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| 1 | Novel biallelic PCNT deletion causing microcephalic osteodysplastic primordial dwarfism type II with congenital heart defect显示文摘Dear Editor, Microcephalic osteodysplastic primordial dwarfism type Ⅱ (MOPD Ⅱ )is characterized by developmental retardation, wherein the affected individuals usually present with intrauterine growth retardation and preterm birth (Majewski et al.,1982;Willems et al.,2010).This leads to an average weight of <1,500g at birth and extremely restricted postnatal growth (Hall et al.,2004;Rauch,2011).Clinical manifestations ofMOPD Ⅱ include microcephaly,disproportionately short stature,mild skeletal dysplasia,unusual facial features including a prominent nose,prominent eyes in infancy and early childhood,some affected individuals exhibit slightly reduced intellectual development and cerebral vascular malformations (Willems et al.,2010;Li et al.,2015;Sam et al.,2015). | Lanlan Meng Chaofeng Tu Guangxiu Lu Ge Lin Yueqiu Tan | 2019 | Science China(Life Sciences)2019，62，1： | 2 |
| 2 | Natural Antifouling Materials from Marine Plants Ulva Pertusa 显示文摘 | Zheng Jiyong Lin Cunguo Di Lanlan | 2009 | Advaned Materials Research2009，，7982： | 1 |
| 3 | Photonic band structures solved by a plane-wave-based transfer-matrix method显示文摘 | Li Zhiyuan Lin Lanlan | 2003 | Phys Rev E2003，67，04： | 1 |
| 4 | Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy显示文摘为功能的肽的设计和优化, unravelling 单个积木的结构以及整体的性质是首要的。TTR1,源于人的 transthyretin,形成纤丝的肽在象家庭淀粉的 polyneuropathy 和老年的全身的淀粉样变性病那样的疾病被含有。基于 TTR1 脚手架,功能的肽 TTR1-RGD 被设计明确地与房间交往。这里,我们过去常扫描通道显微镜学(STM ) 与反向的顺序和修改前面的顺序分析 TTR1 相关的肽的集会结构。sitespecific 分析显示出下列:我) TTR1 肽涉及汇编,将近在订的表以内盖住全部长度组织。ii ) 为 TTR1-RGD 肽集会,当 RGDS 主题采用允许它支持房间粘附的灵活符合构造时, TTR1 主题形成订的表。关键地点清楚地作为连接器残余 Gly13 被识别。iii ) 尽管有在化学的差别,他们显示类似的集合的前面、反向的肽集会表演的仔细的检查特征,说明这些肽的柔韧的性质。iv ) Glycine 连接器残余在强烈建议顺序能被增加更多的连接器残余优化的 -strands, 被包括。进这些肽的装配结构的这些积累的卓见帮助解开驾驶肽集会的机制并且在新窗户中指示 sequenceprogrammed 肽 architectures.Open | Lanlan Yu Yongfang Zheng JingXu Fuyang Qu Yuchen Lin Yimin Zou Yanlian Yang Sally L. Gras Chen Wang | 2018 | Nano Research2018，11，1： | 1 |
| 5 | Characteristics of plankton Hg bioaccumulations based on a global data set and the implications for aquatic systems with aggravating nutrient imbalance显示文摘The bioaccumulation of mercury(Hg)in aquatic ecosystem poses a potential health risk to human being and aquatic organism.Bioaccumulations by plankton represent a crucial process of Hg transfer from water to aquatic food chain.However,the current understanding of major factors affecting Hg accumulation by plankton is inadequate.In this study,a data set of 89 aquatic ecosystems worldwide,including inland water,nearshore water and open sea,was established.Key factors influencing plankton Hg bioaccumulation(i.e.,plankton species,cell sizes and biomasses)were discussed.The results indicated that total Hg(THg)and methylmercury(MeHg)concentrations in plankton in inland waters were significantly higher than those in nearshore waters and open seas.Bioaccumulation factors for the logarithm of THg and MeHg of phytoplankton were 2.4–6.0 and 2.6–6.7 L/kg,respectively,in all aquatic ecosystems.They could be further biomagnified by a factor of 2.1–15.1 and 5.3–28.2 from phytoplankton to zooplankton.Higher MeHg concentrations were observed with the increases of cell size for both phyto-and zooplankton.A contrasting trend was observed between the plankton biomasses and BAF_(MeHg),with a positive relationship for zooplankton and a negative relationship for phytoplankton.Plankton physiologic traits impose constraints on the rates of nutrients and contaminants obtaining process from water.Nowadays,many aquatic ecosystems are facing rapid shifts in nutrient compositions.We suggested that these potential influences on the growth and composition of plankton should be incorporated in future aquatic Hg modeling and ecological risk assessments. | Zhike Li Jie Chi Zhenyu Wu Yiyan Zhang Yiran Liu Lanlan Huang Yiren Lu Minhaz Uddin Wei Zhang Xuejun Wang Yan Lin Yindong Tong | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 1 |
| 6 | Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation显示文摘Uncontrolled and persistent inflammation is closely related to numerous acute and chronic diseases.However,effective targeting delivery systems remain to be developed for precision therapy of inflammatory diseases.Herein we report a novel strategy for engineering inflammationaccumulation nanoparticles via phenolic functionalization.Different phenol-functionalized nanoparticles were first developed,which can undergo in situ aggregation upon triggering by the inflammatory/oxidative microenvironment.Phenolic compound-decorated poly(lactide-co-glycolide)nanoparticles,in particular tyramine(Tyr)-coated nanoparticles,showed significantly enhanced accumulation at inflammatory sites in mouse models of colitis,acute liver injury,and acute lung injury,mainly resulting from in situ cross-linking and tissue anchoring of nanoparticles triggered by local myeloperoxidase and reactive oxygen species.By combining a cyclodextrin-derived bioactive material with Tyr decoration,a multifunctional nanotherapy(TTN)was further developed,which displayed enhanced cellular uptake,antiinflammatory activities,and inflammatory tissue accumulation,thereby affording amplified therapeutic effects in mice with colitis or acute liver injury.Moreover,TTN can serve as a bioactive and inflammation-targeting nanoplatform for site-specifically delivering a therapeutic peptide to the inflamed colon post oral administration,leading to considerably potentiated in vivo efficacies.Preliminary studies also revealed good safety of orally delivered TTN.Consequently,Tyr-based functionalization is promising for inflammation targeting amplification and therapeutic potentiation of nanotherapies. | Qiang Nie Chenwen Li Yu Wang Yi Hu Wendan Pu Qixiong Zhang Jiajun Cai Yongyao Lin Gang Li Chenping Wang Lanlan Li Yin Dou Jianxiang Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 1 |
| 7 | Worldwide impacts of atmospheric vapor pressure deficit on the interannual variability of terrestrial carbon sinks显示文摘Interannual variability of the terrestrial ecosystem carbon sink is substantially regulated by various environmental variables and highly dominates the interannual variation of atmospheric carbon dioxide(CO_(2))concentrations.Thus,it is necessary to determine dominating factors affecting the interannual variability of the carbon sink to improve our capability of predicting future terrestrial carbon sinks.Using global datasets derived from machine-learning methods and process-based ecosystem models,this study reveals that the inter annual variability of the atmospheric vapor pressure deficit(VPD)was significantly negatively correlated with net ecosystem production(NEP)and substantially impacted the inter annual variability of the atmospheric CO_(2)growth rate(CGR).Further analyses found widespread constraints of VPD interannual variability on terrestrial gross primary production(GPP),causing VPD to impact NEP and CGR.Partial correlation analysis confirms the persistent and widespread impacts of VPD on terrestrial carbon sinks compared to other environmental variables.Current Earth system models underestimate the interannual variability in VPD and its impacts on GPP and NEP.Our results highlight the importance of VPD for terrestrial carbon sinks in assessing ecosystems'responses to future climate conditions. | Bin He Chen Chen Shangrong Lin Wenping Yuan Hans WChen Deliang Chen Yafeng Zhang Lanlan Guo Xiang Zhao Xuebang Liu Shilong Piao Ziqian Zhong Rui Wang Rui Tang | 2022 | National Science Review2022，9，4： | 1 |
| 8 | Enthalpy induced phase partition toward hierarchical,nanostructured high-entropy alloys显示文摘Heterogeneous nanostructured metals are emerging strategies for achieving both high strength and ductility,which are particularly attractive for high entropy alloys(HEAs)to combine the synergistic enhancements from multielement composition,grain boundaries,and heterogeneity effects.However,the construction of heterogeneous nanostructured HEAs remains elusive and can involve delicate processes that are not practically scalable.Herein we report using composition design(i.e.,enthalpy engineering)to create hierarchical,nanostructured HEAs as demonstrated by adding Ni into FeCrCoAlTi_(0.5)HEA.The strong enthalpic interaction between(Ni,Co)and(Al,Ti)pairs in FeCrCoAlTi_(0.5)Nix(x=0.5–1.5)induced phase partitions into B2(ordered phase,hard)matrix and A2(disordered phase,soft)precipitates,resulting in a hierarchical structure of B2 grains and sub-grains of near-coherent A2 nanodomains(~12.5 nm)divided by A2 interdendritic regions.As a result,the FeCrCoAlTi_(0.5)Ni_(0.5)HEA with this unique hierarchical nanostructure exhibits the best combination of strength and plasticity,i.e.,a 2-fold increase in compressive strength(2.60 GPa)and significant enhancement of plastic strain(15.8%)as compared with the original FeCrCoAlTi_(0.5)HEA.Enthalpy analysis and simulation study reveal the phase partition process during cooling induced by an enthalpy-driven order-disorder transition while the order parameters illustrate the strong ordering in(Ni,Co)(Al,Ti)-rich B2 phase and high entropy mixing in less interactive FeCrCo-rich A2 phase.Our work therefore provides a strategy for hierarchical nanostructured HEA formation by composition design considering enthalpy and entropy interplay. | Rong Guo Lanlan Yu Zhenyu Liu Jie Pan Yonggang Yao Lin Liu | 2022 | Nano Research2022，15，6： | 1 |
| 9 | Solvothermal syn- thesis of wurtzite ZnS complex spheres with high hierar- chy显示文摘 | J Lanlan Chai Wen He Lin Sun | 2014 | Materials Letters2014，120，： | 1 |
| 10 | Efficiency and optimal performance evaluation of organic Rankine cycle for low grade waste heat power generation显示文摘 | Dongxiang Wang Xiang Ling Hao Peng Lin Liu LanLan Tao | 2012 | Energy2012，，： | 1 |
| 11 | Mechanism and inhibition of trisodium phosphate particle caking: Effect of particle shape and solubility显示文摘 | Mingyang Chen Lanlan Lin Yuqi Zhang Songgu Wu Ergang Liu Kun Wang Jingkang Wang Junbo Gong | 2016 | Particuology2016，14，4： | 0 |
| 12 | DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice显示文摘Dear Editor,Male subfertility,a multifactorial disease affecting~7%of the global male population,is usually caused by abnormalities in sperm flagella.The flagella and motile cilia have similar“9+2”axonemes and are evolutionarily conserved,being widely distributed in bacteria,archaea and eukaryotes1.Cilia defects also lead to primary ciliary dyskinesia(PCD),which affects approximately 1/10,000 individuals worldwide. | Shushu Zhou Shimin Yuan Jintao Zhang Lanlan Meng Xin Zhang Siyu Liu Guangxiu Lu Ge Lin Mingxi Liu Yue-Qiu Tan | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 13 | Two-Stage Edge-Side Fault Diagnosis Method Based on Double Knowledge Distillation显示文摘With the rapid development of the Internet of Things(IoT),the automation of edge-side equipment has emerged as a significant trend.The existing fault diagnosismethods have the characteristics of heavy computing and storage load,and most of them have computational redundancy,which is not suitable for deployment on edge devices with limited resources and capabilities.This paper proposes a novel two-stage edge-side fault diagnosis method based on double knowledge distillation.First,we offer a clustering-based self-knowledge distillation approach(Cluster KD),which takes the mean value of the sample diagnosis results,clusters them,and takes the clustering results as the terms of the loss function.It utilizes the correlations between faults of the same type to improve the accuracy of the teacher model,especially for fault categories with high similarity.Then,the double knowledge distillation framework uses ordinary knowledge distillation to build a lightweightmodel for edge-side deployment.We propose a two-stage edge-side fault diagnosismethod(TSM)that separates fault detection and fault diagnosis into different stages:in the first stage,a fault detection model based on a denoising auto-encoder(DAE)is adopted to achieve fast fault responses;in the second stage,a diverse convolutionmodel with variance weighting(DCMVW)is used to diagnose faults in detail,extracting features frommicro andmacro perspectives.Through comparison experiments conducted on two fault datasets,it is proven that the proposed method has high accuracy,low delays,and small computation,which is suitable for intelligent edge-side fault diagnosis.In addition,experiments show that our approach has a smooth training process and good balance. | Yang Yang Yuhan Long Yijing Lin Zhipeng Gao Lanlan Rui Peng Yu | 2023 | Computers, Materials & Continua2023，76，9： | 0 |
| 14 | High-entropy alloy catalysts:From bulk to nano toward highly efficient carbon and nitrogen catalysis显示文摘High-entropy alloys(HEAs)have attracted widespread attention as both structural and functional materials owing to their huge multielement composition space and unique high-entropy mixing structure.Recently,emerging HEAs,either in nano or highly porous bulk forms,are developed and utilized for various catalytic and clean energy applications with superior activity and remarkable durability.Being catalysts,HEAs possess some unique advantages,including(1)a multielement composition space for the discovery of new catalysts and fine-tuning of surface adsorption(i.e.,activity and selectivity),(2)diverse active sites derived from the random multielement mixing that are especially suitable for multistep catalysis,and(3)a high-entropy stabilized structure that improves the structural durability in harsh catalytic environments.Benefited from these inherent advantages,HEA catalysts have demonstrated superior catalytic performances and are promising for complex carbon(C)and nitrogen(N)cycle reactions featuring multistep reaction pathways and many different intermediates.However,the design,synthesis,characterization,and understanding of HEA catalysts for C-and N-involved reactions are extremely challenging because of both complex high-entropy materials and complex reactions.In this review,we present the recent development of HEA catalysts,particularly on their innovative and extensive syntheses,advanced(in situ)characterizations,and applications in complex C and N looping reactions,aiming to provide a focused view on how to utilize intrinsically complex catalysts for these important and complex reactions.In the end,remaining challenges and future directions are proposed to guide the development and application of HEA catalysts for highly efficient energy storage and chemical conversion toward carbon neutrality. | Lanlan Yu Kaizhu Zeng Chenghang Li Xiaorong Lin Hanwen Liu Wenhui Shi Hua-Jun Qiu Yifei Yuan Yonggang Yao | 2022 | Carbon Energy2022，4，5： | 0 |
| 15 | Robust Co_(3)O_(4)nanocatalysts supported on biomass-derived porous N-doped carbon toward low-pressure hydrogenation of furfural显示文摘The catalytic conversion of biomass platform chemicals using abundant non-noble metal nanocatalysts is a challenging topic.Here,high-density cobalt oxide nanoparticles loaded on biomass-derived porous N-doped carbon(NC)was fabricated by a tandem hydrothermal pyrolysis and mild nitrate decomposition process,which is a green and cheap preparation method.The Co_(3)O_(4) nanoparticles with the average size of 12 nm were uniformly distributed on the porous NC.The nanocomposites also possessed large surface area,high N content,good dispersibility in isopropanol,and furfural absorbability.Due to these characteristics,the novel cobalt nanocatalyst exhibited high catalytic activity for producing furfuryl alcohol,yielding 98.7%of the conversion and 97.1%of the selectivity at 160℃ for 6 h under 1 bar H2.The control experiments implied that both direct hydrogenation and transfer hydrogenation pathways co-existed in the hydrogenation reaction.The excellent catalytic activity of Co_(3)O_(4)@NC was attributed to the cooperative effects of porous NC and Co_(3)O_(4) nanoparticles.This approach provides a new idea to design effective high-density nonnoble metal oxide nanocatalysts for hydrogenation reactions,which can make full use of sustainable natural biomass. | Lin Zhang Lanlan Cheng Yechen Hu Qingguang Xiao Xiufang Chen Wangyang Lu | 2023 | Frontiers of Materials Science2023，17，2： | 0 |
| 16 | Many-body dissipative particle dynamics with energy conservation:temperature-dependent long-term attractive interaction显示文摘Heat and mass transfer during the process of liquid droplet dynamic behaviors has attracted much attention in decades.At mesoscopic scale,numerical simulations of liquid droplets motion,such as impacting,sliding,and coalescence,have been widely studied by using the particle-based method named many-body dissipative particle dynamics(MDPD).However,the detailed information on heat transfer needs further description.This paper develops a modified MDPD with energy conservation(MDPDE)by introducing a temperature-dependent long-term attractive interaction.By fitting or deriving the expressions of the strength of the attractive force,the exponent of the weight function in the dissipative force,and the mesoscopic heat friction coefficient about temperature,we calculate the viscosity,self-diffusivity,thermal conductivity,and surface tension,and obtain the Schmidt number Sc,the Prandtl number P r,and the Ohnesorge number Oh for 273 K to 373 K.The simulation data of MDPDE coincide well with the experimental data of water,indicating that our model can be used to simulate the dynamic behaviors of liquid water.Furthermore,we compare the equilibrium contact angle of droplets wetting on solid surfaces with that calculated from three interfacial tensions by MDPDE simulations.The coincident results not only stand for the validation of Young’s equation at mesoscale,but manifest the reliability of our MDPDE model and applicability to the cases with free surfaces.Our model can be extended to study the multiphase flow withcomplex heat and mass transfer. | Jie LI Kaixuan ZHANG Chensen LIN Lanlan XIAO Yang LIU Shuo CHEN | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，4： | 0 |
| 17 | Molecular imaging:design mechanism and bioapplications显示文摘Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of treatment.Nowadays,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission tomography.In this review,we summarize the development of current state-of-the-art molecular imaging probes.We introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided surgery.Then we discuss the perspectives and challenges in this emerging field.We expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices. | Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan | 2023 | Science China Chemistry2023，66，5： | 0 |
| 18 | Selecting small molecule DNA aptamers with significant conformational changes for constructing transcriptional switches and biosensors显示文摘Small molecule aptamers discovered by traditional selection methods usually lack conformational changes upon target binding.This limits the use of aptamers as molecular probes for small molecule detection and regulatory elements of genetic circuits.Here,we report a new method called capture and in vitro transcription-systematic evolution of ligands by exponential enrichment(CIVT-SELEX)to select DNA aptamers that can not only bind to small molecule ligands but also undergo significant conformational changes.Through this method,we select a structure-switching aptamer of uridine-5′-diphosphate(UDP).Taking advantage of its conformational changes,we first construct a UDP-responsive transcriptional switch by inserting the aptamer in a genetic circuit and demonstrate that it can respond to the addition of UDP and regulate the transcription of downstream genes.We also build a UDP aptamer-based biosensor that can be used for active glycosyltransferase screening.We believe this method can provide a universal platform for selecting small molecule aptamers with conformational changes and expand the use of aptamers in small molecule detection and genetic regulation. | Shaobin Guo Jingjing Lin Lujie Lin Wen Xu Yan Guo Zipeng Xu Chunhua Lu Xianai Shi Lanlan Chen Huanghao Yang | 2023 | Science China Chemistry2023，66，5： | 0 |
| 19 | A mini-review of the electro-peroxone technology for wastewaters:Characteristics,mechanism and prospect显示文摘The electro-peroxone technology,a novel type of advanced oxidation technology,is widely used in wastewater treatment.Herein,this paper reviews the advantages and problems of the electro-peroxone technology compared with electrochemical oxidation technology,ozonation technology,and traditional peroxone technology.Due to the high kinetics of pollutant degradation,the electro-peroxone process can reduce the reaction time and energy consumption of pollutant treatment in wastewater.The electroperoxone technology can promote pollutant degradation and mineralization,which shows obvious synergistic effects of electrochemical oxidation and ozonation for wastewater treatment.Most importantly,the research mechanism of the electro-peroxone technology is systematically introduced from two aspects of cathode reaction and bulk reaction.The influence of experimental parameters on the wastewater treatment effect is also discussed.Finally,the potential applications and future research directions of the electro-peroxone technology in the wastewater field are proposed.The electro-peroxone process can offer a highly efficient and energy saving water treatment method to improve the performance of existing ozonation and electrochemical systems and has therefore become a promising electrochemical advanced oxidation process for wastewater treatment. | Lu Chen Lanlan Wei Yifan Ru Mili Weng Lin Wang Qizhou Dai | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
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