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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer显示文摘 | Couturier-Maillard Aurélie Secher Thomas Rehman Ateequr Normand Sylvain De Arcangelis Adéle Haesler Robert Huot Ludovic Grandjean Teddy Bressenot Aude Delanoye-Crespin Anne Gaillot Olivier Schreiber Stefan Lemoine Yves Ryffel Bernhard Hot D | 2013 | Journal of Clinical Investigation2013，，2： | 5 |
| 3 | High-mobility group box 1 protein plasma concentrations during septic shock显示文摘 | Sébastien Gibot Frédéric Massin Aurélie Cravoisy Damien Barraud Lionel Nace Brune Levy Pierre-Edouard Bollaert | 2007 | Intensive Care Medicine2007，，8： | 2 |
| 4 | Client-level predictors of treatment engagement,outcome and dropout:moving beyond demographics显示文摘Background Despite the availability of evidence-based treatments for posttraumatic stress disorder(PTSD),significant heterogeneity in the effectiveness of PTSD treatment persists,especially in community settings.Client demographics used to understand this variability in treatment outcome and dropout have yielded mixed results.Despite increasing evidence for the importance of attending to treatment engagement in community settings,few studies have explored client-level predictors.Aim The purpose of this study is to explore client-level predictors of treatment outcome and dropout beyond client demographics,and to identify client-level predictors of treatment engagement in community settings.Method Secondary data analysis was conducted with data collected as part of an implementation-effectiveness hybrid study of cognitive processing therapy(CPT)for PTSD in a diverse community healthcentre.Providers(n=19)treated(n=52)clients as part of their routine clinical care.Non-demographic client-level predictors included barriers to treatment,quality of life,session-level language and employment history assessed at baseline.Treatment engagement included number of weeks in the study,number of sessions with repeated CPT content,number of unique CPT sessions attended,frequency of session attendance and consistency of session attendance.Results Results showed language as a significant predictor of treatment engagement.There were significant differences between Spanish and English-speaking clients,with the former having a tendency to repeat more session content than the latter(β=1.4 sessions,p=0.003),and also less likely to attend treatment frequently(r=0.62,p=0.009)and consistently(r=0.57,p=0.027)if high logistical and financial barriers were endorsed.Irrespective of language,clients who reported high quality of life at baseline were less likely to repeat CPT session content(β=-0.3,p=0.04),and those with increased baseline barriers to treatment had deceleration in PTSD symptom improvement over time(β=-0.62,p<0.05).In terms of treatment engagement moderators impacting treatment outcome,clients who repeated more session content were more likely to complete treatment(0R=1.84,p=0.037).Conclusion Identification of client-level predictors of treatment engagement,outcome and dropout is essential to optimise treatment,particularly in community settings. | Soo-jeong Youn Margaret-Anne Mackintosh Shannon Wiltsey Stirman Kay lie A Patrick Yesenia Aguilar Silvan Anna D Bartuska Derri L Shtasel Luana Marques | 2019 | General Psychiatry2019，32，6： | 2 |
| 5 | Further studies of the fire resistance of reinforced concrete columns显示文摘 | Allen D E Lie T T | 1974 | National research Council of Canada1974，416，： | 1 |
| 6 | Use of High-pressure Processing for Oyster Shucking and Shelf-life Extension 显示文摘 | lie H Adams R M Farkas D F | 2002 | Journal of Food Science2002，67，2： | 1 |
| 7 | Experimental investigation of vortex-induced vibration of long marine risers显示文摘 | TRIM A D BRAATEN H LIE H | 2005 | Journal of Fluids and Structures2005，21，3： | 1 |
| 8 | Experimental investigation of vortex-induced vibration of long marine risers 显示文摘 | Trim A D Braaten H Lie H | 2005 | Journal of Fluids and Structures2005，21，3： | 1 |
| 9 | How temperature affects development and reproduction in spiders: a review 显示文摘 | Lie D Q Jackson R R | 1996 | J Therm Biol1996，，4： | 1 |
| 10 | Long-term medical and social conse- quences of preterm birth 显示文摘 | Moster D Lie R T Markestad T | 2008 | N Engl J Med2008，359，3： | 1 |
| 11 | Calculation of the fire resistance of steel hollow structural section columns filled with plain concrete 显示文摘 | Lie T T Stringer D C | 1994 | Can J Civ Eng1994，21，3： | 1 |
| 12 | Wnt signal- ling regulates adult hippocampal neurogenesis 显示文摘 | Lie D C Colamarino S A Song H J | 2005 | Na- ture2005，437，7063： | 1 |
| 13 | Herbals used for diabetes, obesity,andmetabolic syndrome显示文摘 | 'Najm W Lie D | 2010 | Prim Care2010，37，2： | 1 |
| 14 | Three - dimensional numeri- cal study of heat transfer characteristics in the receiver tube of parabolic trough solar collector 显示文摘 | CliENG Z D liE Y L | 2010 | International Communications in Heat & Mass Transfer2010，37，7： | 1 |
| 15 | Strontium ranelate - induced toxic epidermal necrolysis in a patient with post-menopausal osteoporosis 显示文摘 | Lee H Y Lie D Lira K S | 2009 | Osteoporos Int2009，20，1： | 1 |
| 16 | Calculation of the fire resistance of steel hollow structural section columns filled with plain concrete显示文摘 | Lie T T Stringer D C | 1994 | Can J Civ Eng1994，21，3： | 1 |
| 17 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 18 | Efficacy and side effects of swinging eyelid' orbital decompression in Graves' orbitopathy:a proposal for standardized evaluation of diplopia 显示文摘 | Paridaens D Lie A Grootendorst RJ | 2006 | Eye2006，20，2： | 1 |
| 19 | Preoperative predictors for residual tumor after surgery in patients with ovarian carcinoma显示文摘 | de Jong D Eijkemans MJ Lie Fong S | 2007 | Oncology2007，72，56： | 1 |
| 20 | Calculation of the fire resistance of steel hollow structural section columns filled with plain concrete显示文摘 | Lie T T Stringer D C | 1994 | Canadian Journal of Civil Engineering1994，21，： | 1 |
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