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| 1 | Pharmacological Activation of RXR-a Promotes Hematoma Absorption via a PPAR-y-dependent Pathway After Intracerebral Hemorrhage显示文摘Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-ot(RXR-a)in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-a with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH.RXR-ot was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-a and PPAR-y,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the Ml into the M2 phenotype.Furthermore,all the beneficial effects of RXR-a in ICH were reversed by the PPAR-y inhibitor GW9662.In conclusion,the pharmacological activation of RXR-a confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-y-related mechanisms.Our data support the notion that RXR-ot might be a promising therapeutic target for ICH. | Chaoran Xu Huaijun Chen Shengjun Zhou Chenjun Sun Xiaolong Xia Yucong Peng Jianfeng Zhuang Xiongjie Fu Hanhai Zeng Hang Zhou Yang Cao Qian Yu Yin Li Libin Hu Guoyang Zhou Feng Yan Gao Chen Jianru Li | 2021 | Neuroscience Bulletin2021，37，10： | 4 |
| 2 | Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs显示文摘Blastocyst complementation by pluripotent stem cell(PSC)injection is believed to be the most promising method to generate xenogeneic organs.However,ethical issues prevent the study of human chimeras in the late embryonic stage of development.Primate embryonic stem cells(ESCs),which have similar pluripotency to human ESCs,are a good model for studying interspecies chimerism and organ generation.However,whether primate ESCs can be used in xenogenous grafts remains unclear.In this study,we evaluated the chimeric ability of cynomolgus monkey(Macaca fascicularis)ESCs(cmESCs)in pigs,which are excellent hosts because of their many similarities to humans.We report an optimized culture medium that enhanced the anti-apoptotic ability of cmESCs and improved the development of chimeric embryos,in which domesticated cmESCs(D-ESCs)injected into pig blastocysts differentiated into cells of all three germ layers.In addition,we obtained two neonatal interspecies chimeras,in which we observed tissue-specific D-ESC differentiation.Taken together,the results demonstrate the capability of D-ESCs to integrate and differentiate into functional cells in a porcine model,with a chimeric ratio of 0.001-0.0001 in different neonate tissues.We believe this work will facilitate future developments in xenogeneic organogenesis,bringing us one step closer to producing tissue-specific functional cells and organs in a large animal model through interspecies blastocyst complementation. | Rui Fu Dawei Yu Jilong Ren Chongyang Li Jing Wang Guihai Feng Xuepeng Wang Haifeng Wan Tianda Li Libin Wang Ying Zhang Tang Hai Wei Li Qi Zhou | 2020 | Protein & Cell2020，11，2： | 4 |
| 3 | Sources of organic matter and paleo-environmental implications inferred from carbon isotope compositions of lacustrine sediments at Inexpressible Island, Ross Sea, Antarctica显示文摘The carbon isotopic composition of organic matter(δ^(13)C_(org)) was determined in two sediment cores(IIL1 and IIL9) recovered from Inexpressible Island, Ross Sea, Antarctica, and analyzed to identify the sources of that organic matter. The δ^(13)C_(org) values of sediments of IIL9 were found to vary between-14.6‰ and-11.6‰, with a mean of-13.4‰(n=48). These values were significantly higher than those of IIL1 sediments which varied between-23.2‰ and-20.4‰, with a mean of-21.8‰(n=55). The variation in δ^(13)C_(org) values in these two sediment cores indicate different sources of organic matter. The relatively high δ^(13)C_(org) values in IIL9 are in accordance with a source from algae, while the low δ^(13)C_(org) values in IIL1 evince significant influence from penguin guano with algae as the secondary source. Compared with the reference data from other high-latitude lake sediments and plants, the δ^(13)C_(org) values in IIL9 were extremely high, a result likely related to intense competition for CO_2 assimilation among algal species during the growing season in this relatively shallow pond. These results indicate that sedimentary δ^(13)C_(org) is a reliable proxy for paleo-primary productivity in ponds at Inexpressible Island. | WEI Yangyang JIN Jing NIE Yaguang CHEN Xin WU Libin FU Pingqing LIU Xiaodong Steven D.Emslie | 2016 | Advances in Polar Science2016，27，4： | 2 |
| 4 | Periodic modulation effect on self-trapping of two weakly coupled Bose-Einstein condensates 显示文摘 | Wang Guanfang Ye Difa Fu Libin Chen Xuzong Liu Jie | 2006 | Phys Rev A2006，74，03： | 1 |
| 5 | All-fiber Norrow-band grating assisted Sagnae Transmission Filter显示文摘 | Fu Libin An Honglin Xu Wanjjin | 2000 | Chinese Journal of Lasers B2000，9，4： | 1 |
| 6 | Collective dynamics of two-species Bose-Einstein-condensate mixtures in a double-well potential显示文摘 | Qiu Haibo Tian Jing Fu Libin | | 0，，04： | 1 |
| 7 | Two-parameter estimation with three-mode NOON state in a symmetric triple-well potential显示文摘We propose a scheme to realize two-parameter estimation via Bose–Einstein condensates confined in a symmetric triple-well potential.The three-mode NOON state is prepared adiabatically as the initial state.The two parameters to be estimated are the phase differences between the wells.The sensitivity of this estimation scheme is studied by comparing quantum and classical Fisher information matrices.As a result,we find an optimal particle number measurement method.Moreover,the precision of this estimation scheme means that the Heisenberg scaling behaves under the optimal measurement. | Fei Yao Yi-Mu Du Haijun Xing Libin Fu | 2022 | Communications in Theoretical Physics2022，74，4： | 1 |
| 8 | Quantum setp heights in hysteresis loops of molecular magnets 显示文摘 | Liu Jie Wu Biao Fu Libin | 2002 | Phys Rev2002，65，22： | 1 |
| 9 | Theory of nonlinear Landau-Zener tunneling 显示文摘 | Liu J ie Fu Libin Ou Bi-Yiao | 2002 | Phys Rev2002，66，02： | 1 |
| 10 | Analysis of amino acid enantiomers in ambient aerosols:Effects and removal of coexistent aerosol matrix显示文摘Amino acids(AAs)including D-and L-enantiomers are a group of organic nitrogen species in ambient aerosol.Due to the low abundances of AAs(level of ng/m^(3))and the matrix effects by coexistent components,it is challenging to quantify AA enantiomers in ambient aerosols especially under pollution conditions.In this study,we present an optimized method for analyzing AA enantiomers in atmospheric aerosol samples including a pretreatment process and the detection by high performance liquid chromatography coupled to a fuorescence detector(HPLC-FLD).Matrix effects caused by coexistent chemicals on AA enantiomers analysis in ambient aerosol samples were investigated especially for those collected in pollution episodes.The results revealed that the determination of AA enantiomers is significantly affected by the coexistent organic carbon(as a proxy of organic matter)and water-soluble ion of NH_(4)^(+).To remove the matrix effects,we applied a pretreatment using the solid phase extraction column coupled with alkaline adjustment to sample extract.After pretreatment,18 AAs including 6 pairs of D-and L-enantiomers(i.e.,leucine,isoleucine,valine,alanine,serine,and aspartic acid)can be successfully separated and quantified in aerosol samples by HPLC-FLD.The recoveries are in the range of 67%-106%.This method was successfully applied to the urban aerosol samples from pollution and non-pollution periods for AA enantiomers determination.We suggest that the concentrations of D-AAs and the ratio of D-AA/L-AA are indicative of the contribution of bacterial sources and the infuence of biomass burning. | Ying Li Xiaoying Li Libin Wu Luhan Shi ShanWang Pingqing Fu Yingyi Zhang Senchao Lai | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 11 | The Effect and Benefit of Rice Chilo suppressalis Walker Chemical Control Test of Chlorantraniliprole etc.显示文摘In this paper, the first generation and second generation of Chilo suppressalis Walker were conducted as the test objects to investigate control of a new pesticide(chlorantraniliprole) with preparation of chlorantraniliprole 20% SC,abamectin 1.8% EC and chlorpyrifos 40% EC to Chilo suppressalis Walker. The results showed that chlorantraniliprole 20% SC, abamectin 1.8% EC and chlorpyrifos40% EC had effective control to Chilo suppressalis Walker for its excellent control efficacy and long persistence period. Seedling protection efficacies were between84.2%-100%, 90.1% and 92.1%, and insecticidal efficacies were between 84.6%-100%,90.7% and 93.8% 36 days after application of chlorantraniliprole 20% SC in treatments with abamectin 1.8% EC and chlorpyrifos 40% EC for first generation Chilo suppressalis Walker control. The dead panicles were between 0.2%-1.4%, 0.8%and 0.7%, pest plant rate control in 0.4%-2.2%, 1.1% and 0.9%, and the rates of damaged rice plants were between 82.4%-97.6%, 90.2%-91.2% and 91.4%-92.8%,30 days after application of chlorantraniliprole 20% SC, abamectin 1.8% EC and chlorpyrifos 40% EC for the second generation Chilo suppressalis Walker control. It can effectively protect seedlings, protect spike, increase grain number and grain weight, which promoting the increase production income effect. The real estate increased by 9.7%-12.3%, 10.9% and 11.2% than water treatment(CK) with a very significant level, while the incomes were higher than 1 719.19-1 998.22, 1 956.52 and 2 057.83 yuan. | Changjia PENG Pan DING Tikun BAI Libin FENG Huaizhong YIN Wanqiu WANG Zhongyu FU | 2015 | Agricultural Science & Technology2015，16，6： | 0 |
| 12 | An Analysis on the Economic Benefit of Simplified Cultivation Technology for Longan in Hills and Mountains of Maoming City显示文摘According to the characteristics of longan cultivated in the hill and mountain regions of Maoming City,this paper analyzed the economic benefit of the simplified cultivation techniques. With 15-year-old Chuliang longan trees as materials,the economic benefit of four kinds of simplified cultivation technologies was compared and analyzed. After nine years of continuous technological application,it was found that the input costs increased by 1. 62%,and the output profits increased by 56. 10%; in input costs,labor cost decreased by 41. 33%,pesticide cost decreased by 24. 19%,and fertilizer cost increased by 33. 57%. | Jianbin LUO Sheng ZHONG Jun CHEN Xiangyou ZENG Libin FU Yanzong ZHU Zhenquan DENG | 2016 | Asian Agricultural Research2016，8，11： | 0 |
| 13 | Majorana's stellar representation for the quantum geometric tensor of symmetric states显示文摘Majorana's stellar representation provides an intuitive picture in which quantum states in highdimensional Hilbert space can be observed using the trajectory of Majorana stars.We consider the Majorana's stellar representation of the quantum geometric tensor for a spin state up to spin-3/2.The real and imaginary parts of the quantum geometric tensor,corresponding to the quantum metric tensor and Berry curvature,are therefore obtained in terms of the Majorana stars.Moreover,we work out the expressions of quantum geometric tensor for arbitrary spin in some important cases.Our results will benefit the comprehension of the quantum geometric tensor and provide interesting relations between the quantum geometric tensor and Majorana's stars. | Xingyu Zhang Jiancheng Pei Libin Fu Xiaoguang Wang | 2022 | Communications in Theoretical Physics2022，74，6： | 0 |
| 14 | Influence of Heating Rate and Calcining Temperature on Properties of 95 Polycrystalline Alumina Fiber显示文摘The swung gel fibers were heated to 400 ℃ at 0.5, 1, 1.5, 2, 2.5, 3 and 4 ℃·min-1 of heating rate, respectively, and soaked for 1 h; then heated to 600 ℃ at 3 ℃·min-1 of heating rate and soaked for 1 h; at last calcined at 1 000, 1 100, 1 200, 1 300, and 1 400 ℃ for 1 h, respectively. The average single fiber tensile strengths of fibers after calcining at 600 ℃ or higher temperatures were determined and their surface morphology was observed. The results show that: (1) when the heating rate below 400 ℃ is 0.5-1 ℃·min-1, the average single fiber tensile strengths of 95 polycrystalline alumina fibers after calcining at 600 ℃ and 1 000-1 100 ℃ exceed 1 000 and 800 MPa, respectively, surface of the fibers after calcining at 1 000-1 100 ℃ is smooth, α-Al2O3 appears at 1 200 ℃, and a large amount of α-Al2O3 forms above 1 300 ℃; (2) when the heating rate exceeds 3 ℃·min-1, the fibers pulverize obviously. | XU Jianfeng FU Shunde LIU Libin JIA Jia GAN Xiaoming | 2012 | China's Refractories2012，21，3： | 0 |
| 15 | Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota显示文摘At present,clinical interventions for chronic kidney disease are very limited,and most patients rely on dialysis to sustain their lives for a long time.However,studies on the gut—kidney axis have shown that the gut microbiota is a potentially effective target for correcting or controlling chronic kidney disease.This study showed that berberine,a natural drug with low oral availability,significantly ameliorated chronic kidney disease by altering the composition of the gut microbiota and inhibiting the production of gut-derived uremic toxins,including p-cresol.Furthermore,berberine reduced the content of pcresol sulfate in plasma mainly by lowering the abundance of g_Clostridium_sensu_stricto_1 and inhibiting the tyrosine—p-cresol pathway of the intestinal flora.Meanwhile,berberine increased the butyric acid producing bacteria and the butyric acid content in feces,while decreased the renal toxic trimethylamine N-oxide.These findings suggest that berberine may be a therapeutic drug with significant potential to ameliorate chronic kidney disease through the gut—kidney axis. | Libin Pan Hang Yu Jie Fu Jiachun Hu Hui Xu Zhengwei Zhang Mengmeng Bu Xinyu Yang Haojian Zhang Jinyue Lu Jiandong Jiang Yan Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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