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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | Using MRI to determine painful vertebrae to be treated by kyphoplasty in multiple-level vertebral compression fractures:a prospective study显示文摘 | Yang HL Wang GL Niu GQ | 2008 | J Int Med Res2008，36，： | 1 |
| 3 | Improved genome annotation for Zymomonasmobilis 显示文摘 | Yang S Pappas KM Hauser LJ Land ML Chen GL Hurst GB PanC Kouvelis VN Typas MA Pelletier DA Klinqeman DM Chanq YJ Samatova NF Brown SD | 2009 | Nat Biotechnol2009，27，10： | 1 |
| 4 | Rat arterial wall remodeling under sustained twist 显示文摘 | WANG GL WANG LY YANG SX | 2016 | To be submitted2016，，： | 1 |
| 5 | Clay minerals in a soil chronosequence derived from basalt on Hainan Island, China and its implication for pedogenesis显示文摘 | He Y Li DC Velde B Yang YF Huang CM Gong ZT Zhang GL | 2008 | Geoderma2008，148，： | 1 |
| 6 | Surgery for thoracic myelop- athy caused by ossification of the ligamentum flavum 显示文摘 | Chen XQ Yang HL Wang GL | 2009 | J Clin Neurosci2009，16，10： | 1 |
| 7 | Perioperative cimetidine administration enhances tumor infiltration lymphocytes and HLA- DR expression in colorectal cancer 显示文摘 | Chen A J Li Y Yang GL | 2006 | ChineseGerman Clin Oncol2006，，： | 1 |
| 8 | Effect of neonatal isolation on outcome following neonatal sei- zures in rats-the role of eorticosterone 显示文摘 | Lai MC Holmes GL Lee KH Yang SN Wang CA Wu CL | 2006 | Epilepsy Res2006，68，2： | 1 |
| 9 | Protective effect of tetrahydroxystilbene glucoside against hydrogen peroxide- induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells 显示文摘 | Zhang JK Yang L Meng GL | 2012 | European Journal of Pharmacolo- gy2012，689，13： | 1 |
| 10 | The third generation cohort of the National Heart,Lung,and Blood Institute's Framingham Heart Study:design,recruitment,and initial examination显示文摘 | Splansky GL Corey D Yang Q | 2007 | Am J Epidemiol2007，165，11： | 1 |
| 11 | Effect of fluoride on expression of PURA gene and CaM gene in newborn rat osteoblasts显示文摘 | Tang QQ Yang X Tang GL | 2007 | Fluoride2007，40，1： | 1 |
| 12 | Using MRI to determine painful vertebrae to be treated by kyphoplasty in multiplelevel vertebral compression fractures:a prospective study显示文摘 | Yang HL Wang GL Niu GQ | 2008 | J Int Med Res2008，36，5： | 1 |
| 13 | Gene therapy for central nervous systerm injury: the use of cationic liposomes: An invited review 显示文摘 | Yang K Clifton GL Hayes FL | 1997 | J Neurotrauma1997，14，5： | 1 |
| 14 | Effect of β-blocker prescription on the incidence of postoperative myocardial infarction after hip and knee arthroplasty显示文摘 | Van Klei WA Bryson GL Yang H | | Anesthesiology0，，： | 1 |
| 15 | Overexpression of HM- GA2 in bladder cancer and its association with clinicopathologic features and prognosis显示文摘 | YANG GL ZHANG LH BO JJ | 2011 | The Journal of Cancer Surgery2011，，37： | 1 |
| 16 | Analysis of HLA-A,HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer显示文摘 | Yang L Wang LJ Shi GL | 2010 | Genet Mol Res2010，27，2： | 1 |
| 17 | Overexpression of HMGA2 in bladder cancer and its association with clinicopathologic features and prognosis HM- GA2 as a prognostic marker of bladder cancer显示文摘 | Yang GL Zhang LH Bo JJ | 2011 | EurJ Surg Oncol2011，37，3： | 1 |
| 18 | Biphasic insulin aspart 30 as insulin initiation or replacement therapy:the China cohort of the IMPROVE study显示文摘 | Yang WY Gao Y Liu GL | 2010 | Curr Med Res Opin2010，26，1： | 1 |
| 19 | Modified polypeptides containing gamma-benzyl glutamic acid as drug delivery platforms显示文摘 | Markland P Amidon GL Yang VC | | 0，，02： | 1 |
| 20 | Paliperidone extended release显示文摘 | Yang LP Plasker GL | 2007 | CNS Drugs2007，21，5： | 1 |
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