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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | Eremophilane Sesquiterpenes from Cacalia Roborowskii显示文摘Four new eremophilane type sesquitopnes were isolated from the roots of Cacalia roborowrkii (Maxim) Ling. Their tricfores were eStablished as 8-oxo-eremophila-6. 9-dien-12-oic acid (1), 3β -acetoxyl- 8-oxo-eremophila-6, 9 -dien- 12 -oic aci (2), 3β-angeloyoxyl-8-oxo- eremophila-6, 9-dien-12-oic acid (3) and 3β -(2 -methylbutyryloxyl )-8-oxo-eremophila-6, 9-dien-12- oic acid (4) by means of iD and 2D NOR spectroscopy. | Zhang, SM Zhao, GL Li, R Lin, GQ | 1998 | Chinese Chemical Letters1998，9，1： | 5 |
| 3 | Cultivation-dependent and cultivation-independent characterization of the microbial community in acid mine drainage associated with acidic Pb/ Zn mine tailings at Lechang, Guangdong, China显示文摘 | Tan GL Shu WS Hallberg KB Li F Lan CY Huang LN | 2007 | 中国生物学文摘2007，21，7： | 3 |
| 4 | NMR imaging studies of coal swollen with pyridine显示文摘NMR imaging is a new NMR technique which appeared in these twenty years. The most important difference from the traditional NMR technique is that it can distinguish what signals will be provided by which part of the sample. Since Lauterbur reported the first NMR imaging in 1973, this technique has been widely used in biological, medical, geological, and material studies. NMR imaging technique has also been used in the study of coal structure in | Ma, ZR Zhang, PZ Ding, GL Li, LY Ye, CH | 1997 | Chinese Science Bulletin1997，42，16： | 2 |
| 5 | Apoptosis and expression of BECL-2 after compression tranuma to rat spinal cord显示文摘 | Li GL Brodin G Farooque M | 1996 | J Neuropathol Exp Neuro1996，55，： | 1 |
| 6 | An intergroup phase Ⅲ comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer 显示文摘 | Adelstein D J Li Y Adams GL | 2003 | J Clin Oncol2003，21，： | 1 |
| 7 | In vivo immunogenicity of purified allogeneic hepatocytes in a murine hepatocyte transplant model显示文摘 | Bumgardner GL Li J Heininger M | 1998 | Transplantation1998，65，1： | 1 |
| 8 | Pymsequeneing reveals bacterial communities in unchlorinated drinking water distribution system:an integral study of bulk water,suspended solids,loose deposits,and pipe wall hiofilm显示文摘 | Liu G Bakker GL Li S et at | 2014 | Environ Sei Technol2014，48，： | 1 |
| 9 | Determinants and prognostic implications of reperfusion injury during primary percutaueous coronary intervention in Chinese patients with acute myocardial infarction 显示文摘 | Luo Y Li GL Pan YZ | 2009 | Clin Cardiol2009，32，3： | 1 |
| 10 | Phenylpropanoid glycoside from Lamiophlomis rotata显示文摘 | Yi JH Zhang GL Li BG | 1999 | Phytochemistry1999，51，6： | 1 |
| 11 | Comprehensive study of lead pollution in Shanghai by multiple techniques显示文摘 | TAN MG ZHANG GL LI XL | | 0，，23： | 1 |
| 12 | Changes of fas and fas ligand immunoreactivity after compression trauma to rat spinal cord显示文摘 | Li GL Farooque M Olsson Y | 2000 | Acta Neuropathol (Berl)2000，100，： | 1 |
| 13 | Acute Promyelocytic Leukemia Clinical relevance of two major PML-RARa isoforms and detection of two minimal residual diease by RT-PCR to predict relapse显示文摘 | Huang W Sun GL Li Xs | 1993 | Blood1993，82，： | 1 |
| 14 | Efficacy of anti-intercellular adhesion molecule-1 immunotherapy on immue responses to allogeneic hepatocytes in mice显示文摘 | Bumgardner GL Li J Heininger M | 1998 | Hepatology1998，28，4： | 1 |
| 15 | Apoptosis and expression of Bcl-2 after expression trauma to rat spinal cord显示文摘 | Li GL Brodin G Farooque M | 1996 | J Neuropathol Exp neurol1996，55，3： | 1 |
| 16 | Dose escalation of threedimensional conformal radiotherapy for locally recurrent nasopharyngeal carcinoma: a prospective randomized study显示文摘 | Li JC Hu CS Jiang GL | 2006 | Clin Oncol(R Coil Radiol)2006，18，4： | 1 |
| 17 | Clay minerals in a soil chronosequence derived from basalt on Hainan Island, China and its implication for pedogenesis显示文摘 | He Y Li DC Velde B Yang YF Huang CM Gong ZT Zhang GL | 2008 | Geoderma2008，148，： | 1 |
| 18 | Eicosapentanoic acid inhibits hypoxiareoxygenation induced injury by attenuating upregulation of MMP-1 in adult rat myocytes显示文摘 | Chen H Li D Roberts Gl | 2003 | Cardiovas Res2003，59，1： | 1 |
| 19 | Perioperative cimetidine administration enhances tumor infiltration lymphocytes and HLA- DR expression in colorectal cancer 显示文摘 | Chen A J Li Y Yang GL | 2006 | ChineseGerman Clin Oncol2006，，： | 1 |
| 20 | A twenty-four-week, open-label study onziprasidone's efficacy and influence on glucolipid metabolism in patientswith schizophrenia and metabolic disorder显示文摘 | Li CH Shi L Zhan GL | 2013 | Eur Rev Med PharmacolSci2013，17，16： | 1 |
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