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| 1 | Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice显示文摘Mecobalamin,a form of vitamin B12 containing a central metal element(cobalt),is one of the most important mediators of nervous system function.In the clinic,it is often used to accelerate recovery of peripheral nerves,but its molecular mechanism remains unclear.In the present study,we performed sciatic nerve crush injury in mice,followed by daily intraperitoneal administration of mecobalamin(65 μg/kg or 130 μg/kg) or saline(negative control).Walking track analysis,histomorphological examination,and quantitative real-time PCR showed that mecobalamin significantly improved functional recovery of the sciatic nerve,thickened the myelin sheath in myelinated nerve fibers,and increased the cross-sectional area of target muscle cells.Furthermore,mecobalamin upregulated m RNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury,and of neurotrophic factors(nerve growth factor,brain-derived nerve growth factor and ciliary neurotrophic factor) in the L4–6 dorsal root ganglia.Our findings indicate that the molecular mechanism underlying the therapeutic effect of mecobalamin after sciatic nerve injury involves the upregulation of multiple neurotrophic factor genes. | Lin Gan Minquan Qian Keqin Shi Gang Chen Yanglin Gu Wei Du Guoxing Zhu | 2014 | Neural Regeneration Research2014，9，22： | 11 |
| 2 | TMEM43-S358L mutation enhances NF-κBTGFp signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy显示文摘Arrhythmogenic right ventricular dysplasia/cardiomyopathy(ARVD/C)is a genetic cardiac muscle disease that accounts for approximately 30%sudden cardiac death in young adults.The Ser358Leu mutation of transmembrane protein 43(TMEM43)was commonly identified in the patients of highly lethal and fully penetrant ARVD subtype,ARVD5.Here,we generated TMEM43 S358L mouse to explore the underlying mechanism.This mouse strain showed the classic patholo.gies of ARVD patients,including structural abnormalities and cardiac fibrofatty.TMEM43 S358L mutation led to hyper-activated nuclear factor kB(NFkB)activation in heart tissues and primary cardiomy.ocyte cells.Importantly,this hyper activation of NF-κB directly drove the expression of pro-fibrotic gene,transforming growth factor beta(TGFβ),and enhanced downstream signal,indicating that TMEM43 S358L mutation up-regulates NF-κB-TGFβ signal cascade during ARVD cardiac fibrosis.Our study partially reveals the regulatory mechanism of ARVD development. | Guoxing Zheng Changying Jiang Yulin Li Dandan Yang Youcai Ma Bing Zhang Xuan Li Pei Zhang Xiaoyu Hu Xueqiang Zhao Jie Du Xin Lin | 2019 | Protein & Cell2019，10，2： | 5 |
| 3 | Development of the Array Transient Electromagnetic System and Its Experiments显示文摘Transient electromagnetic (TEM) technique plays a significant role in mineral exploration. To accommodate the complicated survey environments in the west part of China, we developed a portable array TEM equipment (ATEM-1), which was implemented based upon the idea to apply the GPS timing signal for the synchronization among transmitters and receivers. The structure of the system and its performance are discussed and the case study is also described. | Lin Jun Cheng Defu Liu Guoxing Duan Qingming Zhang Linhang Yu Shengbao | 2000 | Global Geology2000，5，1： | 3 |
| 4 | A simple inorganic-solvent-thermal route to nanocrystalline niobium diboride显示文摘 | Jianhua Ma Yihong Du Meining Wu Guoxing Li Zhiqing Feng Ming Guo Yixiu Sun Weihua Song Mingjin Lin Xule Guo | 2008 | Journal of Alloys and Compounds2008，，： | 1 |
| 5 | Performance Char- acteristics of a Regeneration Ericsson Refrigeration Cycle Using a Magnetic Composite as the Working Substance 显示文摘 | Diguet G Lin Guoxing Chen Jincan | 2013 | International Journal of Refrigeration2013，36，： | 1 |
| 6 | A GdzHol-x- based Composite and its Performance Characteristics in a Regenerative Ericsson Refrigeration Cycle 显示文摘 | Xu Zhichao Lin Guoxing Chen Jincan | 2015 | Journal of Alloys and Compounds2015，639，： | 1 |
| 7 | Per- formance analysis and multi-objective optimization of a new molten carbonate fuel cell system显示文摘 | Zhang Houcheng Lin Guoxing Chen Jinean | 2011 | Interna- tional Journal of Hydrogen Energy2011，36，6： | 1 |
| 8 | Thermoeco- nomic Optimization of an Irreversible Stirling Cryogenic Refrigerator Cycle 显示文摘 | Tyagi S K Lin Guoxing Kaushik S C | 2004 | International Journal of Refrigera- tion2004，27，： | 1 |
| 9 | Performance characteristics of magnetic Brayton refrigeration cycles using Gd, Gd 0.74 Tb 0.26 and (Gd 3.5 Tb 1.5 )Si 4 as the working substance显示文摘 | Gildas Diguet Guoxing Lin Jincan Chen | 2011 | International Journal of Refrigeration2011，，4： | 1 |
| 10 | Ecological optimization criterion for an irreversible three-heat-source refrigerator 显示文摘 | Zijun Yan Guoxing Lin | 2000 | Applied energy2000，66，： | 1 |
| 11 | Serological Prevalence Survey Among the High-Risk Populations of Brucellosis-Endemic Areas-China,2019−2020显示文摘What is already known about this topic?Timely screening of high-risk population is important to improve the early detection of brucellosis among the endemic areas during the high incidence seasons,which is also required by the National Brucellosis Prevention and Control Plan(2016–2020)(NBPCP).What is added by this report?Seroepidemiological characteristics of brucellosis in high-risk populations were obtained and special occupational populations were found.The seroprevalence of brucellosis has been decreasing compared with that reported in the recent years due to the ongoing implementation of control measures in endemic areas.What are the implications for public health practice?Special occupational populations could be promptly detected using routine screening,which makes it possible to initiate standardized treatment for infected patients as early as possible.It also reminds us to pay attention to special occupational populations to improve their knowledge of brucellosis and reduce the risk of infection. | Shenghong Lin Zhe Wang Xinrong Liu Aizhi Yu Muhtar·Hasan Jiensi·Bayidawulieti Haitan·Aximujiang Ruiqing Li Guoxing Zheng Xinwang Liang Xiaoling Fan Biqiao Hou Xiaolong Fan Dilxat·Abuliti Lusha Shi Cuihong Zhang Yifei Wang Pengjing Ning Caixiong Liu Zhongjie Li Liping Wang | 2021 | China CDC weekly2021，3，6： | 1 |
| 12 | Brucellosis Knowledge and Personal Protective Equipment Usage Among High-Risk Populations in Brucellosis-Endemic Areas-China,2019−2020显示文摘What is already known about this topic?According to the National Brucellosis Prevention and Control Plan(2016–2020)(NBPCP),the awareness rate of high-risk populations in brucellosis-endemic areas should reach 90%by 2020.But the updated results have not been reported.What is added by this report?This report determined the awareness rate of brucellosis(17.74%),utilization of personal protective equipment(PPE)(20.13%),and their relationship with seroprevalence,which provides evidence for the effectiveness of the implementation of NBPCP.What are the implications for public health practice?The results suggest that health education should be conducted for high-risk populations to improve their brucellosis and protection knowledge. | Zhe Wang Shenghong Lin Xinrong Liu Aizhi Yu Muhtar·Hasan Jiensi·Bayidawulieti Haitan·Aximujiang Ruiqing Li Guoxing Zheng Xinwang Liang Xiaoling Fan Biqiao Hou Xiaolong Fan Dilxat·Abuliti Lusha Shi Cuihong Zhang Yifei Wang Pengjing Ning Caixiong Liu Zhongjie Li Liping Wang | 2021 | China CDC weekly2021，3，6： | 1 |
| 13 | Pathological study of pterygium显示文摘 | Xu Guoxing Tong Yi Lin Fasheng | 1995 | Invest Ophthalmol Vis Sci1995，36，1： | 1 |
| 14 | Performance of an irreversible solar driven Braysson heat engine at maximum efficiency显示文摘 | Zheng Shiyan Chen Jincan Lin Guoxing | 2005 | Renewable Energy2005，30，： | 1 |
| 15 | Performance of an irreversible solar driven Braysson heat engine at maximum efficiency显示文摘 | Zheng Shiyan Chen Jincan Lin Guoxing | 2005 | Renewable Energy2005，30，4： | 1 |
| 16 | Parametric optimization of a solar-driven Braysson heat engine with variable heat capacity of the working fluid and radiation-convection heat losses 显示文摘 | Wu Lanmei Lin Guoxing Chen Jincan | 2010 | Renewable Energy2010，35，1： | 1 |
| 17 | The optimal operating temperature of the collector of an irreversible solar-driven refrigerator显示文摘 | Lin Guoxing Yan Zijun | 1999 | Journal of Physics D: Applied Physics1999，32，2： | 1 |
| 18 | SYNTHESIS OF NaA ZEOLITE MEMBRANE FROM CLEAR SOLUTION AND ITS GAS PERMEATION PROPERTIES显示文摘 | Xu Xiaochun Liu Jie Zhu Bing Fang Lianqing Yang Weishen Xiong Guoxing Lin Liwu (State Key Laboratory of Catalysis Dalian Institute of Chemical Physics The Chinese Academy of Sciences Dalian 116023) | 1999 | 催化学报1999，，04： | 1 |
| 19 | Proteomic analysis of a chronic obstructive pulmonary disease mouse model to determine the efficacy of treatment using Guben Zhike decoction显示文摘Background:Guben Zhike decoction(GBZKD)is derived from the experience of Professor Enxiang Chao,an esteemed master of Chinese medicine,while treating chronic obstructive pulmonary disease(COPD).GBZKD reinforces the healthy qi and consolidates defensive qi.This study explored the efficacy and potential mechanism of action of GBZKD in a COPD mouse model using proteomics.Methods:A COPD mouse model was established through cigarette smoke exposure and intranasal lipopolysaccharide administration.The model was verified through lung function test and lung histopathological observation.Label-free quantitative proteomics was used to detect the lung tissue proteins of mice from the GBZKD,COPD,and control groups.Results:GBZKD markedly improved the lung function and associated pathological conditions in the COPD mouse model.Proteomic analysis identified 4316 proteins,of which 3696 were quantitative proteins.We highlighted 287 and 184 proteins with significant regulatory roles in the lung tissues of COPD mice and GBZKD-treated mice,respectively.These proteins participated in multiple functions,including complement/coagulation cascade,immune response,and metabolic pathways.Conclusion:GBZKD exhibits multitarget and multipathway therapeutic effects in a COPD mouse model. | Mingzhe Wang Guoxing Liu Yao Xiao Zhe Cai Chang Liu Lin Pan Ying Liu Mengchao Liu Hongchun Zhang | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 0 |
| 20 | Influence of cerium and yttrium addition on strength and electrical conductivity of pure aluminum alloys显示文摘To develop pure aluminum alloys with high conductivity and strength, Al-0.2Ce and Al-0.2Ce-0.1Y alloys were prepared by rolling and annealing processes in this study. The effects of trace rare earth elements on the strength and electrical conductivity of the pure aluminum alloys were investigated. It is revealed that the addition of Ce and Y to pure aluminum can effectively enhance the strength and electrical conductivity of the alloys. In Al-0.2Ce, the addition of Ce can effectively refine the grain size of a-Al, with an average grain size of 90.68 μm in the as-cast state. The grain size of the alloy is further reduced to 87.55 μm by the simultaneous addition of Y. The synergistic addition of Ce and Y changes the properties of the alloy. The addition of Ce and Y also produces the Al_(11)Ce_(3) and Al_(3)Y second phases, which have coherent relationship with a-Al. The two-dimensional mismatch degree was calculated to be only 4.43%and 0.85%, respectively, which can provide a certain amount of nucleation substrate for a-Al in the incubation stage. The interfacial match between the L1_(2)structure of Al_(3)Y and a-Al was calculated using first-principles simulations. The results indicate that Al_(3)Y has a strong bonding effect with a-Al. Nanoscale second phases at grain boundaries can be effective in reducing resistivity due to dislocation motion.Nanoscale second phases with better matching interfaces to the substrate have no positive effect on the scattering motion of electrons. | Guojian Lin Lu Li Zhengwei Guo Xianjun Jia Xiao Wang Zhentao Yuan Guoxing Zhang Yun Zhan Quan Shan Zulai Li | 2024 | Journal of Rare Earths2024，42，3： | 0 |
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