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| 1 | Immune Responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy显示文摘Objective To break immune tolerance to prion (PrP) proteins using DNA vaccines.Methods Four different human prion DNA vaccine candidates were constructed based on the pcDNA3.1 vector:PrP‐WT expressing wild‐type PrP,Ubiq‐PrP expressing PrP fused to ubiquitin,PrP‐LII expressing PrP fused to the lysosomal integral membrane protein type II lysosome‐targeting signal,and PrP‐ER expressing PrP locating the ER.Using a prime‐boost strategy,three‐doses of DNA vaccine were injected intramuscularly into Balb/c mice,followed by two doses of PrP protein.Two weeks after the last immunization,sera and spleens were collected and PrP‐specific humoral and cellular immune responses evaluated by ELISA and ELISPOT tests.Results Higher levels of serum PrP antibodies were detected in mice vaccinated using the strategy of DNA priming followed by protein boosting.Of these,WT‐PrP,Ubiq‐PrP,and PrP‐LII induced significantly higher humoral responses.ELISPOT tests showed markedly increased numbers of IFN‐γ‐secreting T cells in mice vaccinated using the strategy of DNA priming followed by protein boosting after stimulation with recombinant PrP23‐90 and PrP23‐231.PrP‐ER inducedthe strongest T‐cell response.Conclusion Prion vaccines can break tolerance to PrP proteins and induce PrP‐specific humoral and cellular immune responses. | HAN YanLing LI Yuan SONG Juan WANG Ying SHI Qi CHEN Cao ZHANG BaoYun GUO Yan LI ChaoPing HAN Jun DONG XiaoPing | 2011 | Biomedical and Environmental Sciences2011，24，5： | 2 |
| 2 | Effect of Spray Parameters on the Splashing of Plasma-sprayed Cast Iron Particles显示文摘To understand the effects of spray parameters on the splashing,cast iron particles were plasma-sprayed onto polished surfaces of aluminum substrate to form single splats.Various plasma arc powers and spray distances were applied to adjust the morphology of the splats which was studied using a field emission scanning electron microscope(FESEM).The experimentalresults showed that the splashing of impinging droplets was significantly restrained for the splats deposited with high arc power(30 k W)and short spray distance(80 mm).This finding would be beneficialto improving the adhesive strength of the coating. | 邢亚哲 LI Xinghang ZHANG Yong JIANG Chaoping ZHANG Weiwei | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，2： | 2 |
| 3 | Influence of cerium ions on thermal bleaching of photo-darkened ytterbium-doped fibers显示文摘We studied the influence of cerium (Ce)ions on photo-darkening (PD)behavior in ytterbium/aluminum (Yb/Al)co-doped silica fibers at room and elevated temperatures.Low levels of PD was observed for Ce codoped Yb/Al fiber.And the Yb/Al co-doped fiber was completely bleached at -600℃.The addition of Ce ions as co-dopant can significantly lower the initial recovery and complete bleaching temperatures.The complete recovery temperature is -450℃ and -400℃ for Yb/Al/Ce low fiber and Yb/Al/Ce high fiber respectively.More importantly, Ce co-doping in Yb/Al fiber also decreases the heatinduced loss. | Xiaoxia LIU Chaoping LIU Gui CHEN Haiqing LI | 2018 | Frontiers of Optoelectronics2018，11，4： | 1 |
| 4 | Foam-like boron-doped g-C_(3)N_(4) as acid-base cooperative catalyst for efficient nucleophilic addition in water显示文摘Intramolecular acid-base cooperative catalysis is a powerful strategy to promote the nucleophilic additions in synthetic chemistry,since both substrates and nucleophiles can be activated simultaneously,yielding a lower energy reaction pathway.However,the systems often suffer from catalyst quenching due to the mutual neutralization of acid/base sites.Herein,we doped the boron(B)atoms in the tri-s-triazine ring of graphite-like carbon nitride(g-C_(3)N_(4))framework,to develop the acid-base cooperative catalyst for nucleophilic addition.Characterization results demonstrated a foam-like hierarchical porous structure,as well as the coexistence of Lewis acid and base sites in the as-synthesized samples.As a result,the B-doped g-C_(3)N_(4) acted as the efficient acidbase cooperative catalysts,significantly promoting the Knoevenagel condensation whose key step involves in nucleophilic addition.A wide range of α,β-unsaturated carbonyl compounds with remarkably high yields(>90%)was achieved even within 1 h in water,whereas the acid-free or base-free counterpart was far less efficient.In addition,the bifunctional catalysts exhibited excellent reusability with simple treatment.The novel B-doped g-C_(3)N_(4) catalytic system offers several advantages,such as operational simplicity,mild reaction conditions,high efficiency,and facile reuse of catalyst.All these advantages make it a benign protocol from the sustainability point of view,and inspired us to design the other bifunctional cooperative catalysts for a wide range of sustainable industrial applications. | Jiajun Wang Zewei Liu Shiye Li Chaoping Li Su Liu Jingwen Feng Rong Tan | 2021 | Green Chemical Engineering2021，2，2： | 1 |
| 5 | Evaluation of Microstructure and Wear Properties of Ti-6Al-4V Alloy Plasma Carbonized at Different Temperatures显示文摘Ti-6Al-4V(TC4) alloys were plasma carbonized at different temperatures(900, 950, and 1 000 ℃) for duration of 3 h. Graphite rod was employed as carbon supplier to avoid the hydrogen brittleness which is ubiquitous in traditional gas carbonizing process. Two distinguished structures including a thin compound layer(carbides layer) and a thick layer with the mixed microstructure of Ti C and the α-Ti in carburing layer were formed during carburizing. Furthermore, it was found that the microstructure and the properties of TC4 alloy were signifi cantly related to the carbonizing temperature. The specimen plasma carbonized at 950 ℃ obtained maximum value both in the hardness and wear resistance. | 张勇 WEI Qiulan 邢亚哲 JIANG Chaoping LI Xinghang ZHAO Zhiyu | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，3： | 1 |
| 6 | Leadership styles and employees’ job-related attitudes: An empirical study on the mediating effects of reciprocity and trust显示文摘 | Liangding Jia Jiwen Song Chaoping Li Rongjun Cui Yongxia Chen | 2007 | Frontiers of Business Research in China2007，，4： | 1 |
| 7 | The difference of clinical characteristics of patients with COVID-19 in Fourth-tier city and Wuhan显示文摘Objective:This study mainly analyzed the clinical characteristics of patients with COVID-19 in Suining,one of China’s fourth-tier cities,and Wuhan and compared data between the 2 cities.Methods:A retrospective analysis of the clinical data of 68 patients with COVID-19 diagnosed at Wuhan Red Cross Hospital and 17 patients diagnosed at Suining Central Hospital,was conducted.Results:Among the 68 patients with COVID-19 in Wuhan,30(44.1%)had hypertension,and 25(36.8%)had diabetes.Three out of the 17 patients in Suining(17.6%)had hypertension,and 2 patients(11.8%)had diabetes.In the clinical classification,there were 1(5.9%)and 23(33.8%)patients with severe COVID-19 in Suining and Wuhan,respectively.Chest CT showed that lung consolidation occurred in 2(11.8%)and 26(38.2%)patients with COVID-19 in Suining and Wuhan,respectively.The proportion of patients with diabetes or hypertension,severe COVID-19,lung consolidation in Wuhan was significantly higher than that in Suining.The laboratory tests suggested that percentage of elevated C-reactive protein(CRP)(58.8%),ALT(33.8%),blood glucose(45.6%),creatine kinase(CK)(33.8%)or D-dimer(47.1%)of patients in Wuhan were significantly increased than those in Suining(29.4%,5.9%,17.6%,5.9%,and 17.7%,respectively).Conclusion:The incidence of COVID-19 in fourth-tier city and the disease severity were significantly lower than that in Wuhan. | Xiaojuan Wu Chaoping Wang Gaoyan He Baolin Jia Li Luo Xiaobin Luo | 2021 | Infectious Diseases Research2021，2，3： | 0 |
| 8 | Bactericide Screening against Xanthomonas axonopodis pv.manihotis显示文摘The toxicity of 12 kinds of bactericides against the pathogen of cassava bacterial blight( Xanthomonas axonopodis pv. manihotis) was determined by toxic medium method. The results showed that 2% triadimefon·30% ethylicin EC,80% ethylicin EC,70% mancozeb WP and 72% strepolin SP had the lowest effective concentration and the best inhibitory effect,while 12. 5% myclobutanil SP,20% thiodiazole-copper SC and 20% bismerthlazol WP had the highest effective concentration but the worst inhibitory effect. Field test of six kinds of bactericides was conducted in Zhanjiang City of Guangdong Province in 2011,and the results showed that 3% zhongshengmycin WP,2% triadimefon·30% ethylicin EC and 80% ethylicin EC had good control effect,which were suggested to be used for field control. | Lu Xin Li Chaoping Shi Tao Huang Guixiu | 2014 | Plant Diseases and Pests2014，5，1： | 0 |
| 9 | From moral leadership to positive work behaviors: the mediating roles of value congruence and leader-member exchange显示文摘Limited empirical investigation has been devoted to understanding the multipleeffect mechanisms of moral leadership, especially the relationship between mediators. Drawing from both social learning and social exchange theories, this study examines whether value congruenee and leader-member exchange (LMX) mediate the effect of moral leadership on followers' positive work behaviors. Using two-wave survey data from 395 Chinese employees, the results indicate that both value congruence and LMX act as mediators in the relationship between moral leadership and positive work behaviors. Furthermore, a sequential mediation link from moral leadership to value congruenee, then to LMX, and finally to positive work behaviors was established. Theoretical and practical implications are further discussed. | Yuanjie Bao Chaoping Li | 2019 | Frontiers of Business Research in China2019，13，1： | 0 |
| 10 | Jiaxing Model:An extension from main-branch library system to library service union system显示文摘There are two systems in the Jiaxing Model:the public library service system based on main-branch libraries,and the library service union system.The investigation shows that from the public library service system to the library service union system,a government-oriented model has guaranteed the public library service system to extend vertically.Village libraries have been constructed throughout the area.The model can solve the budget problem related to a loose library service union,and therefore improve the service of the unified platform.This paper is based on the analysis of government documentation and interviews from Jiaxing. | LI Chaoping ZHANG Fengming | 2012 | Journal of Library Science in China2012，，1： | 0 |
| 11 | The historical significance of the China county librarian forum显示文摘This paper describes the background,themes of the past forums,and the four consensuses reached during the China County Librarian Forum.The issues discussed during the forums closely match the political context and social environment of their time,and answer the questions that county-level libraries had.The paper also shows that the four consensuses involve three types of discourses:administrative appeals,appeals to legal system construction,and appeals to professional self-discipline.The historical significance of this forum is that it has placed county-level libraries into spectrum of academic research,and thus has altered the situation of county-level libraries being ignored for a long time. | LI Chaoping | 2013 | Journal of Library Science in China2013，，1： | 0 |
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