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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 3 | The role of ions in plasma catalytic carbon nanotube growth: A review显示文摘当它是著名的时碳 nanotubes (CNT ) 的催化化学蒸汽免职(PECVD ) 在热 CVD 上为很多个优点提供的 plasmaenhanced,各种各样的单个作出贡献因素的影响很好没被理解。特别离子的角色是不清楚的,自从在血浆的离子通常与劈啪作响而非与种材料被联系。甚至这样,各种各样的研究在 CNT 的生长期间表明了离子轰炸的有益的效果。这评论在推出了从的 plasmaenhanced CNT 生长看离子的角色试验性并且模拟研究。特定的注意对离子轰炸的有益的效果被给予。基于可得到的文学,离子能为碳 nanotube 生长有益或有害,这能被结束,取决于在生长过程上的准确条件和控制。 | Erik C. Neyts | 2015 | Frontiers of Chemical Science and Engineering2015，9，2： | 2 |
| 4 | Atomistic simulations of plasma catalytic processes显示文摘 | Erik C. Neyts | 2018 | Frontiers of Chemical Science and Engineering2018，12，1： | 2 |
| 5 | Comparison of Grid Laser, Intravitreal Triamcinolone, and Intravitreal Bevacizumab in the Treatment of Diffuse Diabetic Macular Edema显示文摘 | Sobaci Güng?r ?zge G?khan Erdurman Cüneyt Durukan Hakan A Bayraktar Zeki M | 2012 | Ophthalmologica2012，，2： | 2 |
| 6 | Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata显示文摘 | Damonte E Neyts J Pujol C A | 1994 | Biochem Pharmacoh1994，47，12： | 1 |
| 7 | Ro-vibrating energy states of a diatomic molecule in an empirical potential显示文摘 | Cüneyt Berkdemir | 2009 | Journal of Mathematical Chemistry2009，，2： | 1 |
| 8 | 显示文摘 | Neyts Johan | 2006 | J Med Chem2006，49，： | 1 |
| 9 | Gas discharge plasmas and their applications显示文摘 | Erik Neyts Renaat Gijbels | 2002 | Spectrochimica Acta Part B2002，57，8： | 1 |
| 10 | Angiogenesis:regulators and clinical applications显示文摘 | Liekens S De Clereq E Neyts J | 2001 | Biochem Pharmacol2001，61，3： | 1 |
| 11 | Muta- tions located on both F1 and F2 subunits of the New- castle disease virus fusion protein confer resistance to neutralization with monoclonal antibodies 显示文摘 | NEYT C GELIEBTER J SLAOUI M | 1989 | J Vir-ol1989，63，2： | 1 |
| 12 | Antiviral treatment of chronic hepatitis B virus infections : the past, the present and the future显示文摘 | Geoffrey F e rir Suzanne Kaptein Johan Neyts | 2008 | Revi Med Virol2008，18，1： | 1 |
| 13 | Problems, obstacles and complications with transpalatal distraction in non-congenital deformities 显示文摘 | Neyt N Mommaerts M Abeloos J | 2002 | J Craniomaxillofac Surg2002，30，3： | 1 |
| 14 | Plasma nanoscience: from nano-solids in plasmas to nano-plasmas in solids显示文摘 | K. Ostrikov E.C. Neyts M. Meyyappan | 2013 | Advances in Physics2013，，2： | 1 |
| 15 | Effect of hydrogen on the growth of thin hydrogenated amorphous carbon films from thermal energy radicals显示文摘 | NEYTS E BOGAERTS A van de SANDEN M C M | 2006 | Appl Phys Lett2006，88，14： | 1 |
| 16 | Selective inhibition of hepatitis B virus replication by RNA interference显示文摘 | YING C DE-CLERCQ E NEYTS J | 2003 | Biochem Biophys Res Commun2003，309，2： | 1 |
| 17 | Lamivudine,adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture显示文摘 | Ying C De-Clercq E Neyts J | 2000 | J Viral Hepat2000，7，1： | 1 |
| 18 | Control of Aeromonas on minimally processed vegetables by decontamina- tion with lactic acid, chlorinated water, or thyme essential oil so- lution 显示文摘 | Uyttendaele M Neyts K Vanderswalmen H | 2004 | Int J Food Microbiol2004，90，3： | 1 |
| 19 | Atomic-scale simulations of reactive oxygen plasma species interacting with bacterial cell walls 显示文摘 | YUSUPOV M NEYTS E C KHALILOV U | 2012 | New Journal of Physics2012，14，09： | 1 |
| 20 | Angiogensis: regulators and clinical applications显示文摘 | Liekens S Clereq ED Neyts J | 2001 | Biochem Pharm2001，61，3： | 1 |
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