|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis显示文摘The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available. | Jiuyang Xu Chaolin Huang Guohui Fan Zhibo Liu Lianhan Shang Fei Zhou Yeming Wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang Lixue Huang Xiaoying Gu Hui Li Yi Zhang Yimin Wang Frederick G.Hayden Peter W.Horby Bin Cao Chen Wang | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 2 | Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia显示文摘Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to ICU.Bronchoscopy was performed at bedside within 48 h of ICU admission,and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid.The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy.Sixty-seven patients were included.Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota(R2=0.033;P=0.018),followed by acute kidney injury(AKI;R2=0.032;P=0.011)and plasma MIP-1βlevel(R2=0.027;P=0.044).Random forest identified that the families Prevotellaceae,Moraxellaceae,and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results.Multivariable Cox regression showed that the increase inα-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements.The positive bacteria lab test results,AKI,and plasma MIP-1βlevel were associated with patients’lung microbiota composition on ICU admission.The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements. | Sisi Du Xiaojing Wu Binbin Li Yimin Wang Lianhan Shang Xu Huang Yudi Xia Donghao Yu Naicong Lu Zhibo Liu Chunlei Wang Xinmeng Liu Zhujia Xiong Xiaohui Zou Binghuai Lu Yingmei Liu Qingyuan Zhan Bin Cao | 2022 | Frontiers of Medicine2022，16，3： | 2 |
| 3 | Differentiation of human adipose‐derived stem cells into beating cardiomyocytes显示文摘 | Yu SukChoi Gregory J.Dusting SamanthaStubbs SandeepArunothayaraj Xiao LianHan PhilippeCollas Wayne A.Morrison Rodney J.Dilley | 2010 | Journal of Cellular and Molecular Medicine2010，，4： | 1 |
| 4 | γ-LiAlO_2 Single Crystal Grown by Czochralski Technique and Modified by Vapor Transport Equilibration (VTE) Technique显示文摘大尺寸(2 慢慢推进的 ~ , 50.8 公里) gamma-LiAlO_2 单身者水晶被常规 Czochralski (Cz ) 方法种了,但是水晶有一个似牛奶的、结构上像树的中心。从透明、似牛奶的部分拿的样品被 X 光检查衍射扎根并且检验。Alldiffraction 山峰能在 gamma-LiAlO_2 被索引。水晶质量被 X-rayrocking 曲线描绘。在一半最大值(FWHM ) 完整宽度价值分别地是为透明、似牛奶的部分的 116.9 和 132.0 弧秒。蒸汽运输平衡(VTE ) 技术被介绍修改水晶质量。在 1000 deg C/48 h 以后, 1100 deg C/48 h, 1200 个 deg C/48 hVTE 过程, FWHM 价值落下到 44.2 和 55.2 弧为透明、似牛奶的部分的秒分别地。透明部分的光传播极大地在 190 ~ 的范围从 75% 从似牛奶的部分的 85% to90 百分比,和传播被提高到 80% 1900 nmat 房间温度。当 VTE 温度被提起到 1300 deg C 时,样品裂开了,透明、似牛奶的部分的 FWHMvalues 分别地被增加到 55.2 和 80.9 弧秒。有 VTE 技术的 Bycombining Cz 技术,大尺寸、高质量的 gamma-LiAlO_2 水晶能被获得。 | Jun ZOU Lianhan ZHANG Jun XU Shengming ZHOU | 2006 | Journal of Materials Science & Technology2006，22，4： | 0 |
| 5 | Influence of Nd^(3+) concentration on mid-infrared emission in PbF_(2) crystal co-doped with Ho^(3+) and Nd^(3+) ions显示文摘A promising series of Ho_(y)Nd_(x)Pb_((1-x-y))F_2(x = 0, 0.01, 0.02, 0.03, 0.04;y = 0.02) crystals was grown by the Bridgman method. The influence of the Nd^(3+)ions concentration on mid-infrared(~2.0, ~2.9 and ~3.9 μm)fluorescence emissions of Ho^(3+)ions in the PbF_(2) crystal excited by 808 nm laser diode was investigated in this work. The energy transfer mechanism between Nd^(3+)ions and Ho~(3+)ions under different concentrations of the Nd^(3+)ions was systematically analyzed. The results show that the Nd^(3+)ions have good sensitization and deactivation effect on the Ho^(3+)ions to stimulate the mid-infrared fluorescence emissions. The experimental analysis proves that the sensitization efficiency of the Nd^(3+)ions is relatively stable at around 93.45% with varying Nd^(3+)-doping concentrations. Concentration dependence studies indicate that the concentration of the Nd^(3+)ions has significant influence on mid-infrared emissions.When the doping concentration of the Nd^(3+)ions is up to 2.0 at%, the intensity of ~2.0, ~2.9 and ~3.9 μm emissions all reach the maximum. The output characteristics of a 3.9 μm laser are simulated, and it is found that with the increase of the Nd^(3+)-doping concentration, the peak power, pulse width, and peak energy all meet the trend of first increasing and then decreasing, and Ho_(0.02)Nd_(0.02)Pb_(0.96)F_(2) crystal displays the best performance. All the results show that the Nd^(3+)/Ho^(3+)co-doped PbF_(2) crystals might act as a useful optical medium for mid-infrared laser applications. | Yan Chen Juncheng Tan Peixiong Zhang Weibi Zheng Lin Li Lianhan Zhang Zhen Li Yin Hang Zhenqiang Chen | 2024 | Journal of Rare Earths2024，42，3： | 0 |
| 6 | Comparison of energy structure and spectral properties of Ce:LaAlO_3 and Ce:Lu_2(SiO_4)O显示文摘Undoped LaAlO3 and 1 at.%Ce:LaAlO3 single crystals were grown by the Czochralski process.Absorption and fluorescence spectra were measured at room temperature.Detailed energy levels structure of Ce:LaAlO3 was determined.In this paper,two viewpoints were provided.The first one is:the energy levels structure of Ce:LaAlO3 is very similar to that of Ce:Lu2(SiO4)O which is a well-known scintillator.In the energy levels structure of Ce:LaAlO3 and Ce:Lu2(SiO4)O,the lowest 5d energy level of Ce 3+ is located below the bottom of the conduction band of host crystal and the other higher 5d energy levels of Ce 3+ are located above the bottom of the conduction band of host crystal.The second one is:Ce:LaAlO3 single crystal may not be suitable for scintillation application;by comparing the energy levels structures of Ce:LaAlO3 and Ce:Lu2(SiO4)O,the large energy difference(1.13 eV)between the two lowest 5d energy levels of Ce 3+ in LaAlO3 is a crucial factor that causes the luminescence quenching. | WANG XiaoDan 1 ,PAN Tao 1 ,ZANG TaoCheng 1 ,LI JianKang 1 ,ZHAO ZhiWei 2 ,ZHANG LianHan 2 &XU Jun3 1Department of Applied Physics,University of Science and Technology of Suzhou,Suzhou 215009,China 2Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China 3Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 201800,China | 2009 | Science China(Technological Sciences)2009，52，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员