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| 1 | Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission显示文摘Dear Editor,The occurrence of concentrated pneumonia cases in Wuhan city,Hubei province of China was first reported on December 30,2019 by the Wuhan Municipal Health Commission(WHO,2020).The pneumonia cases were found to be linked to a large seafood and animal market in Wuhan,and measures for sanitation and disinfection were taken swiftly by the local government agency.The Centers for Disease Control and Prevention(CDC)and Chinese health authorities later determined and announced that a novel coronavirus(CoV),denoted as 2019-nCoV,had caused the pneumonia outbreak in Wuhan city(CDC,2020).Scientists from multiple groups had obtained the virus samples from hospitalized patients(Normile,2020).The isolated viruses were morphologically identical when observed under electron microscopy. | Xintian Xu Ping Chen Jingfang Wang Jiannan Feng Hui Zhou Xuan Li Wu Zhong Pei Hao | 2020 | Science China(Life Sciences)2020，63，3： | 737 |
| 2 | No-reflow protection and long-term efficacy for acute myocardial infarction with Tongxinluo: a randomized double-blind placebo- controlled multicenter clinical trial (ENLEAT Trial)显示文摘在紧急情况以后的背景没有回流为尖锐的圣片断举起的经皮的冠的干预(一种总线标准) 心肌的梗塞(STEMI ) 与严重预后有关。这研究的目的是评估 Tongxinluo 的功效,繁体中文药,在在为 219 个病人全部的 STEMI.Methods A 的紧急情况一种总线标准以后的没有回流和梗塞区域上(女性 31 ,14%)从九个临床的中心为 STEMI 经历紧急情况一种总线标准连续地在这被注册使随机化,双窗帘,控制安慰剂, multicenter 对2009年5月的从2007年1月的临床的试用。所有病人随机被划分成 Tongxinluo 在装载的组(n=108 ) 和控制组(n=111 ) ,给定的 Tongxinluo 或安慰剂在紧急情况一种总线标准前分别地为 2.08 g 开 asprin 300 mg 和 clopidogrel 300 mg 一起,然后为在一种总线标准以后的六个月三倍每日的 1.04 g。圣片断举起被心电图在住院记录并且 1, 2, 6, 12,在冠的汽球膨胀到以后的 24 个小时评估心肌的没有流动;在有静态的单个光子的排放的 STEMI 计算了断层摄影术( SPECT )决定在那里的梗塞 area.Results 不是在性别的统计意义以后, 17 个片断的心肌的灌注分数在白天 7 和白天 180 上被评估,年龄经过历史,胸疼痛, onset-to-reperfusion 时间, Killip 分类,就在一种总线标准前后的 TIMI 流动等级,在药治疗的任何一个在follow 在上面期间例如 statin ,-blocker,血管收缩素变换酶禁止者( ACEI )或血管收缩素 rece 在与在 6 个小时的控制组相比的 Tongxinluo 组有重要的圣片断恢复((-0.22????????????????????????????? 慰桴灯票楳汯杯捩污吗?? | ZHANG Hai-tao JIA Zhen-hua ZHANG Jian YE Zan-kai YANG Wei-xian TIAN Yue-qin JIA Xuan LI Wei WU Yi-ling YANG Yue-jin | 2010 | Chinese Medical Journal2010，，20： | 69 |
| 3 | Adamantiades-Behcet's disease-complicated gastroenteropathy显示文摘Adamantiades-Behcet's disease (ABD) is a chronic,relapsing,systemic vasculitis of unknown etiology.It is more prevalent in populations along the ancient Silk Road from Eastern Asia to the Mediterranean Basin,and most frequently affects young adults between the second and fourth decades of life.ABD-complicated gastroenteropathy is a significant cause of morbidity and mortality,with abdominal pain as the most common symptom.The ileocecal region is affected predominantly,with ulcerations that may lead to penetration and/or perforation,whereas other parts of the gastrointestinal system including the esophagus and stomach can also be affected.Endoscopy is useful to locate the site and extent of the lesions,and tissue biopsy is often warranted to examine the histopathology that is often suggestive of underlying vasculitis of small veins/venules or,alternatively in some cases,nonspecific inflammation.Bowel wall thickening is the most common finding on computed tomography scan.Treatment is largely empirical since well-controlled studies are difficult to conduct due to the heterogeneity of the disease,and the unpredictable course with exacerbation and remission.Corticosteroids with or without other immunosuppressive drugs,such as cyclophosphamide,azathioprine,sulfasalazine,tumor necrosis factor α antagonist or thalidomide should be applied before surgery,except in emergency. | Qing-Jun Wu Feng-Chun Zhang Xuan Zhang | 2012 | World Journal of Gastroenterology2012，18，7： | 32 |
| 4 | Multicenter follow-up study of ankle fracture surgery显示文摘在从流行病学、临床的大 multicenter 的中国的脚关节破裂上的很少数据学习的背景是这研究的 available.The 目的是由考察在这研究包括了的 China.Methods 在五所医院经历了脚关节骨折外科的 235 个病人评估流行病学的特征和脚关节破裂的外科的结果经历了脚关节的病人折断外科在到2009年7月 .Age 的从2000年1月的五所中国医院,性,损害的机制, Arbeitsgemeinschaft f | XU Hai-lin LIU Li-min LI Xuan ZHANG Dian-ying FU Zhong-guo WANG Tian-bing ZHANG Pei-xun JIANG Bao-guo SHEN Hui-liang WANG Gang WANG Guang-lin WU Xin-bao | 2012 | Chinese Medical Journal2012，，4： | 27 |
| 5 | Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction显示文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction(AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography(PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3;more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance,sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients. | Wei Wu Linyang Cui Ying Fu Qianqian Tian Lei Liu Xuan Zhang Ning Du Ying Chen Zhijun Qiu Yijun Song Fu-Dong Shi Rong Xue | 2016 | Neuroscience Bulletin2016，32，4： | 28 |
| 6 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 7 | Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer显示文摘瞄准:学习在 Survivin 和 PTEN 表示和淋巴节点转移之间的关系,侵略的深度和在中国的胃的癌症病人的预后。方法:胃的癌症组织的标本从 Jianghan 大学的隶属于的医院被收集。所有 140 个病人有完全的考试数据。所有淋巴结被胖空地的方法发现。染色的打断的连续 4 微米节,平淡的苏木精和曙红和免疫组织化学的方法被用来检测淋巴节点转移。胃的癌症织物微数组被执行由免疫在胃的癌症测试 Survivin 和 PTEN (17A ) 的表示组织化学的方法。所有数据多用 chi2 测试,菲希尔的准确测试, Kaplan-Meyer 木头等级方法和考克斯被处理变量分析(社会科学统计套装软体 12.0 软件) 。结果:118 个标本在我们的织物被使用微数组(利用率是 82.4%) 。7580 淋巴结的一个总数被发现。转移在 90 个标本被发现, 1618 淋巴结被检测。Survivin 和 PTEN 表示的积极的率是 52.5%(62/118 ) 并且 76.2%(90/118 ) 分别地。高度积极的关联在 Survivin 和 PTEN 表示之间被发现(chi2 = 4.17, P = 0.04 ) 。Survivin 表示断然与 UICC N 舞台被相关(chi 2 = 8.69, P = 0.03 ) 并且组织学的分类(chi2 = 4.41, P = 0.04 ) 由 chi2 测试。PTEN 表示断然与侵略的深度被相关(P = 0.02 ) 并且组织学的分类(chi2 = 5.47, P = 0.02 ) 。但是 Survivin 和 PTEN 表情没与胃的癌症病人的预后被联系。在淋巴节点转移和预后之间的重要关联被考克斯多表明变量分析(chi2 = 4.85, P = 0.028 ) 。结论:Survivin 断然在胃的癌症与 PTEN 表示被相关并且当 PTEN 表示是先进胃的癌症的一个分子的标记时,是淋巴节点转移的一个分子的标记。UICC N 舞台是在中国的胃的癌症的最重要的预示的因素。 | Hao Deng Ren-Liang Wu Hong-Yan Zhou Xuan Huang Ying Chen Li-Jiang Liu | 2006 | World Journal of Gastroenterology2006，12，7： | 26 |
| 8 | Comparison of parathyroid hormone (1-34) and elcatonin in postmenopausal women with osteoporosis: an 18-month randomized, multicenter controlled trial in China显示文摘 | LI Ying XUAN Miao WANG Bo YANG Jun ZHANG Hong ZHANG Xiu-zhen GUO Xiao-hui Lü Xiao-feng XUE Qing-yun YANG Gang-yi JI Qiu-he LIU Zhi-min LI Cheng-jiang WU Tian-feng SHENG Zheng-yan LI Peng-qiu TONG Jiu-cui | 2013 | Chinese Medical Journal2013，，3： | 24 |
| 9 | MAP KinaseCascades Responding to Environmental Stress in Plants显示文摘Plant mitogen-activated protein kinases(MAPKs) are involved in growth,evelopment and responses to endogenous and environmental cues.which link stimuli that areactivated by external sensors to cellular responses.In Arabidopsis,as amodel,all of MAP kinase genes have been listed and classified.Based on the Arabidopsis MAPK families.a number of MAPk inase genes in other plant species have been recently isolated and classified.Most of the cloned MAPk inase genes can be activated by avariety of stresss timuli including pathogen infection.wounding.temperature,drought.salinity.osmolarity.UV irradiation.ozone and reactive oxygen species.Some tools and strategies are used to investigate their functions and signal pathways under different environmental stresses.indicating complexity and crosstalk of plant MAPk inase signaling pathways.It is still necessary to explore more novel tools and strategies to clarify MAPK signaling pathways,and how to apply the MAPK cascade to improve the resistance of crop to abiotic and biotic | YUShun—Wu TANGKe—Xuan | 2004 | Acta Botanica Sinica2004，46，2： | 17 |
| 10 | Using Plan-Do-Check-Act Circulation to Improve the Management of Panic Value in the Hospital显示文摘The concept 'panic value' (or critical value) was first brought up by American scholar Lundberg[1] in 1972.It refers to the results of auxiliary examinations that are widely deviating from normal or anticipated results.The occurrence of these abnormal results shows that patients could be in a dangerous situation that their lives might be threatened.If clinicians are able to get the information in time and provide the patients with effective interventions or treatments promptly,lives could be saved.Otherwise,there could be serious consequences and the best opportunities for rescuing the patients might be missing.[2] | Suo-Wei Wu Tong Chen Yong Xuan XJ-Wu Xu Qi Pan Liang-Yu Wei Chao Li Oin Wang | 2015 | Chinese Medical Journal2015，，18： | 16 |
| 11 | Current Control Strategy of Chain Circuit STATCOM显示文摘在链式静止同步补偿器(static synchronous compen-sator,STATCOM)小信号交流模型的基础上,提出简化的STATCOM电流控制闭环系统;分别对典型Ⅰ型、典型Ⅱ型控制系统的电流调节器进行参数优化及比较,分析表明,对于电流阶跃响应,系统处于线性控制状态时超调量相对百分比不变,处于限幅非线性状态时超调量绝对值不变;采用比例调节器的典型I型系统稳态精度稍差,但动态控制精度较高,适合用于链式STATCOM工程装置;在a-b-c坐标系下仿真表明,应用优化设计的典型Ⅰ型系统控制参数,链式STATCOM输出电流可以快速跟踪参考值变化,具有良好的稳定性和跟踪精度。 | WANG Xuan FU Jian TENG Letian SUN Lijing ZHAO Ruibin WU Shouyuan DENG Zhanfeng | 2012 | 中国电机工程学报2012，32，12： | 15 |
| 12 | Research of Medical Expenditure among Inpatients with Unstable Angina Pectoris in a Single Center显示文摘 | Suo-Wei Wu Qi Pan Tong Chen Liang-Yu Wei Yong Xuan Qin Wang Chao Li Jing-Chen Song | 2017 | Chinese Medical Journal2017，，13： | 15 |
| 13 | Inheritance of Rice Seed Germination Ability under Salt Stress显示文摘A population of recombinant inbred lines(RILs,F2:9),derived from a cross between IR26(Oryza sativa subsp.indica)and Jiucaiqing(Oryza sativa subsp.japonica),was used to identify seed germination ability of rice under 100 mmol/L NaCl for 10 days.Six germination traits including imbibition rate,germination rate,germination index,root length,shoot length and vigor index were investigated.A mixed major gene and polygene inheritance model was applied to conduct genetic analysis for germination ability.Significant differences were detected in all the germination traits under salt stress among RILs in rice,and the early germination stage(0-5 days)might be the salt sensitive stage.The frequency distributions of the germination traits under salt stress in the RIL population showed continuous segregation,suggesting that they were quantitative traits controlled by several genes.The germination traits under salt stress were regulated by two or three major genes plus polygene,and mainly dominated by major genes with high heritability values,accounting for 12.5%-99.0%of the total phenotypic variation.Each trait was controlled by the specific genetic model:imbibition rate was controlled by two major genes,germination index and vigor index by two major genes plus polygene,germination rate and shoot length by three major genes plus polygene,and root length by two major genes or two major genes plus polygene. | WANG Zhou-fei WANG Jian-fei BAO Yong-mei Wu Yun-yu Su Xuan ZHANG Hong-sheng | 2010 | Rice science2010，17，2： | 14 |
| 14 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 15 | Secretory Cavity Development and Its Relationship with the Accumulation of Essential Oil in Fruits of Citrus medica L. var. sarcodactylis (Noot.) Swingle显示文摘在柠檬的能分泌的洞的发展类型仍然保持争论。在能分泌的洞开发和在柠檬种类的水果的精油的累积之间的关系也是未知的。以便开发更好的卓见进这些问题,组织学、组织化学、细胞化学的方法被用来在柠檬苜蓿的水果的不同发育阶段调查能分泌的洞开发和精油的累积 L。var。sarcodactylis (Noot ) 打麻器。结果显示变化的能分泌的洞似乎从一个表皮的房间和一个表皮下的房间发源。这二个房间经历了连续部门,导致二部分的形成:(i) 一顶圆锥形的帽子;并且(i i ) 球状的腺。腔的形成是 schizolysigenous。在液泡的尺寸和精油的累积的常规变化在能分泌的洞开发的进程期间被揭示。另外,当水果是一种轻黄或金色的颜色时,能分泌的洞的结构很好被开发,在单个水果的精油的内容到达了最大值。在这时候作为药用的材料收集水果将是很适当的。 | She-Jian Liang Hong Wu Xuan Lun Dong-Wen Lu | 2006 | Journal of Integrative Plant Biology2006，48，5： | 14 |
| 16 | Endogenous Hydrogen Peroxide Plays a Positive Role in the Upregulation of Heme Oxygenase and Acclimation to Oxidative Stress in Wheat Seedling Leaves显示文摘Pretreatment of lower H2O2 doses (0.05, 0.5 and 5 mM) for 24 h was able to dose-dependently attenuate lipid peroxidation in wheat seedling leaves mediated by further oxidative damage elicited by higher dose of H2O2 (150 mM) for 6 h, with 0.5 mM H2O2 being the most effective concentrations. Further results illustrated that 0.5 mM H2O2 pretreatment triggered the biphasic production of H2O2 during a 24 h period. We also noticed that only peak I (0.25 h) rather than peak Ⅱ (4 h) was approximately consistent with the enhancement of heme oxygenase (HO) activity, HO-1 gene expression. Meanwhile, enhanced superoxide dismutase (SOD) activity, Mn-SOD and Cu,Zn-SOD transcripts might be a potential source of peak I of endogenous H2O2. Further results confirmed that 0.5 mM H2O2 treatment for 0.5 h was able to upregulate HO gene expression, which was detected by enzyme activity determination, semi-quantitative reverse transcription-polymerase chain reaction and western blotting. Meanwhile, the application of N,N'-dimethylthiourea, a trap for endogenous H2O2, not only blocked the upregulation of HO, but also reversed the corresponding oxidation attenuation. Together, the above results suggest that endogenous H2O2 production (peak I) plays a positive role in the induction of HO by enhancing its mRNA level and protein expression, thus leading to the acclimation to oxidative stress. | Xiao-Yue Chen Xiao Ding Sheng Xu Ren Wang Wei Xuan Ze-Yu Cao Jian Chen Hong-Hong Wu Mao-Bing Ye Wen-Biao Shen | 2009 | Journal of Integrative Plant Biology2009，51，10： | 14 |
| 17 | Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters显示文摘 | Zhi-tao WU Xin-ming QI Jing-jing SHENG Lei-lei MA Xuan NI Jin REN Cheng-gang HUANG Guo-yu PAN | 2014 | Acta Pharmacologica Sinica2014，35，9： | 13 |
| 18 | Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways显示文摘 | Ruo-ming WU Yan-yan SUN Ting-ting ZHOU Zhi-yuan ZHU Jing-jing ZHUANG Xuan TANG Jing CHEN Li-hong HU Xu SHEN | 2014 | Acta Pharmacologica Sinica2014，35，10： | 13 |
| 19 | A Wheeled Wall-Climbing Robot with Bio-Inspired Spine Mechanisms显示文摘 | Yanwei Liu Shaoming Sun Xuan Wu Tao Mei | 2015 | Journal of Bionic Engineering2015，12，1： | 13 |
| 20 | A randomized, multicenter controlled trial to compare the efficacy of recombinant human parathyroid hormone (1-34) with elcatonin in postmenopausal women with osteoporosis in China显示文摘背景 Recombinant 人的甲状旁腺的荷尔蒙(1-34 )(rhPTH (注射给的 1 -34)) 一新生物产品的第七班药,它被采用基因再结合准备技术。rhPTH (1 -34) 主要被用来对待骨质疏松症,特别为绝经后的 women.This,学习为在中国的 11 个城市的区域与骨质疏松症对待绝经后的女人把 rhPTH (1-34 ) 的临床的功效和安全与 elcatonin 作比较。有骨质疏松症的 205 个女人被注册在的方法一 6 月, multicenter,使随机化的、控制学习。他们被使随机化收到任何一个 rhPTH (1-34 ) 20 ug (200 U ) 日报或 elcatonin 20 U 周刊。腰部的脊骨(L1-4 ) 和大腿骨的颈骨头矿物质密度(BMD ) ,以及骨头周转的生物化学的标记被测量。不利事件是增加的 recorded.Results rhPTH (1-34 ) 腰部的 BMD 非常显著地在 3 个月和 6 个月做了 elcatonin (2.38% 对 0.59% , P < 0.05;5.51% 对 1.55% , P < 0.01 ) ,但是没有在在大腿骨的颈的这二个组的 BMD 的重要增加。在 rhPTH 的骨头标记有更大的吝啬的增加(1 个 -34) 组比在在 3 个月和 6 个月的 elcatonin 组(浆液骨头特定的碱的磷酸酶(BSAP )36.79% 对 0.31% ;92.42% 对 -0.17% ;尿 N-telopeptide/creatinine (NTX/Cr )48.91% 对 -5.32% ;68.82% 对 -10.86%) 。处理很好被容忍,没有重要差别,在任何不利事件和任何严肃的不利事件的比例在二个组之间检测(67.0% 对 59.0% ;0 对 0 ).Conclusions rhPTH (1-34 ) 比 elcatonin 在骨头形成上有更积极的效果,由腰部的 BMD 和骨头形成标记的更大的增长出现与在肝的仅仅温和的不利事件和没有重要变化,肾或 hematological 索引。 | ZHANG Xiu-zhen WANG Bo YANG Jun XUAN Miao SONG Li-ge LI Hong GUO Xiao-hui LU Xiao-feng XUE Qing-yun YANG Gang-yi JI Qiu-he SHEN Jie LIU Zhi-min LI Cheng-jiang WU Tian-feng TONG Xiao-cui JIA Yuan | 2009 | Chinese Medical Journal2009，，24： | 12 |
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