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| 1 | Comparison of loading with maintenance dose of clopidogrel on platelet reactivity in Chinese with different CYP2C19 genotypes prior to percutaneous coronary intervention显示文摘 | Zhang Xiaoxing Yan Lirong Wang Dongxue Li Yan Han Lulu Tian Lei Liu Hong Li Yishi | 2014 | Chinese Medical Journal2014，，14： | 6 |
| 2 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 3 | Governing the Inclination Angle of Graphite Flakes in the Graphite Flake/Al Composites by Controlling the Al Particle Size via Flake Powder Metallurgy显示文摘The inclination angle of the flake particle has a significant impact on the in-plane thermal conductivity of composites.The graphite flake/Al composites(50 vol%)with different inclination angles were fabricated via flake powder metallurgy,and the results show that with increasing the size of Al particle from 25.6 to 50.7μm,the inclination angle of graphite flake decreases from 7.3°to 4.4°,while the in-plane thermal conductivity of composites increases from 473 to 555 Wm-1 K-1.Based on the rules of mixture,an effective model was established to qualify and quantify the relation between the inclination angle and the in-plane thermal conductivity of the corresponding composites.This model can also be applied to other flake particle-reinforced composites. | Dong Li Chaoyu Wang Yishi Su Di Zhang Qiubao Ouyang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 3 |
| 4 | Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2-p65 pathway显示文摘Exposure to particulate matter 2.5(PM2.5)potentially triggers airway inflammation by activating nuclear factor-κB(NF-κB).Sirtuin 2(SIRT2)is a key modulator in inflammation.However,the function and specific mechanisms of SIRT2 in PM2.5-induced airway inflammation are largely understudied.Therefore,this work investigated the mechanisms of SIRT2 in regulating the phosphorylation and acetylation of p65 influenced by PM2.5-induced airway inflammation and bronchial hyperresponsiveness.Results revealed that PM2.5 exposure lowered the expression and activity of SIRT2 in bronchial tissues.Subsequently,SIRT2 impairment promoted the phosphorylation and acetylation of p65 and activated the NF-κB signaling pathway.The activation of p65 triggered airway inflammation,increment of mucus secretion by goblet cells,and acceleration of tracheal stenosis.Meanwhile,p65 phosphorylation and acetylation,airway inflammation,and bronchial hyperresponsiveness were deteriorated in SIRT2 knockout mice exposed to PM2.5.Triptolide(a specific p65 inhibitor)reversed p65 activation and ameliorated PM2.5-induced airway inflammation and bronchial hyperresponsiveness.Our findings provide novel insights into the molecular mechanisms underlying the toxicity of PM2.5 exposure.Triptolide inhibition of p65 phosphorylation and acetylation could be an effective therapeutic approach in averting PM2.5-induced airway inflammation and bronchial hyperresponsiveness. | Manling Liu Zhaoling Shi Yue Yin Yishi Wang Nan Mu Chen Li Heng Ma Qiong Wang | 2021 | Frontiers of Medicine2021，15，5： | 2 |
| 5 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 6 | Strong and ductile particulate reinforced ultrafine-grained metallic composites fabricated by flake powder metallurgy显示文摘 | Xizhou Kai Zhiqiang Li Genlian Fan Qiang Guo Zhanqiu Tan Wenlong Zhang Yishi Su Weijie Lu Won-Jin Moon Di Zhang | 2012 | Scripta Materialia2012，，： | 1 |
| 7 | Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities显示文摘Clinical cases have reported pulmonary arterial structural and functional abnormalities in patients with Kawasaki disease(KD);however,the underlying mechanisms are unclear.In this study,a KD rat model was established via the intraperitoneal injection of Lactobacillus casei cell wall extract(LCWE).The results showed that pulmonary arterial functional and structural abnormalities were observed in KD rats.Furthermore,proliferative endoplasmic reticulum stress(ER stress)was observed in the pulmonary arteries of KD rats.Notably,the level of lipocalin-2(Lcn 2),a trigger factor of inflammation,was remarkably elevated in the plasma and lung tissues of KD rats;increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils(PMNs).Correspondingly,in cultured pulmonary artery smooth muscle cells(PASMCs),Lcn 2 markedly augmented the cleavage and nuclear localization of activating transcription factor-6(ATF6),upregulated the transcription of glucose regulated protein 78(GRP78)and neurite outgrowth inhibitor(NOGO),and promoted PASMCs proliferation.However,proapoptotic C/EBP homologous protein(CHOP)and caspase 12 levels were not elevated.Treatment with 4-phenyl butyric acid(4-PBA,a specific inhibitor of ER stress)inhibited PASMCs proliferation induced by Lcn 2 and attenuated pulmonary arterial abnormalities and right ventricular hypertrophy and reduced right ventricular systolic pressure in KD rats.In conclusion,Lcn 2 remarkably facilitates proliferative ER stress in PASMCs,which probably accounts for KD-related pulmonary arterial abnormalities. | Zhaoling Shi Yue Yin Chen Li Hui Ding Nan Mu Yishi Wang Shanshan Jin Heng Ma Manling Liu Jie Zhou | 2021 | Science China(Life Sciences)2021，64，6： | 1 |
| 8 | Optical image encryption via ptychography 显示文摘 | SHI Yishi LI Tuo WANG Yali | 2013 | Optics Letters(S0146-9592)2013，38，9： | 1 |
| 9 | General Decomposition of Spin Connection and Topological Structurein Gauss-Bonnet-Chern Theorem显示文摘 | Li Xiguo and Duan Yishi(Institute of Theoretical Physics Lanzhou University.) | 1994 | Annual Report of Institute of Modern Physicsthe Chinese Academy of Sciences & National Laboratory of Heavy Ion AcceleratorLanZhou1994，，00： | 1 |
| 10 | Exact solitary wave solutions to nonlinear wave equations显示文摘 | Zhang Guixu Li Zhibin Duan Yishi | 2000 | Science in China(A)2000，30，12： | 1 |
| 11 | 17.1%-Efficiency organic photovoltaic cell enabled with two higher-LUMO-level acceptor guests as the quaternary strategy显示文摘Quaternary blended organic solar cells utilize four blended material components(one donor plus three acceptors, two donors and two acceptors, or three donors plus one acceptor) as the active layer materials. The use of four material components allows us to have more material selections and more mechanism choices to improve the photon-to-electron conversion efficiency. In this contribution, we present a new case of quaternary material system, that shows 17.1% efficiency obtained by adding IDIC and PC71BM as the guest acceptors of the host binary of PM6:Y6. The lowest unoccupied molecular orbital(LUMO) levels of IDIC and PC71BM are both higher than that of Y6, which is one reason to obtain increased open-circuit voltage(Voc) in the quaternary device. Upon introduction of IDIC and PC71BM as the acceptor guests, the hole and electron mobilities are both increased, which contributes to the increased short-circuit current-density(Jsc). Effects of the weight ratios of the three acceptor components are investigated, which demonstrates that the increased hole and electron mobilities, the accelerated hole-transfer, and the reduced monomolecular recombination are the factors contributing to the increased Jscand fill-factor. This case of quaternary device demonstrates the applicability of the quaternary strategy in increasing the device functions and hence the efficiencies in the field of organic photovoltaic cells. | Kun Li Yishi Wu Xuemei Li Hongbing Fu Chuanlang Zhan | 2020 | Science China Chemistry2020，63，4： | 1 |
| 12 | Knotted Wave Dislocation with Hopf Invariant显示文摘 | Zhang Pengming Li Xiguo Wu Shaofeng Duan Yishi | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 13 | Spatial light modulation for femtosecond laser manufacturing:Current developments and challenges显示文摘Since the invention of lasers,spatial-light-modulated laser processing has become a powerful tool for various applications.It enables multidimensional and dynamic modulation of the laser beam,which significantly improves the processing efficiency,accuracy,and flexibility,and presents wider prospects over traditional mechanical technologies for machining three-dimensional,hard,brittle,or transparent materials.In this review,we introduce:(1)The role of spatial light modulation technology in the development of femtosecond laser manufacturing;(2)the structured light generated by spatial light modulation and its generation methods;and(3)representative applications of spatial-light-modulated femtosecond laser manufacturing,including aberration correction,parallel processing,focal field engineering,and polarization control.Finally,we summarize the present challenges in the field and possible future research. | ZANG Xue LIU ZiTing XU YiShi WANG Yi WANG Qing LI ZhenZe WANG Lei | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 14 | Effects of different aggregation forms of LHC Ⅱ from Bryopsis corticulans on the excited state properties of Chl a显示文摘Steady-state and time-resolved fluo- rescence spectroscopies have been used to study the excited state properties of Chl a in different ag- gregation forms of light-harvesting complex II (LHC II) from an intertidal green alga, Bryopsis corticulans, i.e. LHC II monomer, trimer and oligomer. When either Chl a or Chl b was selectively excited, the observed decrease in Chl a fluorescence in the oligomer is proved to be caused mainly by the fast fluorescence quenching among Chl a molecules, rather than by the decrease in Chl b-to-Chl a singlet excitation transfer efficiency. Analyses of the picosecond time-resolved fluorescence kinetics identified two exponential de- cay components in all of the three forms of LHC II: a longer-lived component (4.1―4.7 ns) originating from fluorescence emission of Chl a, and a shorter-lived one (135―540 ps) from the rapid equilibration of singlet excitation among Chl a molecules. The time constant of excitation equilibration is 135 ps in oli- gomer, 520 ps in trimer and 540 ps in monomer. These results imply that LHC II in oligomer form is inherently able to quench Chl a excitation, a mecha- nism which may be related to the photoprotection of PS II via changing the degree of LHC II aggregation in Bryopsis corticulans. | ZUO Ping CHEN Hui WU Yishi SHEN Shihua WANG Peng AI Xicheng ZHANG Jianping LI Liangbi KUANG Tingyun | 2006 | Chinese Science Bulletin2006，51，12： | 0 |
| 15 | Framework of service standard system for the seismological sector and object of the standardization显示文摘China is one of the countries suffering from the most severe earthquake disasters. The death toll from earthquakes in China is estimated to be 600,000, accounting for 1/3 of the global number. Twenty-three provincial capitals in China and two thirds of its big cities, each with a population over one million, are located at high risk areas with seismic intensity over Ⅶ degrees. The two violent earthquakes in the world during the 20th century, which both caused a death toll of over 200,000 and occurred in China. Therefore, as viewed from earthquake disaster mitigation, the seismological sector holds an important position in safeguarding national security, boosting national economic growth and protecting the life and property of people. | Feng Yijun Li Yishi | 2005 | China Standardization2005，50，5： | 0 |
| 16 | On strong structural controllability and observability of linear time-varying systems: a constructive method显示文摘In this paper, we consider the controllability and observability of generalized linear time-varying(LTV) systems whose coefficients are not exactly known. All that is known about these systems is the placement of non-zero entries in their coefficient matrices(A, B). We provide the characterizations in order to judge whether the placements can guarantee the controllability/observability of such LTV systems, regardless of the exact value of each non-zero coefficient. We also present a direct and efficient algorithm with an associated time cost of O (n+m+ν) to verify the conditions of our characterizations, where n and m denote the number of columns of A and B, respectively, and ν is number of non-zero entries in(A, B). | Shaoyuan LI Jianbin MU Yishi WANG | 2019 | Science China(Information Sciences)2019，62，1： | 0 |
| 17 | General Decomposition of Spin Connection and Topological Structurein Gauss-Bonnet-Chern Theorem显示文摘General Decomposition of Spin Connection and Topological Structurein Gauss-Bonnet-Chern Theorem￥LiXiguoandDuanYishi(Institute... | Li Xiguo Duan Yishi | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 18 | From Topological Structure in Gauss-Bonnet-Chern Theorem to Morse Theory显示文摘From Topological Structure in Gauss-Bonnet-Chern Theorem to Morse Theory￥LiXiguoandDuanYishi(IntituteofTheoreticalPhysics,Lan... | Li Xiguo and Duan Yishi(Intitute of Theoretical Physics,Lanzhou University.) | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 19 | Effectiveness and safety of red yeast rice predominated by monacolin Kβ-hydroxy acid form for hyperlipidemia treatment and management显示文摘OBJECTIVE:To assess the lipid-lowering activity and safety of a dietary supplement containing monacolin Kβ-hydroxy acid form(MKA),Heye(Folium Nelumbinis),and Cangzhu(Rhizoma Atractylodis Lanceae),compared to lifestyle modifications.METHODS:Totally 117 subjects with moderate to severe dyslipidemia(according to Chinese guidelines)and low CV risk were randomly assigned into three treatment groups:lifestyle modification(LM),LM plus a low dosage of MKA,LM plus a high dosage of MKA,and treated for 60 d.The primary endpoint was the reduction of low density lipoprotein cholesterol(LDL-C)and total cholesterol(TC).Safeties along with Traditional Chinese Medicine Syndromes were assessed through the study.RESULTS:A low dosage of MKA along with lifestyle modifications caused a significant decrease in LDL-C by 15.6%on average(95%CI,9.6%to 21%)with,a decrease in TC by 15.3%on average(95%CI,9.26%to 21.4%),and a decrease in non-HDL-C by 35.4%(95%CI,25.76%to 41.34%).Weak evidence of a reduction of triglycerides but an increment of HDL-C was observed in patients with severe hyperlipidemia.No severe adverse events occurred during the study.CONCLUSION:Our results confirm the LDL-C and TC lowering properties of MKA is clinically meaningful.It also produces a significant reduction of non-HDL-C,and slightly effects on TG and HDL-C as well. | CHEN Benjian HUANG Xiaodan PENG Huiting LI Yishi CAO Yongtao WU Huanlin XU Danping | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 0 |
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