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| 1 | Calcium phosphate cements for bone engineering and their biological properties显示文摘Calcium phosphate cements(CPCs) are frequently used to repair bone defects. Since their discovery in the 1980 s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability,bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs,including 3 D printing, injectability, stem cell delivery, growth factor and drug delivery, and prevascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. | Hockin HK Xu Ping Wang Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao Xuedong Zhou Mark A Reynolds | 2017 | Bone Research2017，5，4： | 14 |
| 2 | Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia显示文摘 | Wang HK Fung HC Hsu WC Wu YR Lin JC Ro LS Chang KH Hwu FJ Hsu Y Huang SY Lee-Chen GJ Chen CM | 2006 | 中国生物学文摘2006，20，8： | 8 |
| 3 | Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks显示文摘Antibacterial dimethylaminododecyl methacrylate(DMADDM) was recently synthesized. The objectives of this study were to:(1)investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and(2) compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate(QADM).Scotchbond Multi-Purpose(SBMP) bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested: SBMP control primer P, P+2.5% DMADDM, P+5% DMADDM, P+7.5% DMADDM, P+10% DMADDM, and P+10% QADM.S. mutans were impregnated into human dentin blocks, and each primer was applied to dentin to test its ability to kill bacteria in dentinal tubules. Bacteria in dentin were collected via a sonication method, and the colony-forming units(CFU) and inhibition zones were measured. The bacterial inhibition zone of P+10% DMADDM was 10 times that of control primer(Po0.05). CFU in dentin with P+10% DMADDM was reduced by three orders of magnitude, compared with control. DMADDM had a much stronger antibacterial effect than QADM, and antibacterial efficacy increased with increasing DMADDM concentration. Dentin shear bond strengths were similar among all groups(P40.1). In conclusion, antibacterial DMADDM-containing primer was validated to kill bacteria inside dentin blocks, possessing a much stronger antibacterial potency than the previous QADM. DMADDM-containing bonding agent was effective in eradicating bacteria in dentin, and its efficacy was directly proportional to DMADDM mass fraction. Therefore, DMADDM may be promising for use in bonding agents as well as in other restorative and preventive materials to inhibit bacteria. | Chen Chen Lei Cheng Michael D Weir Nancy J Lin Sheng Lin-Gibson Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，4： | 4 |
| 4 | Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement显示文摘White spot lesions(WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate(NACP) with long-term calcium(Ca) and phosphate(P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACPrechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release.The rechargeable cement consisted of pyromellitic glycerol dimethacrylate(PMGDM) and ethoxylated bisphenol A dimethacrylate(EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength(SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release(P40.1). Specimens after one recharge treatment(e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as '1 min 3 times') exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles(P40.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times43 min 2 times41 min 2 times46 min 1 time43 min 1 time41 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets. | Xian-Ju Xie Dan Xing Lin Wang Han Zhou Michael D Weir Yu-Xing Bai Hockin HK Xu | 2017 | International Journal of Oral Science2017，9，1： | 3 |
| 5 | Deregulated TGF-beta signaling in leukemogenesis显示文摘 | Lin HK Bergmann S Pandolti PP | | 0，，37： | 1 |
| 6 | Prognostic implications of myoclonie jerk in children with enterovirus infection 显示文摘 | Lu HK Lin TY Hsia SH | 2004 | J Mierobiol Immunol Infect2004，37，2： | 1 |
| 7 | Akt suppresses androgen-induced ap- optosis by phosphorylating and inhibiting androgen receptor显示文摘 | Lin HK Yeh S Kang HY | 2001 | Proe Natl Acad Sei I5 S A2001，98，13： | 1 |
| 8 | Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence显示文摘 | Lin HK Chen Z Wang G | 2010 | Nature2010，464，7287： | 1 |
| 9 | The novel primary reponse gene MyD118 and the proto-oncogenes myb,myc,and bcl-2 modulate trans-forming growth factor beta 1-induced apoptosis of myeloid leukemia cells显示文摘 | Selvakumaran M Lin HK Sjin RT | 1994 | Mol Cell Biol1994，14，： | 1 |
| 10 | Tumor suppressor p53 is a regulator of bcl - 2 and bax geue expression in vitro and in vivo 显示文摘 | Wang HG Lin HK Liebennann DA | 1994 | Oncogene1994，9，6： | 1 |
| 11 | Serum bilirubin is in- versely associated with insulin resistance and metabolic syndrome among children and adolescents 显示文摘 | Lin LY Kuo HK Hwang JJ | 2009 | Athero- Sclerosis2009，203，2： | 1 |
| 12 | The novelprimary respose gene myD118 and the protooncogenes myb myc and Bcl-2 modulate transform ing grow th factor Betal-induce apoptos is of myeloid leukem ia cell显示文摘 | Selvakumaran M Lin HK Sjin RT | 1994 | Mol Cell Biol1994，14，4： | 1 |
| 13 | Deregulated TGF-beta signaling in leukemogenesis显示文摘 | Lin HK Bergmann S Pandoli PP | 2005 | Oncogene2005，24，： | 1 |
| 14 | Skp2targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence显示文摘 | Lin HK Chen ZB Wang GC | 2010 | Nature2010，464，7287： | 1 |
| 15 | Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents显示文摘 | Lin LY Kuo HK Hwang JJ | | 0，，02： | 1 |
| 16 | Association of HLA class I with severe acute respiratory syndrome coronavirus infection显示文摘 | Line M Tseng HK Trejaut JA Lee IlL Loo JH Chu CC Chert PJ Su YW Lira KH Tsai ZU Lin RY Lin RS and Huang CH | 2003 | BMC Med Genet2003，4，： | 1 |
| 17 | Genetic association analysis of30genes related to obesity in a European American population显示文摘 | Li P Tiwari HK Lin WY | 2014 | Int J Obes(Lond)2014，38，5： | 1 |
| 18 | Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladde显示文摘 | Zhang Y Lin HK Frimberger D | 2005 | BJU Int2005，96，7： | 1 |
| 19 | Reduced expression of transforming growth factor - β1 and correlated elevation of interleukin- 17 and interferon-γ in pediatric patients with chronic primary immune thrombocytopenia (ITP) 显示文摘 | Wang JD Chang TK Lin HK | 2011 | Pediatr Blood Cancer2011，57，4： | 1 |
| 20 | GDF-5 is suppressed by IL-1 beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes显示文摘 | Liu FL Lin LH Sytwu HK | 2010 | Exp Mol Pathol2010，88，1： | 1 |
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