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| 1 | In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L显示文摘 | Chong ZHANG Shuang-shuang ZHOU Lin-yi FENGI Da-yong ZHANG Neng-ming LIN Li-huang ZHANG Jian-ping PAN Jun-bo WANG Jie LI | 2013 | Acta Pharmacologica Sinica2013，34，2： | 9 |
| 2 | Overcoming the limitation of in-situ microstructural control in laser additive manufactured Ti-6Al-4V alloy to enhanced mechanical performance by integration of synchronous induction heating显示文摘Although a variety of processing routes were developed to in-situ manipulate microstructure for fabricating high-performance Ti-6Al-4 V alloy by directed energy deposition(DED),the in-situ microstructural control ability has been limited and lead to a narrowed mechanical property control range.This work proved the microstructural correlation betweenβ-grains andα-laths resulting from the unique thermal characteristics of DED for the first time and solved such a dilemma through synchronous induction heating assisted laser deposition(SILD)technology.The results confirmed that the laser energy and inductive energy have a different effect on the solidification and solid phase transformation conditions.By adjusting the laser-induction parameters,the microstructural correlation can be tuned;theβ-grains andα-laths can be controlled relatively separately,thereby significantly enhancing the ductility of as-deposited sample(elongation from 14.2%to 20.1%).Furthermore,the mechanical properties of the tuned microstructures are even comparable to that of DED Ti-6Al-4 V with post heat treatment,which indicates that the potential of SILD to be a one-step manufacturing process to fabricate high performance components without post heat treatment.Furthermore,the tensile testing results of the tuned microstructures indicate thatα-lath size is more influential on the mechanical properties than theβ-grain size due to its stronger hindering effect on the slipping of dislocations.This work promotes the understanding of the microstructural formation mechanism in DED titanium alloy and proves that the combination of synchronous induction and laser can expand the ability to control the microstructure and properties of multi-layer deposition. | Wei Fan Hua Tan Fengying Zhang Zhe Feng Yongxia Wang Lai-Chang Zhang Xin Lin Weidong Huang | 2021 | Journal of Materials Science & Technology2021，，35： | 3 |
| 3 | Adenine Phosphoribosyl Transferase 1 is a Key Enzyme Catalyzing Cytokinin Conversion from Nucleobases to Nucleotides in Arabidopsis显示文摘在植物,细胞激动素包括细胞激动素生合成,互变现象, inactivation,和降级,新陈代谢的进程在细胞激动素动态平衡和植物开发的规定起关键作用。嘌呤新陈代谢的酶被暗示了在以前的工作催化细胞激动素互变现象。在这研究,我们报导腺嘌 Phosphoribosyl Transferase 1 (APT1 ) 是高剂量的细胞激动素抵抗的异种的原因的基因。APT1 从免费的底催化细胞激动素变换到核苷酸,并且在 Arabidopsis 腺嘌 Phosphoribosyl Transferase 家庭的五个成员之中是机能上地占优势的。在工厂的 APT1 活动的损失导致细胞激动素底的过量累积,因此唤起无数调整细胞激动素的回答例如推迟的叶老朽, anthocyanin 累积,和下游的基因表示。因此,我们的学习把 APT1 定义为由 phosphoribosylation 参予细胞激动素 inactivation 的关键新陈代谢的酶。 | Xinyan Zhang Yutao Chen Xin Lin Xinyu Hong Ying Zhu Wenyang Li Wenrong He Fengying An Hongwei Guo | 2013 | Molecular Plant2013，6，5： | 2 |
| 4 | Vinyl-functionalized multicolor benzothiadiazoles: design,synthesis, crystal structures and mechanically-responsive performance显示文摘Benzothiadiazole(BTD) has been extensively used as a building block in optical materials. In this work, a class of π-conjugated BTD-based luminogens BTD-685, BTD-580, BTD-675 and BTD-565 were designed by varying donor units and facilely synthesized by Heck coupling reaction. It was found that their emission in solid state covered the regio from orange, red to near infrared fluorescence. Investigation on photo-physical property manifested that they had strong solvatochromic behavior except symmetric 2-vinylpyridine substituted BTD-565. Crystal X-ray diffraction analysis revealed that they involved in multi weak intermolecular interactions. And loose molecular packing implied that they can be easily rearranged under external force stimuli.Indeed, all compounds showed reversible mechanically-responsive behavior in solid state. Interestingly, the vinylpyridinecontaining BTD-565 exhibited hypochromatic mechanochromic behavior, whereas others showed bathochromic mechanochromism behavior. It was worth mentioning that BTD-675 had self-recovery behavior after grinding. The powder X-ray diffraction study showed that these chromic processes may be mainly attributed to the reversible morphological changes between crystalline and amorphous phase upon grinding or fuming. These observations suggested that the vinyl-functionalized benzothiadiazoles can be considered as a type of excellent candidates in mechanically-responsive chromic materials. | Jianhua Chen Fengying Ye Yan Lin Zhao Chen Shenghua Liu Jun Yin | 2019 | Science China Chemistry2019，62，4： | 2 |
| 5 | 显示文摘 | Cao Guoxi Lin Fengying Hu Hefang | 2003 | Non- Cryst Solids2003，326，327： | 1 |
| 6 | A new fluorogermanate glass显示文摘 | CAO Guoxi LIN Fengying HU Hefang | 2003 | J Non-Cryst Solids2003，，： | 1 |
| 7 | Structural optimization and evaluation of butenolides as potent antifouling agents: modification of the side chain affects the biological activities of compounds显示文摘 | Yongxin Li Fengying Zhang Ying Xu Kiyotaka Matsumura Zhuang Han Lingli Liu Wenhan Lin Yanxing Jia Pei-Yuan Qian | 2012 | Biofouling2012，，8： | 1 |
| 8 | Effect of hepatocyte growth factor signaling pathway activation on Plasmodium berghei infection显示文摘Objective:To explore the effect of hepatocyte growth factor signaling pathway activation on Plasmodium berghei infection.Methods:In this study,hepatocyte growth factor was detected by ELISA and Western blotting assay.Hepatocyte injury was detected by FITC-dextran absorption assay,and hepatocyte growth factor expression was shown to be expressed in the same injury cells by immunofluorescence against hepatocyte growth factor.In addition,Activation of hepatocyte growth factor and its receptor signaling pathway was detected with immunoprecipitation and detection of phosphorylation status.Results:It was found that injury of hepatocytes by sporozoite migration induced the secretion of hepatocyte growth factor and it was hepatocyte growth factor that rendered hepatocytes susceptible to Plasmodium sporozoite infection.In addition,hepatocyte infections depended on activation of the hepatocyte growth factor and its receptor signaling pathway.Conclusions:Our results indicate that hepatocyte growth factor and its receptor may possibly be potential targets for new approaches to malaria treatment. | Nantian Zhong Fengying Huang Guanghong Tan Jiege Jiao Yingzhi Lin CaichunWang Hua Wang Songlin Zhou Yonghao Huang Fan Chen Yingying Lin | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，3： | 1 |
| 9 | Front and Back contact engineering for high-efficient and low-cost hydrothermal derived Sb_(2)(S, Se)_(3) solar cells by using FTO/SnO_(2) and carbon显示文摘Antimony chalcogenide Sb_(2)(S, Se)_(3) is attracting a lot of attention as photovoltaic absorber owing to its rewarding photoelectric properties, low toxicity, and earth abundance. However, its device efficiency is still limited by the absorber material quality and device interface recombination. In this work, a fluorinedoped tin oxide(FTO) substrate with ultra-thin SnO_(2) layer and a low-cost stabilized carbon paste are introduced as a front and back contact layer respectively in Sb_(2)(S, Se)_(3) based planar solar cells. Over 5.2% efficiency is demonstrated in the structure of FTO/SnO_(2)/Cd S/Sb_(2)(S, Se)_3/Carbon/Ag, where the Sb_(2)(S, Se)_(3) is prepared by hydrothermal technique. The complementary device physics characterizations reveal that the interfacial recombination between TCO and Cd S is significantly suppressed by the introduction of ultra-thin SnO_(2) layer, which is profited from the leakage protection and bandgap offset engineering by its high resistivity and suitable conduction band minimum. Meanwhile, the successful adoption of the lowcost stabilized carbon as a back contact here shows an enormous potential to replace the conventional organic hole transport materials and noble metal. We hope this work can provide positive guidance to optimize Sb_(2)(S, Se)_(3) based planar solar cells in the future. | Liquan Yao Limei Lin Hui Liu Fengying Wu Jianmin Li Shuiyuan Chen Zhigao Huang Guilin Chen | 2020 | Journal of Materials Science & Technology2020，58，23： | 1 |
| 10 | New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities显示文摘(±)-Crataegusnorin A(la/1b) and B(2a/2b),two pairs of rare 8,9’-epoxy-type norlignan enantiomers featuring a y-butyrolactone ring,were isolated from the fruit of Crataegus pinnatifida.Their structures were determined via extensive spectroscopic analyses.Gauge-independent atomic orbital(GIAO) NMR chemical shift calculations,combined with the advanced statistical method DP4+were employed to establish the relative configurations of four compounds.Next,chiral separation was accomplished by chiral chromatographic column and the absolute configurations of the four compounds were unambiguously assigned by comparison between their experimental electronic circular dichroism curves with the quantum-mechanically calculated curves based on time-dependent density functional theory(TDDFT).All the isolates were evaluated fo r their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells.The results showed that two pairs of enantiomers 1a/1b and 2a/2b displayed diff;erent effect on neuroprotective activity.Among them,compound 2a displayed the most potent neuroprotective effect Further flow cytometry analysis indicated that 2a could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis. | Rui Guo Tianming Lv Fengying Han Zilin Hou Guodong Yao Bin Lin Xiaobo Wang Xiaoxiao Huang Shaojiang Song | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 11 | Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy显示文摘Background:Although programmed cell death 1(PD-1)blockade plus chemotherapy can significantly prolong the progression-free survival(PFS)and overall survival(OS)in first-line settings in patients with driver-negative advanced non-small-cell lung cancer(NSCLC),the predictive biomarkers remain undetermined.Here,we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD-1 blockade plus chemotherapy.Methods:Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy alone.Tumor immune microenvironmental markers,including PD-1 ligand(PDL1),CD8,CD68,CD4 and forkhead box P3,were assessed using multiplex immunofluorescence(mIF)assays.Kaplan-Meier curveswere used to determine treatment outcome differences according to their expression status.Mutational profiles were compared between tumors with distinct expression levels of these markers and their combinations.Results:Responders had significantly higher CD8/PD-L1(P=0.015)or CD68/PD-L1 co-expression levels(P=0.021)than non-responders in the camrelizumab plus chemotherapy group,while no difference was observed in the chemotherapy group.Patients with high CD8/PD-L1 or CD68/PD-L1 co-expression level was associated with significantly longer PFS(P=0.002,P=0.024;respectively)and OS(P=0.006,P=0.026;respectively)than those with low co-expression in camrelizumab plus chemotherapy group.When comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD-L1 co-expression stratification,significantly better PFS(P=0.003)and OS(P=0.032)were observed in high co-expression subgroups.The predictive value of CD8/PD-L1 and CD68/PD-L1 co-expression remained statistically significant for PFS and OS when adjusting clinicopathological features.Although the prevalence of TP53 or KRAS mutations was similar between patients with and without CD8/PD-L1 or CD68/PD-L1 co-expression,the positive groups had a significantly higher proportion of TP53/KRAS co-mutations than the negative groups(both 13.0%vs.0.0%,P=0.023).Notably,enriched PI3K(P=0.012)and cell cycle pathway(P=0.021)were found in the CD8/PD-L1 co-expression group.Conclusion:Tumor immune microenvironmental marker expression,especially CD8/PD-L1 or CD68/PD-L1 co-expression,was associated with the efficacy of PD-1 blockade plus chemotherapy as first-line treatment in patients with advanced NSCLC. | Fengying Wu Tao Jiang Gongyan Chen Yunchao Huang Jianying Zhou Lizhu Lin Jifeng Feng Zhehai Wang Yongqian Shu Jianhua Shi Yi Hu Qiming Wang Ying Cheng Jianhua Chen Xiaoyan Lin Yongsheng Wang Jianan Huang Jiuwei Cui Lejie Cao Yunpeng Liu Yiping Zhang Yueyin Pan Jun Zhao LiPing Wang Jianhua Chang Qun Chen Xiubao Ren Wei Zhang Yun Fan Zhiyong He Jian Fang Kangsheng Gu Xiaorong Dong Tao Zhang Wei Shi Jianjun Zou Xuejuan Bai Shengxiang Ren Caicun Zhou | 2022 | Cancer Communications2022，42，12： | 1 |
| 12 | Anal-ysis on the Relationship between EMAT Transmitting Efficiency and the Electrical Conductivity of the Coat-ing on Material Surface显示文摘 | Zhou Zhenggan Huang Fengying Lin Junming | | 0，，3： | 1 |
| 13 | Nitrogen-doped carbon@TiO_(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of dopamine and paracetamol in human serum and saliva显示文摘As the most commonly used antipyretic and analgesic drug,paracetamol(PA)coexists with neurotransmitter dopamine(DA)in real biological samples.Their simultaneous determination is extremely important for human health,but they also interfere with each other.In order to improve the conductivity,adsorption affinity,sensitivity,and selectivity of TiO_(2)-based electrochemical sensor,N-doped carbon@-TiO_(2) double-shelled hollow sphere(HeC/N@TiO_(2))is designed and synthesized by simple alcoholic and hydrothermal method,using polystyrene sphere(PS)as a template.Meanwhile,TiO_(2) hollow spheres(H eTiO_(2))or N-doped carbon hollow spheres(HeC/N)are also prepared by the same method.HeC/N@TiO_(2) has good conductivity,charge separation,and the highly enhanced and stable current responses for the detection of PA and DA.The detection limit and linear range are 50.0 nmol/L and 0.3-50 mmol/L for PA,40.0 nmol/L and 0.3e50 mmol/L for DA,respectively,which are better than those of carbon-based sensors.Moreover,this electrochemical sensor,with high selectivity,strong anti-interference,high reliability,and long time durability,can be used for the simultaneous detection of PA and DA in human blood serum and saliva.The high electrochemical performance of HeC/N@TiO_(2) is attributed to the multifunctional combination of different layers,because of good conductivity,absorption and electrons transfer ability from in-situ N-doped carbon and electrocatalytic activity from TiO_(2). | Hui Yang Gongxun Cao Yongjun Huang Ye Lin Fengying Zheng Luxiu Lin Fengjiao Liu Shunxing Li | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 1 |
| 14 | Current climate overrides past climate change in explaining multi-site beta diversity of Lauraceae species in China显示文摘Background:We aimed to characterise the geographical distribution of Sørensen-based multi-site dissimilarity(β_(sor))and its underlying true turnover(β_(sim))and nestedness(βsne)components for Chinese Lauraceae and to analyse their relationships to current climate and past climate change.Methods:We used ensembles of small models(ESMs)to map the current distributions of 353 Lauraceae species in China and calculated β_(sor) and its β_(sim) and β_(sne) components.We tested the relationship between β_(sor),β_(sne) and β_(sim) with current climate and past climate change related predictors using a series of simultaneous autoregressive(SAR_(err))models.Results:Spatial distribution of β_(sor)of Lauraceae is positively correlated with latitude,showing an inverse rela-tionship to the latitudinalα-diversity(species richness)gradient.High β_(sor) occurs at the boundaries of the warm temperate and subtropical zones and at the Qinghai-Tibet Plateau due to high β_(sne).The optimized SAR_(err) model explainsβ_(sor) andβ_(sne) well,but notβ_(sim).Current mean annual temperature determinesβ_(sor) and β_(sne) of Lauraceae more than anomalies and velocities of temperature or precipitation since the Last Glacial Maximum.Conclusions:Current low temperatures and high climatic heterogeneity are the main factors explaining the high multi-siteβ-diversity of Lauraceae.In contrast to analyses of the β-diversity of entire species assemblages,studies of single plant families can provide complementary insights into the drivers of β-diversity of evolutionarily more narrowly defined entities. | Ziyan Liao Youhua Chen Kaiwen Pan Mohammed A.Dakhil Kexin Lin Xianglin Tian Fengying Zhang Xiaogang Wu Bikram Pandey Bin Wang Niklaus E.Zimmermann Lin Zhang Michael P.Nobis | 2022 | Forest Ecosystems2022，9，2： | 1 |
| 15 | Studies on non-isothermal and isothermal dehydration kinetics of FePO 4 ·2H 2 O显示文摘 | Li Xiao Lin Li Fengying Fu Mingzhong He | 2012 | Thermochimica Acta2012，，： | 1 |
| 16 | Functional Polyselenoureas for Selective Gold Recovery Prepared from Catalyst-Free Multicomponent Polymerizations of Elemental Selenium显示文摘Selenium-containing polymers with fascinating functionalities such as stimuli-responsive property,enzyme mimics,antioxidant activity,promotion of immune-cell activity,anticancer activity,and controlled delivery property,are highly desired,but rarely developed due to their underexplored synthetic methods.Herein,through careful design of monomeric structures and polymerization conditions,we report a series of catalyst-free multicomponent polymerizations(MCPs)of elemental selenium with aliphatic/aromatic diamines and diisocyanides that directly converted selenium to polyselenoureas with long-term stability,good solubility,well-characterized structures,and unique functionalities.The MCPs enjoyed broad monomer scope and fast conversion in 1 min,delivering 18 polyselenoureas with high molecular weights(M_(w)s up to 94,600 g/mol)in high yields(up to 99%).Furthermore,the polyselenoureas could be used for the extraction of Au^(3+)from mixed-metal ion solutions under practical conditions with high selectivity,sensitivity(<1μg/L),efficiency(>99.99%),and capacity(up to 665.60 mg·Au^(3+)/g)within 1 min.Further,the elemental gold was recoverable after the pyrolysis of the polymer complexes. | Xiuying Wu Hua Lin Fengying Dai Rongrong Hu Ben Zhong Tang | 2020 | CCS Chemistry2020，2，3： | 0 |
| 17 | Construction and identification of recombinant plasmid pUIS3-BLC^+显示文摘Objective:To construct and identify recombinant plasmid pUIS3-BLC^+.Methods:The cDNA of B-lymphocyte chemoattractant(BLC) was amplified from the total RNA of spleen tissues by PCR method,and were inserted into plasmid of Plasmodium berghei with U1S3 knockout by digestion of restrictive endonuclease and T7 ligation.The recombinant plasmids were screened,and then underwent restriction enzymatic digestion and DNA sequencing.Then the confirmed plasmid was further transfected into COS-1 cells by lipofectamine and the BLC expression was tested by RT-PCR and Western blotting.Results:The cDNA of BLC gene was correctively amplified by RT-PCR and the recombinant plasmid pUIS3-BLC^+ was constructed successfully,which was confirmed by restriction enzymatic digestion and DNA sequencing.RT-PCR and Western blotting also showed the BLC gene expression in COS-1 cells.Conclusions:The recombinant plasmid pUIS3-BLC^+ has BLC expression in COS-1 cells,and is useful for further study on BLC transgene and UIS3 gene knockout in Plasmodium berghei. | Yingzi Lin Shixiang Bao Guanghong Tan Fengying Huang Huiqin Huang | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 0 |
| 18 | Flexoelectricity-enhanced photovoltaic effect in trapezoid-shaped NaNbO_(3)nanotube array composites显示文摘In this work,we successfully prepared vertically aligned NaNbO_(3)nanotube(NN-NT)with trapezoidal shapes,in which the orthorhombic and monoclinic phases coexisted.According to the structure analysis,the NN-NT/epoxy composite film had excellent flexoelectric properties due to the lattice distortion caused by defects and irregular shape.The flexoelectric effect is the greatest in the vertical direction in the flexible NN-NT/epoxy composite film,and the flexoelectric coefficient()is 2.77×10^(−8)C·m^(−1),which is approximately 5-fold higher than that of the pure epoxy film.The photovoltaic current of the NN-NT/epoxy composite film increased from 39.9 to 71.8 nA·cm^(−2)in the direction of spontaneous polarization when the sample was bent upward due to the flexoelectricity-enhanced photovoltaic(FPV)effect.The flexoelectric effect of the NN-NT/epoxy composite film could modulate the photovoltaic response by increasing it by 80%or reducing it to 65%of the original value.This work provides a new idea for further exploration in efficient and lossless ferroelectric memory devices. | Fang Yu Junyuan Tian Fengying Jiang Yunjie Liu Chaohai Li Chengwei Wang Zhong Lin Wang Kailiang Ren | 2023 | Nano Research2023，16，9： | 0 |
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