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| 1 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 2 | Partitioning regularity of nonionic organic mixtures in organic phase/water system显示文摘The partitioning regularity of nonionic organic mixtures in organic phase/water system is revealed. The equation for calculating the partition coefficients of mixtures (KMD), together with the determination model, is derived from the equilibrium partitioning models (EPMs). Based on these derived equations, the KMD values of 20 mixtures containing halogenated benzenes are obtained. The results show that stronger hydrophobidty of an individual chemical in the mixture results in the stronger hydrophobidty of the mixture and the greater the proportion of this chemical, the stronger the hydrophobidty of the mixture will be. This partitioning regularity is helpful to the study of the toxicity for mixtures and the environmental behavior, such as transfer or accumulation, for mixed organic pollutants. | Lin, ZF Yu, HX Huang, LM Feng, JF Wang, LS | 2001 | Chinese Science Bulletin2001，46，17： | 2 |
| 3 | The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo显示文摘 | Shi HX Cai L Lin BB | 2013 | PLoS One2013，8，59： | 1 |
| 4 | Timing and dose regimens of mar- row mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic stroke 显示文摘 | Wang LQ Lin ZZ Zhang HX | 2014 | CNS Neurosci Ther2014，20，4： | 1 |
| 5 | Pathological mechanisms and dose dependency of erythrocyte-induced vulnerability of atherosclerotic plaques显示文摘 | Lin HL Xu XS Lu HX | | Journal of Molecular and Cellular Cardiology0，，： | 1 |
| 6 | The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo显示文摘 | Shi HX Lin C Lin BB | 2013 | PLo S One2013，8，59： | 1 |
| 7 | Air-liquid interface culture of serially passaged human nasal epithelial cell monolayer for in vitro drug transport studies显示文摘 | Lee MK Yoo JW Lin HX | 2005 | Drug Deliv2005，12，5： | 1 |
| 8 | QTLs for Na^+ and K^+ uptake of theshoots and roots controlling rice salt tolerance显示文摘 | Lin HX Zhu MZ Yano M | 2004 | Theor ApplGenet2004，108，2： | 1 |
| 9 | Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma显示文摘 | Ge N Lin HX Xiao XS | 2010 | J Transl Med2010，8，： | 1 |
| 10 | New descriptors of amino acids and their application to peptides QSAR study 显示文摘 | Lin ZH Long HX Zhu B | 2008 | Peptides2008，29，10： | 1 |
| 11 | The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic poten- tial by targeting GJA1 and KCNJ2显示文摘 | Yang BF Lin HX Xiao JN | 2007 | Nat Med2007，13，4： | 1 |
| 12 | ExpressionTGM2 and BNIP3 have prognostic signifi-cance in laryngeal cancer patients receiv-ing surgery and postoperative radiothera-py :a retrospective study 显示文摘 | Jin T Lin HX Lin H | 2012 | J TranslMed2012，10，： | 1 |
| 13 | Survey on ultramicro structure of differentiation of HL260 cells by bone marrow stromal cells显示文摘 | Fu Q Fan HX Lin Y Wang LJ | 1997 | N Bethune Univ Med Sci1997，23，5： | 1 |
| 14 | Novel approaches for genespecific interference via manipulating actions of microRNAs: examination on the pacemaker channel genesHCN2 and HCN4显示文摘 | Xiao JN Yang BF Lin HX | 2007 | J Cell Physiol2007，212，2： | 1 |
| 15 | Decreased expression of Beclin 1 correlates closely with Bcl - xL expression and poor prognosis of ovarian carcinoma 显示文摘 | Lin HX Qiu H J Zeng F | 2013 | PLOS One2013，8，60： | 1 |
| 16 | Natural variation in rice starch synthase IIa affects enzyme and starch properties显示文摘 | Umemoto T Aoki N Lin HX | 2004 | Functional Plant Biology2004，31，7： | 1 |
| 17 | Jolkinolide B induces apoptosis in MDA-MB-231 cells through inhibition of the PI3K/Akt signaling pathway显示文摘 | Lin Y Cui HX Xu HY | 2012 | Oncol Rep2012，27，： | 1 |
| 18 | Unregulated mir-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a显示文摘 | Lin HX Dai T Xiong HP | | 0，，12： | 1 |
| 19 | Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma 显示文摘 | Ge N Lin HX Xiao XS | 2010 | J Trartsl Med2010，8，： | 1 |
| 20 | Down-regulation of miR - l/miR - 133 contributes to re - expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart显示文摘 | Luo XB Lin HX Pan ZW | 2008 | Biolo Chem2008，283，20： | 1 |
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