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| 1 | Anti-oxidant and anti-inflammatory effects of hydrogenrich water alleviate ethanol-induced fatty liver in mice显示文摘AIM To investigate the effects of hydrogen-rich water(HRW) treatment on prevention of ethanol(Et OH)-induced early fatty liver in mice.METHODS In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control,Et OH,Et OH + silymarin,Et OH + HRW and Et OH + silymarin + HRW. Each group was fed a Lieber-De Carli liquid diet containing Et OH or isocaloric maltose dextrin(control diet). Silymarin was used as a positive control to compare HRW efficacy against chronic Et OH-induced hepatotoxicity. HRW was freshly prepared and given at a dosage of 1.2 m L/mouse trice daily. Blood and liver tissue were collected after chronic-binge liquid-diet feeding for 12 wk.RESULTS The in vitro study showed that HRW directly scavenged hydrogen peroxide. The in vivo study showed that HRW increased expression of acyl ghrelin,which was correlated with food intake. HRW treatment significantly reduced Et OH-induced increases in serum alanine aminotransferase,aspartate aminotransferase,triglycerol and total cholesterol levels,hepatic lipid accumulation and inflammatory cytokines,including tumor necrosis factor-alpha(TNF-α) and interleukin(IL)-6. HRW attenuated malondialdehyde level,restored glutathione depletion and increased superoxide dismutase,glutathione peroxidase and catalase activities in the liver. Moreover,HRW reduced TNF-α and IL-6 levels but increased IL-10 and IL-22 levels.CONCLUSION HRW protects against chronic Et OH-induced liver injury,possibly by inducing acyl ghrelin to suppress the pro-inflammatory cytokines TNF-α and IL-6 and induce IL-10 and IL-22,thus activating antioxidant enzymes against oxidative stress. | Ching-Pin Lin Wen-Chen Chuang Fung-Jou Lu Chih-Yen Chen | 2017 | World Journal of Gastroenterology2017，23，27： | 12 |
| 2 | Effect of Arctium lappa L.in the dextran sulfate sodium colitis mouse model显示文摘AIM:To analyze the possible protective role of Arctium lappa L.(AL)in a murine model of ulcerative colitis(UC).METHODS:BALB/c mice were administered 100 mg/kg AL powder orally each day.After 7 d,colitis was induced by administration of dextran sulfate sodium(DSS)(5% W/V)in drinking water for a further 8 consecutive days.Diarrhea and bloody stools as well as colonic histology were observed.The level of interleukin-6(IL-6)and tu-mor necrosis factor-α(TNF-α)in colonic sections were detected by immunohistochemistry.RESULTS:There were significant differences in mean body weight values and disease activity indices between controls and AL-treated animals.Moreover,the histological findings showed that AL treatment can prevent mucosal edema,submucosal erosions,ulceration,inflammatory cell infiltration and colon damage.In addition,immunohistochemistry analysis showed that the levels of the inflammatory cytokines,IL-6 and TNF-α were also decreased in AL-treated groups.CONCLUSION:We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis.Thus,AL could prove to be a useful food for UC. | Tzou-Chi Huang Shinn-Shyong Tsai Li-Fang Liu Yu Lin Liu Hung-Jen Liu Kuo Pin Chuang | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 3 | Comparison of OA-2000 and IOL Master 500 using in cataract patients with high myopia显示文摘This study was designed to compare optical biometry measurements and predicted refraction in cataract patients with high myopia [axial length(AL) ≥26 mm] using OA-2000 and IOL Master 500. Ocular biometry measurements were performed using both biometers before surgery. Uneventful cataract surgery was performed in all patients. Postoperative manifest refraction was obtained 3 wk after surgery or later. A total of 67 eyes were examined. The AL, keratometry(K), and anterior chamber depth(ACD) of the two biometers showed excellent agreement. Predicted errors were similar and a strong positive correlation was observed(r=0.909). Out of 21 eyes(31.34%) with unsuccessful AL readings using the IOL Master 500, 20 eyes of them could be measured using OA-2000. Therefore, the biometric parameters measured by the two biometers showed good agreement. However, OA-2000 had a lower AL measurement failure rate. | Ya-Li Du Geng Wang Hui-Chun Huang Li-Yu Lin Chuang Jin Li-Fang Liu Xiu-Ru Liu Ming-Zhi Zhang | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 10 |
| 4 | Neural differentiation from embryonic stem cells in vitro : An overview of the signaling pathways显示文摘Neurons derived from embryonic stem cells(ESCs) have gained great merit in both basic research and regenerative medicine. Here we review and summarize the signaling pathways that have been reported to be involved in the neuronal differentiation of ESCs,particularly those associated with in vitro differentiation. The inducers and pathways explored include retinoic acid, Wnt/b-catenin, transforming growth factor/bone morphogenetic protein, Notch, fibroblast growth factor, cytokine, Hedgehog, c-Jun N-terminal kinase/mitogen-activated protein kinase and others. Some other miscellaneous molecular factors that have been reported in the literature are also summarized and discussed. These include calcium, calcium receptor, calcineurin, estrogen receptor, Hox protein, ceramide, glycosaminioglycan, ginsenoside Rg1, opioids, two pore channel 2, nitric oxide, chemically defined medium, cellcell interactions, and physical stimuli. The interaction or crosstalk between these signaling pathways and factors will be explored. Elucidating these signals in detail should make a significant contribution to future progress in stem cell biology and allow, for example, better comparisons to be made between differentiation in vivo and in vitro. Of equal importance, a comprehensive understanding of the pathways that are involved in the development of neurons from ESCs in vitro will also accelerate their application as part of translational medicine. | Jen-Hua Chuang Li-Chu Tung Yenshou Lin | 2015 | World Journal of Stem Cells2015，7，2： | 9 |
| 5 | Early detection of diabetic kidney disease: Present limitations and future perspectives显示文摘Diabetic kidney disease(DKD) is one of the most common diabetic complications, as well as the leading cause of chronic kidney disease and end-stage renal disease around the world. To prevent the dreadful consequence, development of new assays for diagnostic of DKD has always been the priority in the research field of diabetic complications. At present, urinary albumin-to-creatinine ratio and estimated glomerular filtration rate(eG FR) are the standard methods for assessing glomerular damage and renal function changes in clinical practice. However, due to diverse tissue involvement in different individuals, the so-called 'non-albuminuric renal impairment' is not uncommon, especially in patients with type 2 diabetes. On the other hand, the precision of creatinine-based GFR estimates is limited in hyperfiltration status. These facts make albuminuria and eG FR less reliable indicators for early-stage DKD. In recent years, considerable progress has been made in the understanding of the pathogenesis of DKD, along with the elucidation of its genetic profiles and phenotypic expression of different molecules. With the help of ever-evolving technologies, it has gradually become plausible to apply the thriving information in clinical practice. The strength and weakness of several novel biomarkers, genomic, proteomic and metabolomic signatures in assisting the early diagnosis of DKD will be discussed in this article. | Chih-Hung Lin Yi-Cheng Chang Lee-Ming Chuang | 2016 | World Journal of Diabetes2016，7，14： | 9 |
| 6 | Single-incision laparoscopic surgery for biliary tract disease显示文摘Single-incision laparoscopic surgery(SILS), or laparoendoscopic single-site surgery, has been employed in various fields to minimize traumatic effects over the last two decades. Single-incision laparoscopic cholecystectomy(SILC) has been the most frequently studied SILS to date. Hundreds of studies on SILC have failed to present conclusive results. Most randomized controlled trials(RCTs) have been small in scale and have been conducted under ideal operative conditions. The role of SILC in complicated scenarios remains uncertain. As common bile duct exploration(CBDE) methods have been used for more than one hundred years, laparoscopic CBDE(LCBDE) has emerged as an effective, demanding, and infrequent technique employed during the laparoscopic era. Likewise, laparoscopic biliary-enteric anastomosis is difficult to carry out, with only a few studies have been published on the approach. The application of SILS to CBDE and biliary-enteric anastomosis is extremely rare, and such innovative procedures are only carried out by a number of specialized groups across the globe. Herein we present a thorough and detailed analysis of SILC in terms of operative techniques, training and learning curves, safety and efficacy levels, recovery trends, and costs by reviewing RCTs conducted over the past three years and two recently updated meta-analyses. All existing literature on single-incision LCBDE and singleincision laparoscopic hepaticojejunostomy has been reviewed to describe these two demanding techniques. | Shu-Hung Chuang Chih-Sheng Lin | 2016 | World Journal of Gastroenterology2016，22，2： | 9 |
| 7 | Extended central hepatectomy with preservation of segment 6 for patients with centrally located hepatocellular carcinoma显示文摘BACKGROUND: In order to preserve functional liver parenchyma, extended central hepatectomy (segments 4, 5, 7 and 8 resection) was proposed for the management of centrally located hepatocellular carcinoma invading the right and middle hepatic veins, reconstructing segment 6 outflow in the absence of the thick inferior right hepatic vein. The present study was to describe our surgical techniques of extended central hepatectomy.METHODS: Between 2008 and 2012, 5 patients with centrally located hepatocellular carcinoma invading or in the vicinity of the right and middle hepatic veins underwent extended central hepatectomy. The thick inferior right hepatic vein was preserved during dissection. Gore-Tex graft was used for segment 6 outflow reconstruction in the absence of the thick inferior right hepatic vein.RESULTS: The mean future remnant liver volume for segments 2 and 3 was 28% versus 45% on segment 6 preservation. The mean tumor diameter was 7.4 cm. The thick inferior right hepatic vein was found in 1 patient. Outflow reconstruction from segment 6 was performed in 4 patients. Postoperative complications included bile leakage (1 patient), pleural effusion (2) and liver failure (1). The rate of graft patency was 75%. There was no perioperative mortality.CONCLUSION: Extended central hepatectomy is a safe alternative for extended hepatic resection in selected patients attempting to preserve the functional liver parenchyma. | Mahmoud Abdelwahab Ali Jung-Fang Chuang Chee-Chien Yong Chih-Chi Wang Chi-Ying Lin Chao-Long Chen | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，1： | 9 |
| 8 | Retransmission or redundancy:Transmission reliability study in wireless sensor networks显示文摘As an application-driven network,wireless sensor network generally requires data reliability to maintain detection and response capabilities.Although two approaches,namely,retransmission and redundancy,have been proposed to enhance data reliability,the theoretical work is required to evaluate their impact on transmission reliability and energy efficiency.In this paper,we offer a comprehensive theoretical study on packet arrival probability and average energy consumption for both approaches.Our analysis and simulations indicate that when loss probabilities remain low or moderate,erasure coding,a typical redundancy-based scheme,is more energy efficient than retransmission.We also demonstrate that the resistance capability of erasure coding against packet loss weakens as the hop number increases,which motivates us to propose two improved mechanism based on the idea of the loss detection and the loss recovery.Finally,the simulation results carried out using TOSSIM verify the performance of different mechanisms both in the chain topology and the tree topology. | WEN Hao LIN Chuang REN FengYuan ZHOU Jia YUE Yao HUANG XiaoMeng | 2012 | Science China(Information Sciences)2012，55，4： | 7 |
| 9 | Single-incision vs three-incision laparoscopic cholecystectomy for complicated and uncomplicated acute cholecystitis显示文摘AIM:To compare the clinical outcome of single-incision laparoscopic cholecystectomy(SILC)and three-incision laparoscopic cholecystectomy(3ILC)for acute cholecystitis.METHODS:From July 2009 to September 2012,136patients underwent SILC or 3ILC for acute cholecystitis at a tertiary referral hospital.One experienced surgeon performed every procedure using 5 or 10 mm 30-degree laparoscopes,straight instruments,and conventional ports.Five patients with perforated gallbladder and diffuse peritonitis and 23 patients with mild acute cholecystitis were excluded.The remaining 108 patients were divided into complicated and uncomplicated groups according to pathologic findings.Patient demography,clinical data,operative results and complications were recorded and analyzed.RESULTS:Fifty patients with gangrenous cholecystitis,gallbladder empyema,or hydrops were classified as the complicated group,and 58 patients with acute cholecystitis were classified as the uncomplicated group.Twenty-three(46.0%)of the patients in the complicated group(n=50)and 39(67.2%)of the patients in the uncomplicated group(n=58)underwent SILC;all others underwent 3ILC.The postoperative length of hospital stay(PLOS)was significantly shorter in the SILC subgroups than the 3ILC subgroups(3.5±1.1 d vs 4.6±1.3 d,P<0.01 in the complicated group;2.9±1.1 d vs 3.7±1.4 d,P<0.05 in the uncomplicated group).The maximum body temperature recorded at day 1 and at day 2 following the procedure was lower in the SILC subgroups,but the difference reached statistical significance only in the uncomplicated group(37.41±0.56℃vs 37.80±0.72℃,P<0.05 on postoperative day 1;37.10±0.43℃vs 37.57±0.54℃,P<0.01 on postoperative day 2).The operative time,estimated blood loss,postoperative narcotic use,total length of hospital stay,conversion rates,and complication rates were similar in both SILC and 3ILC subgroups.The complicated group had longer operative time(122.2±35.0 min vs 106.6±43.6 min,P<0.05),longer PLOS(4.1±1.3 d vs 3.2±1.2 d,P<0.001),and higher conversion rates(36.0%vs 19.0%,P<0.05)compared with the uncomplicated group.CONCLUSION:SILC is safe and efficacious for patients with acute cholecystitis.The main benefit is a faster recovery than that achieved with 3ILC. | Shu-Hung Chuang Pai-Hsi Chen Chih-Ming Chang Chih-Sheng Lin | 2013 | World Journal of Gastroenterology2013，19，43： | 7 |
| 10 | Research on PCA and KPCA Self-Fusion Based MSTAR SAR Automatic Target Recognition Algorithm显示文摘This paper proposes a PCA and KPCA self-fusion based MSTAR SAR automatic target recognition algorithm. This algorithm combines the linear feature extracted from principal component analysis (PCA) and nonlinear feature extracted from kernel principal component analysis (KPCA) respectively, and then utilizes the adaptive feature fusion algorithm which is based on the weighted maximum margin criterion (WMMC) to fuse the features in order to achieve better performance. The linear regression classifier is used in the experiments. The experimental results indicate that the proposed self-fusion algorithm achieves higher recognition rate compared with the traditional PCA and KPCA feature fusion algorithms. | Chuang Lin Fei Peng Bing-Hui Wang Wei-Feng Sun Xiang-Jie Kong | 2012 | Journal of Electronic Science and Technology2012，10，4： | 6 |
| 11 | How much information is needed in quantized nonlinear control?显示文摘Quantization rate is a crucial measure of complexity in determining stabilizability of control systems subject to quantized state measurements. This paper investigates quantization complexity for a class of nonlinear systems which are subjected to disturbances of unknown statistics and unknown bounds. This class of systems includes linear stablizable systems as special cases. Two lower bounds on the quantization rates are derived which guarantee input-to-state stabilizability for continuous-time and sampled-data feedback strategies, respectively. Simulation examples are provided to validate the results. | Chuang ZHENG Lin LI Leyi WANG Chanying LI | 2018 | Science China(Information Sciences)2018，61，9： | 6 |
| 12 | Effect of preoperative nutrition therapy type and duration on short-time outcomes in gastric cancer patient with gastric outlet obstruction显示文摘Objective:To avoid perioperative complications caused malnutrition,nutrition therapy is necessary in gastric outlet obstruction(GOO)patients.Compared to parenteral nutrition(PN),enteral nutrition(EN)is associated with many advantages.This study aimed to investigate whether preoperative EN has beneficial clinical effects compared to preoperative PN in gastric cancer patients with GOO undergoing surgery.Methods:According to the methods of preoperative nutrition therapy,143 patients were divided into EN group(n=42)and PN group(n=101)between January 2013 and December 2017 at the Chinese People’s Liberation Army General Hospital.Multiple logistic regression models were used to assess the association between the methods of preoperative nutrition therapy and postoperative day of flatus passage.The generalized additive model and twopiecewise linear regression model were used to calculate the inflection point of the preoperative nutritional therapy time on the postoperative day of flatus passage in the PN group.Results:EN shortened the postoperative day of flatus passage in gastric cancer patients with GOO,which is a protective factor,especially in patients who underwent non-radical operations and the postoperative day of flatus passage reduced when the preoperative PN therapy was up to 3 d and a longer PN therapy(>3 d)did not accelerate the postoperative recovery of gastrointestinal functions.Conclusions:Preoperative EN therapy would benefit gastric cancer patients with GOO by accelerating postoperative recovery.For patients with absolute obstruction,no more than 3-day PN therapy is recommended if patients can tolerate general anesthesia and surgery. | Jiyang Li Shaoqing Li Hongqing Xi Peifa Liu Wenquan Liang Yunhe Gao Chuang Wang Bo Wei Lin Chen Yun Tang Zhi Qiao | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
| 13 | Factors relating to the short term effectiveness of percutaneous biliary drainage for hilar cholangiocarcinoma显示文摘AIM: To identify factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and to evaluate the impact of palliative drainage on their survival. METHODS: Seventy-four patients with hilar cholangiocarcinoma who underwent percutaneous biliary drainage were enrolled in the study. The demographic and laboratory data as well as the imaging characteristics were retrospectively analyzed to correlate with the bile output and reduction rate of serum bilirubin 1 wk after drainage.RESULTS: Patients with more bile duct visualized on percutaneous transhepatic cholangiography or absence of multiple liver metastases on imaging studies had more bile output after biliary drainage [odds ratio (OR): 8.471, P = 0.010 and OR: 1.959, P = 0.022, respectively]. Patients with prolonged prothrombin time had a slow decrease in serum bilirubin (OR: 0.437, P = 0.005). The median survival time was not signif icantly different in patients with low or high bile output (75 d vs 125 d, P = 0.573) or in patients with slow or rapid reduction of serum bilirubin (88 d vs 94 d, P = 0.576). CONCLUSION: The short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival. | Hong-Ming Tsai Chiao-Hsiung Chuang Xi-Zhang Lin Chiung-Yu Chen | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 14 | Reaction-diffusion modeling of malware propagation in mobile wireless sensor networks显示文摘Mobile Wireless Sensor Networks (MWSNs) are employed in many fields, such as intelligent transportation, community health monitoring, and animal behavior monitoring. However, MWSNs may be vulnerable to malicious interference because of the large-scale characteristics. One of the threats is to inject malware into some nodes, especially mobile nodes. When a contaminated node communicates with its neighbors, multiple copies of the malware are transmitted to its neighbors, which may destroy nodes, block regular communications, or even damage the integrity of regular data packets. This work develops a modeling framework which mathematically characterizes the process of malware propagation in MWSNs based on the theory of reaction-diffusion equation. Our proposed model can efficiently predict the temporal dynamic behavior and spatial distribution of malware propagation over time, so that targeted immunization measures can be taken on infected nodes, whereas most of the existing models for malware propagation can only predict the temporal dynamic behavior rather than the spatial distribution of malware propagation over time. We conduct extensive simulations on large-scale MWSNs to evaluate the proposed model. The simulation results indicate that the proposed model and method are efficient, and that the mobile speed, communication range, and packet transmission rate of nodes are the main factors affecting malware propagation in MWSNs. | WANG XiaoMing HE ZaoBo ZHAO XueQing LIN Chuang PAN Yi CAI ZhiPeng | 2013 | Science China(Information Sciences)2013，56，9： | 4 |
| 15 | Performability analysis of avionics system with multilayer HM/FM using stochastic Petri nets显示文摘The integrated modular avionics (IMA) architecture is an open standard in avionics industry, in which the number of functionalities implemented by software is greater than ever before. In the IMA architecture, the reliability of the avionics system is highly affected by the software applications. In order to enhance the fault tolerance feature with regard to software application failures, many industrial standards propose a layered health monitoring/fault management (HM/FM) scheme to periodically check the health status of software application processes and recover the malfunctioning software process whenever an error is located. In this paper, we make an analytical study of the HM/FM system for avionics application software. We use the stochastic Petri nets (SPN) to build a formal model of each component and present a method to combine the components together to form a complete system model with respect to three interlayer query strategies. We further investigate the effectiveness of these strategies in an illustrative system. | Wan Jianxiong Xiang Xudong Bai Xiaoying Lin Chuang Kong Xiangzhen Li Jianxiang | 2013 | Chinese Journal of Aeronautics2013，26，2： | 4 |
| 16 | Approximate Design of Alloy Composition of Cathode Target显示文摘为在用合金目标的阴极的弧离子 plating 的作文 demixing 分析的车验式基于平均控告的状态和相对 demixing 参数的概念被建立。作文 demixing 效果的水平被一个元素的 demixingdegree 介绍。为二进制成分合金目标,在涂层的作文变化趋势被讨论,为每个元素的 demixing 度的限制是坚定的。有更高平均的控告的状态的一个元素的内容比在合金目标在涂层变得更大,在同时,有更低的平均控告的状态的一个元素的内容得到更少。为二成分中的每一个,越不在合金目标的原子百分比,越 larger 它在涂层和目标之间的内容的差别。为三倍的成分合金目标,有中等一般水准的一个元素的内容变化控告了状态详细被讨论。它在涂层变得更大或更少的内容被另外的二个元素的内容的联合结果在合金目标决定。为有在三倍的合金目标的中等平均控告的状态的元素的一个给定的内容,到合金目标的从涂层的那个元素的内容偏差水平不比包含仅仅那个元素的那个使用的二元合金目标大并且二其它之一。根据想要的涂层作文,合金目标的作文设计容易从公式被推出。 | Jun ZHANG Yu ZHANG Li LI Guoqiang LIN Chuang DONG | 2006 | Journal of Materials Science & Technology2006，22，5： | 4 |
| 17 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 18 | Development of Trusted Network and Challenges It Faces显示文摘As the information network plays a more and more important role globally, the traditional network theories and technologies, especially those related to network security, can no longer meet the network development requirements. Offering the system with secure and trusted services has become a new focus in network research. This paper first discusses the meaning of and aspects involved in the trusted network. According to this paper, the trusted network should be a network where the network's and users' behaviors and their results are always predicted and manageable. The trustworthiness of a network mainly involves three aspects: service provider, information transmission and terminal user. This paper also analyzes the trusted network in terms of trusted model for network/user behaviors, architecture of trusted network, service survivability and network manageability, which is designed to give ideas on solving the problems that may be faced in developing the trusted network. | Lin Chuang 1, Wang Yuanzhuo 1, Tian Liqin 1,2 (1. Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China 2. Department of Computer, North China Institute of Science and Technology, Beijing 101601, China) | 2008 | ZTE Communications2008，6，1： | 3 |
| 19 | Increase in apoptosis by combination of metformin with silibinin in human colorectal cancer cells显示文摘AIM: To investigate the effect of metformin on silibinin-induced apoptosis in human colorectal cancer(COLO 205) cells.METHODS: MTT assays were performed to quantify cell viability.Western blot assays were applied to identify the expression of signaling proteins.RESULTS: The combined treatment of COLO 205 cells with metformin and silibinin decreased cell survival at a dose insufficient to influence the non-malignant cells [Human colonic epithelial cells(HCo Epi C)].Silibinin and metformin increased phosphatase and tensin homolog and 5'-adenosine monophosphate-activated protein kinase expression in COLO 205 cells and inhibited the phosphorylation of mammol/Lalian target of rapamycin.This combined treatment resulted in an increase in the expression of activated caspase 3 and apoptosis inducing factor, indicating apoptosis.CONCLUSION: The combined treatment of human colorectal cancer cells with silibinin and metformin may induce apoptosis at a dose that does not affect HCo Epi C.This finding reveals a potential therapeutic strategy for the treatment of colorectal cancer. | Cheng-Chia Tsai Tang-Wei Chuang Li-Jen Chen Ho-Shan Niu Kun-Ming Chung Juei-Tang Cheng Kao-Chang Lin | 2015 | World Journal of Gastroenterology2015，21，14： | 3 |
| 20 | A new ent-kaurane diterpenoid from Isodon japonica显示文摘One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray crystallographic analysis. | Di, Xue Mei Yan, Fu Lin Feng, Chuang Xie, Rui Jie Hou, Rui Jie Sun, Han Dong | 2010 | Chinese Chemical Letters2010，21，2： | 3 |
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