars. | Shoudong Wang Shulin Liu Jie Wang Kengo Yokosho Bin Zhou Ya-Chi Yu Zhi Liu Wolf BFrommer Jian Feng Ma Li-Qing Chen Yuefeng Guan Huixia Shou Zhixi Tian | 2020 | National Science Review2020，7，11： | 17 |
| 3 | Signaling in Pollen Tube Growth: Crosstalk, Feedback, and Missing Links显示文摘花粉试管通过作为尖端生长知道的高度极化的房间生长在他们的尖端很快伸长。在尖端的尖端生长 requiresintensive exocytosis,它被一具动态细胞骨架和泡 trafficking 支持。几个发信号 pathwayshave 示威了由调整象肌动朊动力学, exocytosis,和 endocytosis 那样的细胞的活动协调花粉试管生长。这些发信号的小径串音将形成协调细胞的进程 requiredfor 尖端生长的一个发信号的网络。关键发信号的分子的动态平衡为花粉试管尖端的合适的延伸是批评的, andis 通常由积极、否定的规定调整了。除了主要发信号小径,出现 evidenceimplies 在花粉试管生长的规定的另外的信号的角色。这里,我们考察并且讨论怎么这些 signalingnetworks 调制花粉 tubes.Key 词的快速的生长: | Yuefeng Guan Jingzhe Guo Hui Li Zhenbiao Yang | 2013 | Molecular Plant2013，6，4： | 15 |
| 4 | Prevalence of HIV Indeterminate Western Blot Tests and Follow-up of HIV Antibody Sero-Conversion in Southeastern China显示文摘HIV-indeterminate Western blotting(WB)results are typically obtained in WB confirmatory assays,and the number of indeterminate samples may increase with the detection of HIV infections,which will present considerable challenges for the management of HIV/AIDS.Nucleic acid detection has been used as a laboratory test for screening suspected or indeterminate samples.However,the effectiveness of these assays for the differential diagnosis of HIV-indeterminate WB samples remained undetermined.In this study,210 subjects with HIV-indeterminate WB results were detected from 6360 positive HIV screening samples between 2015 and 2016 in southeastern China,in which HIV-indeterminate WB results accounted for 3.30%.The highest proportion of indeterminate results was observed in pregnant and lying-in women receiving physical examinations(16.67%),followed by that in voluntary blood donors(8.82%).The most common WB band patterns were p24,gpl60 and p24,and gpl60.The follow-up study revealed that the highest negative and positive conversion rates of HIV antibodies were in samples with a single p24 band(80.28%),and with gpl60 and p24 bands(86.21%),respectively.Among the Env,Gag,and Pol antibodies,samples with a Gag band showed the highest negative conversion rate(81.25%),whereas the highest positive conversion rate was observed in samples with an Env band(56.76%).In addition,quantitative and qualitative HIV nucleic acid testing exhibited the highest sensitivity(96.3%)and specificity(97.85%),respectively.Our results indicate a lower proportion of HIV indeterminate WB results in southeastern China compared to previous reports,and the follow-up re-examination of patients with HIV indeterminate results should be performed.Nucleic acid testing facilitates the identification of HIV infections. | Shouli Wu Min Gao Jian Zheng Pingping Yan Wei Wang Xiaoli Lu Yuefeng Qiu Yansheng Yan | 2019 | Virologica Sinica2019，34，4： | 15 |
| 5 | Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway显示文摘Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to disability.Inflammatory cell infiltration,severe joint breaking and systemic bone loss are the main clinical symptoms.In this study,we established a collagen-induced arthritis(CIA)model and found a large number of M1 macrophages and pyroptosis,which are important sources of proinflammatory cytokines.Punicalagin(PUN)is an active substance extracted from pomegranate peel.We found that it inhibited joint inflammation,cartilage damage and systemic bone destruction in CIA mice.PUN effectively alleviated the high expression of inflammatory cytokines in synovial tissue in vivo.PUN treatment shifted macrophages from the M1 phenotype to the M2 phenotype after stimulation with lipopolysaccharide(LPS)and interferon(IFN)-γ.The expression of inducible nitric oxide synthase(i NOS)and other proinflammatory cytokines released by M1 macrophages was decreased in the PUN treatment group.However,simultaneously,the expression of markers of anti-inflammatory M2 macrophages,such as arginase(Arg)-1 and interleukin(IL)-10,was increased.In addition,PUN treatment attenuated pyroptosis by downregulating the expression of NLRP3 and caspase-1,thereby preventing inflammatory cell death resulting from the release of IL-1βand IL-18.Mechanistically,PUN inhibited the activation of receptor activators of the nuclear factor-κB(NF-κB)signaling pathway,which contributes to M1 polarization and pyroptosis of macrophages.We concluded that PUN ameliorated pathological inflammation by inhibiting M1 phenotype polarization and pyroptosis and has great potential as a therapeutic treatment for human RA. | Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao Hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu Yuefeng Hao Yi Xue Dechun Geng | 2022 | Science China(Life Sciences)2022，65，3： | 14 |
| 6 | Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species显示文摘 | Jian Wu Yuefeng Sun Yannan Zhao Jian Zhang Lilan Luo Meng Li Jinlong Wang Hong Yu Guifu Liu Liusha Yang Guosheng Xiong Jian-Min Zhou Jianru Zuo Yonghong Wang Jiayang Li | 2015 | Cell Research2015，25，5： | 13 |
| 7 | Paleoclimate Modeling in China: A Review显示文摘This paper provides a review of paleoclimate modeling activities in China. Rather than attempt to cover all topics, we have chosen a few climatic intervals and events judged to be particularly informative to the international community. In historical climate simulations, changes in solar radiation and volcanic activity explain most parts of reconstructions over the last millennium prior to the industrial era, while atmospheric greenhouse gas concentrations play the most important role in the20 th century warming over China. There is a considerable model–data mismatch in the annual and boreal winter temperature change over China during the mid-Holocene [6000 years before present(ka BP)], while coupled models with an interactive ocean generally perform better than atmospheric models. For the Last Glacial Maximum(21 ka BP), climate models successfully reproduce the surface cooling trend over China but fail to reproduce its magnitude, with a better performance for coupled models. At that time, reconstructed vegetation and western Pacific sea surface temperatures could have significantly affected the East Asian climate, and environmental conditions on the Qinghai–Tibetan Plateau were most likely very different to the present day. During the late Marine Isotope Stage 3(30–40 ka BP), orbital forcing and Northern Hemisphere glaciation, as well as vegetation change in China, were likely responsible for East Asian climate change. On the tectonic scale,the Qinghai–Tibetan Plateau uplift, the Tethys Sea retreat, and the South China Sea expansion played important roles in the formation of the East Asian monsoon-dominant environment pattern during the late Cenozoic. | JIANG Dabang YU Ge ZHAO Ping CHEN Xing LIU Jian LIU Xiaodong WANG Shaowu ZHANG Zhongshi YU Yongqiang LI Yuefeng JIN Liya XU Ying JU Lixia ZHOU Tianjun YAN Xiaodong | 2015 | Advances in Atmospheric Sciences2015，32，2： | 12 |
| 8 | 5G Flexible Optical Transport Networks with Large-Capacity, Low-Latency and High-Efficiency显示文摘The fifth generation(5G) of mobile communications are facing big challenges, due to the proliferation of diversified terminals and unprecedented services such as internet of things(IoT), high-definition videos, virtual/augmented reality(VR/AR). To accommodate massive connections and astonish mobile traffic, an efficient 5G transport network is required. Optical transport network has been demonstrated to play an important role for carrying 5G radio signals. This paper focuses on the future challenges, recent studies and potential solutions for the 5G flexible optical transport networks with the performances on large-capacity, low-latency and high-efficiency. In addition, we discuss the technology development trends of the 5G transport networks in terms of the optical device, optical transport system, optical switching, and optical networking. Finally, we conclude the paper with the improvement of network intelligence enabled by these technologies to deterministic content delivery over 5G optical transport networks. | Yuefeng Ji Jiawei Zhang Yuming Xiao Zhen Liu | 2019 | China Communications2019，16，5： | 9 |
| 9 | Generation of seed lipoxygenase-free soybean using CRISPR-Cas9显示文摘Beany flavor induced by three lipoxygenases(LOXs, including LOX1, LOX2, and LOX3)restricts human consumption of soybean. It is desirable to generate lipoxygenase-free new mutant lines to improve the eating quality of soybean oil and protein products. In this study, a pooled clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPRassociated protein 9(Cas9) strategy targeting three GmLox genes(GmLox1, GmLox2, and GmLox3) was applied and 60 T_0 positive transgenic plants were generated, carrying combinations of sg RNAs and mutations. Among them, GmLox-28 and GmLox-60 were gmlox1 gmlox2 gmlox3 triple mutants and GmLox-40 was a gmlox1 gmlox2 double mutant.Sequencing of T_1 mutant plants derived from GmLox-28, GmLox-60, and GmLox-40 showed that mutation in the GmLox gene was inherited by the next generation. Colorimetric assay revealed that plants carrying different combinations of mutations lost the corresponding lipoxygenase activities. Transgene-free mutants were obtained by screening the T_2 generation of lipoxygenase-free mutant lines(GmLox-28 and GmLox-60). These transgeneand lipoxygenase-free mutants could be used for soybean beany flavor reduction without restriction by regulatory frameworks governing transgenic organisms. | Jie Wang Huaqin Kuang Zhihui Zhang Yongqing Yang Long Yan Mengchen Zhang Shikui Song Yuefeng Guan | 2020 | The Crop Journal2020，8，3： | 9 |
| 10 | Photonic integrated technology for multi-wavelength laser emission显示文摘We summarized the design, fabrication challenges and important technologies for multi-wavelength laser transmitting photonic integration. Technologies discussed include multi-wavelength laser arrays, monolithic integration and modularizing coupling and packaging. Fabrication technique requirements have significantly declined with the rise of reconstruction-equivalent-chirp and second nanoimprint mask technologies. The monolithic integration problem between active and passive waveguides can be overcome with Butt-joint and InP array waveguide grating technologies. The dynamic characteristics of multi-factors will be simultaneously measured with multi-port analyzing modules. The performance of photonic integration chips is significantly improved with the autoecious factors compensation packaging technique. | CHEN XiangFei LIU Wen AN JunMing LIU Yu XU Kun WANG Xin LIU JianGuo JI YueFeng ZHU NingHua | 2011 | Chinese Science Bulletin2011，56，28： | 9 |
| 11 | Disinfection byproducts in drinking water and regulatory compliance: A critical review显示文摘消毒副产品(DBP ) 在在很多个国家喝水被调整。这批评评论集中于与 DBP 规章的依从联系的问题,包括为 DBP 分析,出现层次,在各种各样的国家之中的规定比较, DBP 依从策略,和新兴的 DBP 的方法。在中国和美国(美国) 之间的规定比较显示在中国的 DBP 规定基于调整混合物和最大的层次的数字是更紧的。用信息收集规则(ICR ) 数据库的比较评价显示 500 大美国的依从率在中国规定下面浇植物在 US 规定下面是比那低得多的(例如 62.2% 对 89.6% 为全部的 trihalomethanes ) 。先锋移动和其他的 disinfectants 是为 DBP 规章的依从的普通惯例。包括为 haloacetic 酸移动为 trihalomethane 移动和 biodegradation 脱衣的空气,在形成以后的 DBP 移动在 DBP 控制获得了更多的接受。包括 iodinated DBP 和含氮的 DBP,新兴的 DBP 的形成是先锋移动和其他的消毒的非计划中的后果之一。然而,在许多底层,比碳的 DBP,新兴的 DBP 提出了更高的健康风险。 | Xiaomao WANG Yuqin MAO Shun TANG Hongwei YANG Yuefeng E XIE | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 8 |
| 12 | Enhanced high-temperature performance of Li-rich layered oxide via surface heterophase coating显示文摘Li-rich layered oxides have become one of the most concerned cathode materials for high-energy lithiumion batteries, but they still suffer from poor cycling stability and detrimental voltage decay, especially at elevated temperature. Herein, we proposed a surface heterophase coating engineering based on amorphous/crystalline Li3 PO4 to address these issues for Li-rich layered oxides via a facile wet chemical method. The heterophase coating layer combines the advantages of physical barrier effect achieved by amorphous Li3 PO4 with facilitated Li+diffusion stemmed from crystalline Li3 PO4. Consequently, the modified Li(1.2) Ni(0.2) Mn(0.6) O2 delivers higher initial coulombic efficiency of 92% with enhanced cycling stability at 55 °C(192.9 mAh/g after 100 cycles at 1 C). More importantly, the intrinsic voltage decay has been inhibited as well, i.e. the average potential drop per cycle decreases from 5.96 mV to 2.99 mV. This surface heterophase coating engineering provides an effective strategy to enhance the high-temperature electrochemical performances of Li-rich layered oxides and guides the direction of surface modification strategies for cathode materials in the future. | Yuefeng Su Feiyu Yuan Lai Chen Yun Lu Jinyang Dong Youyou Fang Shi Chen Feng Wu | 2020 | Journal of Energy Chemistry2020，29，12： | 7 |
| 13 | The role of climate factors in geographic variation in body mass and wing length in a passerine bird显示文摘Background: Geographic variation in body size is assumed to reflect adaptation to local environmental conditions. Although Bergmann's rule is usually sufficient to explain such variation in homeotherms, some exceptions have been documented. The relationship between altitude, latitude and body size, has been well documented for some vertebrate taxa during the past decades. However, relatively little information is available on the effects of climate variables on body size in birds.Methods: We collected the data of 267 adult Eurasian Tree Sparrow(Passer montanus) specimens sampled at 48 localities in China's mainland, and further investigated the relationships between two response variables, body mass and wing length, as well as a suit of explanatory variables, i.e. altitude, latitude, mean annual temperature(MAT), annual precipitation(PRC), annual sunshine hours(SUN), average annual wind speed(WS), air pressure(AP) and relative humidity(RH).Results: Our study showed that(1) although the sexes did not differ significantly in body mass, males had longer wings than females;(2) body mass and wing length were positively correlated with altitude but not with latitude;(3) body mass and wing length were negatively correlated with AP and RH, but not significantly correlated with WS. Body mass was positively correlated with SUN and inversely correlated with MAT. Wing length was not correlated with MAT in either sex, but was positively correlated with SUN and negatively correlated with PRC in male sparrows;(4) variation in body mass could be best explained by AP and SUN, whereas variation in wing length could be explained by RH and AP in both sexes. In addition, variation in male sparrows can be explained by SUN, WS and PRC but not in females.Conclusions: Two different proxies of body size, body mass and wing length, correlated with same geographic factors and different climate factors. These differences may reflect selection for heat conservation in the case of body mass, and for efficient flight in the case of wing length. | Yanfeng Sun Mo Li Gang Song Fumin Lei Dongming Li Yuefeng Wu | 2017 | Chinese Birds2017，，1： | 7 |
| 14 | Modification of LiCo_(1/3)Ni_(1/3)Mn_(1/3)O_2 cathode material by CeO_2-coating显示文摘LiCo1/3Ni1/3Mn1/3O2 was coated by a layer of 1.0 wt% CeO2 via sol-gel method. The bared and coated LiMn1/3Co1/3Ni1/3O2 was characterized by X-ray diffraction (XRD),scanning electron microscopy (SEM),cyclic voltammogram (CV) and galvanotactic charge-discharge test. The results show that the coating layer has no effect on the crystal structure,only coating on the surface; the 1.0 wt% CeO2-coated LiCo1/3Ni1/3Mn1/3O2 exhibits better discharge capacity and cycling performance than the bared LiCo1/3Ni1/3Mn1/3O2. The discharge capacity of 1.0 wt% CeO2-coated cathode is 182.5 mAh.g-1 at a current density of 20 mA.g-1,in contrast to 165.8 mAh.g-1of the bared sample. The discharge capacity retention of 1.0 wt% CeO2-coated sample after 12 cycles reaches 93.2%,in comparison with 86.6% of the bared sample. CV results show that the CeO2 coating could suppress phase transitions and prevent the surface of cathode material from direct contact with the electrolyte,thus enhance the electro-chemical performance of the coated material. | WANG Meng,WU Feng,SU YueFeng & CHEN Shi Beijing Key Laboratory of Environment,School of Chemical Engineering and Environment,Beijing Institute of Technology National Development Center of High Technology Green Materials,Beijing 100081,China | 2009 | Science China(Technological Sciences)2009，52，9： | 7 |
| 15 | The effect of axial stiffness of mooring lines on the horizontal motion of FDPSO显示文摘FDPSO is a multifunction floating platform,which has the integral function of drilling,production,storage and offloading.A spread mooring system is adopted to position the FDPSO.The coupled analysis in time domain for FDPSO system is conducted in the present paper,using the code DeepC.The effect of axial stiffness of the mooring line on the horizontal motion of FDPSO is studied by employing five types of different axial stiffness in the calculation of the motion response of FDPSO vessel.Furthermore,the results of a model test conducted in the State Key Laboratory of Ocean Engineering in Shanghai Jiao Tong University are used to investigate the feasibility of the numerical method. | WEI YueFeng YANG JianMin CHEN Gang HU ZhiQiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 7 |
| 16 | Phase equilibria for the pseudo-ternary system(NaCl+Na2SO4+H2O)of coal gasification wastewater at T=(268.15 to 373.15)K显示文摘The pseudo-ternary system(Na Cl + Na_2SO_4+ H_2O) of coal gasification wastewater was studied at T =(268.15 to 373.15) K. The solubility and density of the equilibrium liquid phase were determined by the isothermal solution saturation method. The equilibrium solids were also investigated by the Schreinemaker's method of wet residues and X-ray powder diffraction(XRD). According to the experimental data, the phase diagrams were determined. It was found that there was no significant solubility difference on the Na Cl-rich side between the ternary system(Na Cl + Na_2SO_4+ H_2O) in coal gasification wastewater and in pure water. However, the solubility on the Na_2SO_4-rich side of coal gasification wastewater was apparently higher than that of pure water. The increase in the solubility of Na_2SO_4 was most likely caused by the effects of other impurities apart from Na Cl and Na_2SO_4 in coal gasification wastewater. The measured data and phase equilibrium diagrams can provide fundamental basis for salt recovery in coal gasification wastewater. | Haijiao Lu Jingkang Wang Jun Yu Yuefeng Wu Ting Wang Ying Bao Dou Ma Hongxun Hao | 2017 | Chinese Journal of Chemical Engineering2017，25，7： | 7 |
| 17 | Quantitative features of myoelectric signals in the orbicularis oculi muscle during different motion states显示文摘Artificial facial nerve prostheses are thought to restore eye-closed function in peripheral facial paralysis patients. At present,however,there is no adequate quantitative or qualitative information regarding myoelectric signal(MES) features for healthy orbicularis oculi muscle(OOM) . The present study analyzed MES features of normal OOM in rabbits during the natural continuous eye-opening(N1) state,natural continuous eye-closing(N2) state,natural blink(N3) state,and evoked eye-closing(E) state according to time domain and frequency domain analysis. Results showed that OOM electrical activities in N1 and N2 states,as well as myoelectric amplitude,were low and stable. Nevertheless,during N3 and E states,OOM electrical activities were significantly increased and amplitude was much higher in the E state than in the N3 state. In the time domain,differences in MES peak absolute potential were not significant between N1 and N2 states. In the frequency domain,differences in power spectral density peak frequency of electromyogram signals were significant between two sets of four OOM movement states. These results suggest that OOM significantly contracts and induces eyelid-closing action. In addition,OOM is diastolic during the N1 state. A N2 state does not require continuous intensive OOM contraction. Moreover,distinctions of quantitative information in time and frequency domain features of MES can be used as an OOM reference to identify muscle movement patterns. | Dongyue Xu Keyong Li Jingquan Liu Yujuan Wang Yuefeng Rui | 2010 | Neural Regeneration Research2010，5，24： | 6 |
| 18 | Co-electrolysis of CO_2 and H_2O in high-temperature solid oxide electrolysis cells: Recent advance in cathodes显示文摘Co-electrolysis of CO_2 and H_2O using high-temperature solid oxide electrolysis cells(SOECs) into valuable chemicals has attracted great attentions recently due to the high conversion and energy efficiency,which provides opportunities of reducing CO_2 emission, mitigating global warming and storing intermittent renewable energies. A single SOEC typically consists of an ion conducting electrolyte, an anode and a cathode where the co-electrolysis reaction takes place. The high operating temperature and difficult activated carbon-oxygen double-bond of CO_2 put forward strict requirements for SOEC cathode. Great efforts are being devoted to develop suitable cathode materials with high catalytic activity and excellent long-term stability for CO_2/H_2O electro-reduction. The so far cathode material development is the key point of this review and alternative strategies of high-performance cathode material preparation is proposed. Understanding the mechanism of CO_2/H_2O electro-reduction is beneficial to highly active cathode design and optimization. Thus the possible reaction mechanism is also discussed. Especially, a method in combination with electrochemical impedance spectroscopy(EIS) measurement, distribution functions of relaxation times(DRT) calculation, complex nonlinear least square(CNLS) fitting and operando ambient pressure X-ray photoelectron spectroscopy(APXPS) characterization is introduced to correctly disclose the reaction mechanism of CO_2/H_2O co-electrolysis. Finally, different reaction modes of the CO_2/H_2O coelectrolysis in SOECs are summarized to offer new strategies to enhance the CO_2 conversion. Otherwise,developing SOECs operating at 300-600 °C can integrate the electrochemical reduction and the Fischer-Tropsch reaction to convert the CO_2/H_2O into more valuable chemicals, which will be a new research direction in the future. | Xiaomin Zhang Yuefeng Song Guoxiong Wang Xinhe Bao | 2017 | Journal of Energy Chemistry2017，26，5： | 6 |
| 19 | miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1显示文摘到化学疗法的代理人的 Multidrug 抵抗(MDR ) 是到在乳癌病人的成功的治疗的一个主要障碍。这研究的目的是调查 miR-137 是否涉及 MDR 的规定,并且在 MCF-7/ADM 房间的敏感上探索 miR-137 的机制。miR-137 是在 MCF-7/ADM 房间的 downregulated,并且它的表达式被发现相反地在乳癌房间与 Y 盒子有约束力的 protein-1 (YB-1 ) 和 P-glycoprotein (P-gp ) 层次相关。而且, YB-1 被酶记者试金和西方的污点分析作为 miR-137 的一个目标证实。而且, miR-137 的提高的表示减少了 YB-1 和 P-gp 的蛋白质表示层次, mimicking 在到 anticancer 代理人的 MCF-7/ADM 房间的敏感击倒的 YB-1 的效果,而 YB-1 的恢复减少了这效果。在结论,我们的结果证明 miR-137 被指向 YB-1 通过 P-gp 的调整在癌症涉及 MDR,建议 miR-137 可能是为阻止并且逆行在肿瘤房间的 MDR 的一个潜在的目标。 | Xiaolan Zhu Yuefeng Li Huiling Shen Hao Li Lulu Hui Wenlin Xu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，2： | 6 |
| 20 | Examining perception of job satisfaction and intention to leave among ICU nurses in China显示文摘Objectives:Previous studies in China's Mainland found ICU nurses to be less satisfied with their jobs and more inclined to leave them than are nurses in other hospital units.We aimed to determine ICU nurses'perspectives on the factors that influence job satisfaction and whether or not to continue working in the ICU.Methods:Nine ICU nurses were asked five open-ended questions to elicit the nurses'perspectives on job satisfaction and intentions to leave.Data were analyzed according to the process described by Knafl and Webster(1988).Core concepts were identified using the constant comparative method.Results:Two themes emerged as major influences on job dissatisfaction:1)stress experienced from excessive workload demands and the ICU work environment,and 2)a lack of respect and recognition for the nurses'work.Two themes emerged as major influences on job satisfaction:1)recognition of work,and 2)professional opportunities and relationships with coworkers.The effects of job satisfaction or dissatisfaction on the nurses'intentions to leave their jobs varied,although three categories were identified.Conclusions:For ICU nurses in China,sources of job dissatisfaction are potentially remedied with simple interventions.Adequate staffing is necessary but not sufficient for a positive work environment.Administrators should address the factors that directly affect their nurses'levels of job satisfaction,as it will ultimately result in less staff turnover and greater patient care. | Hong Tao Carol H.Ellenbecker Yuefeng Wang Ying Li | 2015 | International Journal of Nursing Sciences2015，2，2： | 6 |
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