|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum显示文摘Colorectal cancer(CRC) is the third most common cancer and the fourth most common cause of cancerrelated death worldwide. Besides the lymphatic and haematogenous routes of dissemination,CRC frequently gives rise to transcoelomic spread of tumor cells in the peritoneal cavity,which ultimately leads to peritoneal carcinomatosis(PC). PC is associated with a poor prognosis and bad quality of life for these patients in their terminal stages of disease. A loco-regional treatment modality for PC combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has resulted in promising clinical results. However,this novel approach is associated with significant morbidity and mortality. A comprehensive understanding of the molecular events involved in peritoneal disease spread is paramount in avoiding unnecessary toxicity. The emergence of PC is the result of a molecular crosstalk between cancer cells and host elements,involving several well-defined steps,together known as the peritoneal metastatic cascade. Individual or clumps of tumor cells detach from the primary tumor,gain access to the peritoneal cavity and become susceptible to the regular peritoneal transport. They attach to the distant peritoneum,subsequently invade the subperitoneal space,where angiogenesis sustains proliferation and enables further metastatic growth. These molecular events are not isolated events but rather a continuous and interdependent process. In this manuscript,we review current data regarding the molecular mechanisms underlying the development of colorectal PC,with a special focus on the peritoneum and the role of the surgeon in peritoneal disease spread. | Lieselotte Lemoine Paul Sugarbaker Kurt Van der Speeten | 2016 | World Journal of Gastroenterology2016，22，34： | 12 |
| 2 | Connecting Growth of Brassinosteroids Immunity and Defense: The and Gibberellins Emerging Roles in Plant Innate显示文摘 | Lieselotte De Bruyne Monica HOfte David De Vleesschauwer | 2014 | Molecular Plant2014，7，6： | 5 |
| 3 | N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography–mass spectrometry显示文摘Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are responsible for these pharmacological actions. Therefore, in the present study, the NAA content of the two plants was analytically characterised. Different extracts were prepared from the roots, the leaves, the stems and the flowers. The structures of NAAs have been assigned in ethanolic extracts of Achillea millefolium and Achillea ptarmica using high performance liquid chromatography – electrospray ionisation – mass spectrometry(HPLC–ESI–MS) and gas chromatography – electron impact – mass spectrometry(GC–EI–MS). Using both analytical techniques, the structures of 14 and 15 NAAs have been assigned in Achillea ptarmica and Achillea millefolium, respectively. Structures of two new NAAs, previously never observed in Achillea ptarmica,were assigned: deca-2E,6Z,8E-trienoic acid 2-methylbutylamide(homospilanthol) or a related isomeric compound and deca-2E,4E-dienoic acid N-methyl isobutylamide. The structure of homospilanthol or a related isomeric compound was also assigned in Achillea millefolium for the first time. | Lieselotte Veryser Lien Taevernier Evelien Wynendaele Yannick Verheust Ann Dumoulin Bart De Spiegeleer | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 3 |
| 4 | The immune response in patients with cutaneous leishmaniasis and the influence of zinc supplementation显示文摘 | Miguel Guzman-Rivero Aleida Verduguez-Orellana Karen Monta?o Lieselotte Cloetens Ernesto Rojas Bj?rn ?kesson Edgar Sejas | 2015 | Biomedicine & Pharmacotherapy2015，，： | 1 |
| 5 | Evaluation of the SD FK70 malaria Ag Plasmodium vivax rapid diangnostic test in a non-endemic setting显示文摘 | Philippe G Katrien B Lieselotte C | 2009 | Malar J2009，，8： | 1 |
| 6 | Changes in pigmentation of phytoplankton species during growth and stationary phase-consequences for reliability of pigment-based methods of biomass determination显示文摘 | Christian W Lieselotte M | 1991 | Journal of Applied Phycology1991，3，： | 1 |
| 7 | Risk evaluation of impurities in topical excipients:The acetol case显示文摘Pharmaceutical excipients for topical use may contain impurities,which are often neglected from a toxicity qualification viewpoint.The possible impurities in the most frequently used topical excipients were evaluated in-silico for their toxicity hazard.Acetol,an impurity likely present in different topical pharmaceutical excipients such as propylene glycol and glycerol,was withheld for the evaluation of its health risk after dermal exposure.An ex-vivo in-vitro permeation study using human skin in a Franz Diffusion Cell set-up and GC as quantification methodology showed a significant skin penetration with an overall K_p value of 1.82 × 10^(-3)cm/h.Using these data,limit specifications after application of a dermal pharmaceutical product were estimated.Based on the TTC approach of Cramer class I substances,i.e.1800 μg/(day·person),the toxicity-qualified specification limits of acetol in topical excipients were calculated to be 90 μg/mL and 180 μg/mL for propylene glycol and glycerol,respectively. | Jente Boonen Lieselotte Veryser Lien Taevernier Nathalie Roche Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 1 |
| 8 | Evaluation of the malaria rapid diagnostic test SDFK90:detection of both PfHRP2 and Pf-pLDH显示文摘 | Marloes H Philippe G Lieselotte C | 2012 | Malar J2012，，11： | 1 |
| 9 | Vali-dation methods to determine phyticand oxalic acids in ' multimistur-as” 显示文摘 | Sandberg A S Giancarlo Ubaldo Nappi Lieselotte Jokl | 1989 | Food science1989，，： | 1 |
| 10 | Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells显示文摘 | Tamara Severi Chunxiao Ying Joris Robert Vermeesch David Cassiman Lieselotte Cnops Chris Verslype Johan Fevery Lutgarde Arckens Johan Neyts Jos F. Pelt PhD Ing | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 11 | A critical quality parameter in quantitative fused-core chromatography: The injection volume显示文摘As part of the method development,the injection volume as a critical quality attribute in fast fused-core chromatography was evaluated.Spilanthol,a pharmaceutically interesting Nalkylamide currently under investigation in our laboratory,was chosen as the model compound.Spilanthol was dissolved in both PBS and MeOH/H2O(70/30,v/v)and subsequently analyzed using a fused-core system hereby selecting fve chromatographic characteristics(retention time,area,height,theoretical plates and symmetry factor)as responses.We demonstrated that the injection volume signifcantly influenced both the qualitative and quantitative performance of fused-core chromatography,a phenomenon which is confounded with the nature of the used sample solvent.From 2 mL up to 100 mL injection volume with PBS as solvent,the symmetry factor decreased favorably by 20%.Moreover,the theoretical plates and the quantitative parameters(area and height)increased up to 30%.On the contrary,in this injection volume range,the theoretical plates for the methanol-based samples decreased by more than 60%,while the symmetry factor increased and the height decreased,both by 30%.The injection volume is thus a critical and often overlooked parameter in fused-core method description and validation. | Jente Boonen Matthias D’hondt Lieselotte Veryser Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2013 | Journal of Pharmaceutical Analysis2013，3，5： | 0 |
| 12 | The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal显示文摘老鼠 pro-B 房间行 Ba/F3 的 Interleukin-3 (IL-3 ) 剥夺导致被 B 房间淋巴瘤 2 废除的房间死亡(Bcl-2 ) overexpression,而是由 pan-caspase 禁止者 carbobenzoxy-valyl-analyl-aspartyl- 未受影响的遗体[O 甲基]-fluoromethylketone (zVAD-fmk ) 。IL-3 退却引起交往受体的蛋白质(裂开) 进 30 和 25 kDa 的 C 终端碎片的 1 劈开,和仅仅导致前者的劈开被 zVAD-fmk 阻止。siRNA 实验证明 25-kDa 碎片的产生高由于 mitochondrial 丝氨酸朊酶的一个 Bcl-2-modulated 版本温度要求蛋白质 A2 (HtrA2 )/Omi。因此, recombinant HtrA2/Omi 高效地在 vitro 劈开老鼠 RIP1,产生匹配在 IL-3-deprived Ba/F3 房间观察的那些的碎片。在老鼠 RIP1 的 HtrA2/Omi 劈开地点被印射到中间的领域和相应 N 终端, C 终端碎片处于他们激活原子因素的能力被损害 --魏 B, c6 月 N 终端 kinase 和 p38 激活 mitogen 的蛋白质 kinase。有趣地, HtrA2/Omi 击倒面对 zVAD-fmk 对 IL-3 导致退却的死亡负担得起保护,由劈开 RIP1 在生长因素退却期间在 caspase 独立的细胞死亡为 HtrA2/Omi 表明一个角色。 | Lieselotte Vande Walle Ellen Wirawanl Mohamed Lamkanfi Nele Festjens Jelle Verspurten Xavier Saelens Tom Vanden Berghe | 2010 | Cell Research2010，20，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员