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| 1 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 2 | Blood micronutrient, oxidative stress, and viral load in patients with chronic hepatitis C显示文摘AIM: To assess the extent of micronutrient and oxidative stress in blood and to examine their linkages with viral loads in chronic hepatitis C patients.METHODS: Hepatitis C virus (HCV)-RNA levels were quantified in the serum from 37 previously untreated patients with chronic hepatitis C. The plasma and erythrocyte micronutrients (zinc, selenium, copper, and iron) were estimated, and malondialdehyde (MDA)contents were determined as a marker to detect oxidative stress. Antioxidant enzymes, superoxide dismutase (SOD),glutathione peroxidase (GPX) and glutathione reductase (GR) activities in blood were also measured. The control group contained 31 healthy volunteers.RESULTS: The contents of zinc (Zn), and selenium (Se)in plasma and erythrocytes were significantly lower in hepatitis C patients than in the controls. On the contrary,copper (Cu) levels were significantly higher. Furthermore,plasma and erythrocyte MDA levels, and the SOD and GR activities in erythrocytes significantly increased in hepatitis C patients compared to the controls. However, the plasma GPX activity in patients was markedly lower. Plasma Se (r= -0.730, P<0.05), Cu (r = 0.635), and GPX (r = -0.675)demonstrated correlations with HCV-RNA loads. Significant correlation coefficients were also observed between HCV-RNA levels and erythrocyte Zn (r = -0.403), Se (r = -0.544), Cu (r = 0.701) and MDA (r = 0.629) and GR (r = 0.441).CONCLUSION: The levels of Zn, Se, Cu, and oxidative stress (MDA), as well as related anti-oxidative enzymes (GR and GPX) in blood have important impact on the viral factors in chronic hepatitis C. The distribution of these parameters might be significant biomarkers for HCV. | Wang-Sheng Ko Chih-Hung Guo Maw-Sheng Yeh Li-Yun Lin Guoo-Shyng W. Hsu Pei-Chung Chen Mei-Ching Luo Chia-Yeh Lin | 2005 | World Journal of Gastroenterology2005，11，30： | 6 |
| 3 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 4 | Lewis blood genotypes of peptic ulcer and gastric cancer patients in Taiwan显示文摘AIM: The Lewis b (Leb) antigen has been implicated as a possible binding site for attachment of Helicobacter pylori (H pylori)to gastric mucosa. However, studies both supporting and denying this association have been reported in the literature. Differences in secretor (Se)genotype have been suggested as a possible reason for previous discrepancies. Therefore, we investigated the relationship between Le and Se genotypes and H pylori infection rates in people with peptic ulcer or gastric cancer.METHODS: Peripheral blood samples were obtained from 347 patients with endoscopic evidence of peptic ulcer disease (235 cases of duodenal ulcer, 62 of gastric ulcer,and 50 of combined duodenal ulcer/gastric ulcer) and 51patients with gastric cancer on endoscopy. Peripheral blood specimens from 101 unrelated normal volunteers were used as controls. Lewis phenotype was determined using an antibody method, whereas Le and Se genotypes were determined by DNA amplification and restriction enzyme analysis. Gastric or duodenal biopsies taken from patients with endoscopic evidence of peptic ulcer or gastric cancer were cultured for H pylori. Isolates were identified as H pylori by morphology and production of urease and catalase. The H pylori infection status was also evaluated by rapid urease test (CLO test), and urea breath test (13C-UBT). Results of studies were analyzed by chi-square test (taken as significant).RESULTS: H pyloriwas isolated from 83.7% (303/347)of patients with peptic ulcer disease. Statistical analysis did not show any significant difference in Lewis phenotype or genotype between patients with and without H pylori infection. No significant association was found between Lewis genotype and peptic ulcer or gastric cancer.CONCLUSION: Lewis blood genotype or phenotype may not play a role in the pathogenesis of H pyloriinfection.However, bacterial strain differences and the presence of more than one attachment mechanism may limit the value of epidemiological studies in elucidating this matter. | Chi-Jung Yei Jan-Gowth Chang Mu-Chin Shih Sheng-Fung Lin Chao-Sung Chang Fu-Tsong Ko Kuang-Yang Lin Ta-Chih Liu | 2005 | World Journal of Gastroenterology2005，11，31： | 5 |
| 5 | Stereotactic Body Radiation Therapy in Recurrent Hepatocellular Carcinoma显示文摘 | Wen-Yen Huang Yee-Min Jen Meei-Shyuan Lee Li-Ping Chang Chang-Ming Chen Kai-Hsiung Ko Kuen-Tze Lin Jang-Chun Lin Hsing-Lung Chao Chun-Shu Lin Yu-Fu Su Chao-Yueh Fan Yao-Wen Chang | 2012 | International Journal of Radiation Oncology Biology Physics2012，，2： | 3 |
| 6 | Pandemic of the aging society—sporadic cerebral small vessel disease显示文摘Age-related sporadic cerebral small vessel disease(CSVD)has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population.The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers’understanding in the in vivo evolution of CSVD,its impact upon the brain,its risk factors,and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD.In this review,we aimed to provide an update on the pathophysiology,risk factors,biomarkers,and the determinants and spectrum of the clinical manifestation of sporadic CSVD. | Alexander Yuk Lun Lau Bonaventure Yiu Ming Ip Ho Ko Bonnie Yin Ka Lam Lin Shi Karen Ka Yan Ma Lisa Wing Chi Au Yannie Oi Yan Soo Thomas Wai Hong Leung Adrian Wong Vincent Chung Tong Mok | 2021 | Chinese Medical Journal2021，，2： | 3 |
| 7 | Stereotactic Body Radiation Therapy in Recurrent Hepatocellular Carcinoma显示文摘 | Wen-Yen Huang Yee-Min Jen Meei-Shyuan Lee Li-Ping Chang Chang-Ming Chen Kai-Hsiung Ko Kuen-Tze Lin Jang-Chun Lin Hsing-Lung Chao Chun-Shu Lin Yu-Fu Su Chao-Yueh Fan Yao-Wen Chang | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，2： | 2 |
| 8 | Broadband omnidirectional light detection in flexible and hierarchical ZnO/Si heterojunction photodiodes显示文摘灵活光电探测器的开发包括灵活图象传感器,生物医学的成像,和聪明的、便携系统为未来 optoelectronic 应用程序收到了大注意。以前,全向的光电探测器由多重光电探测器上的一个半球的 microlens 集会的集成仅仅是可完成的。此处,组织蜂房的 Si ( H-Si )膜上的 ZnO nanowires ( NW )的一个层次光电二极管图案被表明展出优秀全向的轻吸收的能力并且因此在女人上维持高光电流光谱为宽事件角度的范围( 365~1,100 nm )( 0io 是超过 6.00~10 个病人和 35 age-/gender-matched 控制吗(吝啬的 s ?? | Seongdong Lim Doo-Seung Um Minjeong Ha Qianpeng Zhang Youngsu Lee Yuanjing Lin Zhiyong Fan Hyunhyub Ko | 2017 | Nano Research2017，10，1： | 2 |
| 9 | Current status and trends in forest genomics显示文摘Forests are not only the most predominant of the Earth's terrestrial ecosystems,but are also the core supply for essential products for human use.However,global climate change and ongoing population explosion severely threatens the health of the forest ecosystem and aggravtes the deforestation and forest degradation.Forest genomics has great potential of increasing forest productivity and adaptation to the changing climate.In the last two decades,the field of forest genomics has advanced quickly owing to the advent of multiple high-throughput sequencing technologies,single cell RNA-seq,clustered regularly interspaced short palindromic repeats(CRISPR)-mediated genome editing,and spatial transcriptomes,as well as bioinformatics analysis technologies,which have led to the generation of multidimensional,multilayered,and spatiotemporal gene expression data.These technologies,together with basic technologies routinely used in plant biotechnology,enable us to tackle many important or unique issues in forest biology,and provide a panoramic view and an integrative elucidation of molecular regulatory mechanisms underlying phenotypic changes and variations.In this review,we recapitulated the advancement and current status of 12 research branches of forest genomics,and then provided future research directions and focuses for each area.Evidently,a shift from simple biotechnology-based research to advanced and integrative genomics research,and a setup for investigation and interpretation of many spatiotemporal development and differentiation issues in forest genomics have just begun to emerge. | Dulal Borthakur Victor Busov Xuan Hieu Cao Qingzhang Du Oliver Gailing Fikret Isik Jae-Heung Ko Chenghao Li Quanzi Li Shihui Niu Guanzheng Qu Thi Ha Giang Vu Xiao-Ru Wang Zhigang Wei Lin Zhang Hairong Wei | 2022 | Forestry Research2022，2，1： | 2 |
| 10 | Evaluation of a photovoltaic energy mechatronics system with a built-in quadratic maximum power point tracking algorithm显示文摘 | R.M. Chao S.H. Ko F.S. Pai I.H. Lin C.C. Chang | 2009 | Solar Energy2009，，： | 2 |
| 11 | Human Umbilical Mesenchymal Stem Cells Promote Recovery After Ischemic Stroke显示文摘 | Yu-Ching Lin Tsui-Ling Ko Yang-Hsin Shih Maan-Yuh Anya Lin Tz-Win Fu Hsiao-Sheng Hsiao Jung-Yu C. Hsu Yu-Show Fu | 2011 | Stroke2011，，7： | 2 |
| 12 | Reduction of androgen receptor expression by benzo[ a ]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[ a ]pyrene in human lung cells显示文摘 | Pinpin Lin Jinghua Tsai Chang Jiunn-Liang Ko Sheng-Hung Liao Wai-Sze Lo | 2004 | Biochemical Pharmacology2004，，8： | 2 |
| 13 | EEC-Based Assessment of Driver Cognitive Responses in a Dynamic Virtual-reality Driving Environment显示文摘 | Lin Chin-Teng Chung I-Fang Ko Li-Wei | 2007 | IEEE Transactions on Biomedical Engineering2007，54，7： | 1 |
| 14 | Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma 显示文摘 | Ko SY Lin SC Wong YK | 2007 | Cancer Lett2007，245，12： | 1 |
| 15 | Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea 显示文摘 | KO C I-I CI-IEN H I-I LIN Y R | 2003 | Planta Med2003，69，6： | 1 |
| 16 | MicroRNA let-7a-3 gene methylation is associated with karyotyping,CEBPA promoter methylation,and survival in acute myeloid leukemia显示文摘 | Ko YC Fang WH Lin TC | 2014 | Leuk Res2014，38，5： | 1 |
| 17 | The effects of polyethylene glycol (PEG)-derived lipid on the activity of target-sensitive immunoliposome显示文摘 | Ng KO Zhao L Lin Y | 2000 | Int J Pharm2000，193，2： | 1 |
| 18 | Hypolipidemic effect of glycosaminoglycans from the cucumber Metriatyla scabra in rats fed a cholesterol-sipplemented diet 显示文摘 | Liu His Hsien Ko Wen Ching Hu Miao Lin | 2002 | J Agrie Food Chem2002，50，12： | 1 |
| 19 | Hepatie resection for bilateral hep- atolithiasis: a 20-year experience 显示文摘 | Lin CC Lin PY Ko C J | 2013 | ANZ J Surg2013，83，12： | 1 |
| 20 | The effect of precarbonization onmechanical properties of final polyacrylonitrile-based carbon fi- bres显示文摘 | Ko T H Day T C Lin M F | 1993 | J Mater Sci Lett1993，12，5： | 1 |
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