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| 1 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 2 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 3 | 奥曲肽持续皮下泵入治疗恶性肠梗阻的临床观察(英文)显示文摘Objective: The aim of the study was to observe the effectiveness of continuously subcutaneous-pumped octreotide infusion in palliative treatment of malignant bowel obstruction (MBO).Methods: Clinical data were retrospectively analyzed in 26 carcinoma patients complicated with MBO,in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,China,from March 2007 to April 2009.All 26 carcinoma patients with MBO were divided into two groups: the controlling group (CG,routine therapy,15 patients) and the octreotide group (OG,11 patients).The octreotide group received routine therapy combined with octreotide (0.3 mg/d) by 24 hours continuously subcutaneous octreotide infusion.The changes of curative effectiveness related to symptoms,the times of recovering exsufflation and defecation,the average drain of gastrointestinal drainage tube,the duration of gastrointestinal drainage tube and the rate of extubation,were observed and compared between the two groups.Results: After treatment,remarkable changing rates of MBO related symptoms were 81.8% (9/11) in OG,and 46.7% (7/15) in CG (P < 0.05).The 78% of SG and 30% of CG recovered the exsufflation and defecation,and the mean times they needed were 3.2 d and 5.8 d,respectively (P < 0.05).The durations of gastrointestinal drainage tube of OG and CG were (5 ± 1.2) d and (10 ± 2.3) d,respectively,and the rates of extubation were 54.5% and 20%,respectively.The improvement rate in the octreotide group was better than that in the controlling group and the difference was significant (72.7% and 26.7%,P < 0.05).Conclusion: The administration of octreotide in combination with routine treatment can be very effective in the treatment of MBO.It can relieve the symptoms of MBO effectively and improve the quality of life of the end-stage patients.It has provided one kind of new treating thought and method for treatment of malignant bowel obstruction. | Dongfeng Yin Yin Zhu Yuqing Xing Hong Gao Yuzhen Pan Lin Pan Guangyi Tang Xiangrong Xing Lijiang Zhou | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，1： | 2 |
| 4 | Genomic basis of evolutionary adaptation in a warm-blooded fish显示文摘Few fishes have evolved elevated body temperatures compared with ambient temperatures,and only in opah(Lampris spp)is the entire body affected.To understand the molecular basis of endothermy,we analyzed the opah genome and identified 23 genes with convergent amino acid substitutions across fish,birds,and mammals,including slc8b1,which encodes the mitochondrial Na+/Ca2+exchanger and is essential for heart function andmetabolic heat production.Among endothermic fishes,44 convergent genes with suggestive metabolic functions were identified,such as glrx3,encoding a crucial protein for hemoglobin maturation.Numerous genes involved in the production and retention of metabolic heat were also found to be under positive selection.Analyses of opah’s unique inner-heat-producing pectoral muscle layer(PMI),an evolutionary key innovation,revealed that many proteins were co-opted from dorsal swimming muscles for thermogenesis and oxidative phosphorylation.Thus,the opah genome provides valuable resources and opportunities to uncover the genetic basis of thermal adaptations in fish. | Xin Wang Meng Qu Yali Liu Ralf F.Schneider Yue Song Zelin Chen Hao Zhang Yanhong Zhang Haiyan Yu Suyu Zhang Dongxu Li Geng Qin Shaobo Ma Jia Zhong Jianping Yin Shuaishuai Liu Guangyi Fan Axel Meyer Dazhi Wang Qiang Lin | 2022 | The Innovation2022，3，1： | 1 |
| 5 | Mechanical behaviours of sandstone containing intersecting fissures under uniaxial compression显示文摘Predicting rock cracking is important for assessing the stability of underground engineering.The effects of the intersecting angle a and the distribution orientation angleβof intersecting fissures on the uniaxial compressive strength and the failure characteristics of sandstone containing intersecting fissures are investigated through laboratory experiments and two-dimensional particle flow code(PFC2D).The relationship between the mechanical properties of sandstone and the intersecting angle a and the distribution orientation angleβis analysed.Crack initiation forms and the final failure modes are then categorised and determined via empirical methods.In addition,the cracking processes of intersecting fissures with different a andβvalues are discussed.The results show that variations in the peak stress,peak strain,average modulus,and crack initiation stress of sandstone containing intersecting fissures show a“moth”shape in the space of the a-β-mechanical parameters.Two crack initiation forms are identified:inner tip cracking(usually accompanied by one outer tip cracking)and only outer tips cracking.Two failure modes are observed:(1)the main fracture planes are created at the inner tip and one outer tip,and(2)the main fracture planes are formed at the two outer tips.Two main crack evolution processes of sandstone containing intersecting fissures under uniaxial compression are found.Approaches for quickly determining the crack initiation form and the failure mode are proposed.The combination of the determination equations for the crack initiation form and the failure mode can be used to predict the crack evolution.The approach for determining the crack evolution processes is hence proposed with acceptable precision. | Fei Xiong Xinrong Liu Xiaohan Zhou Guangyi Lin Dongshuang Liu Yafeng Han Bin Xu Chunmei He Zijuan Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 6 | MPLS performance evaluation in backbone network显示文摘 | Liu Guangyi Lin Xiaokang | 2002 | IEEE International Conference on Communications New York USA2002，2，： | 1 |
| 7 | Direct somatic embryogenesis and related gene expression networks in leaf explants of Hippeastrum ‘Bangkok Rose’显示文摘Hippeastrum, a highly diverse genus in the Amaryllidaceae family, is a valuable ornamental bulbous flowering plant. Somatic embryogenesis(SE) is an efficient method for mass production of Hippeastrum plantlets. Previous studies have been devoted to the in vitro propagation of Hippeastrum, but the SE and its regulatory networks are rarely reported. In this study, we established a direct SE method of Hippeastrum Bangkok Rose' using leaf bases as explants. MS supplemented with 1.00 mg·L^(-1)NAA +1.00 mg·L^(-1)KT + 0.25 mg·L^(-1)TDZ was the optimal medium for SE. Histological observations showed that the bipolar somatic embryo originated from the epidermal cell layer and underwent initiation,globular, scutellar and coleoptile stages. During SE, endogenous hormones of IAA, CTK, ABA, and SA were highly accumulated. Transcriptomic analysis revealed the genes encoding auxin biosynthesis/metabolic enzymes and efflux carriers were induced, while the auxin receptor of TIR1 and ARF transcriptional repressor of Aux/IAA were down-regulated and up-regulated, respectively, leading to suppression of auxin signaling. In contrast, cytokine signaling was promoted at the early stage of SE, as biosynthesis, transport, and signaling components were up-regulated.Various stress-related genes were up-regulated at the early or late stages of SE. Chromatin remodeling could also be dynamically regulated via distinct expression enzymes that control histone methylation and acetylation during SE. Moreover, key SE regulators, including WOXs and SERKs were highly expressed along with SE. Overall, the present study provides insights into the SE regulatory mechanisms of the Hippeastrum. | Jingjue Zeng Yi Deng Shahid Iqbal Jiarui Zhang Kunlin Wu Guohua Ma Lin Li Guangyi Dai Rufang Deng Lin Fang Songjun Zeng | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 8 | A chromosome-level genome assembly reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in the shoot apex of Isodon rubescens显示文摘The ent-kaurenoids(e.g.,oridonin and enmein)from the Isodon genus(Lamiaceae)are one class of diterpenoids with rich structural diversity and intriguing pharmaceutical activity.In contrast to the well-established gibberellin pathway,oxidative modifications diversifying the ent-kaurene skeleton in Isodon have remained undetermined for half a century.Here we report a chromosome-level genome assembly of I.rubescens,a well-recognized oridonin producer long favored by Asian people as a traditional herb with antitumor effects.The shoot apex was confirmed to be the actual region actively producing ent-kaurene diterpenoids.Through comparative genomics and phylogenetic analyses,we discovered a cluster of tandem-duplicated CYP706V oxygenase-encoding genes located on an ancient genomic block widely distributed in eudicots,whereas almost exclusively emerged in Isodon plants.In the shoot apex,IrCYP706V2 and IrCYP706V7 oxidized the ent-kaurene core in the initial stage of oridonin biosynthesis.Loss of CYP706Vs in other Lamiaceae plants offered an explanation for the specific kaurenoid production in Isodon plants.Moreover,we found that the Isodon genomes encode multiple diterpenoid synthases that are potentially involved in generating diterpenoid diversity.These findings provided new insights into the evolution of the lineage-specific diterpenoid pathway and laid a foundation for improving production of bioactive ent-kaurene-type diterpenoids by molecular breeding and synthetic biology approaches. | Yuwei Sun Jie Shao Haili Liu Hua Wang Guangyi Wang Jianhua Li Yaping Mao Zhuo Chen Ke Ma Lin Xu Yong Wang | 2023 | Molecular Plant2023，16，3： | 0 |
| 9 | Identification of S-RNase genotype and analysis of its origin and evolutionary patterns in Malus plants显示文摘Identification of the S genotype of Malus plants will greatly promote the discovery of new genes,the cultivation and production of apple,the breeding of new varieties,and the origin and evolution of self-incompatibility in Malus plants.In this experiment,88 Malus germplasm resources,such as Aihuahong,Xishuhaitang,and Reguanzi,were used as materials.Seven gene-specific primer combinations were used in the genotype identification.PCR amplification using leaf DNA produced a single S-RNase gene fragment in all materials.The results revealed that 70 of the identified materials obtained a complete S-RNase genotype,while only one S-RNase gene was found in 18 of them.Through homology comparison and analysis,13 S-RNase genotypes were obtained:S_(1)S_(2)(Aihuahong,etc.),S_(1)S_(28)(Xixian Haitang,etc.),S_(1)S_(51)(Hebei Pingdinghaitang),S_(1)S_(3)(Xiangyangcun Daguo,etc.),S_(2)S_(3)(Zhaiyehaitang,etc.),S_(3)S_(51)(Xishan 1),S_(3)S_(28)(Huangselihaerde,etc.),S_(2)S_(28)(Honghaitang,etc.),S_(4)S_(28)(Bo 11),S_(7)S_(28)(Jiuquan Shaguo),S_(10)S_e(Dongchengguan 13),S_(10)S_(21)(Dongxiangjiao)and S_(3)S_(51)(Xiongyue Haitang).Simultaneously,the frequency of the S gene in the tested materials was analyzed.The findings revealed that different S genes had varying frequencies in Malus resources,as well as varying frequencies between intraspecific and interspecific.S_(3)had the highest frequency of 68.18%,followed by S_(1)(42.04%).In addition,the phylogenetic tree and origin evolution analysis revealed that the S gene differentiation was completed prior to the formation of various apple species,that cultivated species also evolved new S genes,and that the S_(50)gene is the oldest S allele in Malus plants.The S_(1),S_(29),and S_(33)genes in apple-cultivated species,on the other hand,may have originated in M.sieversii,M.hupehensis,and M.kansuensis,respectively.In addition to M.sieversii,M.kansuensis and M.sikkimensis may have also played a role in the origin and evolution of some Chinese apples. | Zhao Liu Yuan Gao Kun Wang Jianrong Feng Simiao Sun Xiang Lu Lin Wang Wen Tian Guangyi Wang Zichen Li Qingshan Li Lianwen Li Dajiang Wang | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 10 | Giant excitonic upconverted emission from two-dimensional semiconductor in doubly resonant plasmonic nanocavity显示文摘Phonon-assisted upconverted emission is the heart of energy harvesting,bioimaging,optical cryptography,and optical refrigeration.It has been demonstrated that emerging two-dimensional(2D)semiconductors can provide an excellent platform for efficient phonon-assisted upconversion due to the enhanced optical transition strength and phonon-exciton interaction of 2D excitons.However,there is little research on the further enhancement of excitonic upconverted emission in 2D semiconductors.Here,we report the enhanced multiphoton upconverted emission of 2D excitons in doubly resonant plasmonic nanocavities.Owing to the enhanced light collection,enhanced excitation rate,and quantum efficiency enhancement arising from the Purcell effect,an upconverted emission amplification of>1000-fold and a decrease of 2~3 orders of magnitude in the saturated excitation power are achieved.These findings pave the way for the development of excitonic upconversion lasing,nanoscopic thermometry,and sensing,revealing the possibility of optical refrigeration in future 2D electronic or excitonic devices. | Pengfei Qi Yuchen Dai Yang Luo Guangyi Tao Liheng Zheng Donglin Liu Tianhao Zhang Jiadong Zhou Bo Shen Feng Lin Zheng Liu Zheyu Fang | 2022 | Light(Science & Applications)2022，11，7： | 0 |
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