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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet2001，，9286： | 4 |
| 3 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet . 2001 (9286)2001，，9286： | 4 |
| 4 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | 2001 (9286)2001，，9286： | 4 |
| 5 | 云南省农村地区男男性接触者与HIV相关的风险行为显示文摘目的探讨中国农村地区男男性接触者(MSM)与艾滋病病毒(HIV)相关的风险行为的具体特点和问题。方法采用半结构化深度访谈的方式进行定性研究。通过一个当地的MSM联系网络,以滚雪球和相互转告的方式招集了24名访谈对象。主要测量指标是与HIV有关的风险行为的上升情况。结果在中国农村地区,风险行为、社会歧视、独生子女政策以及传统中医的观念,在HIV的传播中都起着重要的作用。在中国,许多MSM过着双重生活;调查显示,安全套的使用情况也是因人而异,使风险行为'合理化'的意图是决定是否使用安全套的主要因素;就泌尿生殖系统的问题主动寻求医疗帮助的现象很不普遍,而现有卫生系统以及医务人员对此问题表现出来的不敏感,也进一步加剧了这种现象。结论在资源匮乏的农村地区,MSM人群存在着HIV流行的趋势,并有向普通人群传播的危险。 | 张建波 黄志威 T S K Kong D C Y Ling | 2007 | 中国艾滋病性病2007，13，5： | 3 |
| 6 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 7 | Preparation of mesocarbon microbeads from coal tar 显示文摘 | LU Y G LING L C WU D | 1999 | Journal of Material Science1999，34，16： | 1 |
| 8 | Genomic-Sequence Comparison of Two Unrelated Isolates of the Human Gastric Pathogen Helicobacterpylori 显示文摘 | Alm R A Ling L L Moir D T | 1999 | Nature1999，397，14： | 1 |
| 9 | Global existence of solutions for the systems of compressible adiabaatic flow through porous media显示文摘 | HSIAO Ling Serre D | 1996 | SIAM J Math Anal1996，27，1： | 1 |
| 10 | Large-scale shaking table tests on modular-block reinforced soil retaining walls显示文摘 | Ling H I Mohri Y Leshchinsky D | 2005 | Journal of geotechnical and geoenvironmental engineering2005，131，4： | 1 |
| 11 | Amorphous alloy reinforced Whipple shield structure显示文摘 | Huang X Ling Z Liu Z D | | 0，，： | 1 |
| 12 | Changes in micro-RNA profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes显示文摘 | Ling H Y Ou H S Feng S D | | 0，，09： | 1 |
| 13 | The prognostic role of Ki-67/MIB-1 in cervical cancer: a systematic review with meta-analysis 显示文摘 | Pan D Wei K Ling Y | 2015 | Med Sci Monit2015，21，： | 1 |
| 14 | Investigation of the noise reduction provided by tree behs显示文摘 | Fang C F Ling D L | 2003 | Landscape Urban Plan2003，3，： | 1 |
| 15 | Acousto-Optic Tunable Flters: Fundamentals and Applications as Applied to Chemical Analysis Techniques显示文摘 | Ling B Glenn I D Heather M M | 2004 | Progress in Quantum Electronics2004，，28： | 1 |
| 16 | Multiple - input Multiple- output Measurements and Modeling in Manhattan显示文摘 | Chizhik D Ling J Wolniansky P | 2003 | IEEE Journal on Selected Areas in Communications2003，21，3： | 1 |
| 17 | Pricing mortgage -backed securities: Integrating optimal call and empirical models of prepayment 显示文摘 | Archer W R Ling D C | 1993 | AREUEA1993，21，2： | 1 |
| 18 | The EBNA2 polyproline region is dispensable for Epstein-Barr virusmediated immortalization maintenance显示文摘 | Gordadze AV Poston D Ling PD | 2002 | J Virol2002，76，： | 1 |
| 19 | Polymer memories: Bistable electrical switching and device performance显示文摘 | Ling Qidan Liaw D J Teo E Y H | 2007 | Polymer2007，48，18： | 1 |
| 20 | Distribution Of the multidrug effluxpump genes, adeABC, adeDE and adelJK, and class 1 inte-gron genes in multiple-antimicrobial-resistant clinical isolatesof AcinetobacterAcinetobacter calcoaceticus com-plcx显示文摘 | Lin L Ling B D Li X Z | 2009 | International Journal of Antimicrobial Agents2009，33，1： | 1 |
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