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| 1 | Effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients infected with hepatitis B virus显示文摘AIM: To observe the effect of anti-tuberculosis therapy on liver function of pulmonary tuberculosis patients with hepatitis B virus (HBV) infection, and to compare the differences of liver function by two treatments of antituberculosis.METHODS: Forty-seven TB patients with HBV infection and 170 TB patients without HBV infection were divided into HPBE(S) and HLAMKO treatment groups. Liver function tests before and after the treatments were performed once in 2 wk or monthly, and their clinical manifestations were recorded.RESULTS: The rate of hepatotoxicity occurred in 26 (59%)TB patients with HBV during anti-TB treatment, higher than that in 40 (24%) TB patients without HBV. Hepatotoxicity occurred in 66 out of 217 patients, and the incidence of liver dysfunction was 46.1% in HPBE(S) group, significantly higher than that in HLAMKO group (12.7%) (P<0.01).CONCLUSION: TB patients with HBV should choose HLAMKO treatment because of fewer hepatotoxicity. | LeiPan Zhan-ShengJia LinChen En-QingFu Guang-YuLi | 2005 | World Journal of Gastroenterology2005，11，16： | 22 |
| 2 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 3 | Multi-phasic CT arterial portography and CT hepatic arteriography improving the accuracy of liver cancer detection显示文摘AIM: To evaluate the value of multi-phasic CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in differential diagnosis of liver diseases, and to improve the specificity of CTAP and CTHA for liver cancerdetection. METHODS: From January 1999 to December 2002, multiphasic CTAP and CTHA were performed in 20 patients with suspected liver disease. CT scanning was begun 25s, 60s and 120s for the early-, late- and delayed-phase CTAP examinations, and 6sec, 40 s and 120 s for the early-, lateand delayed-phase CTHA examinations respectively, after a transcatheter arterial injection of non-ionic contrast material. If a lesion was diagnosed as a liver cancer, transcatheter hepatic arterial chemoembolization (TACE) treatment was performed, and the follow-up CT was performed three or four weeks later.RESULTS: All eighteen HCCs in 12 cases were shown as nodular enhancement on early-phasic CTHA. The density of the whole tumor decreased rapidly on late and delayed phases, and the edge of 12 tumors (12/18) remained relatively hyperdense compared with the surrounding liver tissue, and demonstrated as rim enhancement. All HCCs were shown as perfusion defect nodules on multi-phasic CTAP. Five tumors (5/18) were shown as rim enhancement on delayed-phasic CTAP. Rim enhancement was shown as 1 to 2-mm-wide irregular, uneven and discontinuous circumferential enhancement at late-, and delayed-phase of CTHA or CTAP. Five pseudolesions and 4 hemoangiomas were found in multi-phasic CTAP and CTHA. No pseudolesions and hemoangiomas were shown as rim enhancement on late- or delayed-phasic CTHA and CTAP.CONCLUSION: Multi-phasic CTAP and CTHA could help to recognize the false-positive findings in CTAP and CTHA images, and improve the accuracy of CTAP and CTHA of liver cancer detection. | LiLi Li-ZhiLiu Zhuan-MiaoXie Yun-XianMo LieZheng Chao-MeiRuan LinChen Pei-HongWu | 2004 | World Journal of Gastroenterology2004，10，21： | 8 |
| 4 | Helicobacter pyloriL-form and patients with chronic gastritis显示文摘AIM: To study the relationship between infection with Helicobacterpylori L-forms and chronic gastritis and its association with possible changes of cellular immune function.METHODS: Gastric mucosal biopsies were taken from 428 patients with chronic gastritis to detect HpyloriL-form by Gram staining and immunohistochemistry staining. Peripheral venous blood samples of patients were taken to detect thepercentage of CD3+, CD4+ and CD8+ by the biotin-streptavidin (BSA) assay and the levels of IL-2, IL-6and IL-8by ELISA.RESULTS: The rate of infection with H pylori L-forms was 48.83% (209/428). The rate was 50.47% (216/428)and 52.80% (226/428), respectively, as detected by immunohistochemistry staining and Gram staining (P>0.05).The rate of H pylori L-forms in males and females was57.8% (136/235) and 37.28% (73/193), respectively,(x^2=17.05, P<0.01). Furthermore, the rate increased with age, with the rate being significantly greater in patients≥40 years old than in those <40 years old (P<0.01). Thepercentage of CD3+, CD4+, CD8+, the ratio of CD4+ / CD8+,and the levels of IL-2, IL-6, IL-8 in Hpylori-positive patients were 47.58+4.44%, 25.51+4.74%, 22.77~7.46%, 1.44+0.51%,1.56+0.47 mg/L, 103.62+5.85 ng/L, and 109.79+7.18 ng/L,respectively. Compared with Hpylori-negative patients, thepercentage of CD3+, CD4+ and the ratio of CD4+ / CD8+and the IL-2 level decreased, but the levels of IL-6, IL-8 increased (P<0.001-P<0.01). Moreover, the percentage of CD3+, CD4+, CD8+, the ratio of CD4+ / CD8+, and the levels of IL-2, IL-6 and IL-8 in patients infected with both H pylori L-forms and vegetative forms were 46.67+5.21%,30.75+4.89%, 22.15+6.45%, 1.32+0.47%, 1.16+0.38 mg/L,116.45+5.44 rig/L, and 118.64+6.24 ng/L, respectively.Compared with patients infected with only vegetative forms,the percentage of CD4^+, the ratio of CD4+ / CD8+and IL- 2 level decreased, but the levels of IL-6 and IL-8 increased(P<0.001 or P<0.01).CONCLUSION: L-form variation often occurs in patients with chronic gastritis and is commonly found in malepatients and associates with ages. The L-form variation may be an important factor causing disorder of cellular immune function in the patients with H pylori-induced chronic gastritis. | Ke-XiaWang LinChen | 2004 | World Journal of Gastroenterology2004，10，9： | 3 |
| 5 | Lightweight and Compromise Resilient Storage Outsourcing with Distributed Secure Accessibility in Mobile Cloud Computing显示文摘Mobile Cloud Computing usually consists of front-end users who possess mobile devices and back-end cloud servers.This paradigm empowers users to pervasively access a large volume of storage resources with portable devices in a distributed and cooperative manner.During the period between up-loading and downloading files (data),the privacy and integrity of files need to be guaranteed.To this end,a family of schemes are proposed for different situations.All schemes are lightweight in terms of computational overhead,resilient to storage compromise on mobile devices,and do not assume that trusted cloud servers are present.Corresponding algorithms are proposed in detail for guiding off-the-shelf implementation.The evaluation of security and performance is also extensively analyzed,justifying the applicability of the proposed schemes. | Wei Ren Linchen Yu Ren Gao Feng Xiong | 2011 | Tsinghua Science and Technology2011，16，5： | 3 |
| 6 | Urban Traffic Information Service Application Grid显示文摘Traffic information processing is very complicated because of dynamic, cooperative and distributed features. This paper describes the prototype system version 2.0 of Urban Traffic Information Service Application Grid (UTISAG),which is based on the previous version. In this version, a new architecture and more enhanced services are introduced.The remarkable characteristic of the new system is providing dynamic information services for travelers by grid technology. Therefore, the key research includes integrating large multi-source traffic data, forecasting route status, simulating regional traffic flow parallelly, and implementing optimum dynamic travel scheme based on massive GPS data. | Chang-JunJiang Zhao-HuiZhang Guo-SunZeng Hong-ZhongChen Duo-QianMiao YuFang Xiao-FengTao QingZhi FengYue YangLuo An-QingZhou LinChen LeiLiu | 2005 | Journal of Computer Science & Technology2005，20，1： | 2 |
| 7 | Generation of insulin‐producing cells from PDX‐1 gene‐modified human mesenchymal stem cells显示文摘 | YanhuaLi RuiZhang HaifaQiao HepingZhang YunfangWang HongfengYuan QinbinLiu DaqingLiu LinChen XuetaoPei | 2007 | J Cell Physiol2007，，1： | 2 |
| 8 | Nitrification kinetics of biofilm as affected by water qualityfactors显示文摘 | SHU LINCHEN JIAN LING JEAN PAUL BLANCHETON | 2006 | Aquacultural Engineering2006，34，3： | 1 |
| 9 | The interaction between collagen and an aluminum tanning agent显示文摘 | HE Li HUA Linchen RONG Luo | 2003 | Macromolecular Bioscience2003，3，7： | 1 |
| 10 | Molecular simulation of the interaction mechanism between CodY protein and DNA in Lactococcus lactis显示文摘In Lactococcus lactis, the global transcriptional regulatory factor CodY can interact with the promoter DNA to regulate the growth, metabolism, environmental adaptation and other biological activities of the strains. In order to study the mechanism of interaction between CodY and its target DNA, molecular docking and molecular dynamics simulations were used to explore the binding process at molecular level. Through the calculations of the free energy of binding, hydrogen bonding and energy decomposition, nine key residues of CodY were identified, corresponding to SERI84, SERI 86, SER20& THR217, ARG21 & SER219, ASN223, LYS242 and GLY243, among which SERI86, ARG218 and LYS242 play a vital role in DNA binding. Our research results provide important theoretical guidance for using wet-lab methods to study and optimize the metabolic network regulated by CodY. | Linchen Yuan Hao Wu Yue Zhao Xiaoyu Qin Yanni Li | 2019 | Frontiers of Chemical Science and Engineering2019，13，1： | 1 |
| 11 | Highly Sensitive Chemiluminescence Detection for PDMS/GIass Micro-chip Electrophoresis显示文摘This paper described a highly sensitive chemiluminescence detection system for micro-chip electrophoresis (MCE) based on luminol-hydrogen peroxide reaction catalyzed by the metal ions. The micro-chip was composed of poly(dimethylsiloxane) (PDMS) and glass, and was fabricated by micro-machining technology. The surface of channels was dynamically modified by polydimethylacrylamide (PDMA) in order to eliminate unhomogeneous electroosmotic flow (EOF) of the PDMS/glass chip, adsorption of molecules, and improve hydrophobicity on PDMS surface.The detection modes, reagent mix procedures and reaction conditions were optimized and the detection limit of 5 × 10^-11mol/L for cobalt (Ⅱ) was achieved by MCE with chemiluminescence detection, which was about four orders of magnitude more sensitive than that reported in the reference. | XiangYiHUANG JiaoNingWANG LinCHEN JiCurtREN | 2004 | Chinese Chemical Letters2004，15，6： | 1 |
| 12 | RISE: A RelIable and SEcure Scheme for Wireless Machine to Machine Communications显示文摘Wireless Machine to Machine (M2M) communications enable ubiquitous sensing, controlling, and acting via sensors, actuators, and actors. Reliability and security are of foremost importance in wireless M2M systems. A simple, target distinguishing attack can result in M2M's failure. This paper presents a RelIable and SEcure scheme, RISE, which is a package of policies that guarantee the reliability of data (including sensor reports and actuator instructions) and devices (including sensors, actuators, and actors). The data reliability is improved by four algorithms, ChooseMedian, ChooseMost, ChooseNearest, and Trust-based Enhancement. Report attainability is improved via m repeat-sending and n multiple-reporting algorithms. Device reliability is guaranteed by device-indistinguishability, which comprises data-indistinguishability and behavior-indistinguishability. The security requirements are formally defined, and the security analysis proves the soundness and completeness of the scheme. | Wei Ren Linchen Yu Liangli Ma Yi Ren | 2013 | Tsinghua Science and Technology2013，18，1： | 1 |
| 13 | CoP: An Ultra-Lightweight Secure Network Coding Scheme via Last Forwarder's Proof显示文摘Network coding can improve network efficiency by extending copy-and-forward paradigm to code-and- forward paradigm. It thus imposes a security problem called pollution attack that some network coding or forwarding nodes may intentionally fabricate, modify, forge, or drop packets. Recently, many authentication methods are proposed to guarantee the correctness of encoding and forwarding results via the verification from receivers. Those methods include homomorphic hashing, homomorphic message authentication code, and homomorphic signature. However, those schemes result in expensive computation overhead due to the homomorphic cryptographic primitives, so that those methods will not be able to work in most applications that confront resource constraints. In this paper, we propose an ultra-lightweight checking protocol to guarantee the secure network coding without any homomorphic cryptographic primitives. The extensive analysis proofs that it has following advantages: the least security assumption for intermediate nodes, the least cryptographic primitive requirement, ultra-lightweight computation, flexible message length with probably proof, and minimal rounds in terms of message exchanging. | Wei Ren Linchen Yu Liangli Ma | 2012 | Tsinghua Science and Technology2012，17，5： | 1 |
| 14 | The prevalence and clinical impact of pulmonary artery sling on school‐aged children: A large‐scale screening study显示文摘 | Jung‐MinYu Chung‐PinLiao ShupingGe Zen‐ChungWeng Ming‐ChonHsiung Jia‐KanChang Fong LinChen | 2008 | Pediatr. Pulmonol2008，，7： | 1 |
| 15 | HA-Fe uptake by plants显示文摘 | LINCHEN D J | | 0，，： | 1 |
| 16 | A Mild and Efficient Oxidation of Alcohols in Water显示文摘A mild and efficient oxidation of alcohols to the corresponding carbonyl compounds using the PhI(OAc)2 (1.1 eq.) with n-Bu4NBr (8 mol %) in water at room temperature is described. This new procedure is very simple and affords the desired carbonyl compounds in high yields. | ChuanZhiXU LinCHEN ZhenLI WeiSUN ChunGuXIA | 2004 | Chinese Chemical Letters2004，15，10： | 1 |
| 17 | The prevalence and clinical impact of pulmonary artery sling on school‐aged children: A large‐scale screening study显示文摘 | Jung‐MinYu Chung‐PinLiao ShupingGe Zen‐ChungWeng Ming‐ChonHsiung Jia‐KanChang Fong LinChen | 2008 | Pediatr Pulmonol2008，，7： | 1 |
| 18 | Chronic pretreatment of ACEI reduces no‐reflow in patients with acute myocardial infarction treated with primary angioplasty显示文摘 | Jing‐LinZhao Yue‐JinYang Yuan‐HuiZhang Wei‐DongPei Yu‐Hua Sun Ji‐LinChen Run‐LinGao | 2007 | Clin Cardiol2007，，3： | 1 |
| 19 | Microwave Irradiation Promoted Synthesis of Aryloxy Acetic Acids显示文摘Several aryloxy acetic acids were synthesized under microwave irradiation. The factors, which affect the reaction, were investigated and optimized. It was revealed that the best yields(92.7%—97.4%) were obtained when the molar ratio of the reactants was n(ArOH)∶n(NaOH)∶n(ClCH 2CO 2H) =1∶2.5∶1.2 with microwave irradiation power of 640 W for 65—85 s. | LINMin ZHOUJin-mei XIAHai-ping YANGRui-feng LINChen | 2004 | Chemical Research in Chinese Universities2004，20，2： | 1 |
| 20 | Synthesis and antibacterial activity of novel 3-O-carbamoyl de- rivatives of clarithromycin and 11,12-cyclic carbonate azithro- mycin显示文摘 | ZHANG LING SONG LINCHEN LIU ZHAOPENG | 2010 | European Journal of Medicinal Chemistry2010，45，3： | 1 |
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