|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Simulation of hydraulic fracture utilizing numerical manifold method显示文摘A 2nd order numerical manifold method(NMM) based method is developed to simulate the hydraulic fractures propagating process in rock or concrete. The proposed method uses a weak coupling technique to analyze the fluid phase and solid phase. To study the seepage behavior of the fluid phase, all the fractures in solid are identified by a block cutting algorithm and form a flow network. Then the hydraulic heads at crack ends are solved. To study the deformation and destruction of solid phase, the 2-order NMM and sub-region boundary element method are combined to solve the stress-strain field. Crack growth is controlled by the well-accepted criterion, including the tension criterion or Mohr-Coulomb criterion for the initialization of cracks and the maximum circumferential stress theory for crack propagation. Once the crack growth occurs, the seepage and deformation analysis will be resolved in the next simulation step. Such weak coupling analysis will continue until the structure becomes stable or is destructed. Five examples are used to verify the new method. The results demonstrate that the method can solve the SIFs at crack tip and fluid flow in crack network precisely, and the method is effective in simulating the hydraulic facture problem. Besides, the NMM shows great convenience and is of high accuracy in simulating the crack growth problem. | ZHANG GuoXin LI Xu LI HaiFeng | 2015 | Science China(Technological Sciences)2015，58，9： | 15 |
| 2 | Prognostic factors of primary gastrointestinal stromal tumors: a cohort study based on high-volume centers显示文摘Objective: We aimed to evaluate the clinicopathologic characteristics, immunohistochemical expression and prognostic factors of patients with primary gastrointestinal stromal tumors(GISTs).Methods: Data from 2,570 consecutive GIST patients from four medical centers in China(January2001–December 2015) were reviewed. Survival curves were constructed by the Kaplan-Meier method, and Cox regression models were used to identify independent prognostic factors.Results: Of the included patients, 1,375(53.5%) were male, and the patient age range was 18 to 95(median, 58)years. The tumors were mostly found in the stomach(64.5%), small intestine(25.1%) and colorectal region(5.1%).At the time of diagnosis, the median tumor size was 4.0(range: 0.1–55.0) cm, and the median mitotic index per 50 high power fields(HPFs) was 3(range: 0–254). Of the 2,168 resected patients, 2,009(92.7%) received curative resection. According to the modified National Institutes of Health(NIH) classification, 21.9%, 28.9%, 14.1% and35.1% were very low-, low-, intermediate-and high-risk tumors, respectively. The rate of positivity was 96.4% for c-Kit, 87.1% for CD34, 96.9% for delay of germination 1(DOG-1), 8.0% for S-100, 31.0% for smooth muscle actin(SMA) and 5.1% for desmin. However, the prognostic value of each was limited. Multivariate analysis showed that age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors. Furthermore, we found that high-risk patients benefited significantly from postoperative imatinib(P<0.001), whereas intermediate-risk patients did not(P=0.954).Conclusions: Age, tumor size, mitotic index, tumor site, occurrence of curative resection and postoperative imatinib were independent prognostic factors in patients with GISTs. Moreover, determining whether intermediate-risk patients can benefit from adjuvant imatinib would be of considerable interest in future studies. | Xuechao Liu Haibo Qiu Peng Zhang Xingyu Feng Tao Chen Yong Li Kaixiong Tao Guoxin Li Xiaowei Sun Zhiwei Zhou | 2018 | Chinese Journal of Cancer Research2018，30，1： | 14 |
| 3 | A review on tribology of polymer composite coatings显示文摘Self-lubricating polymer composite coatings,with tailorable tribological and mechanical properties,have been widely employed on mechanical parts to reduce friction and wear,which saves energy and improves the overall performance for applications such as aerospace satellite parts,shafts,gears,and bushings.The addition of functional fillers can overcome the limitations of single-polymer coatings and extend the service life of the coatings by providing a combination of low friction,high wear resistance,high load bearing,high temperature resistance,and high adhesion.This paper compares the heat resistance,and the tribological and mechanical properties of common polymer matrices,as well as the categories of functional fillers that improve the coating performance.Applicable scopes,process parameters,advantages,and limitations of the preparation methods of polymer coatings are discussed in detail.The tribological properties of the composite coatings with different matrices and fillers are compared,and the lubrication mechanisms are analyzed.Fillers reduce friction by promoting the formation of transfer films or liquid shear films.Improvement of the mechanical properties of the composite coatings with fillers of different morphologies is described in terms of strengthening and toughening mechanisms,including a stress transfer mechanism,shear yielding,crack bridging,and interfacial debonding.The test and enhancement methods for the adhesion properties between the coating and substrate are discussed.The coating adhesion can be enhanced through mechanical treatment,chemical treatment,and energy treatment of the substrate.Finally,we propose the design strategies for high-performance polymer composite coating systems adapted to specific operating conditions,and the limitations of current polymer composite coating research are identified. | Yilong REN Lin ZHANG Guoxin XIE Zhanbo LI Hao CHEN Hanjun GONG Wenhu XU Dan GUO Jianbin LUO | 2021 | Friction2021，9，3： | 13 |
| 4 | Rolling texture and its effect on tensile property of a near-α titanium alloy Ti60 plate显示文摘Rolling texture and its effect on tensile properties of Ti60 alloy plates were investigated in the present study. The plates were β-rolled at 1070℃ and(α+β)-rolled at 980℃, using uni-directionally rolling(UDR) and cross-directionally rolling(CDR) processes, respectively.β-rolled plates exhibited weak textures, which were attributed to the dispersive orientations of secondary α during the β→α phase transformation. Strong deformation textures formed in(α+β)-rolled plates as a result of slipping mechanisms: the strong T-type texture in UDR plate was related to {10 1 0}[11 2 0] slipping, while the B-type texture in CDR plate was relevant with {0001}[11 2 0] slip. Strong T-type textures led to anisotropic tensile properties. B-type textures would decrease such an anisotropy. The(α+β)-CDR process was found to be a candidate process for reducing anisotropy of Ti60 alloy plates. | Wenyuan Li Zhiyong Chen Jianrong Liu Shaoxiang Zhu Guoxin Sui Qingjiang Wang | 2019 | Journal of Materials Science & Technology2019，35，5： | 11 |
| 5 | Clp Protease and OR Directly Control the Proteostasis of Phytoene Synthase, the Crucial Enzyme for Carotenoid Biosynthesis in Arabidopsis显示文摘Phytoene synthase (PSY ) 是在类胡萝卜素 biosynthetic 小径的关键 plastidial 酶。然而,它的 translational 以后规定留下逃犯。同样, Clp 朊酶组成质体朊酶网络的中央部分,但是它为降级的底层不是众所周知的。在这研究,我们报导 PSY 是 Clp 朊酶的底层。PSY 被揭开身体上与各种各样的 Clp 朊酶子单元交往(即, ClpS1, ClpC1,和 ClpD ) 。在 clpc1, clpp4,和 clpr1-2 异种的 PSY 和几另外的 carotenogenic 酶蛋白质 overaccumulate 高级。overaccumulated PSY 被发现部分酶地活跃。在 clpc1 的 Clp 活动的缺陷导致 PSY 蛋白质周转的减少的率,进一步在降级的 PSY 支持 Clp 朊酶的角色蛋白质。在另一方面, ORANGE (或) 蛋白质,有 holdase 女伴活动的 PSY 的一个主要 translational 以后管理者,提高 PSY 蛋白质稳定性并且在 clpc1 增加 PSY 的酶地活跃的比例, counterbalancing 在维持 PSY 蛋白质动态平衡的调停 Clp 的解朊作用。一起,这些调查结果提供新奇卓见进质体局部性的蛋白质的质量控制并且建立迄今未辩别出的 translational 以后在在植物的 modulating 类胡萝卜素生合成的 carotenogenic 酶的规章的机制。 | Ralf Welsch Xiangjun Zhou Hui Yuan Daniel Alvarez Tianhu Sun Dennis Schlossarek Yong Yang Guoxin Shen Hong Zhang Manuel Rodriguez-Concepcion Theodore W. Thannhauser Li Li | 2018 | Molecular Plant2018，11，1： | 10 |
| 6 | Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy显示文摘Objective:The proximal margin(PM)distance for distal gastrectomy(DG)of gastric cancer(GC)remains controversial.This study investigated the prognostic value of PM distance for survival outcomes,and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction nomogram.Methods:Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery,Nanfang Hospital,Southern Medical University were included.The first endpoints of the prognostic value of PM distance(assessed in 0.5 cm increments)for disease-free survival(DFS)and overall survival(OS)were assessed.Multivariate analysis by Cox proportional hazards regression was performed using the training set,and the nomogram was constructed,patients were chronologically assigned to the training set for dates from June 1,2004 to January 30,2012(n=493)and to the validation set from February 1,2012 to June 30,2014(n=211).Results:Among 704 patients with p TNM stage I,p TNM stage II,T1-2,T3-4,N0,differentiated type,tumor size≤5.0 cm,a PM of(2.1-5.0)cm vs.PM≤2.0 cm showed a statistically significant difference in DFS and OS,while a PM>5.0 cm was not associated with any further improvement in DFS and OS vs.a PM of 2.1-5.0 cm.In patients with p TNM stage III,N1,N2-3,undifferentiated type,tumor size>5.0 cm,the PM distance was not significantly correlated with DFS and OS between patients with a PM of(2.1-5.0)cm and a PM≤2 cm,or between patients with a PM>5.0 cm and a PM of(2.1-5.0)cm,so there were no significant differences across the three PM groups.In the training set,the C-indexes of DFS and OS,were 0.721 and 0.735,respectively,and in the validation set,the C-indexes of DFS and OS,were 0.752 and 0.751,respectively.Conclusions:It is necessary to obtain not less than 2.0 cm of PM distance in early-stage disease,while PM distance was not associated with long-term survival in later and more aggressive stages of disease because more advanced GC is a systemic disease.Different types of patients should be considered for removal of an individualized PM distance intra-operatively.We developed a universally applicable prediction model for accurately determining the 1-year,3-year and 5-year DFS and OS of GC patients according to their preoperative clinicopathologic characteristics and PM distance. | Jun Luo Yuming Jiang Xinhua Chen Yuehong Chen Jhang Lopsang Gurung Tingyu Mou Liying Zhao Guoqing Lyu Tuanjie Li Guoxin Li Jiang Yu | 2020 | Chinese Journal of Cancer Research2020，32，2： | 8 |
| 7 | Growth and characterization of 0.8-μm gate length AlGaN/GaN HEMTs on sapphire substrates显示文摘AlGaN/GaN high electron mobility transistor (HEMT) structures were grown on 2 inch sapphire substrates by MOCVD, and 0.8-μm gate length devices were fabricated and measured. It is shown by resistance mapping that the HEMT structures have an average sheet resistance of approximately 380 ?/sq with a uniformity of more than 96%. The 1-mm gate width devices using the materials yielded a pulsed drain current of 784 mA/mm at Vgs=0.5 V and Vds=7 V with an extrinsic transconductance of 200 mS/mm. A 20-GHz unity current gain cutoff frequency (?T ) and a 28-GHz maximum oscillation frequency (?max) were obtained. The device with a 0.6-mm gate width yielded a total output power of 2.0 W/mm (power density of 3.33 W/mm) with 41% power added efficiency (PAE) at 4 GHz. | WANG Xiaoliang WANG Cuimei HU Guoxin WANG Junxi RAN Junxue FANG Cebao LI Jianping ZENG Yiping LI Jinmin LIU Xinyu LIU Jian QIAN He | 2005 | Science in China(Series F)2005，48，6： | 7 |
| 8 | Corrosion mechanism of micro-arc oxidation treated biocompatible AZ31 magnesium alloy in simulated body fluid显示文摘The rapid degradation of magnesium(Mg) based alloys has prevented their further use in orthopedic trauma fixation and vascular intervention,and therefore it is essential to investigate the corrosion mechanism for improving the corrosion resistance of these alloys. In this work, the effect of applied voltage on the surface morphology and the corrosion behavior of micro-arc oxidation(MAO) with different voltages were carried out to obtain biocompatible ceramic coatings on AZ31 Mg alloy. The effects of applied voltage on the surface morphology and the corrosion behavior of MAO samples in the simulated body fluid(SBF) were studied systematically. Scanning electron microscope(SEM) and X-ray diffractometer(XRD)were employed to characterize the morphologies and phase compositions of coating before and after corrosion. The results showed that corrosion resistance of the MAO coating obtained at 250 V was better than the others in SBF. The dense layer of MAO coating and the corrosion precipitation were the key factors for corrosion behavior. The corrosion of precipitation Mg(OH)2and the calcium phosphate(Ca–P) minerals on the surface of MAO coatings could enhance their corrosion resistance effectively. In addition, the mechanism of MAO coated Mg alloys was proposed. | Ying Li Fang Lu Honglong Li Wenjun Zhu Haobo Pan Guoxin Tan Yonghua Lao Chengyun Ning Guoxin Ni | 2014 | Progress in Natural Science:Materials International2014，24，5： | 7 |
| 9 | Promoting Bone Mesenchymal Stem Cells and Inhibiting Bacterial Adhesion of Acid-Etched Nanostructured Titanium by Ultraviolet Functionalization显示文摘Titanium(Ti) and its alloys are used extensively in orthopedic implants because of their excellent biocompatibility,mechanical properties and corrosion resistance. However,titanium-based implant materials face many severe complications,such as implant loosening due to poor osseointegration and bacterial infections,which may lead to implant failure. Hence,preparing a biomaterial surface,which enhances the interactions with host cells and inhibits bacterial adhesion,may be an optimal strategy to reduce the incidence of implant failure. This study aims to improve osseointegration and confer antibacterial properties on Ti through a combination of two surface modifications including nanostructuring generated by acid etching and ultraviolet(UV) light treatment.Our results showed that without UV treatment,the acid etching treatment of Ti surface was effective at both improving the adhesion of bone mesenchymal stem cells(BMSCs) and increasing bacterial adhesion. A further UV treatment of the acid-etched surface however,not only significantly improved the cell adhesion but also inhibited bacterial adhesion. The acid-etched nanostructured titanium with UV treatment also showed a significant enhancement on cell proliferation,alkaline phosphatase(ALP) activity and mineralization. These results suggest that such nanostructured materials with UV treatment can be expected to have a good potential in orthopedic applications. | Guobo Lan Mei Li Ying Tan Lihua Li Xiaoming Yang Limin Ma Qingshui Yin Hong Xia Yu Zhang Guoxin Tan Chengyun Ning | 2015 | Journal of Materials Science & Technology2015，31，2： | 7 |
| 10 | Implications of clinical research on adjuvant chemotherapy for gastric cancer: Where to go next?显示文摘Postoperative adjuvant chemotherapy(ACT)confers superior gastric cancer(GC)survival in the Eastern cohort.However,is the current standard of ACT already excessive,or is it still necessary to increase its intensity for specific subgroups?Tailored ACT strategies for GC depend on gradual exploration by clinical trials in selected patients.Thus,understanding the implications of previous and current research can help us respond wisely and design effective,rational trials,save medical resources and make better decisions in clinical practice.After reviewing and analyzing studies on ACT for GC patients undergoing curative resection,we found that research strategies for conducting'addition''ACT for specific stages of the disease have achieved great progress in making ACT more tailored and personalized in consideration of pathology stages.Furthermore,trials indicate that'addition'ACT strategies for GC patient subgroups based on histological characteristics might be helpful to move toward a more specific tailored and personalized management approach.Designing ACT research focused on different node statuses should also be conducted according to the biological specificity of lymph node(LN)metastasis.Therefore,future trials designed to determine tailored treatment based on histological and biological characteristics for specific subgroups are urgently needed and conducted as the theme of the 2019 American Society of Clinical Oncology(ASCO):Caring for Every Patient,Learning from Every Patient. | Xinhua Chen Hao Liu Guoxin Li Jiang Yu | 2019 | Chinese Journal of Cancer Research2019，31，6： | 6 |
| 11 | Laparoscopic distal gastrectomy with D2 dissection for advanced gastric cancer显示文摘The successful application of the laparoscopic distal gastrectomy with D2 dissection for gastric cancer requires adequate understanding of the anatomic characteristics of peripancreatic and intrathecal spaces, the role of pancreas and vascular bifurcation as the surgical landmarks, as well as the variations of gastric vascular anatomy. The standardized surgical procedures based on distribution of regional lymph node should be clarified. | Jiang Yu Yanfeng Hu Tao Chen Tingyu Mou Xia Cheng Guoxin Li | 2013 | Chinese Journal of Cancer Research2013，25，4： | 6 |
| 12 | Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation显示文摘Host interferon-stimulated gene 20(ISG20)exerts antiviral effects on viruses by degrading viral RNA or by enhancing IFN signaling.Here,we examined the role of ISG20 during pseudorabies virus(PRV)proliferation.We found that ISG20 modulates PRV replication by enhancing IFN signaling.Further,ISG20 expression was upregulated following PRV infection and poly(I:C)treatment.Ectopic expression of ISG20 inhibited PRV proliferation in PK15 cells,whereas knockdown of ISG20 promoted PRV proliferation.In addition,ISG20 expression upregulated IFN-βexpression and enhanced IFN downstream signaling during PRV infection.Notably,PRV UL24 suppressed the transcription of ISG20,thus antagonizing its antiviral effect.Further domain mapping analysis showed that the N terminus(amino acids 1-90)of UL24 was responsible for the inhibition of ISG20 transcription.Collectively,these findings characterize the role of ISG20 in suppressing PRV replication and increase the understanding of host-PRV interplay. | Xiaoyong Chen Dage Sun Sujie Dong Huanjie Zhai Ning Kong Hao Zheng Wu Tong Guoxin Li Tongling Shan Guangzhi Tong | 2021 | Virologica Sinica2021，36，5： | 4 |
| 13 | Highly Stable Molecular Borromean Rings显示文摘 | Ye Lu Yuejian Lin Zhenhua Li Guoxin Jin | 2018 | Chinese Journal of Chemistry2018，36，2： | 4 |
| 14 | Damages on the lubricated surfaces in bearings under the influence of weak electrical currents显示文摘A special bearing tester was constructed to investigate the damage behavior on the lubricated surfaces in bearings with the passage of weak electrical currents as low as^1 mA.The results showed that when polar glycerine was used as the lubricant,many narrow and deep pits formed on the lubricated surfaces.In contrast,when the experimental conditions under the lubrication of the nonpolar paraffin oil were close to those under the lubrication of polar glycerine oil,damages on the lubricated surfaces were unobvious.Emergence of microbubbles in polar lubricants with the passage of electrical currents was proposed to be responsible for the observed damages on the lubricated surfaces. | XIE GuoXin LUO JianBin GUO Dan LIU ShuHai LI Gang | 2013 | Science China(Technological Sciences)2013，56，12： | 4 |
| 15 | A novel intronic circular RNA,circGNG7,inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82显示文摘Background:There is increasing evidence that circular RNAs(circRNAs)play a significant role in pathological processes including tumorigenesis.In contrast to exonic circRNAs,which are the most frequently reported circRNAs in cancer so far,the studies of intronic circRNAs have been greatly lagged behind.Here,we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma(HNSCC).Methods:We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC patients.Then,we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC patients.We also identified interactions between circGNG7 and functional proteins,which alter downstream signaling that regulate HNSCC progression.Results:In this study,we identified a new intronic circRNA,circGNG7,and validated its functional roles in HNSCC progression.CircGNG7 was predominately localized to the cytoplasm,and its expression was downregulated in both HNSCC tissues andCAL27,CAL33,SCC4,SCC9,HN6,and HN30 cells.Low expression of circGNG7 was significantly correlated with poor prognosis in HNSCC patients.Consistent with this finding,overexpression of circGNG7 strongly inhibited tumor cell proliferation,colony formation,in vitro migration,and in vivo tumor growth.Mechanistically,the expression of circGNG7 in HNSCC cells was regulated by the transcription factor SMAD family member 4(SMAD4).Importantly,we discovered that circGNG7 could bind to serine residues 78 and 82 of the functional heat shock protein 27(HSP27),occupying its phosphorylation sites and hindering its phosphorylation,which reduced HSP27-JNK/P38 mitogen-activated protein kinase(MAPK)oncogenic signaling.Downregulation of circGNG7 expression in HNSCC increased HSP27-JNK/P38 MAPK signaling and promoted tumor progression.Conclusions:Our results revealed that a new intronic circRNA,circGNG7,functions as a strong tumor suppressor and that circGNG7/HSP27-JNK/P38 MAPK signaling is a novel mechanism by which HNSCC progression can be controlled. | Houyu Ju Zhenrong Hu Dongliang Wei Jinyun Huang Xinyi Zhang Mengyu Rui Zhi Li Xiaomeng Zhang Jingzhou Hu Wei Guo Guoxin Ren | 2021 | Cancer Communications2021，41，11： | 4 |
| 16 | Phase boundary engineering of metal-organic-framework-derived carbonaceous nickel selenides for sodium-ion batteries显示文摘Nano Research volume 13,pages2289–2298(2020)Cite this article 347 Accesses 1 Altmetric Metrics details Abstract Sodium-ion batteries(SIBs)are promising power sources due to the low cost and abundance of battery-grade sodium resources,while practical SIBs suffer from intrinsically sluggish diffusion kinetics and severe volume changes of electrode materials.Metal-organic framework(MOFs)derived carbonaceous metal compound offer promising applications in electrode materials due to their tailorable composition,nanostructure,chemical and physical properties.Here,we fabricated hierarchical MOF-derived carbonaceous nickel selenides with bi-phase composition for enhanced sodium storage capability.As MOF formation time increases,the pyrolyzed and selenized products gradually transform from a single-phase Ni3Se4 into bi-phase NiSex then single-phase NiSe2,with concomitant morphological evolution from solid spheres into hierarchical urchin-like yolk-shell structures.As SIBs anodes,bi-phase NiSex@C/CNT-10h(10 h of hydrothermal synthesis time)exhibits a high specific capacity of 387.1 mAh/g at 0.1 A/g,long cycling stability of 306.3 mAh/g at a moderately high current density of 1 A/g after 2,000 cycles.Computational simulation further proves the lattice mismatch at the phase boundary facilitates more interstitial space for sodium storage.Our understanding of the phase boundary engineering of transformed MOFs and their morphological evolution is conducive to fabricate novel composites/hybrids for applications in batteries,catalysis,sensors,and environmental remediation. | Shiyao Lu Hu Wu Jingwei Hou Limin Liu Jiao Li Chris J.Harris Cheng-Yen Lao Yuzheng Guo Kai Xi Shujiang Ding Guoxin Gao Anthony K.Cheetham R.Vasant Kumar | 2020 | Nano Research2020，13，8： | 4 |
| 17 | Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma显示文摘 | Sun Kai Su Guiyuan Deng Haijun Dong Jingqing Lei Shangtong Li Guoxin | 2014 | Chinese Medical Journal2014，，10： | 4 |
| 18 | Fine mapping of the awn gene on chromosome 4 in rice by association and linkage analyses显示文摘Awnness is a key trait in rice domestication, yet no studies have been conducted on fine mapping or association mapping of the rice awn gene. In this study, we investigated the awnness and genotype of a core collection of 303 cultivated rice varieties and a BC5F2 segregating population of 200 individuals. Combining association and linkage analyses, we mapped the awnness related genes to chromosome 4. Primary association analysis using 24 SSR markers revealed five loci significantly associated with awnness on chromosome 4. The associated markers cover previously identified regions. Fine association mapping was conducted using another 29 markers within a 4-Mb region, covering the associated marker in34, which is close to the awn gene Awn4.1. Seven associated markers were revealed, distributed over an 870-kb region. Combining the fine association mapping and linkage analysis of awnness in the 200 BC5F2 segregating population, we finally identified a 330-kb region as the candidate region for Awn4.1. The results indicate that combining association mapping and linkage mapping provides an efficient and precise approach to both genome-wide mapping and fine mapping of rice genes. | HU GuangLong ZHANG DongLing PAN HuiQiao LI Ben WU JianTao ZHOU XueYa ZHANG QunYuan ZHOU Lei YAO GuoXin LI JunZhou LI JinJie ZHANG HongLiang LI ZiChao | 2011 | Chinese Science Bulletin2011，56，9： | 4 |
| 19 | A'One Engine with Six Gears'System Engineering Methodology for the Economic Development of Unconventional Oil and Gas in China显示文摘Unconventional oil and gas resources have become the most important and realistic field for increasing China’s domestic oil and gas reserves and production.At present,the production scale does not match the massive amount of resources and the rapid growth of proven geological reserves.The challenges of technology,cost,management,and methodology restrict large-scale and economic development.Based on successful practices,a'one engine with six gears'system engineering methodology is put forward,which includes life-cycle management,overall synergy,interdisciplinary cross-service integration,marketoriented operation,socialized support,digitalized management,and low-carbon and green development.The methodology has been proved to be effective in multiple unconventional oil and gas national demonstration areas,including the Jimusar continental shale oil demonstration area.Disruptive views are introduced-namely,that unconventional oil and gas do not necessarily yield a low return,nor do they necessarily have a low recovery factor.A determination to achieve economic benefit must be a pervasive underlying goal for managers and experts.Return and recovery factors,as primary focuses,must be adhered to during China’s development of unconventional oil and gas.The required methodology transformation includes a revolution in management systems to significantly decrease cost and increase production,resulting in technological innovation. | Guoxin Li Chenggang Xian He Liu | 2022 | Engineering2022，，11： | 3 |
| 20 | A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform显示文摘The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery. | Yibin Yu Ruoxi Feng Jinyu Li Yuanyuan Wang Yiming Song Guoxin Tan Dandan Liu Wei Liu Xinggang Yang Hao Pan Sanming Li | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员