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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity 显示文摘 | You LR Lin FJ I ee CT | 2005 | Nature2005，435，7038： | 1 |
| 3 | The effect of intravenous opioid patient- con trolled analgesia with and without background infusion on respira tory depression : a meta - analysis显示文摘 | George JA Lin EE | 2010 | J Opioid Manag2010，6，1： | 1 |
| 4 | Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells显示文摘 | Lin CI Whang EE Abramson MA | | 0，，02： | 1 |
| 5 | Custom-contoured ablation pattern method for the treatment of decentered laser ablations显示文摘 | Lin DY Manche EE | 2004 | J Cataract Refract Surg2004，30，8： | 1 |
| 6 | Calectin-3 regulates apoptosis and doxouubicin chemoresistance in papillary thyroid cancer cells显示文摘 | Lin CI Whang EE Abramson MA | 2009 | Biockem Biophys Res Commun2009，379，2： | 1 |
| 7 | Cyclopamine-mediated hedge-hog pathway inhibition depletes stem-like cancer cells in glioblasto-ma 显示文摘 | Bar EE Chaudhry A Lin A | 2007 | Stem Cells2007，25，10： | 1 |
| 8 | Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres 显示文摘 | Bar EE Lin A Mahairaki V | 2010 | Am J Pathol2010，177，3： | 1 |
| 9 | High prevalence ofhyperuricemia in elderly Taiwanese 显示文摘 | I^ee MS Lin SC Chang HY | 2005 | Asia Pac J Clin Nutr2005，14，3： | 1 |
| 10 | Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres显示文摘 | Bar EE Lin A Mahairaki V | 2010 | Am J Pathol2010，177，3： | 1 |
| 11 | Galectin-3 targeted thera- py with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer 显示文摘 | Lin CI Whang EE Donner DB | 2009 | Mol Cancer Res2009，7，10： | 1 |
| 12 | Inhibition of SARS coronavir us infection in vitro with clinically approved antiviral drugs 显示文摘 | Tan EL Ooi EE Lin CY | 2004 | Emerg Infect Dis2004，10，： | 1 |
| 13 | Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma 显示文摘 | Bar EE Chaudhry A Lin A et d | 2007 | Stem cells2007，25，10： | 1 |
| 14 | Galectin-3regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells显示文摘 | Lin CI Whang EE Abramson MA | 2009 | Biochem Biophys Res Commun2009，379，2： | 1 |
| 15 | Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma 显示文摘 | Bar EE Chaudhry A Lin A | 2007 | Stem Ceils2007，25，10： | 1 |
| 16 | Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres 显示文摘 | Bar EE Lin A Mahairaki V | 2010 | Am J Pathol2010，177，3： | 1 |
| 17 | The prediction of dimensional error for sculptured surface productions using the ball-end milling process. Part 1: Chip geometry analysis and cutting force prediction显示文摘 | Ee Meng Lim Hsi-Yung Feng Chia-Hsiang Menq Zhi-hang Lin | 1995 | International Journal of Machine Tools and Manufacture1995，，8： | 1 |
| 18 | The protective effect of curc:umin on is- el/emia-reperfusion-induced liver injm7 显示文摘 | Lin CM l ee JF Chiang 1 1 | 2012 | Transplant Proc2012，44，： | 1 |
| 19 | Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells显示文摘 | Lin CI Whang EE Abramson MA | 2009 | Biochem Biophys Res Commun2009，379，2： | 1 |
| 20 | Inhibition of SARS coronavirus infection in vitro with clinically approved antiviraI drugs显示文摘 | Tan EL Ooi EE Lin CY | 2004 | Emerg lnfect Dis2004，10，4： | 1 |
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