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| 1 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 2 | Seed metabolomic study reveals significant metabolite variations and correlations among different soybean cultivars显示文摘Soybean[Glycine max(L.) Merr.]is one of the world's major crops,and soybean seeds are a rich and important resource for proteins and oils.While 'omics' studies,such as genomics,transcriptomics,and proteomics,have been widely applied in soybean molecular research,fewer metabolomic studies have been conducted for largescale detection of low molecular weight metabolites,especially in soybean seeds.In this study,we investigated the seed metabolomes of 29 common soybean cultivars through combined gas chromatography-mass spectrometry and ultra-performance liquid chromatography-tandem mass spectrometry.One hundred sixty-nine named metabolites were identified and subsequently used to construct a metabolic network of mature soybean seed.Among the 169 detected metabolites,104 were found to be significantly variable in their levels across tested cultivars.Metabolite markers that could be used to distinguish genetically related soybean cultivars were also identified,and metabolitemetabolite correlation analysis revealed some significant associations within the same or among different metabolite groups.Findings from this work may potentially provide the basis for further studies on both soybean seed metabolism and metabolic engineering to improve soybean seed quality and yield. | Hong Lin Jun Rao Jianxin Shi Chaoyang Hu Fang Cheng Zoe A.Wilson Dabing Zhang Sheng Quan | 2014 | Journal of Integrative Plant Biology2014，56，9： | 7 |
| 3 | Adaptive PMD Compensation in 10 Gbit/s RZ Optical Communication System显示文摘We report an experiment of adaptive compensation for polarization mode dispersion (PMD) in 10Gbit/s return zero (RZ) optical communication system. The quasi-real-time PMD compensation is realized. The algorithm so-called particle swarm optimization (PSO) is used to control feedback compensation system. | Yu Li Zhang Xiaoguang Zhou Guangtao Shen Yu Zheng Yuan Li Chaoyang Liu Yumin Chen Lin Yang Bojun | 2003 | 光学学报2003，23，S1： | 3 |
| 4 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 5 | Anti-VEGF therapy prevents Müller intracellular edema by decreasing VEGF-A in diabetic retinopathy显示文摘Background:Although vascular endothelial growth factor A(VEGF-A)is known to play a key role in causing retinal edema,whether and how VEGF-A induces intracellular edema in the retina still remains unclear.Methods:Sprague-Dawley rats were rendered diabetic with intraperitoneal injection of streptozotocin.Intravitreal injection of ranibizumab was performed 8 weeks after diabetes onset.rMC-1 cells(rat Müller cell line)were treated with glyoxal for 24 h with or without ranibizumab.The expression levels of inwardly rectifying K^(+)channel 4.1(Kir4.1),aquaporin 4(AQP4),Dystrophin 71(Dp71),VEGF-A,glutamine synthetase(GS)and sodium-potassium-ATPase(Na^(+)-K^(+)-ATPase)were examined using Western blot.VEGF-A in the supernatant of the cell culture was detected with ELISA.The intracellular potassium and sodium levels were detected with specific indicators.Results:Compared with normal control,protein expressions of Kir4.1 and AQP4 were down-regulated significantly in diabetic rat retinas,which were prevented by ranibizumab.The above changes were recapitulated in vitro.Similarly,the intracellular potassium level in glyoxal-treated rMC-1 cells was increased,while the intracellular sodium level and Na^(+)-K^(+)-ATPase protein level remained unchanged,compared with control.However,ranibizumab treatment decreased intracellular sodium,but not potassium.Conclusion:Ranibizumab protected Müller cells from diabetic intracellular edema through the up-regulation of Kir4.1 and AQP4 by directly binding VEGF-A.It also caused a reduction in intracellular osmotic pressure. | Tianqin Wang Chaoyang Zhang Hai Xie Mengmeng Jiang Haibin Tian Lixia Lu Guo-Tong Xu Lin Liu Jingfa Zhang | 2021 | Eye and Vision2021，8，1： | 3 |
| 6 | Adenovirus-mediated human brain-derived neurotrophic factor gene-modified bone marrow mesenchymal stem cell transplantation for spinal cord injury显示文摘Rat bone marrow mesenchymal stem cells expressing brain-derived neurotrophic factor were successfully obtained using a gene transfection method,then intravenously transplanted into rats with spinal cord injury.At 1,3,and 5 weeks after transplantation,the expression of brain-derived neurotrophic factor and neurofilament-200 was upregulated in the injured spinal cord,spinal cord injury was alleviated,and Basso-Beattie-Bresnahan scores of hindlimb motor function were significantly increased.This evidence suggested that intravenous transplantation of adenovirus-mediated brain-derived neurotrophic factor gene-modified rat bone marrow mesenchymal stem cells could play a dual role,simultaneously providing neural stem cells and neurotrophic factors. | ChangshengWang Jianhua Lin Chaoyang Wu Rongsheng Chen | 2011 | Neural Regeneration Research2011，6，16： | 2 |
| 7 | Improved performance of GaN-based light-emitting diodes by using short-period superlattice structures | Yi-jung LIU~1,Chien-chang HUANG~1,Tai-you CHEN~1,Chi-shiang HSU~1,Shiou-ying CHENG~2, Kun-wei LIN~3,Jian-kai LIOU~1,Wen-chau LIU~1 1.Institute of Microelectronics,Department of Electrical Engineering,National Cheng-Kung University, Tainan 70101,Taiwan,China 2.Department of Electronic Engineering,Nation Ilan University,I-Lan 26041,Taiwan,China 3.Department and Graduate Institute of Computer Science and Information Engineering, Chaoyang University of Technology,Taichung 41349,Taiwan,China | 2010 | Progress in Natural Science:Materials International2010，20，1： | 2 |
| 8 | A built-in strategy for contaimnent of transgenic plants: Creation of selectively terminable transgenic rice显示文摘 | Lin Chaoyang Fang Jun Xu Xiaoli | 2008 | PLoS ONE2008，3，18： | 1 |
| 9 | A novel model of drug cue-induced behaviours in rhesus macaque subjected to chronic ketamine exposure显示文摘To the Editor,Non-human primate(NHP)models are advantageous for mimicking human addiction with high behavioural validity.1 However,current NHP drug addiction models(eg,self-administration)often require a comprehensive behavioural training paradigm,relatively expensive apparatus and invasive surgical procedures. | Meng Qin Jiaoqiong Guan Yichun Huang He Lin Ding Cui Tao Yao Chaoyang Tian Mali Wong Zhe Shi Tifei Yuan | 2023 | General Psychiatry2023，36，1： | 1 |
| 10 | A selectively terminable transgenic rice line expressinghuman lactoferrin显示文摘 | LIN Chaoyang NIE Peng LU Wei | 2010 | Protein Expr Purif2010，74，1： | 1 |
| 11 | Determination of multi-residue for malachite green, gentian violet and their metabolites in aquatic products by high-performance liquid chromatography coupled with molecularly imprinted solid-phase extraction显示文摘 | Chaoyang Long Zhibin Mai Yingfen Yang Binghui Zhu Xiumin Xu Lin Lu Xiaoyong Zou | 2009 | Journal of Chromatography A2009，，12： | 1 |
| 12 | Clinical Study on the Treatment of Low Anal Fistula in Infants and Young Children by Anal Gland Excision and Virtual Hanging Procedure显示文摘Objective:To compare the efficacy of anal adenectomy with virtual hanging wire and anal fistulotomy in the treatment of low anal fistula in infants and children.Methods:60 children with low anal fistula who were admitted to our hospital from October 2021 to March 2022 and met the inclusion criteria were randomly divided into two groups of 30 cases each;the treatment group was treated with anal adenectomy and virtual hanging wire surgery,and the control group was treated with anal fistula resection.The clinical efficacy after treatment was compared.Results:The total effective rate of both groups was 96.67%and the difference between the two groups was not statistically significant(P>0.05).The postoperative pain score of the treatment group was lower than that of the control group(P<0.05).The length of hospitalization and healing time of the treatment group was lower than that of the control group(P<0.05).The anal function of the patients in both groups was normal,and there was no adverse reaction.Conclusion:Anal gland excision and virtual hanging surgery for the treatment of low anal fistula in infants and children have the advantages of mild pain,reduced length of hospitalization,short healing time,and better patient experience as compared to anal fistula excision. | Hongbo Su Linmei Sun Yimiao Liang Jiansheng Hu Yongli Zhang Ni Wei Chaoyang Li Lin Tang | 2024 | Journal of Clinical and Nursing Research2024，8，3： | 0 |
| 13 | Analysis of oil shedding and ligaments formation on bearing rotary elements显示文摘For designing efficient lubrication system of an aeroengine bearing chamber,sufficient knowledge on oil/air two-phase flow characteristics is required.When analyzing bearing chamber two-phase flow,the essential prerequisite is quantifying the oil ligaments,which are detached from bearing rotary elements and shed into the bearing chamber.Related investigations are mainly targeted at liquid shedding on the rotating disk as opposed to the bearing rotary elements.Moreover,the research based on bearing rotary elements is conducted by experiment.Due to the limited operating conditions,experimental studies cannot guide engineering applications.To overcome these limitations,a theoretical model is established in this paper,for revealing the mechanism of oil shedding from bearing rotary elements and quantifying the shedding ligaments.The theoretical model is validated against experimental results from classical studies.In addition,the correlation for shedding ligaments number based on aeroengine bearing structural and operational parameters is obtained via theoretical analysis.The analytical results demonstrate that oil shedding and ligaments formation appear at the edge of bearing inner race outer-periphery.The number of shedding ligaments increases with the rise of shaft rotational speed while decreases with the growth of oil viscosity. | Donglei ZHU Guoding CHEN Yanjun LI Chaoyang ZHANG Lin WANG | 2023 | Chinese Journal of Aeronautics2023，36，2： | 0 |
| 14 | Are our clone detectors good enough?An empirical study of code effects by obfuscation显示文摘Clone detection has received much attention in many fields such as malicious code detection,vulnerability hunting,and code copyright infringement detection.However,cyber criminals may obfuscate code to impede violation detection.To date,few studies have investigated the robustness of clone detectors,especially in-fashion deep learning-based ones,against obfuscation.Meanwhile,most of these studies only measure the difference between one code snippet and its obfuscation version.However,in reality,the attackers may modify the original code before obfuscating it.Then what we should evaluate is the detection of obfuscated code from cloned code,not the original code.For this,we conduct a comprehensive study evaluating 3 popular deep-learning based clone detectors and 6 commonly used traditional ones.Regarding the data,we collect 6512 clone pairs of five types from the dataset BigCloneBench and obfuscate one program of each pair via 64 strategies of 6 state-of-art commercial obfuscators.We also collect 1424 non-clone pairs to evaluate the false positives.In sum,a benchmark of 524,148 code pairs(either clone or not)are generated,which are passed to clone detectors for evaluation.To automate the evaluation,we develop one uniform evaluation framework,integrating the clone detectors and obfuscators.The results bring us interesting findings on how obfuscation affects the performance of clone detection and what is the difference between traditional and deep learning-based clone detectors.In addition,we conduct manual code reviews to uncover the root cause of the phenomenon and give suggestions to users from different perspectives. | Weihao Huang Guozhu Meng Chaoyang Lin Qiucun Yan Kai Chen Zhuo Ma | 2023 | Cybersecurity2023，6，4： | 0 |
| 15 | Differential immune responses in pregnant patients recovered from COYID-19显示文摘Pregnant women are generally more susceptible to viral infection.Although the impact of SARS-CoV-2 in pregnancy remains to be determined,evidence indicates that the risk factors for severe COVID-19 are similar in pregnancy to the general population.Here we systemically analyzed the clinical characteristics of pregnant and non-pregnant female COVID-19 patients who were hospitalized during the same period and found that pregnant patients developed marked lymphopenia and higher inflammation evident by higher C-reactive protein and IL-6.To elucidate the pathways that might contribute to immunopathology or protective immunity against COVID-19 during pregnancy,we applied single-cell mRNA sequencing to profile peripheral blood mononuclear cells from four pregnant and six non-pregnant female patients after recovery along with four pregnant and three non-pregnant healthy donors.We found normal clonal expansion of T cells in the pregnant patients,heightened activation and chemotaxis in NK,NKT,and MAIT cells,and differential interferon responses in the monocyte compartment.Our data present a unique feature in both innate and adaptive immune responses in pregnant patients recovered from COVID-19. | Ge Chen Yiming Zhang Yaoyao Zhang Jihui Ai Bin Yang Mengge Cui Qiuyue Liao Hanxiao Chen Hualin Bai Dashing Shang Jing Chen ChaoYang Sun Haiyi Liu Fengyuan Liu Bin Mao Guoqiang Sun Lu Chen Jing-wen Lin Kezhen Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 16 | Profiling of immune features to predict immunotherapy efficacy显示文摘Immune checkpoint blockade(ICB)therapies exhibit substantial clinical benefit in different cancers,but relatively low response rates in the majority of patients highlight the need to understand mutual relationships among immune features.Here,we reveal overall positive correlations among immune checkpoints and immune cell populations.Clinically,patients benefiting from ICB exhibited increases for both immune stimulatory and inhibitory features after initiation of therapy,suggesting that the activation of the immune microenvironment might serve as the biomarker to predict immune response.As proof-of-concept,we demonstrated that the immune activation score(ISD)based on dynamic alteration of interleukins in patient plasma as early as two cycles(4-6 weeks)after starting immunotherapy can accurately predict immunotherapy efficacy.Our results reveal a systematic landscape of associations among immune features and provide a noninvasive,cost-effective,and time-efficient approach based on dynamic profiling of pre-and on-treatment plasma to predict immunotherapy efficacy. | Youqiong Ye Yongchang Zhang Nong Yang Qian Gao Xinyu Ding Xinwei Kuang Rujuan Bao Zhao Zhang Chaoyang Sun Bingying Zhou Li Wang Qingsong Hu Chunru Lin Jianjun Gao Yanyan Lou Steven HLin Lixia Diao Hong Liu Xiang Chen Gordon B.Mills Leng Han | 2022 | The Innovation2022，3，1： | 0 |
| 17 | A 3D CFD simulation of oil spray-collection and delivery process in an aeroengine inter-shaft bearing显示文摘Under-race lubrication applied to the inter-shaft bearing of aeroengine is characterized by spray oil collection and oil delivery to the bearing via flow-path structure. Droplet splashing induced by the collision between spray oil and the scoop as well as oil flowing characteristics in the flow-path influence bearing lubrication efficiency. In previous investigations, the spray oil collection and oil delivery analysis were separated, and the effect of droplet splashing on bearing lubrication efficiency was not considered. Moreover, time-varying characteristics of oil delivered to the bearing were not accounted for. This is caused by time variations of the circumferential position of rollers and under-race feed holes. To overcome these limitations, a numerical model which integrates the spray oil collection and oil delivery analysis is proposed in this paper. The model is embedded with the function of calculating the flow rate of splashing droplets and analyzing time-varying characteristics of the oil fed to the bearing. Furthermore, the numerical model is validated by experimental investigation. The proposed numerical model facilitates the accurate calculation of bearing lubrication efficiency as well as the design of an efficient lubrication structure. | Donglei ZHU Guoding CHEN Yanjun LI Chaoyang ZHANG Lin WANG | 2022 | Chinese Journal of Aeronautics2022，35，9： | 0 |
| 18 | Research Progress in Genetics and Molecular Biology of Curcuma L.显示文摘There are few studies on the genetic evolution of Curcuma L.,and it is easy to have synonyms or homonyms.In order to make better development and utilization of Curcuma L.,by consulting the relevant literature,the molecular biology and genetics of Curcuma L.were summarized,and discussed in this paper,in order to lay a foundation for the study of phylogeny and genetic evolution of Curcuma L. | Xuejiao HE Zhicheng YU Jinshui LIN Kunxiu CAI Chaoyang HUANG | 2021 | Medicinal Plant2021，12，6： | 0 |
| 19 | The environmental effect of cadmium-rich Pb-Zn deposit, as exemplified by Niujiaotang Cd-rich Zn deposit, Guizhou, China显示文摘 | Lin YE Ziping PAN Chaoyang LI Tiegeng LIU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 20 | WMO:an ontology for the semantic enrichment of wetland monitoring data显示文摘Rich observation data generated by ubiquitous sensors are vital for wetland monitoring,spanning from the prediction of natural disasters to emergency response.Such sensors use different data acquisition and description methods and,if combined,could provide a comprehensive description of the wetland.Unfortunately,these data remain hidden in isolated silos,and their variety makes integration and interoperability a significant challenge.In this work,we develop a semantic model for wetland monitoring data using an agile and modular approach,namely,wetland monitoring ontology(WMO),which containsfive modules:wetland ecosystem,monitoring indicator,monitoring context,geospatial context,and temporal context.The proposed ontology supports the semantic interoperability and integration of wetland monitoring data from multiple sources,domains,modes,and spatiotemporal scales.We also provide two real-world use cases to validate the WMO and demonstrate the WMO’s usability and reusability. | Xin Xiao Hui Lin Chaoyang Fang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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