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| 1 | Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway显示文摘Whether and how garlic-derived S-allylmercaptocysteine(SAMC) inhibits hepatocellular carcinoma(HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor(LDLR)-related protein 6(LRP6) in HCC progression and the anti-HCC mechanism of SAMC was examined in clinical sample, cell model and xenograft/orthotopic mouse models. We demonstrated that SAMC inhibited cell proliferation and tumorigenesis, while induced apoptosis of human HCC cells without influencing normal hepatocytes. SAMC directly interacted with Wnt-pathway co-receptor LRP6 on the cell membrane. LRP6 was frequently over-expressed in the tumor tissue of human HCC patients(66.7% of 48 patients) and its overexpression only correlated with the over-expression of β-catenin, but not with age, gender, tumor size, stage and metastasis. Deficiency or over-expression of LRP6 in hepatoma cells could partly mimic or counteract the anti-tumor properties of SAMC, respectively. In vivo administration of SAMC significantly suppressed the growth of Huh-7 xenograft/orthotopic HCC tumor without causing undesirable side effects. In addition, stable down-regulation of LRP6 in Huh-7 facilitated the anti-HCC effects of SAMC. In conclusion, LRP6 can be a potential therapeutic target of HCC. SAMC is a promising specific anti-tumor agent for treating HCC subtypes with Wnt activation at the hepatoma cell surface. | Jia Xiao Feiyue Xing Yingxia Liu Yi Lv Xiaogang Wang Ming-Tat Ling Hao Gao Songying Ouyang Min Yang Jiang Zhu Yu Xia Kwok-Fai So George L.Tipoe | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
| 2 | Molecular basis of von Hippel-Lindau syndrome in Chinese patients显示文摘背景 Von Hippel-Lindau ( VHL )症候群是预先安排的正染色体的主导的家庭癌症症候群影响个人到在用南部的汉语的 VHL 的基因基础大部分是的各种各样的 organs.The 的多重瘤 unknown.In 这研究,我们在九无关的南部的中国 families.Methods 描绘了 VHL 的变化光谱有 VHL 的临床的特征的九 probands ,二征兆并且八个无征状的家庭成员在这 study.Prenatal | SIU Wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan CHAN Kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung CHAN Albert Yan-wo | 2011 | Chinese Medical Journal2011，，2： | 6 |
| 3 | Tumor necrosis factoralpha is toxic to embryonic mesencephalic dopamine neurons显示文摘 | McGuire SO Ling ZD Lipton JW | 2001 | Exp Neurol2001，169，2： | 1 |
| 4 | The symptom cluster of fatigue, pain,anxiety,and depression and the effect on the quality of life of women receiving treatment for breast eancer:a multieenter study显示文摘 | So WK Marsh G Ling WM | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 5 | The symptom cluster of fa- tigue, pain, anxiety, and depression and the effect on the quality of life of women receiving treatment for breast cancer: a multi- center study显示文摘 | So WK Marsh G Ling WM | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 6 | Anxiety, depression and quality of lifeamong Chinese breast cancer patients during adjuvant therapy显示文摘 | So WK Manh G Ling WM el al | 2010 | Ear JOncol Nurs2010，14，1： | 1 |
| 7 | Effect of craniovertebral decompression on CSF dynamics in Chiari malformation type I studied with computational fluid dynamics: laboratory investigation 显示文摘 | Linge SO Mardal KA Helgeland A | 2014 | J Neurosurg Spine2014，21，4： | 1 |
| 8 | Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons 显示文摘 | McGuire SO Ling ZD Lipton JW | 2001 | Exp Neurol2001，169，： | 1 |
| 9 | The Symptom Cluster of Fatigue,Pain,Anxiety,and Depression and the Effect on the Quality of Life of Women Receiving Treatment for Breast Cancer:a Multicenter Study显示文摘 | So W K Marsh G Ling W M | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 10 | The symptom cluster of fatigue, pain,anxiety, and depression and the effect on the quality of life of womenreceiving treatment for breast cancer : a multicenter study显示文摘 | So WK Marah G Ling WM | 2009 | Oncol NursForum2009，36，4： | 1 |
| 11 | Enhancing the competitiveness and sustainability of social enterprises in Hong Kong: A three-dimensional analysis显示文摘Running a social enterprise(SE) is more difficult than running a small or medium-sized enterprise because SEs have to achieve both economic sustainability as business enterprises and their social mission for the benefit of society.After a few years of operation, many SEs fail or struggle for survival. In this study, we examine some of the factors that affect an SE’s profitability, financial management, and business planning and management. Based on in-depth interviews with 22 social enterprises in Hong Kong, we find that SEs with the dual investment objectives of social mission and financial return are more sustainable and competitive than SEs with social impact as their sole objective. Furthermore, SEs managed by non-owner managers have better financial planning and performance than those managed by owner managers. In addition, SEs with an oversight/advisory committee are more competitive and have better management practices than those without such a committee. Our findings have policy implications for government, SEs, funding bodies, and non-profit organizations to enhance and promote the development of the social enterprise sector. | Sidney Leung Phyllis Mo Howard Ling Yanto Chandra So Sum Ho | 2019 | China Journal of Accounting Research2019，，2： | 1 |
| 12 | Neuroprotective effects of D3 dopamine receptor agonists显示文摘 | Carvey PM McGuire SO Ling ZD | 2001 | Parkinsonism Relat Disord2001，7，3： | 1 |
| 13 | The symptom cluster of fatigue, pain,anxiety,and depression and the effect on the quality of life of women receiving treatment for breast cancer:a multicenter study 显示文摘 | So WK Marsh G Ling WM | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 14 | The symptom cluster of fatigue,pain, anxiety,and depression and the effect on the quality of life of women receiving treatment for breast cancer:a multicenter study显示文摘 | So WK Marsh G Ling WM | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 15 | Resampling and editing of mischarged tRNA prior to translation elongation 显示文摘 | Ling J So B R Yadavalli S S | 2009 | Mol Cell2009，33，5： | 1 |
| 16 | Anxiety, depression and quality of life among Chinese breast cancer patients during adjuvant therapy显示文摘 | Winnie K.W. So Gene Marsh W.M. Ling F.Y. Leung Joe C.K. Lo Maggie Yeung George K.H. Li | 2009 | European Journal of Oncology Nursing2009，，1： | 1 |
| 17 | CSF flow dy- namics at the craniovertebral junction studied with an ide- alized model of the subarachnoid space and computational flow analysis 显示文摘 | Linge SO Haughton V Lovgren AE | 2010 | AJNR Am J Neuroradiol2010，31，1： | 1 |
| 18 | The symptom cluster of fatigue, pain, anxiety, and depression and the effect on the quality of life of women receiving treatment for breast cancer: a multieenter study显示文摘 | So WKW Marsh G Ling WM | 2009 | Oncology Nursing Forum2009，36，4： | 1 |
| 19 | Reflective practise in clinical teaching显示文摘 | Lau annie kit ling Chuk kai cheung So winnie kwok wei | 2002 | Nursing & Health Science2002，4，4： | 1 |
| 20 | The symptoms cluster of fa-tigue,pain,anxiety,and depression and effect on the quality of life of women receiving treatment for breast cancer: A multicenter study显示文摘 | So WK Marsh G Ling WM | 2009 | Oncology Nursing Forum2009，36，4： | 1 |
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