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| 1 | Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy显示文摘AIM:To evaluate the predictive value of the lymph node(LN) ratio(LNR,number of metastatic LNs/ examined LNs) for recurrence in patients with rectal cancer and to compare its applicability according to preoperative chemoradiotherapy(PCRT).METHODS:From 2000 to 2009,967 patients with metastatic LNs after curative resection for locally advanced rectal cancer were identified.Patients were categorized according to PCRT(PCRT vs No PCRT).The cut-off LNR was determined based on the p N1 vs p N2 when the recommended number of LNs was harvested.The 5-year recurrence-free survival(RFS) rates using the Kaplan-Meier method were compared according to p/yp N stage and the LNR in each group.RESULTS:Among patients with the same p/yp N stage,the 5-year RFS rate differed according to the LNR.In addition,the 5-year RFS rate was significantly different between p N and LNR groups in patients with No PCRT.In PCRT group,however,only LNR was associated with prognosis.On multivariate analysis,both p N and LNR were significant independent prognostic factors for 5-year RFS in the No PCRT group.In the PCRT group,only LNR category was found to be associated with RFS(HR = 2.36,95%CI:1.31-3.84,and P = 0.001).CONCLUSION:The LNR is an important prognostic predictor of RFS in rectal cancer patients especially treated with PCRT.Current p N categories could not discriminate between prognostic groups of RFS after PCRT. | In Ja Park Chang Sik Yu Seok-Byung Lim Yong Sik Yoon Chan Wook Kim Tae Won Kim Jong Hoon Kim Jin Cheon Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 8 |
| 2 | Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease显示文摘AIM To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn's disease(CD) patients.METHODS This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000 and December 2010 at Asan Medical Center(Seoul, South Korea). The median follow-up period was 101 mo.RESULTS During the follow-up period, 66 patients(25.4%) underwent a second operation for disease recurrence.At 1, 5 and 10 years after the first operation, the cumulative rate of surgical recurrence was 1.1%, 8.3% and 35.9% and clinical recurrence occurred in 1.2%, 23.6% and 68.1%, respectively. In multivariate analysis, undergoing an emergency operation was a significant risk factor for surgical recurrence-free survival(SRFS) [HR = 2.431, 95%CI: 1.394-4.240, P = 0.002], as were the presence of perianal disease after the first operation(HR = 1.715, 95%CI: 1.005-2.926, P = 0.048) and history of smoking(HR = 1.798, 95%CI: 1.088-2.969, P = 0.022). The postoperative use of antitumor necrosis factor(TNF) agents reduced SRFS risk(HR = 0.521, 95%CI: 0.300-0.904, P = 0.02).CONCLUSION History of smoking, postoperative perianal disease and undergoing an emergency operation were independent risk factors for surgical recurrence. Using anti-TNF agents may reduce surgical recurrence. | Kwan Mo Yang Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Sang Hyoung Park Byong Duk Ye Suk-Kyun Yang Jin Cheon Kim | 2017 | World Journal of Gastroenterology2017，23，38： | 3 |
| 3 | Intestinal endometriosis:Diagnostic ambiguities and surgical outcomes显示文摘BACKGROUND Endometriosis is a common disease for women of reproductive age. However,when it involves intestines, it is difficult to diagnose preoperatively because its symptoms overlap with other diseases and the results of evaluations can be unspecific. Thus it is important to know the clinical characteristics of intestinal endometriosis and how to exactly diagnose.AIM To analyze patients in whom intestinal endometriosis was diagnosed after surgical treatments, and to evaluate the clinical characteristics of preoperatively misdiagnosed cases.METHODS We retrospectively reviewed the pathologic reports of 30 patients diagnosed as having intestinal endometriosis based on surgical specimens between January2000 and December 2017. We reviewed their clinical characteristics and surgical outcomes.RESULTS Twenty-three(76.6%) patients showed symptoms associated with endometriosis,with dysmenorrhea being the most common(n = 9, 30.0%). Thirteen patients(43.3%) had a history of pelvic surgeries. Ten patients(33.3%) had a history of treatment for endometriosis. Only 4 patients(13.3%) had a diagnosis of endometriosis based on endoscopic biopsy findings. According to preoperative evaluations, 13 patients(43.3%) had an initial diagnosis of pelvic endometriosis and 17 patients(56.6%) were misdiagnosed as having other diseases. The most common misdiagnosis was submucosal tumor in the large intestine(n = 8, 26.7%),followed by malignancies of the colon/rectum(n = 3, 10.0%) and ovary(n = 3,10.0%). According to the Clavien-Dindo classification, 5 complications were grade I or II and 2 complications were grade IIIa. The median follow-up period was 26.9(0.6-132.1) mo, and only 1 patient had a recurrence of endometriosis.CONCLUSION Intestinal endometriosis is difficult to diagnose preoperatively because it mimics various intestinal diseases. Thus, if women of reproductive age have ambiguous symptoms and signs with nonspecific radiologic and/or endoscopic findings,intestinal endometriosis should be included in the differential diagnosis. | Jun Woo Bong Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim | 2019 | World Journal of Clinical Cases2019，7，4： | 3 |
| 4 | Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer显示文摘AIM: To ascertain pathologic stage as a prognostic indicator for rectal cancer patients receiving preoperative chemoradiotherapy(PCRT).METHODS: Patients with mid- and low rectal carcinoma(magnetic resonance imaging- based clinical stage Ⅱ or Ⅲ) between 2000 and 2009 and treated with curative radical resection were identified. Patients were divided into two groups: PCRT and No-PCRT. Recurrence-free survival(RFS) was examined according to pathologic stage and addition of adjuvant treatment.RESULTS: Overall, 894 patients were identified. Of these, 500 patients received PCRT. Adjuvant chemotherapy was delivered to 81.5% of the No-PCRT and 94.8% of the PCRT patients. Adjuvant radiotherapy was given to 29.4% of the patients in the No PCRT group. The 5-year RFS for the No-PCRT group was 92.6% for StageⅠ, 83.3% for Stage Ⅱ, and 72.9% for Stage Ⅲ. The 5-year RFS for the PCRT group was 95.2% for yp Stage 0, 91.7% for yp StageⅠ, 73.9% for yp Stage Ⅱ, and 50.7% for yp Stage Ⅲ.CONCLUSION: Pathologic stage can predict prognosis in PCRT patients. Five-year RFS is significantly lower among PCRT patients than No-PCRT patients in pathologic stage Ⅱ and Ⅲ. These results should be taken into account when considering adjuvant treatment for patients treated with PCRT. | Kyungyeon Hwang In Ja Park Chang Sik Yu Seok-Byung Lim Jong Lyul Lee Yong Sik Yoon Chan Wook Kim Jin Cheon Kim | 2015 | World Journal of Gastroenterology2015，21，2： | 3 |
| 5 | Laparoto- my versus laparoscopy for the treatment of adnexal masses during -pregnancy显示文摘 | Yu-Jin KO0 Hyun Ja KIM Kyung-Taek LIM | 2012 | ANZJOG2012，52，： | 1 |
| 6 | thyroglobulin in washout fluid from lymph node fine-needle aspiration biopsy in papillary thyroid cancer: large-scale validation of the cutoff value to determine malignancy and evaluation of discrepant results 显示文摘 | Moon JH Kim YI Lim JA | 2013 | J Clin Endocrinol Metab2013，98，3： | 1 |
| 7 | Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice 显示文摘 | Lim DS Kang MS Jeong JA | 2009 | Eur J Immunol2009，39，5： | 1 |
| 8 | 'Normal' prever- tebral soft tissue swelling following elective anterior cervical decompression and fusion 显示文摘 | Sanfilippo JA Jr Lim MR Jacoby SM | 2006 | J Spinal Disord Tech2006，19，6： | 1 |
| 9 | Therapeutic effects of human umbili- cal cord blood-derived mesenchymal stem cells alter intrathecal ad- ministration by lumbar puncture in a rat model of cerebral ischemia 显示文摘 | Lim JY Jeong CH Jun JA | 2011 | Stem Cell Res Ther2011，2，5： | 1 |
| 10 | Cabbage compression early breast care on breast engorgement in primiparous women after cesarean birth:a controlled clinical trial显示文摘 | Lim AR Song JA Hur MH | 2015 | Int J Clin Exp Med2015，8，21： | 1 |
| 11 | Nocturia and complementary indices :determination and quantification of the cause of nocturia by frequency-volume charts in women with lower urinary tract symptoms 显示文摘 | Ja Hyeon Ku Dae Jung Lim Seok-Soo Byun | 2004 | Urological Research2004，32，3： | 1 |
| 12 | Technial optimization of spiral CT for depicition of renal artery stenosis in vitro analysis显示文摘 | Brink JA Lim JT Wang G | 1995 | Radiology1995，194，： | 1 |
| 13 | Prevalence of resistance tomacrolide,lincosamide and streptogramin antibiotics in Grain-positive cocci isolated in a Korean hospital显示文摘 | Lim JA Kwon AR Kim SK | 2002 | J Antimicmb Chemother2002，49，： | 1 |
| 14 | Neuropsychiatric application of DTI-a review 显示文摘 | Lim KO Helpem JA | 2002 | NMR Biomed2002，15，： | 1 |
| 15 | Combination of Transarterial Chemoembolization and Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma With Inferior Vena Cava Tumor Thrombus显示文摘 | Ja Eun Koo Jong Hoon Kim Young-Suk Lim Soo Jung Park Hyung Jin Won Kyu-Bo Sung Dong Jin Suh | 2010 | International Journal of Radiation Oncology Biology Physics2010，，1： | 1 |
| 16 | Activity of adenylyl cyclase and protein kinase A contributes to morphine-induced spinal apoptosis显示文摘 | Lim G Wang S Lim JA | | 0，，02： | 1 |
| 17 | Multiplex PCR for the detection of genes encoding aminoglycoside modifying enzymes and methicillin resistance among Staphylococcus species显示文摘 | Lim JA Kim SH Kim H J | 2003 | J Korean Med Sci2003，18，5： | 1 |
| 18 | Adrenal 21-hydroxylase deficiency in childhood:25 years' experience显示文摘 | Lim YJ Batch JA Wame GL | | 0，，： | 1 |
| 19 | Loss of beta2-spectrin prevents cardiomyocyte differentiation and heart development 显示文摘 | Lim JA Baek HJ Jang MS | 2014 | Cardiovasc Res2014，101，1： | 1 |
| 20 | Prevalence of resistance to macrolide,lincosamide and streptogramin antibiotics in Grampositive cocci isolated in a Korean hospital显示文摘 | Lim JA Kwon AR Kim SK | 2002 | J Antimicrob chemother2002，49，3： | 1 |
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