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| 1 | Petrology and ^(40)Ar/^(39)Ar iso-topic ages of blueschists in Gangmar, central Qiangtang, northern Tibet显示文摘The petrology and mineral assemblages of blueschists in the Gangmar, central Qiangtang, northern Tibet were examined, which indicates that the metamorphic condition is high-pressure low-temperature. In this note, we reported the 40Ar/39Ar dating results of glaucophane from two blueschist samples. Their apparent ages are (275.0±1.3) Ma and (287.6±2.3) Ma and similar isochron ages are (275.0±0.9) Ma and (282.4±0.8) Ma, respectively. These iso-topic datings show the high-pressure metamorphism occurring in Lower Permian. The ages also coincide with the evolution of Palaeo-Tethys ocean in Late Palaeozoic. | DENG Xiguang, DING Lin, LIU Xiaohan & ZHOU YongLaboratory of Lithospheric Tectonic Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2001 | Chinese Science Bulletin2001，46，5： | 13 |
| 2 | Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution显示文摘Alveolar bone is the thickened ridge of jaw bone that supports teeth.It is subject to constant occlusal force and pathogens invasion,and is therefore under active bone remodeling and immunomodulation.Alveolar bone holds a distinct niche from long bone considering their different developmental origin and postnatal remodeling pattern.However,a systematic explanation of alveolar bone at single-cell level is still lacking.Here,we construct a single-cell atlas of mouse mandibular alveolar bone through single-cell RNA sequencing(scRNA-seq).A more active immune microenvironment is identified in alveolar bone,with a higher proportion of mature immune cells than in long bone.Among all immune cell populations,the monocyte/macrophage subpopulation most actively interacts with mesenchymal stem cells(MSCs)subpopulation.Alveolar bone monocytes/macrophages express a higher level of Oncostatin M(Osm)compared to long bone,which promotes osteogenic differentiation and inhibits adipogenic differentiation of MSCs.In summary,our study reveals a unique immune microenvironment of alveolar bone,which may provide a more precise immune-modulatory target for therapeutic treatment of oral diseases. | Weimin Lin Qiwen Li Danting Zhang Xiaohan Zhang Xingying Qi Qian Wang Yaqian Chen Caojie Liu Hanwen Li Shiwen Zhang Yuan Wang Bin Shao Li Zhang Quan Yuan | 2021 | Bone Research2021，9，1： | 6 |
| 3 | Thermally stable and highly efficient red-emitting Eu^(3+)-doped Cs3GdGe309 phosphors for WLEDs:non-concentration quenching and negative thermal expansion显示文摘Red phosphor materials play a key role in improving the lighting and backlit display quality of phosphor-converted white light-emitting diodes(pc-WLEDs).However,the development of a red phosphor with simultaneous high efficiency,excellent thermal stability and high colour purity is still a challenge.In this work,unique non-concentration quenching in solid-solution Cs_(3)Gd_(1-x)Ge_(3)O_(9):xEu^(3+)(CGGO:xEu^(3+))(x=0.1-1.0)phosphors is successfully developed to achieve a highly efficient red-emitting Cs_(3)EuGe_(3)0_(9)(CEGO)phosphor.Under the optimal 464 nm blue light excitation,CEGO shows a strong red emission at 611 nm with a high colour purity of 95.07%and a high internal quantum efficiency of 94%.Impressively,this red-emitting CEGO phosphor exhibits a better thermal stability at higher temperatures(175-250℃,>90%)than typical red K2SiF6:Mn^(4+)and Y203:Eu^(3+)phosphors,and has a remarkable volumetric negative thermal expansion(coefficient of thermal expansion,a=—5.06×10^(-5)/℃,25-250℃).By employing this red CEGO phosphor,a fabricated pc-WLED emits warm white light with colour coordinates(0.364,0.383),a high colour rendering index(CRI=89.7),and a low colour coordinate temperature(CCT=4508 K).These results indicate that this highly efficient red-emitting phosphor has great potential as a red component for pc-WLEDs,opening a new perspective for developing new phosphor materials. | Peipei Dang Guogang Li Xiaohan Yun Qianqian Zhang Dongjie Liu Hongzhou Lian Mengmeng Shang Jun Lin | 2021 | Light(Science & Applications)2021，10，2： | 6 |
| 4 | Heterojunction: important strategy for constructing composite photocatalysts显示文摘As an ideal solution to energy and environment issues,conversion of sunlight into solar fuels by photocatalytic water splitting and greenhouse gas(CO_2)reduction has attracted keen research interest of multi-field scientists.In the past four decades,a large number of semiconductor photocatalysts have been | Xiaohan An Ying Wang Jinjin Lin Jinni Shen Zizhong Zhang Xuxu Wang | 2017 | Science Bulletin2017，62，9： | 5 |
| 5 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 6 | SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder显示文摘 | Xiaohan Hu Qiang Liu Zhao Zhang Zhiqiang Li Shilin Wang Lin He Yongyong Shi | 2010 | Cell Research2010，20，7： | 5 |
| 7 | Intrinsically Stretchable Organic-Tribotronic-Transistor for Tactile Sensing显示文摘Stretchable electronics are of great significance for the development of the next-generation smart interactive systems.Here,we propose an intrinsically stretchable organic tribotronic transistor(SOTT)without a top gate electrode,which is composed of a stretchable substrate,silver nanowire electrodes,semiconductor blends,and a nonpolar elastomer dielectric.The drain-source current of the SOTT can be modulated by external contact electrification with the dielectric layer.Under 0-50%stretching both parallel and perpendicular to the channel directions,the SOTT retains great output performance.After being stretched to 50%for thousands of cycles,the SOTT can survive with excellent stability.Moreover,the SOTT can be conformably attached to the human hand,which can be used for tactile signal perception in human-machine interaction and for controlling smart home devices and robots.This work has realized a stretchable tribotronic transistor as the tactile sensor for smart interaction,which has extended the application of tribotronics in the human-machine interface,wearable electronics,and robotics. | Junqing Zhao Tianzhao Bu Xiaohan Zhang Yaokun Pang Wenjian Li Zhi Zhang Guoxu Liu Zhong Lin Wang Chi Zhang | 2020 | Research2020，，1： | 4 |
| 8 | Dichotomous roles of neutrophils in modulating pathogenic and repair processes of inflammatory bowel diseases显示文摘Neutrophils are considered as complex innate immune cells and play a critical role in maintaining intestinal mucosal homeostasis.They exert robust pro-inflammatory effects and recruit other immune cells in the acute phase of pathogen infection and intestinal inflammation,but paradoxically,they also limit exogenousmicrobial invasion and facilitate mucosal restoration.Hyperactivation or dysfunction of neutrophils results in abnormal immune responses,leading to multiple autoimmune and inflammatory diseases including systemic lupus erythematosus,rheumatoid arthritis,and inflammatory bowel diseases(IBD).As a refractory intestinal inflammatory disease,the pathogenesis and progression of IBD are associated with complicated immune response processes in which neutrophils are profoundly involved.However,the consensus on potential roles of neutrophils in modulating pathogenic and repair processes of IBD remains not fully understood.Accumulated infiltrating neutrophils cross the epithelial barrier and contribute to microbial dysbiosis,aggravated intestinal architectural damage,compromised resolution of intestinal inflammation and increased risk of thrombosis during IBD.Paradoxically,activated neutrophils are also associated with effective elimination of invaded microbiota,promoted angiogenesis and tissue restoration of gutmucosa in IBD.Here,we discuss the beneficial and detrimental roles of neutrophils in the onset and resolution of intestinalmucosal inflammation,hoping to provide a precise overview of neutrophil functions in the pathogenesis of IBD. | Huimin Chen Xiaohan Wu Chunjin Xu Jian Lin Zhanju Liu | 2021 | Precision Clinical Medicine2021，4，4： | 3 |
| 9 | METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis显示文摘The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic cells.How METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear.Here we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced keratinocytes.Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds.Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery.Mechanically,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and FZD7.Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation. | Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi Xu Quan Yuan | 2022 | International Journal of Oral Science2022，14，3： | 2 |
| 10 | Targeted therapeutics and novel signaling pathways in nonalcohol-associated fatty liver/steatohepatitis(NAFL/NASH)显示文摘Non-alcohol-associated fatty liver/steatohepatitis(NAFL/NASH)has become the leading cause of liver disease worldwide.NASH,an advanced form of NAFL,can be progressive and more susceptible to developing cirrhosis and hepatocellular carcinoma.Currently,lifestyle interventions are the most essential and effective strategies for preventing and controlling NAFL without the development of fibrosis.While there are stll limited appropriate drugs specifically to treat NAFL/NASH,growing progress is being seen in elucidating the pathogenesis and identifying therapeutic targets.In this review,we discussed recent developments in etiology and prospective therapeutic targets,as well as pharmacological candidates in pre/clinical trials and patents,with a focus on diabetes,hepatic lipid metabolism,inflammation,and fibrosis.Importantly,growing evidence elucidates that the disruption of the gut-liver axis and microbederived metabolites drive the pathogenesis of NAFL/NASH.Extracellular vesicles(EVs)act as a signaling mediator,resulting in lipid accumulation,macrophage and hepatic stellate cell activation,further promoting inflammation and liver fibrosis progression during the development of NAFL/NASH.Targeting gut microbiota or EVs may serve as new strategies for the treatment of NAFL/NASH.Finally,other mechanisms,such as cell therapy and genetic approaches,also have enormous therapeutic potential.Incorporating drugs with different mechanisms and personalized medicine may improve the efficacy to better benefit patients with NAFL/NASH. | Xiaohan Xu Kyle L.Poulsen Ljuan Wu Shan Liu Tatsunori Miyata Qiaoling Song Qingda Wei Chenyang Zhao Chunhua Lin Jinbo Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 11 | Liposoluble quinone promotes the reduction of hydrophobic mineral and extracellular electron transfer of Shewanella oneidensis MR-1显示文摘A large number of reaction systems are composed of hydrophobic interfaces and microorganisms in natural environment.However,it is not clear how microorganisms adjust their breathing patterns and respond to hydrophobic interfaces.Here,Shewanella oneidensis MR-1 was used to reduce ferrihydrite of a hydrophobic surface.Through Fe(II)kinetic analysis,it was found that the reduction rate of hydrophobic ferrihydrite was 1.8 times that of hydrophilic one.The hydrophobic surface of the mineral hinders the way the electroactive microorganism uses the water-soluble electron mediator riboflavin for indirect electron transfer and promotes MR-1 to produce more liposoluble quinones.Ubiquinone can mediate electron transfer at the hydrophobic interface.Ubiquinone-30(UQ-6)increases the reduction rate of hydrophobic ferrihydrite from 38.5±4.4 to 52.2±0.8 mM$h1.Based on the above experimental results,we propose that liposoluble electron mediator ubiquinone can act on the extracellular hydrophobic surface,proving that the metabolism of hydrophobic minerals is related to endogenous liposoluble quinones.Hydrophobic modification of minerals encourages electroactive microorganisms to adopt differentiated respiratory pathways.This finding helps in understanding the electron transfer behavior of the microbes at the hydrophobic interface and provides new ideas for the study of hydrophobic reactions that may occur in systems,such as soil and sediment. | Xiaohan Lin Fan Yang Le-xing You Huan Wang Feng Zhao | 2021 | The Innovation2021，2，2： | 2 |
| 12 | Influence of the alkyl side chain length on the room-temperature phosphorescence of organic copolymers显示文摘Pure organic room-temperature phosphorescence(RTP)materials have attracted wide attention owing to their excellent luminescent properties and great potential in various applications.In this work,iminostilbene and its analogues are applied to realize RTP emission by copolymerizing with acrylamide.It can be concluded that the growth of alkane chain in monomers can enhance the lifetime and photoluminescence quantum yield of RTP emission,and polymers with the larger conjugated structure of the monomer show a longer RTP emission wavelength.This work provides a series of new pure organic RTP materials and might provide new thoughts for designing more advanced and superior RTP materials. | Qingyang Xu Liangwei Ma Xiaohan Lin Qiaochun Wang Xiang Ma | 2022 | Chinese Chemical Letters2022，33，6： | 2 |
| 13 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 14 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 15 | Mapping of wheat stripe rust resistance gene Yr041133 by BSR-Seq analysis显示文摘Puccinia striiformis Westend. f. sp. tritici(Pst) pathotype CYR34 is widely virulent and prevalent in China.Here, we report identification of a strpie rust resistance(Yr) gene, designated Yr041133, in winter wheat line 041133. This line produced a hypersensitive reaction to CYR34 and conferred resistance to 13 other pathotypes. Resistance to CYR34 in line 041133 was controlled by a single dominant gene. Bulked segregant RNA sequencing(BSR-Seq) was performed on a pair of RNA bulks generated by pooling resistant and susceptible recombinant inbred lines. Yr041133 was mapped to a 1.7 c M genetic interval on the chromosome arm 7 BL that corresponded to a 0.8 Mb physical interval(608.9–609.7 Mb) in the Chinese Spring reference genome. Based on its unique physical location Yr041133 differred from the other Yr genes on this chromosome arm. | Yahui Li Ruiming Lin Jinghuang Hu Xiaohan Shi Dan Qiu Peipei Wu Gebremedhin Habteab Goitom Siqi Wang Hongjun Zhang Li Yang Hongwei Liu Qiuhong Wu Jingzhong Xie Yang Zhou Zhiyong Liu Hongjie Li | 2022 | The Crop Journal2022，10，2： | 1 |
| 16 | Solid polymer electrolytes in all-solid-state lithium metal batteries:From microstructures to properties显示文摘All-solid-state lithium(Li)metal batteries(ASSLMBs)are considered one of the most promising secondary batteries due to their high theoretical capacity and high safety performance.However,low room-temperature ionic conductivity and poor interfacial stability are two key factors affecting the practical application of ASSLMBs,and our understanding of the mechanisms behind these key problems from microscopic perspective is still limited.In this review,the mechanisms and advanced characterization techniques of ASSLMBs are summarized to correlate the microstructures and properties.Firstly,we summarize the challenges faced by solid polymer electrolytes(SPEs)in ASSLMBs,such as the low roomtemperature ionic conductivity and the poor interfacial stability.Secondly,several typical improvement methods of polymer ASSLMBs are discussed,including composite SPEs,ultra-thin SPEs,SPEs surface modification and Li anode surface modification.Finally,we conclude the characterizations for correlating the microstructures and the properties of SPEs,with emphasis on the use of emerging advanced techniques(e.g.,cryo-transmission electron microscopy)for in-depth analyzing ASSLMBs.The influence of the microstructures on the properties is very important.Until now,it has been difficult for us to understand the microstructures of batteries.However,some recent studies have demonstrated that we have a better understanding of the microstructures of batteries.Then we suggest that in situ characterization,nondestructive characterization and sub-angstrom resolution are the key technologies to help us further understand the batteries'microstructures and promote the development of batteries.And potential investigations to understand the microstructures evolution and the batteries behaviors are also prospected to expect further reasonable theoretical guidance for the design of ASSLMBs with ideal performance. | Zongxi Lin Ouwei Sheng Xiaohan Cai Dan Duan Ke Yue Jianwei Nai Yao Wang Tiefeng Liu Xinyong Tao Yujing Liu | 2023 | Journal of Energy Chemistry2023，，6： | 1 |
| 17 | lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy,leading to atherogenesis显示文摘Long noncoding RNAs(lncRNAs)play a critical role in the regulation of atherosclerosis.Here,we investigated the role of the lncRNA growth arrest-specific 5(lncR-GAS5)in atherogenesis.We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis,which presented as increased plaque size and reduced collagen content.Moreover,impaired autophagy was observed,as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells.By contrast,lncR-GAS5 knockdown promoted autophagy.Moreover,serine/arginine-rich splicing factor 10(SRSF10)knockdown increased the LC3II/LC3I ratio and decreased the P62 level,thus enhancing the formation of autophagic vacuoles,autolysosomes,and autophagosomes.Mechanistically,lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium,which was reversed by the knockdown of SRSF10.Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene,SRSF10.Notably,miR-193-5p overexpression decreased plaque size and increased collagen content.Altogether,these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy.In conclusion,lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway.Thus,miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis. | Yuhua Fan Yue Zhang Hongrui Zhao Wenfeng Liu Wanqing Xu Lintong Jiang Ranchen Xu Yue Zheng Xueqing Tang Xiaohan Li Limin Zhao Xin Liu Yang Hong Yuan Lin Hui Chen Yong Zhang | 2023 | Frontiers of Medicine2023，17，2： | 1 |
| 18 | Over 50,000 Metagenomically Assembled Draft Genomes for the Human Oral Microbiome Reveal New Taxa显示文摘The oral cavity of each person is home to hundreds of bacterial species.While taxa for oral diseases have been studied using culture-based characterization as well as amplicon sequencing,metagenomic and genomic information remains scarce compared to the fecal microbiome.Here,using metagenomic shotgun data for 3346 oral metagenomic samples together with 808 published samples,we obtain 56,213 metagenome-assembled genomes(MAGs),and more than 64%of the 3589 species-level genome bins(SGBs)contain no publicly available genomes.The resulting genome collection is representative of samples around the world and contains many genomes from candidate phyla radiation(CPR)that lack monoculture.Also,it enables the discovery of new taxa such as a genus Candidatus Bgiplasma within the family Acholeplasmataceae.Large-scale metagenomic data from massive samples also allow the assembly of strains from important oral taxa such as Porphyromonas and Neisseria.The oral microbes encode genes that could potentially metabolize drugs.Apart from these findings,a strongly male-enriched Campylobacter species was identified.Oral samples would be more user-friendly collected than fecal samples and have the potential for disease diagnosis.Thus,these data lay down a genomic framework for future inquiries of the human oral microbiome. | Jie Zhu Liu Tian Peishan Chen Mo Han Liju Song Xin Tong Xiaohuan Sun Fangming Yang Zhipeng Lin Xing Liu Chuan Liu Xiaohan Wang Yuxiang Lin Kaiye Cai Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Liang Xiao Tao Zhang Huijue Jia Zhuye Jie | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 1 |
| 19 | Mechanical behaviours of sandstone containing intersecting fissures under uniaxial compression显示文摘Predicting rock cracking is important for assessing the stability of underground engineering.The effects of the intersecting angle a and the distribution orientation angleβof intersecting fissures on the uniaxial compressive strength and the failure characteristics of sandstone containing intersecting fissures are investigated through laboratory experiments and two-dimensional particle flow code(PFC2D).The relationship between the mechanical properties of sandstone and the intersecting angle a and the distribution orientation angleβis analysed.Crack initiation forms and the final failure modes are then categorised and determined via empirical methods.In addition,the cracking processes of intersecting fissures with different a andβvalues are discussed.The results show that variations in the peak stress,peak strain,average modulus,and crack initiation stress of sandstone containing intersecting fissures show a“moth”shape in the space of the a-β-mechanical parameters.Two crack initiation forms are identified:inner tip cracking(usually accompanied by one outer tip cracking)and only outer tips cracking.Two failure modes are observed:(1)the main fracture planes are created at the inner tip and one outer tip,and(2)the main fracture planes are formed at the two outer tips.Two main crack evolution processes of sandstone containing intersecting fissures under uniaxial compression are found.Approaches for quickly determining the crack initiation form and the failure mode are proposed.The combination of the determination equations for the crack initiation form and the failure mode can be used to predict the crack evolution.The approach for determining the crack evolution processes is hence proposed with acceptable precision. | Fei Xiong Xinrong Liu Xiaohan Zhou Guangyi Lin Dongshuang Liu Yafeng Han Bin Xu Chunmei He Zijuan Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 20 | 肝脏移植术后糖尿病患者肠道微生物组的变化显示文摘Post-transplant diabetes mellitus(PTDM)increases the risk of graft failure and death in liver transplant(LT)recipients.Experimental studies have indicated that enteric dysbiosis mediated by immunosuppressive tacrolimus(TAC)could contribute to glucose disorders,but no data on human recipients with PTDM have been reported.Here,by combining high-throughput shotgun metagenomics sequencing and metabolomics profiling,we characterized the intestinal microbiome(IM)in LT recipient cohort with or without PTDM and deciphered the potential relationship among IM,TAC dosage,and diabetes.By comparing with both non-PTDM and classical type 2 diabetes mellitus(T2DM),we identified microbial signatures of PTDM,which was characterized by the enriched Proteobacteria and decreased Bacteroidetes.Additionally,the altered microbes,as well as the microbial metabolomics,correlated with the dosage of TAC.Specifically,the levels of beneficial microbes associated with PTDM were lowered in recipients with the high TAC trough concentrations(>5 ng·mL^(-1))than those with low ones(<5 ng·mL^(-1)),which was accompanied by reduced faecal metabolites involved in the biosynthesis of a-linolenic acid and arachidonic acid-lowering factors of developing T2DM.Moreover,these microbial signatures linked with the extent of glucose disorders in LT recipients.In summary,the faecal microbiome and metabolome differed between PTDM and non-PTDM patients,which were linked with TAC dosage.This study was the first to explore taxonomic alterations and bacterial gene functions to better understand the contribution of the IM to PTDM. | Qi Ling Yuqiu Han Yue Ma Xiaosen Wang Zheng Zhu Jingyu Wang Jiaying Cao Lin Xiaohan Jun Wang Baohong Wang | 2023 | Engineering2023，31，12： | 0 |
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