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| 1 | Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair显示文摘间充质的干细胞(MSC ) 为治疗各种各样的疾病有大潜力,特别那些与织物有关损坏包含有免疫力的反应。各种各样的研究证明了 MSC 在 vitro 并且在 vivo 是强烈抑制免疫力的。我们的最近的研究证明了那未刺激的 MSC 确实不能免疫力的抑制;他们与 TNF- 伪, IL-1 伪或 IL-1 尾与激活的淋巴细胞的上层清液,或与 IFN- 纬的联合在刺激之上变得 potently 抑制免疫力。这观察表明在某些情形下面,煽动性的 cytokines 能实际上变得抑制免疫力。我们证明在调停 MSC 的免疫力的抑制的机制有一个种类变化:由告知 cytokine 的老鼠 MSC 的免疫力的抑制被氮的氧化物调停(没有) 而由告知 cytokine 的人的 MSC 的免疫力的抑制通过 indoleamine 被执行 2, 3-dioxygenase (伊多语) 。在有煽动性的 cytokines 的刺激之上,另外,老鼠和人的 MSC 分泌几白血球 chemokines 显然服务与 MSC 吸引有免疫力的房间进最近,在哪儿不或伊多语被预言很活跃。因此,由煽动性的刺激 cytokine 的 MSC 的免疫力的抑制经由 chemokines 的一致行动发生并且免疫者禁止没有或伊多语由 MSC 生产了。因此,我们的结果在对待有免疫力的回答导致的织物损害关于调停 MSC 的免疫力的抑制并且为 MSC 的更好的申请的机制提供新奇信息。 | Yufang Shi Gangzheng Hu Juanjuan Su Wenzhao Li Qing Chen Peishun Shou Chunliang Xu Xiaodong Chen Yin Huang Zhexin Zhu Xin Huang Xiaoyan Han Ningxia Xie Guangwen Ren | 2010 | Cell Research2010，20，5： | 72 |
| 2 | 中国糖尿病发病率和检出率地域性差异——98058例成年受试者数据多水平空间分析显示文摘目的探究中国糖尿病发病率和检出率地域性差异。方法选取分布在中国大陆162个地区的98058例18岁以上成年受试者的自述报告和生物学数据(90.5%反馈率),采用美国糖尿病协会糖尿病诊疗标准评估受试者的糖尿病症状,根据先前诊断结果 ,做出其是否患有糖尿病的判断。以各省为单位,使用分区统计图表法评估各调研数据结果的地域性差异。应用多元logistic回归分析法,校正个体和地域层级的差别后,评估每个结果出现的概率。结果各省糖尿病患者的地理分布反映出中国糖尿病发病率和检出率地域性差异。校正年龄、性别和城市/农村社会经济状况等因素后,糖尿病发病率自东北部向北部,从8.3%(95%CI 7.2%,9.7%)上升至12.7%(11.1%,14.6%)。从较好社会经济状况(socioeconomic circumstances,SEC)的城市到农村较差社会经济状况的县/区,糖尿病发病率呈下降趋势,分别为13.1%(12.0%,14.4%)和8.7%(7.8%,9.6%)。校正健康知识水平和个人原因两个因素后,地域性差异仍具有统计学意义。仅三分之一的糖尿病患者在接受此次测试前有糖尿病诊断史,但此结果因地域不同而不同。校正年龄、性别和城市/农村SEC后,糖尿病检出率自北向西南从40.4%(34.9%,46.3%)下降至15.6%(11.7%,20.5%)。与较好SEC县市的40.8%(37.3%,44.4%)检出率相比,农村较差SEC地区的检出率最低,仅为20.5%(17.7%,23.7%)。糖尿病检出率的地域性差异并不完全是个体差异造成的。结论加强防控糖尿病意识,提高检测准确率应从地域性因素出发。 | 陈研 陈刚 Maigeng Zhou Thomas Astell-Burt Yufang Bi | 2015 | 创伤与急诊电子杂志2015，3，4： | 42 |
| 3 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 4 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 5 | Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation显示文摘Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death. | Yufang Wang Peiliang Shi Qin Chen Zan Huang Dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin | 2019 | Journal of Molecular Cell Biology2019，11，12： | 23 |
| 6 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 7 | Effects of arbuscular mycorrhizal fungi inoculation on arsenic accumulation by tobacco (Nicotiana tabacum L.)显示文摘A pot experiment was conducted to study the effects of arbuscular mycorrhizal(AM) fungi(from contaminated or uncontaminated soils) on arsenic(As) uptake of tobacco(Nicotiana tabacum L.) in As-contaminated soil.Mycorrhizal colonization rate,dry weight,As and P uptake by plants,concentrations of water-extractable As and As fractions were determined.A low mycorrhizal colonization rate(<25%) was detected.Our research indicated that AM fungi isolated from polluted soils were no more effective than those from unpolluted soils when grown in symbiosis with tobacco.No significant differences were observed in roots and stalks dry weights among all treatments.Leaves and total plant dry weights were much higher in Glomus versiforme treatment than that in control treatment.As contents in roots and stalks from mycorrhizal treatments were much lower than that from control treatment.Total plant As content exhibited the same trend.P concentrations in tobacco were not affected by colonization,nor were stalks,leaves and total plant P contents.Roots P contents were remarkably lower in HN treatments than in other treatments.Meanwhile,decreased soil pH and lower water-extractable As concentrations and higher levels of As fraction bound to well-crystallized hydrous oxides of Fe and Al were found in mycorrhizal treatments than in controls.The protective effect of mycorrhiza against plant As uptake may be associated with changes in As solubility mediated by changing soil pH.These results indicated that under As stress,proper mechanisms employed by AM fungi can protect tobacco against As uptake.Results confirmed that AM fungi can play an important role in food quality and safety. | HUA Jianfeng LIN Xiangui YIN Rui JIANG Qian SHAO Yufang | 2009 | Journal of Environmental Sciences2009，21，9： | 19 |
| 8 | Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice显示文摘In the present study,we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer’s disease model mice.Immunofluorescence staining revealed that the number of newly generated(BrdU+)cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer’s disease mice after adipose-derived mesenchymal stem cell transplantation,and there was also a significant increase in the number of BrdU+/DCX+neuroblasts in these animals.Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well.Furthermore,adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice.Based on these findings,we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer’s disease mice,thereby facilitating functional recovery. | Yufang Yan Tuo Ma Kai Gong Qiang Ao Xiufang Zhang Yao Gong | 2014 | Neural Regeneration Research2014，9，8： | 16 |
| 9 | The impact of high-temperature stress on rice: Challenges and solutions显示文摘Heat stress (HS) caused by rapidly warming climate has become a serious threat to global food security.Rice (Oryza sativa L.) is a staple food crop for over half of the world’s population,and its yield and quality are often reduced by HS.There is an urgent need for breeding heat-tolerant rice cultivars.Rice plants show various morphological and physiological symptoms under HS.Precise analysis of the symptoms(phenotyping) is essential for the selection of elite germplasm and the identification of thermotolerance genes.In response to HS,rice plants trigger a cascade of events and activate complex transcriptional regulatory networks.Protein homeostasis under HS is especially important for rice thermotolerance,which is affected by protein quality control,effective elimination of toxic proteins,and translational regulation.Although some agronomic and genetic approaches for improving heat tolerance have been adopted in rice,the molecular mechanisms underlying rice response to HS are still elusive,and success in engineering rice thermotolerance in breeding has been limited.In this review,we summarize HS-caused symptoms in rice and progress in heat-stress sensing and signal cascade research,and propose approaches for improving rice thermotolerance in future. | Yufang Xu Chengcai Chu Shanguo Yao | 2021 | The Crop Journal2021，9，5： | 14 |
| 10 | NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。 | Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian | 2012 | Cell Research2012，22，5： | 13 |
| 11 | Apoptosis signaling pathways and lymphocyte homeostasis显示文摘自从术语起,现在是几乎三十年“ apoptosis ”首先被制造描述包含的房间死亡的一种唯一的形式有序,基因依赖者细胞 disintegration.It 现在很好被接受那 apoptosis 是为后生动物的动物的一个必要生活过程并且为纸巾和器官的形成和功能是批评的。在成年哺乳动物的身体, apoptosis 为免疫系统的合适的工作是特别重要的。在最近的年里,与分子、细胞的生物学的快速的前进一起,大进步在理解导致 apoptosis 的机制被取得了。有 apoptotic 房间死亡正式就职的二条主要小径,这通常被接受:通过导致导致死亡的发信号的形成的死亡受体的外来的发信号建筑群(圆盘) ,并且主要通过导致 apoptosome 的形成的线粒体的内在的发信号。分别地,磁盘 orapoptosome 的形成激活开始者和执行 theapoptosis 过程的普通受动器 caspases。在免疫系统,两条小径操作;然而,他们是否是足够的维持淋巴细胞动态平衡,不被知道。最近, includingcaspase 独立的小径和开始 granzyme 的小径被显示出在淋巴细胞存在的新 apoptotic 机制。这评论将总结我们控制各种各样的淋巴细胞人口的动态平衡的机制的理解。 | Guangwu Xu Yufang Shi | 2007 | Cell Research2007，17，9： | 13 |
| 12 | Morphological evolution of mouth bars on the Yangtze estuarine waterways in the last 100 years显示文摘在 Yangtze 河口水路的嘴酒吧在河口,洪水分泌物和上海港口的建设以内在航行运输上有重要影响。在这份报纸, Yangtze 河口水路的嘴酒吧形成的词法进化和机制被分析几百年历史的数据学习,一些或主要的嘴的最近的侧面地图在 Yangtze 河口锁隧道。结果如下被显示出:在北方布朗奇的嘴酒吧从在嘴外面逐渐地搬到里面并且形成了一个巨大的沙酒吧。在北方隧道,嘴酒吧的头下游地移植了大约 30 公里,并且自从 2001,一个隧道酒吧发展中。二个嘴酒吧顶,总是在北方经过存在,消失在 2010。在南方经过的嘴酒吧的头下游地移植了大约 14 km,顶的数字起初增加了,但是现在被归结为仅仅。根据结果,我们能断定嘴酒吧的进化不同取决于他们的地点。在它是的北方布朗奇,直接,与在 Chongming 岛的大规模开垦有关,但是在诺思经过,它与 Yangtze 河口深海的隧道的规定有一种靠近的关系。然而,在北方隧道和南方经过的嘴酒吧的进化是不仅在浅的东方 Hengsha 和 Qingcaosha 水库的闭合与 Yangtze 河口深海的隧道规定工程,而且与开垦连接了。 | HE Yufang CHENG Heqin CHEN Jiyu | 2013 | Journal of Geographical Sciences2013，23，2： | 9 |
| 13 | Toluene decomposition performance and NOx by-product formation during a DBD-catalyst process显示文摘Characteristics of toluene decomposition and formation of nitrogen oxide(NOx) by-products were investigated in a dielectric barrier discharge(DBD) reactor with/without catalyst at room temperature and atmospheric pressure. Four kinds of metal oxides, i.e., manganese oxide(Mn Ox), iron oxide(Fe Ox), cobalt oxide(Co Ox) and copper oxide(Cu O), supported on Al2O3/nickel foam, were used as catalysts. It was found that introducing catalysts could improve toluene removal efficiency, promote decomposition of by-product ozone and enhance CO2 selectivity. In addition, NOx was suppressed with the decrease of specific energy density(SED) and the increase of humidity, gas flow rate and toluene concentration, or catalyst introduction. Among the four kinds of catalysts, the Cu O catalyst showed the best performance in NOx suppression. The Mn Ox catalyst exhibited the lowest concentration of O3 and highest CO2 selectivity but the highest concentration of NOx. A possible pathway for NOx production in DBD was discussed. The contributions of oxygen active species and hydroxyl radicals are dominant in NOx suppression. | Yufang Guo Xiaobin Liao Mingli Fu Haibao Huang Daiqi Ye | 2015 | Journal of Environmental Sciences2015，27，2： | 7 |
| 14 | Genetic-algorithm-based deep neural networks for highly efficient photonic device design显示文摘While deep learning has demonstrated tremendous potential for photonic device design,it often demands a large amount of labeled data to train these deep neural network models.Preparing these data requires high-resolution numerical simulations or experimental measurements and cost significant,if not prohibitive,time and resources.In this work,we present a highly efficient inverse design method that combines deep neural networks with a genetic algorithm to optimize the geometry of photonic devices in the polar coordinate system.The method requires significantly less training data compared with previous inverse design methods.We implement this method to design several ultra-compact silicon photonics devices with challenging properties including power splitters with uncommon splitting ratios,a TE mode converter,and a broadband power splitter.These devices are free of the features beyond the capability of photolithography and generally in compliance with silicon photonics fabrication design rules. | YANGMING REN LINGXUAN ZHANG WEIQIANG WANG XINYU WANG YUFANG LEI YULONG XUE XIAOCHEN SUN WENFU ZHANG | 2021 | Photonics Research2021，9，6： | 6 |
| 15 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 16 | The secretion profile of mesenchymal stem cells and potential applications in treating human diseases显示文摘Mesenchymal stromal/stem cells(MSCs)possess multi-lineage differentiation and self-renewal potentials.MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases,due to the potent immunoregulatory functions of MSCs.An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions.Growth factors,cytokines,chemokines,extracellular matrix components,and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms.These secretory factors contribute to immune modulation,tissue remodeling,and cellular homeostasis during regeneration.In this review,we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. | Yuyi Han Jianxin Yang Jiankai Fang Yipeng Zhou Eleonora Candi Jihong Wang Dong Hua Changshun Shao Yufang Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 6 |
| 17 | Investigating long-term vehicle speed prediction based on GA-BP algorithms and the road-traffic environment显示文摘Dear editor,Effective and accurate long-term speed prediction is crucial for intelligent transportation and automobile intelligent energy management systems of intelligent connected vehicles.These predictions have important research value and broad application prospects including widespread use in improving traffic efficiency and safety,fuel economy,remaining driving range estimation[1]. | Yufang LI Chen REN Hongwei ZHAO Guoping CHEN | 2020 | Science China(Information Sciences)2020，63，9： | 6 |
| 18 | Triterpenoids from Erythrophleum fordii显示文摘A phytochemical investigation of the bark of Erythroph/eum fordii Oliv. furnished five compounds.One is a new triterpenoid, namely 20S, 24S-epoxy-23S, 25-dihydroxy-dammarane-3-one (1), and four areknown, identified to be 20S, 25-epoxy-24R-hydroxydammarane-3-one (2), 20S, 24S-epoxydammarane-3β,25-diol (3), betulinic acid (4), morolic acid acetate (5). All the known compounds were isolated from thespecies for the first time. The structure of compound 1 was elucidated on the basis of spectroscopicanalyses. | LINan YUFang YUShi-Shan | 2004 | Acta Botanica Sinica2004，46，3： | 6 |
| 19 | Research on optimized GA-SVM vehicle speed prediction model based on driver-vehicle-road-traffic system显示文摘The accurate prediction of vehicle speed plays an important role in vehicle's real-time energy management and online optimization control. However, the current forecast methods are mostly based on traffic conditions to predict the speed, while ignoring the impact of the driver-vehicle-road system on the actual speed profile. In this paper, the correlation of velocity and its effect factors under various driving conditions were firstly analyzed based on driver-vehicle-road-traffic data records for a more accurate prediction model. With the modeling time and prediction time considered separately, the effectiveness and accuracy of several typical artificial-intelligence speed prediction algorithms were analyzed. The results show that the combination of niche immunegenetic algorithm-support vector machine(NIGA-SVM) prediction algorithm on the city roads with genetic algorithmsupport vector machine(GA-SVM) prediction algorithm on the suburb roads and on the freeway can sharply improve the accuracy and timeliness of vehicle speed forecasting. Afterwards, the optimized GA-SVM vehicle speed prediction model was established in accordance with the optimized GA-SVM prediction algorithm at different times. And the test results verified its validity and rationality of the prediction algorithm. | LI YuFang CHEN MingNuo LU XiaoDing ZHAO WanZhong | 2018 | Science China(Technological Sciences)2018，61，5： | 5 |
| 20 | Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy显示文摘Checkpoint blockade-based immunotherapy offers new options and powerful weapons for the treatment of cancer,but its efficacy varies greatly among different types of cancer and across individual patients.Thus,the development of the right tools that can be used to identify patients who could benefit from this therapy is of utmost importance in order to maximize the therapeutic benefit,minimize risk of toxicities,and guide combination approaches.Multiple predictors have emerged that are based on checkpoint receptor ligand expression,tumor mutational burden,neoantigen and microsatellite instability,tumor-infiltrating immune cells,and peripheral blood biomarkers.In this review,we discuss the current state and progress of predictors as aids in checkpoint blockadebased immunotherapy in cancer. | Xiaolei Li Wenhui Song Changshun Shao Yufang Shi Weidong Han | 2019 | Cellular & Molecular Immunology2019，16，1： | 5 |
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