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12019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W 2020中华高血压杂志2020,28,3:516
2Tectonic evolution of the Dabieshan orogen: In the view from polyphase deformation of the Beihuaiyang metamorphic zone显示文摘The Beihuaiyang metamorphic zone was formed by the Early Mesozoic collision of the North and South China Blocks. It consisted of the Foziling and Luzhenguan complexes and was thought to have never afforded a deep subduction. A similar feature of the deformation in the Dabieshan UHP metamorphic rocks implies that these different tectonic units share the same geodynamic background. The early stage of deformation can be preserved on account of their relatively shallower subduction than that for UHP rocks. On the basis of an analysis of the geo- logical structure and geochronological results, five deformational stages have been recognized: a D1-Early compressional deformation which represents the continental subduction; a D2-Early exhumation deformation producing a syn-convergence exhumation; a D3-Main deformation, represented by an exhumation deformation with Late Triassic age; a D4-Doming and its margin extensional gravity collapse deformation and finally a D5-regional extensional deformation of Cretaceous that was mostly introduced by the migmatization and plutonism.LIN Wei1, 2, Faure Michel3, WANG Qingchen1 & Arnaud Nicolas4 1. LTE, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Earth and Planetary Sciences, Graduate School of Science, Nagoya University, Japan 3. ISTO, UMR CNRS 6113, Batiment Géosciences, Orléans Université d’Orléans, 45067 Orléans Cedex 2, France 4. UMR 6524 'Magmas et Volcans', 5 Rue Kessler, 63000 Clermont-Ferrand, France 2005Science China Earth Sciences2005,48,7:25
3Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng 2009Cell Research2009,19,3:9
4欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F 2018中华高血压杂志2018,26,4:3
5Charge control and mobility studies for an AlGaN/GaN high electron mobility transistor显示文摘Zhang Y Zhang H B Lin G D Chen P, Yuan Y Z, Tsai K R 0,,:3
6全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A 2016饲料博览2016,0,12:2
7A hierarchical genetic algorithm for the TSP 显示文摘Lin W Delgado-Frias J G Gause D C 1996Mathematical Modeling and Scientic Computing1996,6,:2
8The gene for an abundant parasite coat protein predicts tandemly repetitive mental binding domains 显示文摘Clark T G Lin Tian-Long Jackwood D A 1999Gene1999,229,:2
9Model prediction of rutting in asphalt concrete显示文摘Ramsamooj D V Ramadan J Lin G S 1998Journal of Transportation Engineering1998,24,5:2
10显示文摘 Zhang H B Lin G D 1997Carbon1997,35,:1
11Synthesis of (±)- -N1-nitrosoanatabine, a tobacco-specific nitrosamine 显示文摘Desai D Lin G Morimoto H 2002Journal of Labelled Compounds & Radiopharmaeeutieals2002,45,13:1
12Single-crystal- line sodium-doped p-type ZnO and ZnMgO nanowires via eombination of thin-film and nano techniques 显示文摘HE H P LIN S S YUAN G D 2011Jour- nal of Physical Chemistry: C2011,115,39:1
13Study of W/HZSM-5-based catalysts for dehydro-aromatization of CH4 in absence of 02 (11):Action of promoters Zn and Li 显示文摘Xiong Z T Zhang H B Lin G D Zeng J L 2001Catalysis Letters2001,74,34:1
14Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D 2014Nature Genetics2014,46,4:1
15Two novel aquaporin- 2 mutations responsible for congenital nephrogenic diabe- tes insipidus in Chinese families显示文摘Lin S H Biehet D G Sasaki S 2002J Clin Endocrinol Metab2002,87,06:1
16Anti-inflammatory activity of Chinese medicinal vine plants 显示文摘Li R W Lin G D Myers S P 2003J Ethnopharmacol2003,85,:1
17Growth of carbon nanotubes by catalytic decomposition of CH4 or CO on a Ni-MgO catalyst显示文摘Chen P Zhang H B Lin G D 1997Carbon1997,35,:1
18A three-dimensional photonic crystal operating at infrared wavelengths显示文摘LIN S Y FLEMING J G HETHERINGTON D L 1998Nature1998,394,:1
19Modeling and performance analysis of QoS-aware load balancing of Web server clusters显示文摘SHAN Z G LIN C MARINESCU D C 2002Computer Networks Elsevier Science2002,40,2:1
20Effects of carbon coating and iron phosphides on the electrochemical proper-ties of LiFeP04/C 显示文摘LIN Y GAO M X ZHU D LIU X F PAN H G 2008J Power Sources2008,184,:1
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