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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effect of hygroscopic expansion on the push-out resistance of glass ionomer-based cements used for the luting of glass fiber posts 显示文摘 | Cury AH Goracei C de Lima Navarro MF | 2006 | Endod2006，32，6： | 1 |
| 3 | Sodium hyaluronate accelerates the healing process in tooth sockets of rats 显示文摘 | Mendes RM Silva GA Lima MF | 2008 | Arch Oral Biol2008，53，12： | 1 |
| 4 | Effect of hygroscopic expansion on the push-out resistance of glass ionomer-based cements used for the luting of glass fiber posts显示文摘 | Cury AH Goracci C de Lima Navarro MF | 2006 | J Endod2006，32，6： | 1 |
| 5 | Comparative study of the cutaneous sensation of leprosy-suspected lesions using Semmes-Weinstein monofilaments and quantitative thermal testing显示文摘 | Villarroel MF Orsini MB Lima RC | | 0，，： | 1 |
| 6 | TNF-alpha and IL-4 levels in generalized aggressive periodontitis subjects 显示文摘 | Bastos MF Lima JA Vieira PM | 2009 | Oral Dis2009，15，1： | 1 |
| 7 | Investigation of preconcentration strategies for the trace analysis of multi-residue pesticides in real samples by capillary electrophoresis 显示文摘 | da Silva CL de Lima EC Tavares MF | 2003 | J Chromatogr A2003，1014，12： | 1 |
| 8 | The effect of timpanoplasty on tinnitus in patients with conductive hearing loss:a six month follow-up显示文摘 | Lima Ada S Sanchez TG Bonadia Moraes MF | 2007 | Braz J Otorhinolaryngol2007，73，3： | 1 |
| 9 | Ami- triptyline aggravates the fibrosis process in a rat model of infravesical obstruction 显示文摘 | de Almeida Prado PS Soares MF Lima FO | 2012 | Int J Exp Pathol2012，93，3： | 1 |
| 10 | Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats:similarity with polycystic ovary syndrome显示文摘 | Prata Lima MF Baracat EC Simfes MJ | 2004 | Braz J Med Biol Res2004，37，7： | 1 |
| 11 | Sodium hyaluronate accelcrates the ne aling process in tooth sockets of rats显示文摘 | Mendes RM Silva GA Lima MF | 2008 | Arch Oral Biol2008，53，12： | 1 |
| 12 | Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction 显示文摘 | de Almeida PP Soares MF Lima FO | 2012 | Int J Exp Pathol2012，93，3： | 1 |
| 13 | Chronic constipaton the role of clinical assessment and eoloreetal physiologic tests to obtain an etiologic diagnosis显示文摘 | Lacerda-Filho K Lima MJ Magalbaes MF | 2008 | Arg Gastroenterol2008，45，1： | 1 |
| 14 | Sodium hyaluronate accelerates the healing process in tooth sockets of rats显示文摘 | Mendes RM Silva GA Lima MF | 2008 | Arch Oral Biol2008，53，12： | 1 |
| 15 | Sodium hyaluro- nate accelerates the healing process in tooth sockets of rats显示文摘 | MENDES RM SILVA GA LIMA MF | 2008 | Arch Oral Biol2008，53，12： | 1 |
| 16 | Effects of me- latonin on the ovarian response to pinealectomy or continu- ous light in female rats : similarity with polycstic ovary syn- drome显示文摘 | Prata Lima MF Baracat EC Simoes MJ | 2004 | Braz J Med Biol Res2004，37，7： | 1 |
| 17 | Exaggerated blood pressure response during the exercise treadmill test as a risk factor for hypertension 显示文摘 | Lima SG Albuquerque MF Oliveira JR | 2013 | Braz J Med Bid Res2013，46，4： | 1 |
| 18 | Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction显示文摘 | De Almeida Prado PS Soares MF Lima FO | 2012 | Int J Exp Pathol2012，93，3： | 1 |
| 19 | Sodium hyalu- ronate accelerates the healing process in tooth sockets of rats显示文摘 | Mendes RM Silva GA Lima MF | 2008 | Arch Oral Biol2008，53，12： | 1 |
| 20 | Hearing screening in a neonatal in- tensive care unit 显示文摘 | Lima GM Marba ST Santos MF | 2006 | J Pediatr (Rio J)2006，82，2： | 1 |
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