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| 1 | Effects of protein deprivation and re-feeding on P2X_2 receptors in enteric neurons显示文摘AIM:To investigate the effects of malnutrition and refeeding on the P2X2 receptor,nitric oxide synthase(NOS),calretinin,calbindin and choline acetyltransferase(ChAT) in neurons of the rat ileum.METHODS:We analyzed the co-localization,numbers and sizes of P2X2-expressing neurons in relation to NOS-immunoreactive(IR),calbindin-IR,ChAT-IR,and calretinin-IR neurons of the myenteric and submucosal plexus.The experimental groups consisted of:(1) rats maintained on normal feed throughout pregnancy until 42 d post-parturition(N);(2) rats deprived of protein throughout pregnancy and 42 d post-parturition(D);and(3) rats undernourished for 21 d post-parturition and then given a protein diet from days 22 to 42(DR).The myenteric and submucosal plexuses were evaluated by double labeling by immunohistochemical methods for P2X2 receptor,NOS,ChAT,calbindin and calretinin.RESULTS:We found similar P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of myenteric and submucosal neurons from the N,D and DR groups.Double labeling of the myenteric plexus demonstrated that approximately 100% of NOS-IR,calbindin-IR,calretinin-IR and ChAT-IR neurons in all groups also expressed the P2X2 receptor.In the submucosal plexus,the calretinin-IR,ChAT-IR and calbindin-IR neurons were nearly all immunoreactive for the P2X2 receptor.In the myenteric plexus,there was a 19% increase in numbers per cm2 for P2X2 receptor-IR neurons,64% for NOS-IR,84% for calretinin-IR and 26% for ChAT-IR neurons in the D group.The spatial density of calbindin-IR neurons,however,did not differ among the three groups.The submucosal neuronal density increased for calbindin-IR,calretinin-IR and ChAT-IR neurons.The average size of neurons in the myenteric plexus neurons in the D group was less than that in the controls and,in the re-fed rats;there was a 34% reduction in size only for the calretinin-IR neurons.CONCLUSION:This work demonstrates that expression of the P2X2 receptor is present in inhibitory,intrinsic primary afferent,cholinergic secretomotor and vasomotor neurons.Undernutrition affected P2X2 receptor expression in the submucosal plexus,and neuronal and size.These changes were rescued in the re-fed rats. | Rúbia Misawa Priscila Azevedo Girotti Márcia Sanae Mizuno Edson Aparecido Liberti John Barton Furness Patricia Castelucci | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 2 | Role of 5-aminolevulinic acid in the diagnosis and treatment of superficial bladder cancer:improvement in diagnostic sensitivity显示文摘 | De Dominicis C Liberti M Perugia G | 2001 | Urology2001，57，6： | 1 |
| 3 | Lidocaine-prilocaine (EMLA) cream as analgesia for hysterosalpingography:a prospective,randomized,controlled,double blinded study显示文摘 | Liberty G Gal M Halevy-Shalem T | | 0，，： | 1 |
| 4 | Development of an immunoassay-based lateral flow dipstick for the rapid detection of aflatoxin B1 in pig feed显示文摘 | BARBARA S D SARAH M D G S LIBERTY S | 2005 | Agric Food Chem2005，53，： | 1 |
| 5 | Role of 5-aminolevulinic acid in the diagnosis and treatment of superficial bladder cancer:improvement in diagnostic sensitivity显示文摘 | De Dominicis C Liberti M Perugia G | 2001 | Urology2001，57，： | 1 |
| 6 | Microdosimetry in the Microwave Range:A Quantitative Assessment at Single Cell Level显示文摘 | Liberti M Apollonio F Merla C | | 0，，： | 1 |
| 7 | Quantitative assessment of dielectric parameters for membrane lipid bi-layers from RF permittiv- ity measurements显示文摘 | Merla C Liberti M Apollonio F | 2009 | Bioelectromagnetics2009，30，4： | 1 |
| 8 | Advanced treatment and disinfection for municipal wastewater reuse in agriculture显示文摘 | Notarnicola M | 1999 | War Sci Tech1999，40，5： | 1 |
| 9 | Air pollution from a large steel factory: polycyclic aromatic hydrocarbon emissions from coke-oven batteries 显示文摘 | Liberti L Notarnicola M Primerano R | 2006 | Journal of Air & Waste Management Association2006，56，3： | 1 |
| 10 | Anticancer activities ofcranberry phytochemicals:an update显示文摘 | Neto C C Amoroso J W Liberty A M | 2008 | Molecular Nutrition andFood Research2008，52，1： | 1 |
| 11 | Estimation of vegetation cover resilience from satellite time series显示文摘 | SIMONIELLO T LANFREDI M LIBERTI M | 2008 | Hydrol Earth Syst Sci2008，12，4： | 1 |
| 12 | Comparision of advanced disinfection methods for municipal wastewater rescue in agriculture显示文摘 | Liberti L Lopez A Notarnicola M | 2000 | Water Science Technol2000，42，12： | 1 |
| 13 | Superficial bladder tumors in patients under 40 years of age: clinical , prognostic and cytogenetic aspects显示文摘 | Iori F De DC Liberti M | 2001 | Urol Int2001，67，3： | 1 |
| 14 | Internal validation of the Amp Fl STR Yfiler amplification kit for use in forensic casework显示文摘 | GROSS A M LIBERTY A A ULLAND M M | 2008 | J Forensic Sci2008，53，1： | 1 |
| 15 | Mercury removal with powdered activated carbon from flue gases at the coriano municipals solid waste incineration plant 显示文摘 | LIBERTI L NOTARNICOLA M AMICARELI V | 1998 | Waste Manage Research1998，16，2： | 1 |
| 16 | Comparison of advanced disinfecting methods for municipal wastewater reuse in agriculture 显示文摘 | Liberti L Lopez A Notamicola M | 2000 | Water Science & Technology2000，42，12： | 1 |
| 17 | (2009) Map- ping badland areas using LANDSAT TM/ETM satellite imagery and morphological data 显示文摘 | Liberti M Simoniello T Carone M T | 2009 | Journal of Geo- morphology2009，106，： | 1 |
| 18 | Rehearsal and organiza- tional processes in children's memory 显示文摘 | Omstein P A Naus M J Liberty C | 1975 | Child Develop- ment1975，46，3： | 1 |
| 19 | Use of local hyperthermia as prophylaxis of fibrosis and modification in penile length following radical retropubic prostatectomy显示文摘 | LIBERTI M VICINI P | 2005 | Int J Hyperthermia2005，21，4： | 1 |
| 20 | Advanced treatment and disinfection for municipal wastewater reuse in agriculture 显示文摘 | L Liberti and M Notartnicola | 1999 | Water Science Technology1999，40，45： | 1 |
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