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| 1 | Full-thickness tissue engineered skin constructed with autogenic bone marrow mesenchymal stem cells显示文摘To explore the feasibility of repairing clinical cutaneous deficiency, autogenic bone marrow mesen-chymal stem cells (BMSCs) were isolated and differentiated into epidermal cells and fibroblasts in vitro supplemented with different inducing factors and biomaterials to construct functional tissue- engineered skin. The results showed that after 72 h induction, BMSCs displayed morphologic changes such as typical epidermal cell arrangement, from spindle shape to round or oval; tonofibrils, melano-somes and keratohyaline granules were observed under a transmission electronic microscope. The differentiated cells expressed epidermal stem cell surface marker CK19 (59.66% ± 4.2%) and epidermal cells differentiation marker CK10. In addition, the induced epidermal cells acquired the anti-radiation capacity featured by lowered apoptosis following exposure to UVB. On the other hand, the collagen microfibrils deposition was noticed under a transmission electronic microscope after differentiating into dermis fibroblasts; RT-PCR identified collagen type I mRNA expression in differentiated cells; radioimmunoassay detected the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) (up to 115.06 pg/mL and 0.84 ng/mL, respectively). Further in vivo implanting BMSCs with scaffold material short-ened skin wound repair significantly. In one word, autogenic BMSCs have the potential to differentiate into epidermal cells and fibroblasts in vitro, and show clinical feasibility acting as epidermis-like and dermis-like seed cells in skin engineering. | HE LiJuan, NAN Xue, WANG YunFang, GUAN LiDong, BAI CiXian, SHI ShuangShuang, YUAN HongFeng, CHEN Lin, LIU DaQing & PEI XueTao Laboratory of Stem Cells and Regenerative Medicine, Institute of Blood Transfusion, Academy of Military Medical Sciences, Beijing 100850, China | 2007 | Science China(Life Sciences)2007，50，4： | 16 |
| 2 | Influence of surfactants on the morphology and photocatalytic activity of Bi_2WO_6 by hydrothermal synthesis显示文摘The flower-like microsphere Bi2WO6 with an average diameter of 2.5 μm is synthesized by a simple hydrothermal method in the presence of surfactant sodium dodecyl sulfate (SDS) or polyvinylpyrrolidone (PVP).The crystalline phase,compositions,morphology,microstructure,surface area and band gap energy of the Bi2WO6 are characterized by X-ray diffraction,X-ray energy-dispersive spectrum,scanning electron microscopy,transmission electron microscopy and absorption spectra.It is found that surfactant has a significant influence on the microstructure and properties of the samples.The surfactant SDS enhances the surface area and photocatalytic activity of Bi2WO6,while the surfactant PVP has an opposite effect.Under Xe lamp irradiation,the Bi2WO6 sample prepared in the presence of SDS can degrade dye Rhodamine B (RhB) effectively. | HUANG Yi,WU JiHuai,HUANG MiaoLiang,LIN JianMing & HUANG YunFang Engineering Research Center of Environment-Friendly Functional Materials,Ministry of Education Institute of Materials Physical Chemistry,Huaqiao University,Quanzhou 362021,China | 2011 | Science China Chemistry2011，54，1： | 6 |
| 3 | Halide Homogenization for High-Performance Blue Perovskite Electroluminescence显示文摘Metal halide perovskite light-emitting diodes(LEDs)have achieved great progress in recent years.However,bright and spectrally stable blue perovskite LED remains a significant challenge.Three-dimensional mixed-halide perovskites have potential to achieve high brightness electroluminescence,but their emission spectra are unstable as a result of halide phase separation.Here,we reveal that there is already heterogeneous distribution of halides in the as-deposited perovskite films,which can trace back to the nonuniform mixture of halides in the precursors.By simply introducing cationic surfactants to improve the homogeneity of the halides in the precursor solution,we can overcome the phase segregation issue and obtain spectrally stable single-phase blueemitting perovskites.We demonstrate efficient blue perovskite LEDs with high brightness,e.g.,luminous efficacy of 4.7,2.9,and 0.4 lmW^(-1) and luminance of over 37,000,9,300,and 1,300 cdm^(-2) for sky blue,blue,and deep blue with Commission Internationale de l’Eclairage(CIE)coordinates of(0.068,0.268),(0.091,0.165),and(0.129,0.061),respectively,suggesting real promise of perovskites for LED applications. | Lu Cheng Chang Yi Yunfang Tong Lin Zhu Gunnar Kusch Xiaoyu Wang Xinjiang Wang Tao Jiang Hao Zhang Ju Zhang Chen Xue Hong Chen Wenjie Xu Dawei Liu Rachel AOliver Richard HFriend Lijun Zhang Nana Wang Wei Huang Jianpu Wang | 2020 | Research2020，，1： | 4 |
| 4 | High-Performance and Hysteresis-Free Perovskite Solar Cells Based on Rare-Earth-Doped SnO_(2) Mesoporous Scaffold显示文摘Tin oxide(SnO_(2)),as electron transport material to substitute titanium oxide(TiO_(2))in perovskite solar cells(PSCs),has aroused wide interests.However,the performance of the PSCs based on SnO_(2) is still hard to compete with the TiO_(2)-based devices.Herein,a novel strategy is designed to enhance the photovoltaic performance and long-term stability of PSCs by integrating rare-earth ions Ln^(3+)(Sc^(3+),Y^(3+),La^(3+))with SnO_(2) nanospheres as mesoporous scaffold.The doping of Ln promotes the formation of dense and large-sized perovskite crystals,which facilitate interfacial contact of electron transport layer/perovskite layer and improve charge transport dynamics.Ln dopant optimizes the energy level of perovskite layer,reduces the charge transport resistance,and mitigates the trap state density.As a result,the optimized mesoporous PSC achieves a champion power conversion efficiency(PCE)of 20.63%without hysteresis,while the undoped PSC obtains an efficiency of 19.01%.The investigation demonstrates that the rare-earth doping is low-cost and effective method to improve the photovoltaic performance of SnO_(2)-based PSCs. | Qiyao Guo Jihuai Wu Yuqian Yang Xuping Liu Zhang Lan Jianming Lin Miaoliang Huang Yuelin Wei Jia Dong Jinbiao Jia Yunfang Huang | 2019 | Research2019，，1： | 3 |
| 5 | Proliferation and differentiation into endothelial cells of human bone marrow mesenchymal stem cells (MSCs) on poly DL-lactic-co-glycolic acid (PLGA) films显示文摘The functional realization is the most important problem in vascular tissue engineering. The small-caliber blood vessel substitutes are prone to thrombi, which results in functional loss of blood vessels. However, this is probably due to the imper- fection of endothelial layer in the substitutes. In this study, MSCs were seeded on a series of porous PLGA films with various porosity and pore size made by sodium chloride (NaCl) particulate leaching, and cell proliferation on each film was inspected. The film made of the 75% (w/w) particulate proportion and 30―50 μm pore size maximized the proliferation rate and was chosen as the scaffolds for the differentia- tion of MSCs into endothelial cells. The induced cells expressed endothelial cells specific Flk-1, Ⅷ factor and CD34, possessed endothelial cells specific Weible-palade (W-P) body, and had the abilities of ingesting low density lipoprotein and secreting prostacyclin (PGI2). The results show that MSCs not only have the ideal biological compatibility with the porous PLGA films, but also have the potency of dif- ferentiating into functional endothelial cells, whichshould facilitate the endothelialization in vascular tissue engineering. | YUE Huimin ZHANG Lei WANG Yunfang LIANG Feng GUAN Lidong Li Shaoqing YAN Fang NAN Xue BAI Cixian LIN Feng YAN Yongnian PEI Xuetao | 2006 | Chinese Science Bulletin2006，51，11： | 3 |
| 6 | Application of a novel redox-active electrolyte in MnO_2-based supercapacitors显示文摘This paper reports a novel strategy for preparing redox-active electrolyte through introducing a redox-mediator(p-phenylenediamine,PPD) into KOH electrolyte for the application of ball-milled MnO 2-based supercapacitors.The morphology and compositions of ball-milled MnO 2 were characterized using scanning electron microscopy(SEM) and X-ray diffraction(XRD).The electrochemical properties of the supercapacitor were evaluated by cyclic voltammetry(CV),galvanostatic charge-discharge(GCD),and electrochemical impedance spectroscopy(EIS) techniques.The introduction of p-phenylenediamine significantly improves the performance of the supercapacitor.The electrode specific capacitance of the supercapacitor is 325.24 F g-1,increased by 6.25 folds compared with that of the unmodified system(44.87 F g-1) at the same current density,and the energy density has nearly a 10-fold increase,reaching 10.12 Wh Kg-1.In addition,the supercapacitor exhibits good cycle-life stability. | YU HaiJun WU JiHuai FAN LeQing LIN YouZhen CHEN ShuHong CHEN Yuan WANG JiangLi HUANG MiaoLiang LIN JianMing LAN Zhang HUANG YunFang | 2012 | Science China Chemistry2012，55，7： | 3 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | Adaptive probabilities of crossover and mutation in genetic algorithms based on cloud generators显示文摘 | Zhu Yunfang Dai Chaohua Chen Weirong Lin Jianhui | 2005 | Journal of Computational Information Systems2005，1，4： | 1 |
| 9 | Natural dyes as photosensitizers for dye-sensitized solar cell显示文摘 | Sancun Hao Jihuai Wu Yunfang Huang Jianming Lin | 2005 | Solar Energy2005，，2： | 1 |
| 10 | A Comparative Study About the Neuroprotective Effects of EPA-Enriched Phosphoethanolamine Plasmalogen and Phosphatidylethanolamine Against Oxidative Damage in Primary Hippocampal Neurons显示文摘s Oxidative stress is involved in the progression of neurodegenerative diseases.Previous evidences showed that plasma-logens could improve neurodegenerative diseases.In this study,we investigated the function of phosphoethanolamine plasmalogens enriched with EPA(EPA-pPE)and phosphatidylethanolamine enriched with EPA(EPA-PE)on oxidative damage prevention after hy-drogen peroxide(H2O2)and tert-butylhydroperoxide(t-BHP)challenge in primary hippocampal neurons.Results showed that neurons pretreated with EPA-pPE and EPA-PE demonstrated the ability to alleviate oxidative damage,which was proved by the in-creased cell viability.Moreover,the shape and number of neurons were more similar to those of the control group.Antioxidant acti-vity,apoptosis,as well as TrkB/ERK/CREB signaling pathway were investigated to explore the mechanisms.The results suggested that EPA-PE was superior to EPA-pPE in regulating mitochondrial apoptosis.EPA-pPE was more prominent than EPA-PE in upre-gulating TrkB/ERK/CREB signaling pathway.Phospholipids with EPA exerted neuroprotective effects via inhibiting oxidative stress,suppressing apoptosis,and regulating TrkB/ERK/CREB signaling pathway.Therefore,the results provide a scientific basis for utili-zation of phospholipids enriched with EPA on the treatment of neurodegenerative disease. | ZHU Yunfang ZHANG Tiantian DING Lin SHI Haohao XUE Changhu XIE Wancui CHE Hongxia WANG Yuming | 2021 | Journal of Ocean University of China2021，20，5： | 1 |
| 11 | Photocatalytic property of nitrogen-doped layered perovskite K2La2Ti3O10显示文摘 | Yunfang Huang Yuelin Wei Shuhong Cheng Leqing Fan Yibin Li Jianmin Lin Jihuai Wu | 2010 | Solar Energy Materials & Solar Cells2010，94，： | 1 |
| 12 | Synthesis and photocatalytic properties of layered nanocomposite H 2 La 2 Ti 3 O 10 /Fe 2 O 3显示文摘 | Jihuai Wu Yunfang Huang Taohai Li Jianming Lin Miaoliang Huang Yuelin Wei | 2006 | Scripta Materialia2006，，7： | 1 |
| 13 | Synthesis and photocatalytic properties of H2La2Ti3O10/TiO2 intercalated nanomaterial显示文摘 | Yunfang Huang Jihuai Wu Taohai Li Shancun Hao Jianming Lin | 2006 | Journal of Porous Materials2006，，1： | 1 |
| 14 | Role of epimorphin in bile duct formation of rat liver epithelial stem‐like cells: Involvement of small G protein RhoA and C/EBPβ显示文摘 | Yali Jia Hailei Yao Junnian Zhou Lin Chen Quan Zeng Hongfeng Yuan Lei Shi Xue Nan Yunfang Wang Wen Yue Xuetao Pei | 2011 | J Cell Physiol2011，，11： | 1 |
| 15 | Adaptive probabilities of crossover and mutation in genetic algorithms based on cloud generators显示文摘 | Zhu Yunfang Dai Chaohua Chen Weirong Lin Jianhui | 2005 | Journal of Computational Information Systems2005，1，4： | 1 |
| 16 | Local Anomalies of the Load-Unload Response of the Geomagnetic Field to Solar Wind and Earthquakes in Southwest China显示文摘Many earthquakes occurred during the period 1994 -1996 in Sichuan and Yunnan Provinces, Southwest China. Taking the process of the initial main phase recovery phase of the magnetic storm as the process of load-unload response of the geomagnetic field to the solar wind, we have estimated and analyzed the distribution in time and space of the load-unload response ratio P(z) of the storm time disturbance daily variation of the vertical component Z of the geomagnetic field at ten stations in Southwest China. We found that the area with high ratio P(z) was just the area where moderately strong earthquakes would occur from 44 days to 15 months later. The relationship between the high ratio P(z) and weather disasters in both seismic and non-seismic areas is discussed briefly. | Xu Chunrong, Lin Yunfang, Lu Guifang, Zhao Ming, Li Shengxiang, Gou Xianbin, Yu Jingzhong, and Zeng XiaopingInstitute of Crustal Dynamics, CSB, Beijing 100085, China Institute of Geophysics, CSB, Beijing 100081, China Seismological Bureau of Yunnan Province, Kunming 650041, China Seismological Office of Chongqing Municipality, Chongqing 630056, China | 1998 | Earthquake Research in China1998，12，4： | 0 |
| 17 | Abnormally large short-term and impending earthquake geomagnetic anomaly implies a possibility of earthquake pre-warning显示文摘The study found that strong magnetic anomalies repeatedly took place before big earthquakes. Based on geomagnetic record analysis results,we discussed a possible pattern of the magnetic anomalies prior to earthquake. In meizoseismal area or epicenter,in a time period of 36 h to about 10 min before earthquake,the exceptional big geomagnetic change increases with the magnitude of earthquake. We calculated that,in a place of 1 km from the epicenter,the magnetic anomaly before destructive earthquakes of Ms 6~9 can reach to 102~104 nT(the magnitude of earth magnetic field is 104 nT) ,rather than the magnitude of 10 nT from seismomagnetic effect theories since 1960s. From this we speculated the abnormal magnetic ULF near epicenter before earthquake seems to be an 'intermittent magnetic eruption'. Accordingly,we proposed that geomagnetic induction earthquake alarm can be a new pre-warning method to surmount hardship in solving the puzzledom of earthquake imminent prediction. | Zeng Xiaoping Zheng Ji'ang Wang Zhaoyi Zhang Suqin Lin Yunfang | 2011 | Engineering Sciences2011，9，4： | 0 |
| 18 | Luteolin suppresses oral carcinoma 3(OC3) cell growth and migration via modulating polo-like kinase 1(PLK1) expression and cellular energy metabolism显示文摘Oral squamous cell carcinoma(OSCC)is a prevalent malignant tumor affecting the head and neck region(Leemans et al.,2018).It is often diagnosed at a later stage,leading to a poor prognosis(Muzaffar et al.,2021;Li et al.,2023).Despite advances in OSCC treatment,the overall 5-year survival rate of OSCC patients remains alarmingly low,falling below 50%(Jehn et al.,2019;Johnson et al.,2020).According to statistics,only 50%of patients with oral cancer can be treated with surgery.Once discovered,it is more frequently at an advanced stage.In addition,owing to the aggressively invasive and metastatic characteristics of OSCC,most patients die within one year of diagnosis.Hence,the pursuit of novel therapeutic drugs and treatments to improve the response of oral cancer to medication,along with a deeper understanding of their effects. | Pengfei GAO Wentao ZHANG Yujie LIN Ruijie LU Zijian LOU Gang LU Ruolang PAN Yunfang CHEN | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，12： | 0 |
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