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| 1 | Assessment of Changes in the Cesarean Scar and Uterus Between One and Two Years after Cesarean Section Using 3D T2w SPACE MRI显示文摘Objective Io evaluate changes in morphology of the cesarean scar and uterus between one and two years after cesarean section using high-resolution,three dimensional T2-weighted sampling perfection with application optimized contrast using diflerent flip angle evolutions Magnetic Resonance Imaging(3DT2w SPACE MRI).Methods This prospective study was performed to investigate morphological changes in the cesarean scars and uterus from one to two years after cesarean section using high-resolution,3D T2w SPACE MRI.The healthy volunteers having no childbearing history were recruited as the controls.All data were measured by two experienced radiologists.All data with normal distribution between the one-year and two-year groups were compared using a paired-sample t test or independent t test.Results Finally,46 women took a pelvic MR examination one year after cesarean section,and a subset of 15 completed the same examination again after two years of cesarean section.Both the uterine length and the anterior wall thickness after two years of cesarean section(5.75±0.46 and 1.45±0.35 cm)were significantly greater than those measured at one year(5.33±0.59 and 1.25±0.27 cm)(t=-2.363 and-2.175,P=0.033 and 0.048).No significant difference was shown in myometrial thickness two years after cesarean section(1.45±0.35 cm)with respect to the control group(1.58±0.21 cm,P=0.170).Nine women who underwent MRI twice were considered to have scar diverticula one year after cesarean section,and still had diverticula two years after cesarean section.The thickness,height,and width of the uterine scar showed no significant change from one to two years(all P>0.05).Conclusions 3D T2w SPACE MRI provides overall morphologic details and shows dynamic changes in the scar and the uterus between one and two years after cesarean section.Scar morphology after cesarean section reached relatively stable one year after cesarean section,and uterine morphology was closer to normal two years after cesarean section. | Yafei Qi Yonglan He Ning Ding Liangkun Ma Tianyi Qian Yuan Li Huadan Xue Zhengyu Jin | 2022 | Chinese Medical Sciences Journal2022，37，2： | 3 |
| 2 | Coculturing Dendritic Cells with Zoledronate Acid Efficiently Enhance the Anti-Tumor Effects of Cytokine-Induced Killer Cells显示文摘 | Xiaosan Su Lei Zhang Liangkun Jin Junsong Ye Zheng Guan Rui Chen | 2010 | Journal of Clinical Immunology2010，，5： | 3 |
| 3 | Prevalence of depression and anxiety symptoms and their influence factors during menopausal transition and postmenopause in Beijing city显示文摘 | Ying Li Qi Yu Liangkun Ma Zhengyi Sun Xia Yang | 2008 | Maturitas2008，，3： | 2 |
| 4 | Prevalence of depression and anxiety symptoms and their influence factors during menopausal transition and postmenopause in Beijing city显示文摘 | Ying Li Qi Yu Liangkun Ma | 2008 | Maturitas2008，61，： | 1 |
| 5 | Prevalence of depression and anxiety symptoms and their influence factors during menopausal transition and postmenopause in Beijing city 显示文摘 | Ying LI Qi YU Liangkun MA | 2008 | Maturitas2008，61，： | 1 |
| 6 | Prevalence of depression and anxiety symptoms and their influence factors during menopausal transition and postmenopause in Beijing city 显示文摘 | Ying Li Qi Yu Liangkun M | 2008 | Maturitas2008，61，3： | 1 |
| 7 | Coculturing Dendritic Cells with Zoledronate Acid Efficiently Enhance the Anti-Tumor Effects of Cytokine-Induced Killer Cells 显示文摘 | Xiaosan Su Lei Zhang Liangkun Jin | 2010 | J Clin Immunol2010，30，5： | 1 |
| 8 | The effects of screening and intervention of subclinical hypothyroidism on pregnancy outcomes : a prospective multicenter single-blind, randomized, controlled study of thyroid function screening test during pregnancy 显示文摘 | MA Liangkun QI Hong CHAI Xiaofeng | 2016 | The Journal of Matemal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine the Federation of Asia and Oceania Perinatal Societies the International Society of Perinatal Obstetricians2016，29，9： | 1 |
| 9 | Prevalence of depression and anxiety symptoms and their influence factors during menopausal transition and postmenopause in Beijing city显示文摘 | Ying Li Qi Yu Liangkun Ma | 2008 | Maturitas2008，61，： | 1 |
| 10 | Prevalence of depression and anxiety symptoms and heir influence factors during menopausal transition and postmenopause in Beijing city显示文摘 | Ying Li Qi Yu Liangkun Ma | 2008 | Maturitas2008，61，： | 1 |
| 11 | Prevalence of depression and anxiety symptoms and their influence factors during menopausal transition and post menopause in Beijing city显示文摘 | Ying Li Qi Yu Liangkun Ma | 2008 | Maturitas2008，61，3： | 1 |
| 12 | Optimal Gestational Weight Gain for Women with Gestational Diabetes Mellitus—China,2011–2021显示文摘Summary What is already known about this topic?Joint effects of gestational weight gain(GWG)and hyperglycemia on adverse pregnancy outcomes suggest that lower optimal GWG is optimal for women with gestational diabetes mellitus(GDM).However,there is still a lack of guidelines.What is added by this report?Optimal weekly GWG range after diagnosis of GDM for underweight,normal-weight,overweight,and obese women was 0.37–0.56 kg/week,0.26–0.48 kg/week,0.19–0.32 kg/week,and 0.12–0.23 kg/week,respectively.What are the implications for public health practice?The findings may be used to inform prenatal counseling regarding optimal gestational weight gain for women with gestational diabetes mellitus,and suggest the need for weight gain management. | Jinlang Lyu Yin Sun Yuelong Ji Nana Liu Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai Ma Na Han Yang Mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Liangkun Ma Haijun Wang | 2023 | China CDC weekly2023，5，9： | 0 |
| 13 | Chiral Lewis Acid-Catalyzed Norrish Type II Cyclization to Synthesizeα-Oxazolidinones via Enantioselective Protonation显示文摘The Norrish type II reaction is an interesting photochemical process through Csp3-H functionalization of N,N-disubstituted oxo-amine or oxo-amide provides access to diverse synthetic building blocks by different pathways.Due to the finite lifetime of the excited state and rapid changes in the intermediates,there are significant challenges in controlling the stereochemical outcomes of this reaction over the strong racemic background reaction.The oxazolidin-4-one skeleton is a useful structural motif found in bioactive molecules,and it is the one that is produced by a not well-studied route among the three routes in Norrish type II cyclization.Herein we report the asymmetric version of this process,and a variety of oxazolidin-4-ones is achieved from arylα-oxoamides via triplet excimers with three H-transfer steps interspersed by a cyclization step under mild,visible light.In the presence of chiral N,N-dioxide/metal complex catalysts,diastereo-and enantiocontrol in this photochemical reaction happens with enantioselective protonation of enol intermediates as the crucial stereo-determining step,getting the better of the thermodynamical control pathway.Trans-oxazolidine-4-ones can be obtained in high enantioselectivity,which can be transferred into optically active cis-oxazolidine-4-ones after the treatment with a base. | Tangyu Zhan Liangkun Yang Qiyou Chen Rui Weng Xiaohua Liu Xiaoming Feng | 2023 | CCS Chemistry2023，5，9： | 0 |
| 14 | Jointly optimizing user clustering,power management,and wireless channel allocation for NOMA-based Internet of Things显示文摘In order to accommodate the large number of Internet of Things(IoT)connections in mobile networks,Non-Orthogonal Multiple Access(NOMA)has been applied as the resource sharing mechanism in mobile access networks to improve the spectrum efficiency.The NOMA-based resource management for uplink communications comprises two problems,i.e.,user clustering and power&wireless channel allocation.User clustering refers to assigning users in terms of IoT devices to different clusters(where users in the same cluster are sharing the wireless channels to upload their data),and power&wireless channel allocation is to optimize the transmission power of the users and the number of wireless channels allocated to the users in a cluster.The two problems are coupled together,thus making it difficult to solve the NOMA-based resource management problem.In this paper,we propose a QoS-aWarE resourcE managemenT(SWEET)for NOMA algorithm to jointly optimize the user clustering,power management,and wireless channel allocation such that the number of wireless channels is minimized and the data rate requirements of the users can be satisfied.The performance of SWEET is validated via extensive simulations. | Xiang Sun Liangkun Yu Yin Yang | 2021 | Digital Communications and Networks2021，7，1： | 0 |
| 15 | Weekly Weight Gain in Women with Gestational Diabetes Mellitus and Neonatal Birth Weight - China, 2011–2021显示文摘What is already known about this topic?Elevated gestational weight gain(GWG)during pregnancy among women diagnosed with gestational diabetes mellitus(GDM)is correlated with an increased instance of large for gestational age(LGA)and macrosomia.However,it remains uncertain whether managing weekly GWG following a GDM diagnosis positively impacts fetal birth weight.What is added by this report?Our study found that GWG following GDM diagnosis correlates positively with the risk of LGA and macrosomia among all body mass index(BMI)subgroups,especially for overweight and obese women.What are the implications for public health practice?The results of this research highlight the importance of enforcing a more stringent regulation on GWG on a weekly basis for overweight and obese women diagnosed with GDM,particularly when considering neonatal growth. | Nana Liu Jinlang Lyu Haijun Wang Yin Sun Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai Ma Na Han Yang Mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Yuelong Ji Liangkun Ma | 2023 | China CDC weekly2023，5，32： | 0 |
| 16 | Integrated bioinformatics analysis reveals correlations of high TRIM59 expression with worse prognosis and immune infiltrates in lung adenocarcinoma显示文摘Objective:Most patients with advanced lung cancer have a poor prognosis.Recent studies have identified TRIM59 as a novel molecule that serves as a prognostic factor for the progression of non-small cell lung cancer.In the present study,we investigated the role of TRIM59 in predicting the prognosis of lung adenocarcinoma(LUAD)as well as the correlation between TRIM59 expression and immune infiltrates.Methods:We analyzed TRIM59 expression in normal and tumor tissues based on RNA-sequencing datasets from The Cancer Genome Atlas and Genotype-Tissue Expression databases.Forty-seven cases of LUAD tissues and their matching adjacent tissues were collected,and TRIM59 expression in tissue samples was demonstrated by immunohistochemistry.All tissue specimens were obtained under the approval of the Medical Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine(approval No.IR2019001101;approved on April 3,2019).The immune cell scores were calculated using the CIBERSORT database.The Tumor Immune Estimation Resource database was used to analyze the correlation between TRIM59 and immune cell activities.Results:TRIM59 was up-regulated in most cancer types.High TRIM59 expression predicted a worse prognosis in patients with LUAD(overall survival,P=0.00096;disease-specific survival,P=0.00056;disease-free interval,P=0.0009;progression-free interval,P=0.0012).Moreover,TRIM59 was highly expressed in patients with LUAD who had a poorer prognosis.TRIM59 also showed a significant correlation with the ESTIMATE score(P=0.04)and stromal score(P=0.005)in patients with LUAD.Notably,a significant correlation between TRIM59 and the tumor mutation burden was found in LUAD but in no other cancer types(P<0.001).Further investigation showed that TRIM59 had a significant correlation with gene markers on neutrophils and dendritic cells.Conclusion:TRIM59 is a potential prognosticator in LUAD and may be correlated with immune cell identification,immune cell infiltration,and immunotherapy checkpoints in LUAD. | Lingge Yang Yuan Wu Liangkun You Binbin Xie Jun Lou Weidong Han Kai Wang | 2022 | Journal of Bio-X Research2022，5，2： | 0 |
| 17 | Thermoelectric characteristics of semiconductor minerals in earth's deep crust and their seismogenic significance显示文摘Geo-electric anomalies are generated during the process of stress accumulation and release associated with earthquakes.However,the mechanism of these anomalies remains equivocal.Based on the analysis of thermoelectric characteristics of semiconductor minerals of the earth’s deep crust such as graphite,ferrosilicon alloy,magnetite etc.,we perform finite element analysis to evaluate the principles governing the thermoelectric power generated by minerals and rocks.The results show that graphite,ferrosilicon alloy and magnetite all exhibit Seebeck effect and can be superimposed.And the thermo-electric field can be enhanced with the activation temperature increases,the content of thermoelectric minerals increases,the size of aggregates increases,and the spacing of thermoelectric minerals grains decreases.Seismogenic processes would generate a similar thermal gradient.The natural semiconductor minerals in this thermal field show a thermoelectric effect,forming a thermoelectric field that interferes with the background electric field.This study indicates that thermoelectric effect may have an important influence on the formation of geoelectric field. | Shuhao Wang Junfeng Shen M.Santosh Yuanyuan Li Cheng-Xue Yang Liangkun Ma | 2022 | Geoscience Frontiers2022，13，2： | 0 |
| 18 | Comparative metagenomic analysis of the vaginal microbiome in healthy women显示文摘The composition of these vaginal microbiome has a significant impact on women’s health.However,few studies have characterized the vaginal microbiome of healthy Chinese women using metagenomic sequencing.Here,we carried out a comparative metagenomic analysis to survey taxonomic,functional levels,and microbial communities’genome content in healthy women’s vaginal microbiome.Overall,we observed a total of 111 species,including all dominant vaginal Lactobacillus species,such as L.iners,L.crispatus,L.gasseri,and L.jensenii.Unlike microbial taxa,several pathways were ubiquitous and prevalent across individuals,including adenosine ribonucleotides de novo biosynthesis and pyruvate fermentation to acetate and lactate Ⅱ.Notably,our diversity analysis confirmed a significant difference in healthy women from different ethnic groups.Moreover,we binned vaginal assemblies into 62 high-quality genomes,including 9 L.iners,7 A.vaginae,5 L.jensenii,and 5 L.crispatus.We identified the pan and core genomes of L.iners and A.vaginae and revealed the genetic diversity.Primary differences between strains were the hypothetical genes and mobile element-like genes.Our results provide a framework for understanding the implications of the female reproductive tract’s composition and functional potential and highlight the importance of genome-resolved metagenomic analysis to further understand the human vaginal microbiome. | Fei Liu Yingshun Zhou Lisi Zhu Zhiyi Wang LiangKun Ma Yuan He Pengcheng Fu | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 0 |
| 19 | Establishment of a Rat Model of Liver Venous Deprivation:Simultaneous Portal and Hepatic Vein Ligation显示文摘Background and Aims:The aim was to establish a liver venous deprivation(LVD)model in rats,compare hepatic hypertrophy between LVD and associated liver partition and portal vein ligation for staged hepatectomy(ALPPS),and explore the underlying mechanisms.Methods:The LVD or extended-LVD(e-LVD)group received portal vein ligation(PVL)combined with hepatic vein ligation(HVL).The ALPPS or eALPPS group received PVL plus parenchyma ligation.Liver regeneration was assessed by measuring the liver weight and performing pathological analysis.Liver functions and the sphingosine kinase 1(SPHK1)/sphingosine-1-phosphate(S1P)/sphingosine-1-phosphate receptor 1(S1PR1)pathway were also investigated.Results:All future liver remnants(FLRs)in the ALPPS,e-ALPPS,LVD,and e-LVD groups exhibited significant hypertrophy compared with the control group.The LVD and e-LVD procedures induced similar liver hypertrophy than that in the corresponding ALPPS groups.Furthermore,the LVD and e-LVD methods led to obvious cytolysis in the venous-deprived lobes as well as a noticeable increase in serum transaminase levels,while no necrosis was observed in the ALPPS and e-ALPPS groups.SPHK1/S1P/S1PR1 pathway were distinctly activated after operation,especially in congestive/ischemic livers.Conclusions:We describe the first rat model of LVD and e-LVD with simultaneously associated HVL and PVL.Compared with the ALPPS technique,the LVD or e-LVD procedure had a comparable overall effect on the hypertrophy response and a stronger effect on liver function.The SPHK1/S1P/S1PR1 pathway was involved in the LVD-or ALPPS-induced liver remodeling. | Yuefeng Zhang Xiaoqin He Peng Ma Liangkun Xiong Wenhui Bai Gaoshuo Zhang Yangtao Xu Wei Song Kaihuan Yu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 0 |
| 20 | High-performance flexible organic field effect transistors with print-based nanowires显示文摘Polymer nanowire(NW)organic field-effect transistors(OFETs)integrated on highly aligned large-area flexible substrates are candidate structures for the development of high-performance flexible electronics.This work presents a universal technique,coaxial focused electrohydrodynamic jet(CFEJ)printing technology,to fabricate highly aligned 90-nm-diameter polymer arrays.This method allows for the preparation of uniformly shaped and precisely positioned nanowires directly on flexible substrates without transfer,thus ensuring their electrical properties.Using indacenodithiophene-co-benzothiadiazole(IDT-BT)and poly(9,9-dioctylfluorene-co-benzothiadiazole)(F8-BT)as example materials,5 cm^(2) arrays were prepared with only minute size variations,which is extremely difficult to do using previously reported methods.According to 2D-GIXRD analysis,the molecules inside the nanowires mainly adopted face-onπ-stacking crystallite arrangements.This is quite different from the mixed arrangement of thin films.Nanowire-based OFETs exhibited a high average hole mobility of 1.1 cm^(2) V^(−1) s^(−1) and good device uniformity,indicating the applicability of CFEJ printing as a potential batch manufacturing and integration process for high-performance,scalable polymer nanowire-based OFET circuits.This technique can be used to fabricate various polymer arrays,enabling the use of organic polymer semiconductors in large-area,high-performance electronic devices and providing a new path for the fabrication of flexible displays and wearable electronics in the future. | Liangkun Lu Dazhi Wang Changchang Pu Yanyan Cao Yikang Li Pengfei Xu Xiangji Chen Chang Liu Shiwen Liang Liujia Suo Yan Cui Zhiyuan Zhao Yunlong Guo Junsheng Liang Yunqi Liu | 2023 | Microsystems & Nanoengineering2023，9，3： | 0 |
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