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| 1 | Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses显示文摘His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation and migration of immune cells into lung and muscle are associated with interstitial lung disease, myositis, and morbidity. It is unknown whether the sequestration of HARS is an epiphenomenon or plays a causal role in the disease. Here, we show that HARS circulates in healthy individuals, but it is largely undetectable in the serum of anti-Jo-1-positive antisynthetase syndrome patients. In cultured primary human skeletal muscle myoblasts (HSkMC), HARS is released in increasing amounts during their differentiation into myotubes. We further show that HARS regulates immune cell engagement and inhibits CD4+ and CD8+ T-cell activation. In mouse and rodent models of acute inflammatory diseases, HARS administration downregulates immune activation. In contrast, neutralization of extracellular HARS by high-titer antibody responses during tissue injury increases susceptibility to immune attack, similar to what is seen in humans with anti-Jo-1-positive disease. Collectively, these data suggest that extracellular HARS is homeostatic in normal subjects, and its sequestration contributes to the morbidity of the anti-Jo-1-positive antisynthetase syndrome. | Ryan AAdams Cátia Fernandes-Cerqueira Antonella Notarnicola Elisabeth Mertsching Zhiwen Xu Wing-Sze Lo Kathleen Ogilvie Kyle PChiang Jeanette Ampudia Sanna Rosengren Andrea Cubitt David JKing John DMendlein Xiang-Lei Yang Leslie ANangle Ingrid ELundberg Per-Johan Jakobsson Paul Schimmel | 2021 | Cellular & Molecular Immunology2021，18，6： | 2 |
| 2 | Synergic effect of eicosapentaenoic acid and lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells 显示文摘 | Notarnicola M Messa C Refolo M G | 2010 | Lipids Health Dis2010，9，： | 1 |
| 3 | Progress in working towards a more sustainable agri-food industry显示文摘 | Notarnicola B Hayashi K Curran M A | 2012 | Journal of Cleaner Production2012，28，3： | 1 |
| 4 | Diagnostic dilemma of a subcutaneous nodule following a trauma in a child: examination put the final diagnosis of deep granulama annulare 显示文摘 | Pesce V Notarnicola A Moretti B | 2010 | Musculoskelet Surg2010，94，1： | 1 |
| 5 | Soil moisture retrieval from remotely sensed data: Neural network approach versus Bayesian method显示文摘 | Notarnicola C Angiulli M Posa F | 2008 | IEEE Transactions on Geoscience and Remote Sensing2008，46，2： | 1 |
| 6 | Health risk assessment of air emissions from a municipal solid waste incineration plant – A case study显示文摘 | Federico Cangialosi Gianluca Intini Lorenzo Liberti Michele Notarnicola Paolo Stellacci | 2007 | Waste Management2007，，5： | 1 |
| 7 | Global Warning Agreement, Iinternational trade and Eenergy/Carbon Eembodim- ents: Aan Input--output Aapproach to the Italian Case 显示文摘 | Mongelli I Tassielli G Notarnicola t3 | 2006 | Energy Policy2006，35，1： | 1 |
| 8 | Use of radar and optical remotely sensed data for soil moisture retrieval over vegetated areas显示文摘 | Notarnicola C Angiulli M Posa F | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006，44，4： | 1 |
| 9 | Serum lipid profile in colorectal cancer patients with and without synchronous distant metastases显示文摘 | Notarnicola M Altomare DF Correale M | 2005 | Oncology2005，68，46： | 1 |
| 10 | Advanced treatment and disinfection for municipal wastewater reuse in agriculture显示文摘 | Notarnicola M | 1999 | War Sci Tech1999，40，5： | 1 |
| 11 | Air pollution from a large steel factory: polycyclic aromatic hydrocarbon emissions from coke-oven batteries 显示文摘 | Liberti L Notarnicola M Primerano R | 2006 | Journal of Air & Waste Management Association2006，56，3： | 1 |
| 12 | Comparision of advanced disinfection methods for municipal wastewater rescue in agriculture显示文摘 | Liberti L Lopez A Notarnicola M | 2000 | Water Science Technol2000，42，12： | 1 |
| 13 | 显示文摘 | | 2000 | Dig Liver Dis2000，32，2： | 1 |
| 14 | Global warming agreements, international trade and energy/carbon embodiments: an input-output approach to the Italian case 显示文摘 | Mongelli I Tassielli G Notarnicola B | 2006 | Energy Policy2006，34，1： | 1 |
| 15 | The biological effects of extracorporeal shock wave therapy(eswt)on tendon tissue显示文摘 | Notarnicola A Moretti B | 2012 | Muscles Ligaments Tendons J2012，2，1： | 1 |
| 16 | Mercury removal with powdered activated carbon from flue gases at the coriano municipals solid waste incineration plant 显示文摘 | LIBERTI L NOTARNICOLA M AMICARELI V | 1998 | Waste Manage Research1998，16，2： | 1 |
| 17 | Effects of one-month continuous passive motion after arthroseopic rotator cuff repair: results at 1-year follow-up of a prospective randomized study显示文摘 | Garofalo R Conti M Notarnicola A | 2010 | Musculoskelet Surg2010，94，1： | 1 |
| 18 | Global warning agreements, international trade and energy/carbon embodiments: An input-output approach to Italian case 显示文摘 | Mongeli I Tassielli G Notarnicola B | 2006 | Energy Policy2006，34，1： | 1 |
| 19 | The biological effects of extracorporeal shock wave therapy(eswt)on tendon tissue显示文摘 | Notarnicola A Moretti B | 2012 | Muscles Ligaments Tendons J2012，2，1： | 1 |
| 20 | Extracorporeal shock waves down - regulate the expression of interleukin - 10 and tumor necrosis factor - alpha in osteoarthritic chondrocytes 显示文摘 | Moretti B Iannone F Notarnicola A | 2008 | BMC Mus-culoskelet Disord2008，9，： | 1 |
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